Detailed information for compound 934082

Basic information

Technical information
  • TDR Targets ID: 934082
  • Name: 1-[(E)-10-(4-amino-2-methylquinolin-1-ium-1-y l)dec-5-enyl]-2-methylquinolin-1-ium-4-amine diiodide
  • MW: 708.458 | Formula: C30H38I2N4
  • H donors: 2 H acceptors: 0 LogP: 8.1 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: Nc1cc(C)[n+](c2c1cccc2)CCCC/C=C/CCCC[n+]1c(C)cc(c2c1cccc2)N.[I-].[I-]
  • InChi: 1S/C30H36N4.2HI/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34;;/h3-4,9-12,15-18,21-22,31-32H,5-8,13-14,19-20H2,1-2H3;2*1H/b4-3+;;
  • InChiKey: PYCLBDXZNROUIR-CZEFNJPISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(E)-10-(4-amino-2-methyl-quinolin-1-ium-1-yl)dec-5-enyl]-2-methyl-quinolin-1-ium-4-amine diiodide
  • 1-[(E)-10-(4-amino-2-methyl-1-quinolin-1-iumyl)dec-5-enyl]-2-methyl-4-quinolin-1-iumamine diiodide
  • [1-[(E)-10-(4-amino-2-methyl-quinolin-1-ium-1-yl)dec-5-enyl]-2-methyl-quinolin-1-ium-4-yl]amine diiodide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase C, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis telomerase reverse transcriptase subunit Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus protein kinase C gamma type Get druggable targets OG5_129482 All targets in OG5_129482
Brugia malayi Protein kinase c protein 2 Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis serine threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Calcium-dependent protein kinase C, putative Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C alpha type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Candida albicans protein kinase C similar to S. cerevisiae PKC1 (YBL105C) Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma japonicum Protein kinase C gamma type, putative Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus granulosus Protein kinase C brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis Protein kinase C, brain isozyme Get druggable targets OG5_129482 All targets in OG5_129482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129482 All targets in OG5_129482
Echinococcus multilocularis RNA directed DNA polymerase Get druggable targets OG5_129482 All targets in OG5_129482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.0741 0.0741
Brugia malayi STAT protein, DNA binding domain containing protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0025 0.0741 0.0743
Schistosoma mansoni ephrin receptor 0.0025 0.0741 0.0743
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Onchocerca volvulus 0.0088 0.7384 0.7192
Brugia malayi RhoGAP domain containing protein 0.0095 0.8151 0.814
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0088 0.7384 0.7359
Echinococcus multilocularis SH2 motif 0.0088 0.7384 0.7401
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0095 0.8151 0.814
Brugia malayi Variant SH3 domain containing protein 0.0088 0.7384 0.7359
Schistosoma mansoni tensin 0.0088 0.7384 0.7401
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis protein kinase atn1, putative 0.0025 0.0741 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi Raf kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0741 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.5163 0.5175
Schistosoma mansoni suppressor of cytokine signaling 0.0088 0.7384 0.7401
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0765 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0088 0.7384 0.7401
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0025 0.0741 0.0593
Onchocerca volvulus 0.0088 0.7384 0.7192
Loa Loa (eye worm) TK/ACK protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.9977 0.9977
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0025 0.0741 0.0743
Echinococcus multilocularis SHC transforming protein 3 0.0088 0.7384 0.7401
Echinococcus granulosus suppressor of cytokine signaling 7 0.0088 0.7384 0.7384
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0025 0.0741 0.0741
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0113 0.9977 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus Protein kinase C brain isozyme 0.0067 0.5163 0.5163
Onchocerca volvulus 0.0088 0.7384 0.7192
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Onchocerca volvulus 0.0113 0.9977 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0159 0.016
Echinococcus multilocularis SH2 motif 0.0088 0.7384 0.7401
Plasmodium vivax protein kinase, putative 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0113 0.9977 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.0741 0.0741
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0741 0.0593
Brugia malayi SH2 domain containing protein 0.0088 0.7384 0.7359
Brugia malayi protein-tyrosine kinase 0.0113 0.9977 1
Echinococcus multilocularis SH2 domain containing protein 7 0.0088 0.7384 0.7401
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0088 0.7384 0.7401
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0025 0.0741 0.0593
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.0741 0.0593
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0765 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0025 0.0741 0.0743
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0088 0.7384 0.7401
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus granulosus tyrosine protein kinase shark 0.0113 0.9977 0.9977
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0025 0.0741 0.0743
