Detailed information for compound 929765

Basic information

Technical information
  • TDR Targets ID: 929765
  • Name: (3S,8S,9S,10R,13S,14S,17S)-17-(3H-imidazol-4- yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16 ,17-dodecahydro-1H-cyclopenta[a]phenanthren-3 -ol
  • MW: 340.502 | Formula: C22H32N2O
  • H donors: 2 H acceptors: 2 LogP: 4.28 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2c2nc[nH]c2)C)C1)C
  • InChi: 1S/C22H32N2O/c1-21-9-7-15(25)11-14(21)3-4-16-17-5-6-19(20-12-23-13-24-20)22(17,2)10-8-18(16)21/h3,12-13,15-19,25H,4-11H2,1-2H3,(H,23,24)/t15-,16-,17-,18-,19+,21-,22-/m0/s1
  • InChiKey: BBUJYEQSYYZBDG-SPHVDITISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NSC58246
  • C14998
  • 17beta-(1H-Imidazol-4-yl)androst-5-en-3beta-ol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cytochrome P450 17A1 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 17, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans cytochrome P450 similar to phenylacetate hydroxylase Cytochrome P450 17A1   507 aa 510 aa 19.6 %
Trypanosoma cruzi cytochrome P450, putative Cytochrome P450 17A1   507 aa 428 aa 22.7 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 502 aa 25.5 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 424 aa 24.3 %
Trypanosoma cruzi cytochrome P450, putative Cytochrome P450 17A1   507 aa 428 aa 22.9 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 532 aa 25.4 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 17, subfamily A, polypeptide 1 508 aa 468 aa 25.2 %
Drosophila melanogaster CG1829 gene product from transcript CG1829-RB Cytochrome P450 17A1   507 aa 476 aa 22.3 %
Loa Loa (eye worm) cytochrome P450 family protein Cytochrome P450 17A1   507 aa 454 aa 25.3 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 502 aa 23.1 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 423 aa 22.9 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 502 aa 22.5 %
Drosophila melanogaster CG7241 gene product from transcript CG7241-RA Cytochrome P450 17A1   507 aa 477 aa 27.9 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 485 aa 24.3 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 490 aa 20.4 %
Onchocerca volvulus Cytochrome P450 17A1   507 aa 453 aa 24.1 %
Brugia malayi Cytochrome P450 family protein Cytochrome P450 17A1   507 aa 434 aa 25.6 %
Drosophila melanogaster shadow Cytochrome P450 17A1   507 aa 470 aa 23.0 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 518 aa 24.7 %
Candida albicans cytochrome P450 similar to phenylacetate hydroxylase Cytochrome P450 17A1   507 aa 510 aa 19.6 %
Dictyostelium discoideum cytochrome P450 family protein Cytochrome P450 17A1   507 aa 413 aa 24.5 %
Drosophila melanogaster Cytochrome P450-4d1 Cytochrome P450 17A1   507 aa 465 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.018 0.0063 0.8252
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0121 0.0034 0.003
Echinococcus multilocularis serotonin receptor 0.0121 0.0034 0.003
Brugia malayi Dopamine receptor 0.0121 0.0034 0.0034
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0104 0.0026 0.0022
Schistosoma mansoni adenoreceptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Onchocerca volvulus 0.0121 0.0034 0.4264
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Onchocerca volvulus 0.0121 0.0034 0.4264
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0494 0.0214 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0121 0.0034 0.003
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0225 0.0084 0.3658
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0494 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Brugia malayi Trypsin family protein 0.0205 0.0075 0.0075
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0225 0.0084 0.3826
Brugia malayi G protein-coupled receptor F59B2.13 0.0121 0.0034 0.0034
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0104 0.0026 0.1054
Brugia malayi larval opioid receptor 0.0121 0.0034 0.0034
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0494 0.0214 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0121 0.0034 0.003
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis G-protein coupled receptor, putative 0.0121 0.0034 0.003
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0121 0.0034 0.003
Echinococcus granulosus g-protein coupled receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus granulosus hypothetical protein 0.0121 0.0034 0.003
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0494 0.0214 0.0209
Schistosoma mansoni opsin-like receptor 0.0121 0.0034 0.003
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0006 0.0002
Brugia malayi Kringle domain containing protein 0.0058 0.0004 0.0004
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0143 0.0045 0.0041
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) neuropeptide F receptor 0.0121 0.0034 0.0034
Loa Loa (eye worm) TYRA-2 protein 0.0121 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0045 0.5092
Loa Loa (eye worm) hypothetical protein 2.0871 1 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.0225 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0026 0.0026
