Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Dengue virus 2 | Genome polyprotein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0091 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0899 | 0.6146 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0091 | 0 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0125 | 0.0255 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0 | 0.5 |
Brugia malayi | nicalin | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0091 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0091 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0091 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.1373 | 0.9745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1281 | 0.905 | 0.905 |
Brugia malayi | Peptidase family M28 containing protein | 0.0091 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0091 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0125 | 0.0255 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0091 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0091 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0091 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | 0.0091 | 0 | 0.5 | |
Brugia malayi | FXNA | 0.0091 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0091 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0091 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0933 | 0.6401 | 0.6401 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.6 uM | Inhibition of Dengue virus serotype 2 NS2B-NS3 protease by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Inhibition (binding) | = 9.2 % | Inhibition of thrombin (unknown origin) at 25 uM by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Inhibition (binding) | = 98.4 % | Inhibition of West Nile virus serotype 2 NS2B-NS3 protease at 50 uM by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Inhibition (binding) | = 99.6 % | Inhibition of Dengue virus serotype 2 NS2B-NS3 protease at 50 uM by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.