Loa Loa (eye worm) TK/FAK protein kinase 0.0025 0.0741 0.0593
Echinococcus multilocularis integrin linked protein kinase 0.0025 0.0741 0.0743
Brugia malayi Protein kinase c protein 2 0.0057 0.4101 0.4015
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0025 0.0741 0.0743
Brugia malayi SRC-1 0.0113 0.9977 1
Echinococcus granulosus SH2 domain containing protein 7 0.0088 0.7384 0.7384
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0025 0.0741 0.0741
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0113 0.9977 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.0741 0.0741
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Brugia malayi SH2 domain containing protein 0.0113 0.9977 1
Schistosoma mansoni SH2A 0.0088 0.7384 0.7401
Brugia malayi SH2 domain containing protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Echinococcus granulosus tyrosine kinase 0.0113 0.9977 0.9977
Giardia lamblia Kinase, NEK 0.0025 0.0741 0.5
Schistosoma mansoni hypothetical protein 0.0088 0.7384 0.7401
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.3152 0.3159
Brugia malayi Protein kinase domain containing protein 0.0113 0.9977 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.0741 0.0743
Brugia malayi hypothetical protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK/DDR protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.0741 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0025 0.0741 0.0593
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0025 0.0741 0.0743
Trypanosoma brucei protein kinase, putative 0.0025 0.0765 1
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.0741 0.0741
Echinococcus multilocularis growth factor receptor bound protein 2 0.0088 0.7384 0.7401
Echinococcus multilocularis protein kinase 0.0025 0.0741 0.0743
Brugia malayi SH2 domain containing protein 0.0088 0.7384 0.7359
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein kinase Blk 0.0113 0.9977 1
Brugia malayi hypothetical protein 0.0025 0.0741 0.0593
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0025 0.0741 0.0741
Schistosoma mansoni vav2 0.0095 0.8151 0.817
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0088 0.7384 0.7359
Echinococcus granulosus NCK adaptor protein 0.0088 0.7384 0.7384
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0025 0.0741 0.0743
Schistosoma mansoni GTPase activating protein 0.0088 0.7384 0.7401
Onchocerca volvulus 0.0113 0.9977 1
Schistosoma mansoni tensin-related 0.0088 0.7384 0.7401
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Entamoeba histolytica protein kinase domain containing protein 0.0025 0.0765 0.0025
Echinococcus granulosus tyrosine protein kinase HCK 0.0025 0.0741 0.0741
Echinococcus granulosus retinal guanylyl cyclase 2 0.0025 0.0741 0.0741
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0741 0.0593
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Schistosoma mansoni suppressor of cytokine signaling 0.0088 0.7384 0.7401
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0025 0.0741 0.0743
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0088 0.7384 0.7401
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Brugia malayi Furin-like cysteine rich region family protein 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Onchocerca volvulus 0.0113 0.9977 1
Echinococcus granulosus signal transduction protein lnk realted 0.0088 0.7384 0.7384
Echinococcus granulosus tyrosine protein kinase Blk 0.0113 0.9977 0.9977
Giardia lamblia Kinase 0.0025 0.0741 0.5
Brugia malayi SH2 domain containing protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) SH2 domain-containing protein 0.0088 0.7384 0.7359
Schistosoma mansoni ephrin receptor 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus expressed conserved protein 0.0088 0.7384 0.7384
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0088 0.7384 0.7401
Echinococcus granulosus growth factor receptor bound protein 2 0.0088 0.7384 0.7384
Loa Loa (eye worm) TK/ALK protein kinase 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0113 0.9977 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0025 0.0741 0.0593
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0088 0.7407 0.7218
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.0741 0.0741
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0088 0.7384 0.7192
Echinococcus granulosus tyrosine protein kinase Src42A 0.0088 0.7384 0.7384
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0113 0.9977 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0113 0.9977 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0025 0.0741 0.0743
Brugia malayi Variant SH3 domain containing protein 0.0095 0.8151 0.814
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0025 0.0741 0.0741
Schistosoma mansoni protein tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis c src tyrosine kinase 0.0113 0.9977 1
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis heat shock protein 70 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Brugia malayi Protein kinase domain containing protein 0.0113 0.9977 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0025 0.0741 0.0741
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0095 0.8151 0.817
Echinococcus multilocularis tyrosine protein kinase Abl 0.0113 0.9977 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0088 0.7384 0.7359
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0741 0.5