Brugia malayi GnHR receptor homolog 0.0121 0.0034 0.0034
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0121 0.0034 0.003
Trypanosoma brucei lanosterol synthase 0.015 0.0048 0.5155
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0121 0.0034 0.0034
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0034 0.003
Brugia malayi hypothetical protein 0.007 0.001 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0006 0.0006
Echinococcus multilocularis geminin 0.0168 0.0057 0.0053
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.007 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0104 0.0026 0.0022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0143 0.0045 0.0041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0121 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0168 0.0057 0.0053
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0121 0.0034 0.003
Echinococcus granulosus neuropeptide FF receptor 2 0.0121 0.0034 0.003
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0225 0.0084 1
Echinococcus multilocularis snurportin 1 0.0306 0.0123 0.0119
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0494 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0143 0.0045 0.4725
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Trypanosoma brucei hypothetical protein, conserved 0.0143 0.0045 0.4725
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0121 0.0034 0.0034
Echinococcus granulosus snurportin 1 0.0306 0.0123 0.0119
Echinococcus granulosus neuropeptides capa receptor 0.0121 0.0034 0.003
Echinococcus granulosus alpha 16 mannosyl glycoprotein 2.0871 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni histamine h1 receptor 0.0121 0.0034 0.003
Brugia malayi G-protein coupled receptor 0.0121 0.0034 0.0034
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.007 0.001 0.0695
Brugia malayi Serotonin receptor 0.0121 0.0034 0.0034
Brugia malayi ORL1-like opioid receptor 0.0121 0.0034 0.0034
Onchocerca volvulus 0.0205 0.0075 1
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0225 0.0084 0.3658
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0225 0.0084 0.5702
Loa Loa (eye worm) hypothetical protein 0.0084 0.0017 0.0017
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.007 0.001 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0034 0.003
Schistosoma mansoni hypothetical protein 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus granulosus alpha 1A adrenergic receptor 0.0121 0.0034 0.003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0121 0.0034 0.003
Loa Loa (eye worm) G-protein coupled receptor 0.0121 0.0034 0.0034
Giardia lamblia Rab geranylgeranyltransferase 0.0143 0.0045 0.1
Brugia malayi AKH receptor 0.0121 0.0034 0.0034
Loa Loa (eye worm) RNA binding protein 0.0063 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0034 0.003
Toxoplasma gondii hypothetical protein 0.0143 0.0045 0.2903
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0034 0.003
Schistosoma mansoni opsin-like receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0351 0.0145 0.6621
Brugia malayi putative neuropeptide receptor 0.0121 0.0034 0.0034
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0121 0.0034 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.0034 0.003
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0143 0.0045 0.1948
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0225 0.0084 0.3658
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0494 0.0214 0.0214
Onchocerca volvulus 0.0121 0.0034 0.4264
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis fmrfamide receptor 0.0121 0.0034 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Echinococcus granulosus dro:myosuppressin receptor 0.0121 0.0034 0.003
Brugia malayi G-protein coupled receptor 0.0121 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Onchocerca volvulus 0.0121 0.0034 0.4264
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0034 0.003
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0096 0.0022 0.0018
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0121 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0121 0.0034 0.003
Schistosoma mansoni neuropeptide receptor 0.0121 0.0034 0.003
Brugia malayi RNA, U transporter 1 0.0081 0.0015 0.0015
Schistosoma mansoni opsin-like receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0121 0.0034 0.1431
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0436 0.0186 0.8627
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0121 0.0034 0.0034
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni biogenic amine receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0006 0.0002
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0104 0.0026 0.081
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0225 0.0084 0.3658
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0121 0.0034 0.003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0006 0.0006
Onchocerca volvulus 0.0121 0.0034 0.4264
