Detailed information for compound 922125

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.474 | Formula: C21H22N2O6S
  • H donors: 1 H acceptors: 3 LogP: 2.54 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cc(cc1OC)C(=O)c1ccn(c1)c1cccc(c1)NS(=O)(=O)C
  • InChi: 1S/C21H22N2O6S/c1-27-18-10-15(11-19(28-2)21(18)29-3)20(24)14-8-9-23(13-14)17-7-5-6-16(12-17)22-30(4,25)26/h5-13,22H,1-4H3
  • InChiKey: OYSWJDZJQQPEGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.003 0.053 0.053
Giardia lamblia Beta tubulin 0.003 0.053 0.0608
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0071 0.3033 0.3033
Entamoeba histolytica type A flavoprotein, putative 0.0071 0.3033 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0186 1 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0186 1 1
Toxoplasma gondii beta-tubulin, putative 0.003 0.053 0.1228
Schistosoma mansoni cytochrome P450 reductase 0.0186 1 1
Leishmania major beta tubulin 0.003 0.053 0.053
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0071 0.3033 0.3033
Schistosoma mansoni NADPH flavin oxidoreductase 0.0093 0.4402 0.4402
Echinococcus multilocularis tubulin, beta 4A class IVa 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0071 0.3033 0.3033
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0186 1 1
Echinococcus granulosus tubulin beta 1 chain 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Toxoplasma gondii beta tubulin 0.003 0.053 0.1228
Brugia malayi Tubulin beta-1 chain 0.003 0.053 0.053
Plasmodium falciparum nitric oxide synthase, putative 0.0186 1 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0071 0.3033 0.2643
Treponema pallidum flavodoxin 0.0071 0.3033 1
Trypanosoma brucei beta tubulin 0.003 0.053 0.053
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0071 0.3033 0.3033
Mycobacterium tuberculosis Possible oxygenase 0.0021 0 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.053 0.053
Leishmania major hypothetical protein, conserved 0.0071 0.3033 0.3033
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0192 0.0192
Giardia lamblia Nitric oxide synthase, inducible 0.0164 0.8717 1
Leishmania major cytochrome P450 reductase, putative 0.0164 0.8717 0.8717
Leishmania major p450 reductase, putative 0.0186 1 1
Schistosoma mansoni tubulin subunit beta 0.003 0.053 0.053
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0186 1 1
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0186 1 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0186 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.003 0.053 0.053
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0186 1 1
Giardia lamblia Beta tubulin 0.003 0.053 0.0608
Loa Loa (eye worm) beta-tubulin 0.003 0.053 0.053
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Trypanosoma brucei beta tubulin 0.003 0.053 0.053
Plasmodium vivax flavodoxin domain containing protein 0.0164 0.8717 0.8717
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0186 1 1
Leishmania major beta tubulin 0.003 0.053 0.053
Echinococcus granulosus tubulin beta 4A class IVa 0.003 0.053 0.053
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0071 0.3033 0.3033
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0186 1 1
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0186 1 1
Chlamydia trachomatis sulfite reductase 0.0115 0.5684 1
Echinococcus granulosus beta tubulin 0.003 0.053 0.053
Trypanosoma brucei beta tubulin 0.003 0.053 0.053
Echinococcus granulosus beta tubulin 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.053 0.053
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.053 0.053
Echinococcus multilocularis beta tubulin 0.003 0.053 0.053
Entamoeba histolytica type A flavoprotein, putative 0.0071 0.3033 1
Entamoeba histolytica type A flavoprotein, putative 0.0071 0.3033 1
Mycobacterium tuberculosis Probable monooxygenase 0.0021 0 0.5
Leishmania major beta tubulin 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Echinococcus multilocularis tubulin beta 1 chain 0.003 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0186 1 1
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0115 0.5684 0.5684
Schistosoma mansoni diflavin oxidoreductase 0.0092 0.4316 0.4316
Loa Loa (eye worm) FAD binding domain-containing protein 0.0186 1 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0164 0.8717 0.8646
Loa Loa (eye worm) tubulin beta-2A chain 0.003 0.053 0.053
