Detailed information for compound 922486

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 485.404 | Formula: C17H17F6N5O3S
  • H donors: 2 H acceptors: 5 LogP: 1.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ccc(cn1)C(C(F)(F)F)(C(F)(F)F)O
  • InChi: 1S/C17H17F6N5O3S/c18-16(19,20)15(29,17(21,22)23)11-1-4-14(26-9-11)27-5-7-28(8-6-27)32(30,31)12-2-3-13(24)25-10-12/h1-4,9-10,29H,5-8H2,(H2,24,25)
  • InChiKey: CKLVLBHPCGYRLW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus glucokinase Starlite/ChEMBL References
Homo sapiens glucokinase (hexokinase 4) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hexokinase family protein glucokinase 465 aa 473 aa 29.4 %
Brugia malayi Hexokinase family protein glucokinase (hexokinase 4) 465 aa 470 aa 30.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni adenoreceptor 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0096 0.0096
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0096 0.0096
Brugia malayi GnHR receptor homolog 0.0039 0.0096 0.0096
Echinococcus multilocularis sex peptide receptor 0.0039 0.0096 0.0096
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0096 0.0096
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0096 0.0096
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptide receptor 0.0039 0.0096 0.0096
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.2825 1 1
Brugia malayi G-protein coupled receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni amine GPCR 0.0039 0.0096 0.0096
Schistosoma mansoni amine GPCR 0.0039 0.0096 0.0096
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.2825 1 1
Schistosoma mansoni hypothetical protein 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0096 0.0096
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni biogenic amine receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi neuropeptide F receptor 0.0039 0.0096 0.0096
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0096 0.0096
Trypanosoma brucei hexokinase, putative 0.0192 0.0641 0.0622
Brugia malayi putative neuropeptide receptor 0.0039 0.0096 0.0096
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0096 0.0096
Loa Loa (eye worm) hexokinase 0.0192 0.0641 0.0641
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0021 0.0021
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus granulosus hexokinase type 2 0.0192 0.0641 0.0641
Brugia malayi Cytochrome P450 family protein 0.0029 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Trypanosoma brucei hexokinase 0.0192 0.0641 0.0622
Loa Loa (eye worm) hypothetical protein 0.0036 0.0085 0.0085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0096 0.0096
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.2825 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis hexokinase 0.0192 0.0641 0.0641
Echinococcus granulosus somatostatin receptor 0.0039 0.0096 0.0096
Echinococcus granulosus orexin receptor type 2 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Trypanosoma cruzi hexokinase, putative 0.0192 0.0641 0.0622
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0096 0.0096
Echinococcus granulosus g protein coupled receptor 0.0039 0.0096 0.0096
Schistosoma mansoni amine GPCR 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0096 0.0096
Echinococcus granulosus sex peptide receptor 0.0039 0.0096 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0118 0.0118
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0096 0.0096
Brugia malayi hexokinase type II 0.0061 0.0175 0.0175
Brugia malayi Hexokinase family protein 0.0192 0.0641 0.0641
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0104 0.0104
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.2825 1 1
Schistosoma mansoni myosin xvIII 0.0039 0.0096 0.0096
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.2825 1 1
Brugia malayi Melatonin receptor type 1A 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0096 0.0096
Onchocerca volvulus 0.0192 0.0641 1
Echinococcus granulosus g protein coupled receptor 0.0039 0.0096 0.0096
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.2825 1 0.5
Brugia malayi neuropeptide F receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0096 0.0096
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0096 0.0096
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0096 0.0096
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.2825 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.2825 1 1
Echinococcus granulosus fmrfamide receptor 0.0039 0.0096 0.0096
Echinococcus granulosus hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0096 0.0096
Treponema pallidum hexokinase (hxk) 0.0192 0.0641 0.5
Brugia malayi Dopamine receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis serotonin receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis hexokinase 0.0192 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0118 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Schistosoma mansoni histamine h1 receptor 0.0039 0.0096 0.0096
Onchocerca volvulus 0.0192 0.0641 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0096 0.0096
Onchocerca volvulus 0.0121 0.0386 0.5323
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0096 0.0096
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0096 0.0096
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.2825 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi AKH receptor 0.0039 0.0096 0.0096
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0096 0.0096
Trypanosoma brucei hexokinase 0.0192 0.0641 0.0622
Brugia malayi ORL1-like opioid receptor 0.0039 0.0096 0.0096
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.2825 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Brugia malayi larval opioid receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis serotonin receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0096 0.0096
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0096 0.0096
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0096 0.0096
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0096 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0096 0.0096
Schistosoma mansoni amine GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi Cytochrome P450 family protein 0.0018 0.0021 0.0021
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0096 0.0096
Brugia malayi hexokinase 0.0192 0.0641 0.0641
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0096 0.0096
Echinococcus granulosus serotonin receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi Hexokinase family protein 0.006 0.0169 0.0169