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0143 0.0045 0.5092
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0121 0.0034 0.003
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 2.0871 1 1
Leishmania major farnesyltransferase beta subunit 0.0225 0.0084 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Echinococcus granulosus allatostatin A receptor 0.0121 0.0034 0.003
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0104 0.0026 0.1054
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.007 0.001 0.0695
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0104 0.0026 0.1571
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0436 0.0186 0.0181
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0225 0.0084 0.008
Brugia malayi G protein-coupled receptor 0.0121 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0034 0.003
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni growth hormone secretagogue receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0121 0.0034 0.0034
Giardia lamblia Prenyltransferase 0.0225 0.0084 0.3099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Echinococcus multilocularis g protein coupled receptor 0.0121 0.0034 0.003
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0121 0.0034 0.4264
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0121 0.0034 0.003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0143 0.0045 0.0041
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0494 0.0214 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0494 0.0214 0.0214
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0143 0.0045 0.0041
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0143 0.0045 0.4725
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0044 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0121 0.0034 0.003
Echinococcus multilocularis neuropeptide FF receptor 2 0.0121 0.0034 0.003
Echinococcus granulosus geminin 0.0168 0.0057 0.0053
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0121 0.0034 0.003
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0436 0.0186 0.0181
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0104 0.0026 0.081
Echinococcus granulosus neuropeptide Y receptor 0.0121 0.0034 0.003
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0143 0.0045 0.0045
Echinococcus multilocularis sex peptide receptor 0.0121 0.0034 0.003
Echinococcus multilocularis neuropeptide receptor A26 0.0121 0.0034 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0121 0.0034 0.003
Echinococcus granulosus biogenic amine 5HT receptor 0.0121 0.0034 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Schistosoma mansoni hypothetical protein 0.0121 0.0034 0.003
Trypanosoma cruzi lanosterol synthase, putative 0.015 0.0048 0.5492
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0225 0.0084 0.3658
Brugia malayi Peptidase family M1 containing protein 0.0154 0.005 0.005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0006 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Echinococcus multilocularis neuropeptide s receptor 0.0121 0.0034 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0104 0.0026 0.2755
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0121 0.0034 0.003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0121 0.0034 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Echinococcus multilocularis g protein coupled receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0143 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0121 0.0034 0.003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0121 0.0034 0.0034
Echinococcus granulosus g protein coupled receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Loa Loa (eye worm) hypothetical protein 0.0058 0.0004 0.0004
Echinococcus granulosus g protein coupled receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0121 0.0034 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0034 0.003
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0104 0.0026 0.2755
Schistosoma mansoni neuropeptide receptor 0.0121 0.0034 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Echinococcus granulosus biogenic amine 5HT receptor 0.0121 0.0034 0.003
Echinococcus multilocularis g-protein coupled receptor 0.0121 0.0034 0.003
Echinococcus multilocularis allatostatin A receptor 0.0121 0.0034 0.003
Echinococcus multilocularis somatostatin receptor 0.0121 0.0034 0.003
Echinococcus granulosus peptide allatostatin:somatostatin 0.0121 0.0034 0.003
Trypanosoma cruzi protein farnesyltransferase, putative 0.0225 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus granulosus neuropeptide receptor A26 0.0121 0.0034 0.003
Schistosoma mansoni neuropeptide receptor 0.0121 0.0034 0.003
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0121 0.0034 0.003
Schistosoma mansoni amine GPCR 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0143 0.0045 0.5092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Brugia malayi Dopamine receptor protein 2 0.0121 0.0034 0.0034
Brugia malayi Tachykinin-like peptides receptor 99D 0.0121 0.0034 0.0034
Echinococcus granulosus tm gpcr rhodopsin 0.0121 0.0034 0.003