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0088 0.7384 0.7384
Schistosoma mansoni tyrosine kinase 0.0113 0.9977 1
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK/ABL protein kinase 0.0113 0.9977 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0025 0.0741 0.0743
Schistosoma mansoni hypothetical protein 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Echinococcus granulosus tyrosine kinase 0.0113 0.9977 0.9977
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.9977 0.9977
Echinococcus multilocularis tyrosine protein kinase HCK 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Echinococcus granulosus tensin 0.0088 0.7384 0.7384
Loa Loa (eye worm) serine/threonine protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis activin receptor type 0.0025 0.0765 0.0766
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.9977 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0067 0.5163 0.5175
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0025 0.0741 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0741 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) SRC-1 0.0113 0.9977 1
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0741 0.0593
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Echinococcus granulosus tyrosine protein kinase ABL1 0.0113 0.9977 0.9977
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Brugia malayi Tyrosine-protein kinase PR2 0.0025 0.0741 0.0593
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0088 0.7384 0.7192
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus epidermal growth factor receptor 0.0025 0.0741 0.0741
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0088 0.7384 0.7401
Echinococcus granulosus epidermal growth factor receptor 0.0025 0.0741 0.0741
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0113 0.9977 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0025 0.0741 0.0741
Plasmodium falciparum protein kinase, putative 0.0025 0.0765 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0741 0.0593
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0025 0.0741 0.0743
Echinococcus granulosus SH2 motif 0.0088 0.7384 0.7384
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0025 0.0765 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0025 0.0741 0.0741
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus raf serine:threonine protein kinase 0.0032 0.1508 0.1508
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Onchocerca volvulus 0.0088 0.7384 0.7192
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0025 0.0741 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0025 0.0741 0.5
Loa Loa (eye worm) protein kinase domain-containing protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK/INSR protein kinase 0.0025 0.0741 0.0593
Brugia malayi SH2 domain containing protein 0.0113 0.9977 1
Echinococcus multilocularis serine threonine protein kinase 0.0059 0.4396 0.4406
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus SH2 motif 0.0088 0.7384 0.7384
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Echinococcus granulosus activated cdc42 kinase 1 0.0025 0.0741 0.0741
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.0159 0.016
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Onchocerca volvulus 0.0088 0.7384 0.7192
Echinococcus granulosus SHC transforming protein 3 0.0088 0.7384 0.7384
Echinococcus granulosus N chimaerin 0.0095 0.8151 0.8151
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0049 0.3334 0.3234
Schistosoma mansoni tyrosine kinase 0.0113 0.9977 1
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.0741 0.0743
Brugia malayi SH2 domain containing protein 0.0088 0.7384 0.7359
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Brugia malayi tRNA modification GTPase TrmE family protein 0.0088 0.7384 0.7359
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis tensin 0.0088 0.7384 0.7401
Loa Loa (eye worm) TK protein kinase 0.0113 0.9977 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0025 0.0741 0.5
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0088 0.7384 0.7401
Entamoeba histolytica SH2 domain containing protein 0.0088 0.7384 0.7192
Schistosoma mansoni tensin 0.0088 0.7384 0.7401
Echinococcus multilocularis tyrosine protein kinase pr2 0.0025 0.0741 0.0743
Echinococcus multilocularis protein tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus granulosus suppressor of cytokine signaling 6 0.0088 0.7384 0.7384
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0113 0.9977 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.0741 0.0743
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0113 0.9977 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine kinase 0.0113 0.9977 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.9977 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0025 0.0741 0.0741
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0088 0.7384 0.7401
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0025 0.0741 0.0593
Echinococcus granulosus fibroblast growth factor receptor 4 0.0025 0.0741 0.0741
Echinococcus granulosus natriuretic peptide receptor 1 0.0025 0.0741 0.0741
Brugia malayi Tyrosine-protein kinase abl-1 0.0113 0.9977 1
Brugia malayi SH2 domain containing protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0095 0.8151 0.817
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.9977 1
