TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 307.434 | Formula: C14H17N3OS2
H donors: 1 H acceptors: 1 LogP: 3.02 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC1SC(=NC1=O)N/N=C/CCCSc1ccccc1
InChi: 1S/C14H17N3OS2/c1-11-13(18)16-14(20-11)17-15-9-5-6-10-19-12-7-3-2-4-8-12/h2-4,7-9,11H,5-6,10H2,1H3,(H,16,17,18)/b15-9+
InChiKey: KCSVKRINPHWIDN-OQLLNIDSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2088	0.1946
Echinococcus granulosus	serine:threonine protein kinase Chk2	0.0159	0.8396	1
Leishmania major	cathepsin L-like protease	0.0077	0.377	1
Echinococcus multilocularis	exocyst complex component 2	0.0021	0.0584	0.0695
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0177	0.0177
Schistosoma mansoni	hypothetical protein	0.0021	0.0584	0.0584
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2088	0.1946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0584	1
Schistosoma mansoni	hypothetical protein	0.0021	0.0584	0.0584
Schistosoma mansoni	serine/threonine protein kinase	0.0159	0.8396	0.8396
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.3392	0.8997
Echinococcus granulosus	semaphorin 1A	0.0047	0.2088	0.2487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0177	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0113	0.5819	0.5744
Echinococcus granulosus	calcium:calmodulin dependent protein kinase I	0.0159	0.8393	0.9996
Onchocerca volvulus		0.002	0.0555	0.067
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Brugia malayi	Cathepsin L-like precursor	0.002	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.002	0.0555	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0.0897	0.1069
Brugia malayi	cathepsin L-like precursor	0.0014	0.0177	0.0177
Echinococcus multilocularis	serine:threonine protein kinase Chk2	0.0159	0.8396	1
Entamoeba histolytica	protein kinase, putative	0.0159	0.8396	1
Schistosoma mansoni	serine/threonine protein kinase	0.0187	1	1
Onchocerca volvulus		0.002	0.0555	0.067
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0555	0.0661
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0555	0.067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Onchocerca volvulus		0.0047	0.2088	0.3388
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.377	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0014	0.0177	0.3024
Brugia malayi	plexin A	0.0134	0.6992	0.6992
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0555	1
Echinococcus multilocularis	hypothetical protein	0.0047	0.2088	0.2487
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0584	1
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0555	0.1472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Echinococcus granulosus	exocyst complex component 2	0.0021	0.0584	0.0695
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.377	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.377	1
Schistosoma mansoni	hypothetical protein	0.0047	0.2088	0.2088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Schistosoma mansoni	plexin	0.0066	0.3141	0.3141
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0584	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0187	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2088	0.1946
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2088	0.1946
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0014	0.0177	0.0177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Entamoeba histolytica	cell surface protease gp63, putative	0.0021	0.0584	0.0695
Echinococcus granulosus	semaphorin 5B	0.0047	0.2088	0.2487
Entamoeba histolytica	hypothetical protein	0.0021	0.0584	0.0695
Brugia malayi	hypothetical protein	0.0047	0.2088	0.2088
Entamoeba histolytica	tyrosin kinase, putative	0.0026	0.0897	0.1069
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0584	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0584	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0555	0.0555
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0555	0.0555
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Entamoeba histolytica	protein kinase, putative	0.0159	0.8396	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0555	0.0555
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0555	0.0661
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.377	1
Plasmodium vivax	vivapain-2	0.002	0.0555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Plasmodium vivax	vivapain-2	0.002	0.0555	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0555	0.0555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0584	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0021	0.0584	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0021	0.0584	1
Loa Loa (eye worm)	cysteine protease	0.002	0.0555	0.0385
Schistosoma mansoni	semaphorin 5-related	0.0047	0.2088	0.2088
Brugia malayi	Probable exocyst complex component Sec5	0.0021	0.0584	0.0584