Onchocerca volvulus 0.0143 0.0045 0.5773
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0225 0.0084 0.3658
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.0045 0.5092
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Plasmodium falciparum geranylgeranyltransferase, putative 0.0104 0.0026 0.1054
Trypanosoma cruzi Aminopeptidase M1, putative 0.007 0.001 0.0695
Echinococcus granulosus neuropeptide Y receptor 0.0121 0.0034 0.003
Echinococcus granulosus tar DNA binding protein 0.0063 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0121 0.0034 0.003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0225 0.0084 0.008
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0143 0.0045 0.1728
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0143 0.0045 0.0041
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0121 0.0034 0.003
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0436 0.0186 0.0181
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0225 0.0084 0.0084
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0494 0.0214 0.0209
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0225 0.0084 0.3826
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Brugia malayi Peptidase family M1 containing protein 0.007 0.001 0.001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0121 0.0034 0.0034
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0121 0.0034 0.0034
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0143 0.0045 0.5092
Echinococcus granulosus 7tm_1 domain containing protein 0.0121 0.0034 0.003
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0143 0.0045 0.1948
Toxoplasma gondii hypothetical protein 0.0351 0.0145 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0006 0.0002
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0104 0.0026 0.081
Brugia malayi Dopamine receptor protein 1 0.0121 0.0034 0.0034
Echinococcus multilocularis neuropeptide receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.007 0.001 0.0788
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0121 0.0034 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0121 0.0034 0.003
Echinococcus multilocularis neuropeptide Y receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Brugia malayi RNA binding protein 0.0063 0.0006 0.0006
Echinococcus granulosus neuropeptide receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni cathepsin D (A01 family) 0.014 0.0044 0.0039
Schistosoma mansoni hypothetical protein 0.0168 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.0129 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0205 0.0075 0.0075
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0104 0.0026 0.2213
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.007 0.001 0.0695
Mycobacterium ulcerans aminopeptidase N PepN 0.007 0.001 0.5
Brugia malayi neuropeptide F receptor 0.0121 0.0034 0.0034
Loa Loa (eye worm) aminopeptidase N 0.007 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Echinococcus granulosus serotonin receptor 0.0121 0.0034 0.003
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0494 0.0214 0.0209
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni biogenic amine receptor 0.0121 0.0034 0.003
Echinococcus multilocularis neuropeptide Y receptor 0.0121 0.0034 0.003
Echinococcus granulosus neuropeptides capa receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Schistosoma mansoni biogenic amine receptor 0.0121 0.0034 0.003
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0006 0.0002
Brugia malayi follicle stimulating hormone receptor 0.0121 0.0034 0.0034
Schistosoma mansoni biogenic amine (5HT) receptor 0.0121 0.0034 0.003
Echinococcus multilocularis G protein coupled receptor 139 0.0121 0.0034 0.003
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0143 0.0045 0.4725
Echinococcus granulosus neuropeptide s receptor 0.0121 0.0034 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.7311 0.3488 0.3485
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0121 0.0034 0.003
Echinococcus multilocularis fmrfamide receptor 0.0121 0.0034 0.003
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0121 0.0034 0.003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Schistosoma mansoni hypothetical protein 0.0306 0.0123 0.0119
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0104 0.0026 0.1571
Echinococcus granulosus tm gpcr rhodopsin 0.0121 0.0034 0.003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0121 0.0034 0.003
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0225 0.0084 0.0084
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0121 0.0034 0.003
Schistosoma mansoni amine GPCR 0.0121 0.0034 0.003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Echinococcus granulosus fmrfamide receptor 0.0121 0.0034 0.003
Echinococcus granulosus G protein coupled receptor 139 0.0121 0.0034 0.003
Schistosoma mansoni hypothetical protein 0.0121 0.0034 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.0034 0.003
Echinococcus multilocularis dro:myosuppressin receptor 0.0121 0.0034 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0436 0.0186 0.0186