Brugia malayi Variant SH3 domain containing protein 0.0088 0.7384 0.7359
Schistosoma mansoni tensin-related 0.0088 0.7384 0.7401
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Brugia malayi bone morphogenetic protein type 1 receptor 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0032 0.1508 0.1512
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Schistosoma mansoni hypothetical protein 0.0088 0.7384 0.7401
Echinococcus granulosus tyrosine protein kinase Srms 0.0113 0.9977 0.9977
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis protein KINase family member (kin 25) 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Onchocerca volvulus 0.0088 0.7384 0.7192
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.0741 0.0743
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0741 0.0593
Entamoeba histolytica protein kinase, putative 0.0088 0.7407 0.7218
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0025 0.0741 0.5
Trichomonas vaginalis STE family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0113 0.9977 0.9977
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0765 1
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis NCK adaptor protein 0.0088 0.7384 0.7401
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis tensin 0.0088 0.7384 0.7401
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0113 0.9977 1
Brugia malayi integrin-linked kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0025 0.0741 0.5
Echinococcus granulosus insulin receptor 0.0025 0.0741 0.0741
Echinococcus granulosus protein kinase 0.0025 0.0741 0.0741
Echinococcus multilocularis tyrosine protein kinase csk 0.0025 0.0741 0.0743
Schistosoma mansoni adapter molecule crk 0.0088 0.7384 0.7401
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0025 0.0765 0.0766
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Schistosoma mansoni tyrosine kinase 0.0113 0.9977 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Brugia malayi SH2 domain containing protein 0.0088 0.7384 0.7359
Echinococcus multilocularis activated cdc42 kinase 1 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0113 0.9977 1
Echinococcus granulosus c src tyrosine kinase 0.0113 0.9977 0.9977
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.0741 0.0743
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0088 0.7384 0.7401
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0113 0.9977 1
Giardia lamblia Protein 21.1 0.0025 0.0741 0.5
Echinococcus granulosus tyrosine kinase 0.0025 0.0741 0.0741
Schistosoma mansoni protein kinase 0.0025 0.0765 0.0766
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0113 0.9977 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0025 0.0741 0.0593
Brugia malayi Protein kinase domain containing protein 0.0113 0.9977 1
Onchocerca volvulus 0.0113 0.9977 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0088 0.7384 0.7359
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0113 0.9977 0.9977
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis SH2 motif 0.0088 0.7384 0.7401
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0741 0.0593
Echinococcus granulosus kinase suppressor of Ras 1 0.0025 0.0741 0.0741
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis protein kinase 0.0025 0.0741 0.0743
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0088 0.7384 0.7359
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Brugia malayi Tensin 0.0088 0.7384 0.7359
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0088 0.7384 0.7401
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0088 0.7384 0.7384
Loa Loa (eye worm) hypothetical protein 0.0055 0.3919 0.3829
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0113 0.9977 0.9977
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) STAT protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0025 0.0741 0.0743
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0113 0.9977 0.9977
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK/RYK protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.3152 0.3048
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Schistosoma mansoni tyrosine kinase 0.0113 0.9977 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.0088 0.7384 0.7384
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Echinococcus granulosus tyrosine protein kinase 0.0025 0.0741 0.0741
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi ephrin receptor 1 precursor 0.0025 0.0741 0.0593
Schistosoma mansoni tyrosine protein kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.0741 0.0743
Echinococcus multilocularis natriuretic peptide receptor 1 0.0025 0.0741 0.0743
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0095 0.8151 0.817
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Loa Loa (eye worm) SH2 domain-containing protein 0.0088 0.7384 0.7359
Schistosoma mansoni serine/threonine RGC 0.0025 0.0741 0.0743
Echinococcus granulosus tyrosine protein kinase csk 0.0025 0.0741 0.0741
Echinococcus granulosus activin receptor type 0.0025 0.0765 0.0765
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Schistosoma mansoni nck2/grb4 0.0088 0.7384 0.7401
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.5163 0.5175
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.0741 0.0741
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.9977 0.9977
