Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1529 | 0.1529 |
Schistosoma mansoni | nicalin (M28 family) | 0.0084 | 0.1529 | 0.1529 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0084 | 0.1529 | 0.1529 |
Brugia malayi | nicalin | 0.0084 | 0.1529 | 0.1529 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.1529 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0084 | 0.1529 | 0.1529 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0084 | 0.1529 | 0.1529 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0084 | 0.1529 | 0.1529 |
Brugia malayi | leucyl aminopeptidase | 0.0084 | 0.1529 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1529 | 0.1529 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0084 | 0.1529 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0084 | 0.1529 | 0.1529 |
Mycobacterium tuberculosis | Conserved protein | 0.0084 | 0.1529 | 0.5 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0084 | 0.1529 | 0.1529 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0084 | 0.1529 | 0.1529 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0529 | 1 | 1 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0084 | 0.1529 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0084 | 0.1529 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.1529 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 1 | 1 |
Brugia malayi | FXNA | 0.0084 | 0.1529 | 0.1529 |
Leishmania major | glutaminyl cyclase, putative | 0.0084 | 0.1529 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0529 | 1 | 1 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0084 | 0.1529 | 0.1529 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0084 | 0.1529 | 0.1529 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0084 | 0.1529 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0084 | 0.1529 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0084 | 0.1529 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1529 | 0.1529 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1529 | 0.1529 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.1529 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.1529 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0084 | 0.1529 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0529 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0084 | 0.1529 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.1529 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0529 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 20.3 nM | Antagonist activity against human TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced channel activation by FLIPR assay | ChEMBL. | 25011915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.