Loa Loa (eye worm) neuropeptide F receptor 0.0121 0.0034 0.0034
Brugia malayi putative neuropeptide receptor NPR1 0.0121 0.0034 0.0034
Onchocerca volvulus 0.0121 0.0034 0.4264
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0436 0.0186 0.0186
Loa Loa (eye worm) G-protein coupled receptor 0.0121 0.0034 0.0034
Echinococcus multilocularis orexin receptor type 2 0.0121 0.0034 0.003
Echinococcus granulosus aminopeptidase N 0.0154 0.005 0.0046
Giardia lamblia Rab geranylgeranyltransferase 0.0494 0.0214 1
Brugia malayi neuropeptide F receptor 0.0121 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Loa Loa (eye worm) peptidase family M1 containing protein 0.0109 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0205 0.0075 0.0075
Echinococcus granulosus puromycin sensitive aminopeptidase 0.007 0.001 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0121 0.0034 0.003
Echinococcus multilocularis neuropeptides capa receptor 0.0121 0.0034 0.003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0121 0.0034 0.0034
Echinococcus granulosus neuropeptide receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Leishmania major geranylgeranyltransferase, putative 0.0104 0.0026 0.2755
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0205 0.0075 0.0071
Brugia malayi Protein kinase domain containing protein 0.0058 0.0004 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0086 1
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 2.0871 1 1
Schistosoma mansoni neuropeptide receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0104 0.0026 0.0026
Echinococcus granulosus sex peptide receptor 0.0121 0.0034 0.003
Schistosoma mansoni myosin xvIII 0.0121 0.0034 0.003
Echinococcus granulosus orexin receptor type 2 0.0121 0.0034 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.7311 0.3488 0.3485
Loa Loa (eye worm) hypothetical protein 0.0494 0.0214 0.0214
Onchocerca volvulus Neuropeptide F receptor homolog 0.0121 0.0034 0.4264
Schistosoma mansoni amine GPCR 0.0121 0.0034 0.003
Echinococcus granulosus g protein coupled receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0121 0.0034 0.4264
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0006 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0034 0.003
Plasmodium vivax geranylgeranyltransferase, putative 0.0104 0.0026 0.1054
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0121 0.0034 0.003
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0143 0.0045 0.1728
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Loa Loa (eye worm) TK/ROR protein kinase 0.0058 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Schistosoma mansoni neuropeptide f receptor 76f 0.0121 0.0034 0.003
Brugia malayi sulfakinin receptor protein 0.0121 0.0034 0.0034
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Onchocerca volvulus 0.0121 0.0034 0.4264
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0104 0.0026 0.2755
Echinococcus granulosus somatostatin receptor 0.0121 0.0034 0.003
Onchocerca volvulus 0.0154 0.005 0.6496
Trypanosoma cruzi aminopeptidase, putative 0.007 0.001 0.0695
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0104 0.0026 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0205 0.0075 0.0071
Echinococcus multilocularis g protein coupled receptor 0.0121 0.0034 0.003
Brugia malayi RE15519p 0.0121 0.0034 0.0034
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0225 0.0084 0.008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.0123 0.0123
Loa Loa (eye worm) melatonin receptor type 1A 0.0121 0.0034 0.0034
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0121 0.0034 0.003
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0225 0.0084 0.3658
Schistosoma mansoni neuropeptide F-like receptor 0.0121 0.0034 0.003
Brugia malayi TAR-binding protein 0.0063 0.0006 0.0006
Echinococcus multilocularis serotonin receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Echinococcus multilocularis aminopeptidase N 0.0154 0.005 0.0046
Brugia malayi Serotonin receptor 0.0121 0.0034 0.0034
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0436 0.0186 0.8627
Brugia malayi Melatonin receptor type 1A 0.0121 0.0034 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0034 0.003
Brugia malayi hypothetical protein 0.0121 0.0034 0.0034
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0436 0.0186 0.0181
Trypanosoma cruzi lanosterol synthase, putative 0.015 0.0048 0.5492
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0121 0.0034 0.003
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0494 0.0214 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0121 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0121 0.0034 0.0034
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0143 0.0045 0.5092

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 66 nM Inhibition of human testicular microsomal Cytochrome P450 17A1 ChEMBL. 9379450
IC50 (binding) = 91 nM Inhibition of rat testicular microsomal Cytochrome P450 17A1 ChEMBL. 9379450

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.