Loa Loa (eye worm) flavodoxin family protein 0.0071 0.3033 0.3033
Leishmania major beta tubulin 0.003 0.053 0.053
Entamoeba histolytica type A flavoprotein, putative 0.0071 0.3033 1
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0186 1 1
Echinococcus multilocularis beta tubulin 0.003 0.053 0.053
Schistosoma mansoni tubulin subunit beta 0.003 0.053 0.053
Entamoeba histolytica type A flavoprotein, putative 0.0071 0.3033 1
Leishmania major beta tubulin 0.003 0.053 0.053
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.053 0.053
Trypanosoma cruzi p450 reductase, putative 0.0186 1 1
Loa Loa (eye worm) tubulin beta chain 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Echinococcus multilocularis tubulin subunit beta 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0071 0.3033 0.3033
Onchocerca volvulus 0.0021 0 0.5
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.053 0.053
Plasmodium vivax tubulin beta chain, putative 0.003 0.053 0.053
Schistosoma mansoni tubulin subunit beta 0.003 0.053 0.053
Toxoplasma gondii flavodoxin domain-containing protein 0.0092 0.4316 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0 0.5
Loa Loa (eye worm) BEN-1 protein 0.003 0.053 0.053
Plasmodium vivax hypothetical protein, conserved 0.0071 0.3033 0.3033
Echinococcus granulosus methionine synthase reductase 0.0115 0.5684 0.5684
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0071 0.3033 0.2643
Loa Loa (eye worm) tubulin beta-1 chain 0.003 0.053 0.053
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0021 0 0.5
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0186 1 1
Trypanosoma brucei beta tubulin 0.003 0.053 0.053
Brugia malayi beta-tubulin, identical 0.003 0.053 0.053
Schistosoma mansoni tubulin subunit beta 0.003 0.053 0.053
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0071 0.3033 0.2643
Leishmania major beta tubulin 0.003 0.053 0.053
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0186 1 1
Trypanosoma cruzi beta tubulin, putative 0.003 0.053 0.053
Schistosoma mansoni tubulin subunit beta 0.003 0.053 0.053
Loa Loa (eye worm) FAD binding domain-containing protein 0.0115 0.5684 0.5684
Echinococcus multilocularis Tubulin beta 2C chain 0.003 0.053 0.053
Brugia malayi FAD binding domain containing protein 0.0115 0.5684 0.5684
Leishmania major beta tubulin 0.003 0.053 0.053
Brugia malayi Cytochrome P450 family protein 0.0024 0.0192 0.0192
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Giardia lamblia Hypothetical protein 0.0164 0.8717 1
Brugia malayi FAD binding domain containing protein 0.0186 1 1
Giardia lamblia Beta tubulin 0.003 0.053 0.0608
Toxoplasma gondii beta-1 tubulin, putative 0.003 0.053 0.1228
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Leishmania major beta tubulin 0.003 0.053 0.053
Echinococcus granulosus Tubulin beta 2C chain 0.003 0.053 0.053
Toxoplasma gondii flavodoxin domain-containing protein 0.0092 0.4316 1
Plasmodium falciparum tubulin beta chain 0.003 0.053 0.053
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0071 0.3033 0.2643
Echinococcus multilocularis methionine synthase reductase 0.0115 0.5684 0.5684
Loa Loa (eye worm) BEN-1 protein 0.003 0.053 0.053
Trichomonas vaginalis sulfite reductase, putative 0.0186 1 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0186 1 1
Schistosoma mansoni tubulin subunit beta 0.003 0.053 0.053
Echinococcus granulosus tubulin subunit beta 0.003 0.053 0.053
Brugia malayi flavodoxin family protein 0.0071 0.3033 0.3033
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0021 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 61 % Cell cycle arrest in human K562 cells assessed as mitotic index at 10 times IC50 (Rvb = 3 +/- 1%) ChEMBL. 25025991
IC50 (functional) = 18 nM Cytotoxicity against human K562 cells assessed as growth inhibition after 96 hrs by Giemsa staining-based light microscopy ChEMBL. 25025991
IC50 (binding) = 0.86 uM Inhibition of tubulin (unknown origin) polymerization incubated 15 mins prior to GTP addition by spectrophotometry ChEMBL. 25025991
Inhibition (binding) = 84 % Displacement of [3H]colchicine from tubulin (unknown origin) at 5 uM after 10 mins ChEMBL. 25025991

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 25025991

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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