Loa Loa (eye worm) hexokinase 0.0192 0.0641 0.0641
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0096 0.0096
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0175
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0096 0.0096
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.2825 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0096 0.0096
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0096 0.0096
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Trypanosoma cruzi hexokinase, putative 0.0192 0.0641 0.0622
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0096 0.0096
Schistosoma mansoni opsin-like receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Onchocerca volvulus Hexokinase homolog 0.0121 0.0386 0.5323
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis hexokinase 0.0192 0.0641 0.0641
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0096 0.0096
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0096 0.0096
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.2825 1 1
Echinococcus granulosus hexokinase 0.0192 0.0641 0.0641
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi RE15519p 0.0039 0.0096 0.0096
Echinococcus granulosus hexokinase 0.0192 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.2825 1 1
Leishmania major hexokinase, putative 0.0192 0.0641 0.0622
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0096 0.0096
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0096 0.0096
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi follicle stimulating hormone receptor 0.0039 0.0096 0.0096
Brugia malayi Serotonin receptor 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0096 0.0096
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.2825 1 1
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0096 0.0096
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0096 0.0096
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi Serotonin receptor 0.0039 0.0096 0.0096
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.2825 1 1
Brugia malayi Dopamine receptor protein 1 0.0039 0.0096 0.0096
Mycobacterium ulcerans hypothetical protein 0.1233 0.4342 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni biogenic amine receptor 0.0039 0.0096 0.0096
Schistosoma mansoni neuropeptide receptor 0.0039 0.0096 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Echinococcus granulosus hexokinase 0.0192 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0104 0.0104
Schistosoma mansoni amine GPCR 0.0039 0.0096 0.0096
Schistosoma mansoni neuropeptide receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0096 0.0096
Onchocerca volvulus 0.0192 0.0641 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0096 0.0096
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0104 0.0104
Schistosoma mansoni neuropeptide receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0096 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0096 0.0096
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hexokinase 0.006 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0061 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0096 0.0096
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0096 0.0096
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0096 0.0096
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis 0.2825 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0096 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Brugia malayi G protein-coupled receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0021 0.0021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0096 0.0096
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0096 0.0096
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0096 0.0096
Brugia malayi Cytochrome P450 family protein 0.0018 0.0021 0.0021
Echinococcus granulosus g protein coupled receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi G-protein coupled receptor 0.0039 0.0096 0.0096
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0096 0.0096
Leishmania major hexokinase, putative 0.0192 0.0641 0.0622
Echinococcus multilocularis hexokinase type 2 0.0192 0.0641 0.0641
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hexokinase type II 0.0192 0.0641 0.0641
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0096 0.0096
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.2825 1 1
Schistosoma mansoni neuropeptide receptor 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0096 0.0096
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0021 0.0021
Schistosoma mansoni biogenic amine receptor 0.0039 0.0096 0.0096
Brugia malayi Hexokinase family protein 0.0121 0.0386 0.0386
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0096 0.0096
Brugia malayi Dopamine receptor protein 2 0.0039 0.0096 0.0096
Schistosoma mansoni opsin-like receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hexokinase 0.0121 0.0386 0.0386
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0096 0.0096
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0096 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0096 0.0096
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Brugia malayi sulfakinin receptor protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0096 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0096 0.0096
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.1233 0.4342 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0096 0.0096
Echinococcus granulosus allatostatin A receptor 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0131 0.0424 0.0424
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0062 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0096 0.0096
Schistosoma mansoni opsin-like receptor 0.0039 0.0096 0.0096
Echinococcus granulosus neuropeptide receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0096 0.0096
Echinococcus multilocularis somatostatin receptor 0.0039 0.0096 0.0096
Schistosoma mansoni hexokinase 0.0192 0.0641 0.0641
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0096 0.0096
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0096 0.0096

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) < 14 microL/min/mg Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH ChEMBL. 25001129
EC50 (binding) > 12.5 uM Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay ChEMBL. 25001129
IC50 (binding) = 0.176 uM Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by AlphaScreen assay ChEMBL. 25001129

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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