Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Purinergic receptor P2Y12 | Starlite/ChEMBL | References |
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuropeptide receptor | Purinergic receptor P2Y12 | 343 aa | 349 aa | 22.6 % |
Echinococcus multilocularis | rhodopsin orphan GPCR | Purinergic receptor P2Y12 | 343 aa | 347 aa | 20.2 % |
Schistosoma mansoni | neuropeptide receptor | Purinergic receptor P2Y12 | 343 aa | 305 aa | 24.9 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Purinergic receptor P2Y12 | 343 aa | 359 aa | 20.9 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Purinergic receptor P2Y12 | 343 aa | 334 aa | 21.6 % |
Schistosoma japonicum | Myosin-XVIIIa, putative | Purinergic receptor P2Y12 | 343 aa | 325 aa | 22.8 % |
Onchocerca volvulus | Purinergic receptor P2Y12 | 343 aa | 323 aa | 22.3 % | |
Echinococcus multilocularis | neuropeptide receptor | Purinergic receptor P2Y12 | 343 aa | 325 aa | 23.7 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Purinergic receptor P2Y12 | 343 aa | 372 aa | 19.6 % |
Onchocerca volvulus | Purinergic receptor P2Y12 | 343 aa | 281 aa | 22.8 % | |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Purinergic receptor P2Y12 | 343 aa | 328 aa | 23.5 % |
Echinococcus multilocularis | allatostatin A receptor | Purinergic receptor P2Y12 | 343 aa | 337 aa | 21.4 % |
Echinococcus granulosus | allatostatin A receptor | Purinergic receptor P2Y12 | 343 aa | 337 aa | 21.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.6551 | 1 |
Echinococcus granulosus | netrin 1 | 0.0192 | 0.6551 | 1 |
Brugia malayi | Unc-6 protein precursor | 0.0192 | 0.6551 | 1 |
Echinococcus multilocularis | netrin 1 | 0.0192 | 0.6551 | 1 |
Schistosoma mansoni | netrin | 0.0192 | 0.6551 | 1 |
Schistosoma mansoni | netrin | 0.0192 | 0.6551 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | = 6 % | Metabolic stability in human liver microsomes assessed as compound metabolism after 20 mins incubation in presence of 1 mM NADPH | ChEMBL. | 25075638 |
IC50 (binding) | = 574 nM | Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis | ChEMBL. | 25075638 |
IC50 (binding) | = 8 uM | Antagonist activity at P2Y12 receptor in Sprague-Dawley rat platelet rich plasma assessed as inhibition of ADP-induced aggregation | ChEMBL. | 25075638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.