Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 7 (matrilysin, uterine) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 10 (stromelysin 2) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 14 (membrane-inserted) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 10 (stromelysin 2) | 476 aa | 429 aa | 33.1 % |
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 8 (neutrophil collagenase) | 467 aa | 467 aa | 33.4 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 7 (matrilysin, uterine) | 267 aa | 234 aa | 41.0 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 477 aa | 431 aa | 34.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0754 | 0.7358 | 0.7358 |
Loa Loa (eye worm) | matrixin family protein | 0.0593 | 0.5217 | 0.709 |
Brugia malayi | acyl-CoA desaturase | 0.0754 | 0.7358 | 1 |
Brugia malayi | Matrixin family protein | 0.0593 | 0.5217 | 0.709 |
Brugia malayi | Hemopexin family protein | 0.0276 | 0.1018 | 0.1383 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.0313 | 0.2008 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0954 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0754 | 0.7358 | 0.7358 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0873 | 0.8927 | 1 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0954 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.023 | 0.0404 | 0.0549 |
Onchocerca volvulus | Matrilysin homolog | 0.023 | 0.0404 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.0404 | 0.0549 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.028 | 0.1068 | 1 |
Brugia malayi | Matrixin family protein | 0.023 | 0.0404 | 0.0549 |
Leishmania major | fatty-acid desaturase, putative | 0.0954 | 1 | 1 |
Onchocerca volvulus | 0.0276 | 0.1018 | 0.1018 | |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0199 | 0 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.028 | 0.1068 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0317 | 0.1557 | 1 |
Brugia malayi | Matrixin family protein | 0.023 | 0.0404 | 0.0549 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.028 | 0.1068 | 0.1452 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0754 | 0.7358 | 0.5 |
Brugia malayi | Matrixin family protein | 0.023 | 0.0404 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.3567 | 0.4847 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.1018 | 0.6538 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0754 | 0.7358 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.051 | 0.4114 | 0.4114 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.1557 | 0.2116 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.0313 | 0.035 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.0607 | 0.068 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.0404 | 0.0549 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0754 | 0.7358 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.023 | 0.0404 | 0.0549 |
Loa Loa (eye worm) | matrixin family protein | 0.051 | 0.4114 | 0.5592 |
Onchocerca volvulus | 0.023 | 0.0404 | 0.0404 | |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0873 | 0.8927 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.1068 | 0.1452 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.028 | 0.1068 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0597 | 0.5267 | 0.5267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.6 nM | Inhibition of recombinant human AMPA-activated MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (binding) | = 12 nM | Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | = 12 nM | Inhibition of human recombinant MMP13 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | = 300 nM | Inhibition of human recombinant MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | = 300 nM | Inhibition of human recombinant MMP2 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | = 300 nM | Inhibition of recombinant human AMPA-activated MMP2 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (binding) | = 1100 nM | Inhibition of human recombinant MMP8 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | = 1100 nM | Inhibition of human recombinant MMP8 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | = 1100 nM | Inhibition of recombinant human AMPA-activated MMP8 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (binding) | = 3400 nM | Inhibition of human recombinant MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | = 3400 nM | Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | = 3400 nM | Inhibition of recombinant human AMPA-activated MMP10 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant TACE using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSRNH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant GST-tagged MMP14 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP9 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP7 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP3 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP1 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetry | ChEMBL. | 25264600 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP1 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP3 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP7 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP9 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant MMP14 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (binding) | > 10000 nM | Inhibition of human recombinant TACE using Cy3-PLAQAV(Cy5QL-2,3-diaminopropionic acid)-RSSSR-NH2 substrate by fluorescence assay | ChEMBL. | 25192810 |
IC50 (ADMET) | > 10000 nM | Inhibition of recombinant human TACE using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (ADMET) | > 10000 nM | Inhibition of recombinant human AMPA-activated MMP1 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human AMPA-activated MMP9 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (ADMET) | > 10000 nM | Inhibition of recombinant human GST-tagged MMP14 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human AMPA-activated MMP7 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
IC50 (binding) | > 10000 nM | Inhibition of recombinant human AMPA-activated MMP3 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate measured after 40 mins by spectrofluorimetric method | LITERATURE. | 27825552 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.