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Onchocerca volvulus		0.002	0.0555	0.067
Onchocerca volvulus		0.002	0.0555	0.067
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0584	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0555	0.0555
Loa Loa (eye worm)	fibroinase	0.002	0.0555	0.0385
Brugia malayi	Cathepsin L-like precursor	0.002	0.0555	0.0555
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0555	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0584	0.0414
Schistosoma mansoni	hypothetical protein	0.0066	0.3141	0.3141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Echinococcus granulosus	transcription factor collier	0.0021	0.0584	0.0695
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0177	0.0177
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0555	0.0661
Schistosoma mansoni	hypothetical protein	0.0047	0.2088	0.2088
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0555	0.0661
Onchocerca volvulus		0.0113	0.5819	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0584	0.0414
Loa Loa (eye worm)	sema domain-containing protein	0.0047	0.2088	0.1946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0584	0.0414
Brugia malayi	hypothetical protein	0.0047	0.2088	0.2088
Loa Loa (eye worm)	sema domain-containing protein	0.0047	0.2088	0.1946
Brugia malayi	Cathepsin L-like precursor	0.002	0.0555	0.0555
Loa Loa (eye worm)	ctsf protein	0.002	0.0555	0.0385
Leishmania major	cathepsin L-like protease	0.0077	0.377	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Brugia malayi	DNA-binding protein LAG-1	0.0021	0.0584	0.0584
Brugia malayi	Sema domain containing protein	0.0047	0.2088	0.2088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Onchocerca volvulus		0.002	0.0555	0.067
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase I	0.0159	0.8393	0.9996
Brugia malayi	Plexin repeat family protein	0.0113	0.5819	0.5819
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0555	0.067
Entamoeba histolytica	hypothetical protein	0.0021	0.0584	0.0695
Schistosoma mansoni	cathepsin F (C01 family)	0.0014	0.0177	0.0177
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0555	0.9505
Onchocerca volvulus		0.002	0.0555	0.067
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0021	0.0584	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.2837	0.7525
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0021	0.0584	1
Entamoeba histolytica	cysteine proteinase, putative	0.0014	0.0177	0.021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0021	0.0584	1
Schistosoma mansoni	fibrocystin l	0.0021	0.0584	0.0584
Brugia malayi	Sema domain containing protein	0.0047	0.2088	0.2088
Echinococcus granulosus	cathepsin l1	0.002	0.0555	0.0661
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3141	0.3018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0555	0.9505
Echinococcus multilocularis	plexin a4	0.0134	0.6992	0.8327
Toxoplasma gondii	cathepsin CPL	0.002	0.0555	0.5
Onchocerca volvulus		0.002	0.0555	0.067
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0555	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2088	0.1946
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0555	0.067
Echinococcus granulosus	cathepsin l1	0.0014	0.0177	0.021
Entamoeba histolytica	cysteine protease, putative	0.002	0.0555	0.0661
Echinococcus granulosus	plexin a4	0.0134	0.6992	0.8327
Echinococcus multilocularis	transcription factor collier	0.0021	0.0584	0.0695
Echinococcus multilocularis	cysteine protease	0.002	0.0555	0.0661
Echinococcus multilocularis	semaphorin 5B	0.0047	0.2088	0.2487
Brugia malayi	IPT/TIG domain containing protein	0.0021	0.0584	0.0584
Loa Loa (eye worm)	plexin A	0.0134	0.6992	0.6938
Entamoeba histolytica	hypothetical protein	0.0021	0.0584	0.0695
Entamoeba histolytica	hypothetical protein	0.0021	0.0584	0.0695
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0555	0.0385
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0555	0.0661
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0555	0.0385
Schistosoma mansoni	plexin	0.0113	0.5819	0.5819
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.377	1
Leishmania major	cathepsin L-like protease	0.0077	0.377	1
Echinococcus multilocularis	cysteine protease	0.002	0.0555	0.0661
Loa Loa (eye worm)	hypothetical protein	0.0047	0.2088	0.1946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0555	0.9505
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0584	0.0414
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0555	0.0661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0555	0.9505

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.4 uM	Inhibition of Trypanosoma cruzi cruzain	ChEMBL.	25072876

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3329474

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 927199