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.3152 0.3152
Brugia malayi hypothetical protein 0.0113 0.9977 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Loa Loa (eye worm) SH2 domain-containing protein 0.0088 0.7384 0.7359
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0095 0.8151 0.8151
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni shc transforming protein 0.0088 0.7384 0.7401
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0741 0.5
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0113 0.9977 0.9977
Echinococcus granulosus hypothetical protein 0.0088 0.7384 0.7384
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0088 0.7384 0.7359
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni tyrosine kinase 0.0113 0.9977 1
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis transfer RNA-Thr 0.0025 0.0741 0.0743
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Schistosoma mansoni protein kinase 0.0025 0.0765 0.0766
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0088 0.7384 0.7384
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Brugia malayi Sex muscle abnormal protein 5 0.0088 0.7384 0.7359
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0741 0.0743
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Onchocerca volvulus 0.0113 0.9977 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0025 0.0741 0.0741
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0088 0.7384 0.7401
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.9977 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0113 0.9977 1
Giardia lamblia Kinase, NEK 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0025 0.0741 0.0593
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis insulin receptor 0.0025 0.0741 0.0743
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0025 0.0741 0.0593
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0025 0.0741 0.0741
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0741 0.0593
Echinococcus multilocularis epidermal growth factor receptor 0.0025 0.0741 0.0743
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.9977 1
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.0159 0.0159
Echinococcus granulosus protein tyrosine kinase 0.0025 0.0741 0.0741
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Schistosoma mansoni protein kinase 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0113 0.9977 0.9977
Schistosoma mansoni tyrosine kinase 0.0025 0.0741 0.0743
Onchocerca volvulus 0.0113 0.9977 1
Echinococcus granulosus integrin linked protein kinase 0.0025 0.0741 0.0741
Loa Loa (eye worm) TK/FER protein kinase 0.0025 0.0741 0.0593
Leishmania major protein kinase, putative 0.0025 0.0765 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0113 0.9977 1
Brugia malayi C-terminal src kinase protein 1 0.0025 0.0741 0.0593
Schistosoma mansoni growth factor receptor-bound protein 0.0088 0.7384 0.7401
Loa Loa (eye worm) hypothetical protein 0.0025 0.0741 0.0593
Echinococcus multilocularis tyrosine protein kinase Srms 0.0113 0.9977 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.3152 0.3159
Echinococcus granulosus ephrin type A receptor 4 A 0.0025 0.0741 0.0741
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Echinococcus multilocularis N chimaerin 0.0095 0.8151 0.817
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.9977 1
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Schistosoma mansoni growth factor receptor-bound protein 0.0088 0.7384 0.7401
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0088 0.7384 0.7384
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0088 0.7384 0.7401
Brugia malayi hypothetical protein 0.0088 0.7384 0.7359
Schistosoma mansoni tensin 0.0088 0.7384 0.7401
Loa Loa (eye worm) hypothetical protein 0.0088 0.7384 0.7359
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0088 0.7384 0.7401
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0025 0.0741 0.0743
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Brugia malayi Variant SH3 domain containing protein 0.0089 0.7543 0.7521
Echinococcus granulosus activated cdc42 kinase 1 0.0025 0.0741 0.0741
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0089 0.7543 0.7521
Echinococcus multilocularis 0.0088 0.7384 0.7401
Echinococcus multilocularis tyrosine kinase 0.0025 0.0741 0.0743
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0113 0.9977 0.9977
Loa Loa (eye worm) TK protein kinase 0.0025 0.0741 0.0593
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0025 0.0741 0.0741
Echinococcus multilocularis FL cytokine receptor 0.0025 0.0741 0.0743
Echinococcus granulosus protein kinase C gamma type 0.0059 0.4396 0.4396
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0025 0.0765 0.0765
Trichomonas vaginalis protein tyrosine kinase, putative 0.0025 0.0741 0.5
Trichomonas vaginalis TK family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni protein kinase 0.0025 0.0765 0.0766
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Brugia malayi Protein kinase domain containing protein 0.0025 0.0741 0.0593
Trichomonas vaginalis TKL family protein kinase 0.0025 0.0741 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.1508 0.1512

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12 uM Inhibition of human recombinant PKCalpha ChEMBL. 10753478

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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