Detailed information for compound 934181

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 572.662 | Formula: C31H39F3N4O3
  • H donors: 0 H acceptors: 2 LogP: 6.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(Cc1ccc2c(c1)OCO2)CN1CC2CCCCC2C(C1)C(=O)N1CCN(CC1)c1cccc(n1)C(F)(F)F
  • InChi: 1S/C31H39F3N4O3/c1-21(15-22-9-10-26-27(16-22)41-20-40-26)17-36-18-23-5-2-3-6-24(23)25(19-36)30(39)38-13-11-37(12-14-38)29-8-4-7-28(35-29)31(32,33)34/h4,7-10,16,21,23-25H,2-3,5-6,11-15,17-20H2,1H3
  • InChiKey: GGRJANYEADBCKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens somatostatin receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromobox protein 2 0.0011 0.0023 0.0021
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.0539 0.1251
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0139 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0429 0.0984
Brugia malayi SET domain containing protein 0.0013 0.0048 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0786 0.0767
Echinococcus granulosus Chromobox protein 3 0.0011 0.0023 0.0021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0341 0.0786
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Schistosoma mansoni intermediate filament proteins 0.0026 0.0251 0.0231
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0203 0.0438
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0255 0.0556
Brugia malayi hypothetical protein 0.0011 0.0023 0.0049
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0203 0.0552
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0836 0.1969
Loa Loa (eye worm) hypothetical protein 0.003 0.0305 0.0662
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0278 0.0276
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0358 0.4129
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0067 0.0143
Brugia malayi CXXC zinc finger family protein 0.0028 0.0277 0.0605
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0203 0.0444
Loa Loa (eye worm) hypothetical protein 0.0023 0.0203 0.044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0074 0.0124
Schistosoma mansoni DNA polymerase eta 0.0044 0.0513 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0261 0.0579
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0023 0.0049
Leishmania major pyruvate kinase 0.0065 0.0836 1
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0062 0.0131
Schistosoma mansoni hypothetical protein 0.0081 0.1072 0.1053
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.0836 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0248
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0115 0.0077
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0203 0.0234
Onchocerca volvulus 0.0023 0.0203 0.0544
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0398 0.4424
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0836 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0303 0.0301
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0513 0.5891
Onchocerca volvulus 0.0011 0.0023 0.000000055302
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0139 0.0202
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0067 0.0147
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.1072 0.1071
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0836 0.1969
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.0836 0.3965
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.1072 0.1071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2051 0.205
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0139 0.0062
Onchocerca volvulus 0.0041 0.0471 0.1348
Giardia lamblia Pyruvate kinase 0.0065 0.0836 0.1737
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4152 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0473 0.109
Echinococcus multilocularis muscleblind protein 0.0146 0.2051 0.205
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0836 0.2446
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0786 0.0767
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0062 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0203 0.0234
Leishmania major DNA polymerase eta, putative 0.0044 0.0513 0.5372
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0046
Brugia malayi RNA binding protein 0.0062 0.0786 0.1716
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0261 0.0579
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0473 0.1354
Schistosoma mansoni chromobox protein 0.0011 0.0023 0.0001
Echinococcus granulosus pyruvate kinase 0.0034 0.0358 0.0357
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0248
Echinococcus granulosus pyruvate kinase 0.0034 0.0358 0.0357
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0303 0.0301
Echinococcus multilocularis cpg binding protein 0.003 0.0301 0.03
Loa Loa (eye worm) glutaminase 0.0268 0.3874 0.8452
Onchocerca volvulus 0.003 0.0305 0.085
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0023 0.0001
Schistosoma mansoni inositol monophosphatase 0.0036 0.0398 0.0378
Echinococcus multilocularis chromobox protein 1 0.0068 0.0879 0.0878
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0786 0.1712
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0879 0.2075
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0023 0.0049
Echinococcus granulosus intermediate filament protein 0.0026 0.0251 0.025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0203 0.0234
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0398 0.0909
Brugia malayi CHD4 protein 0.0013 0.0047 0.0102
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.4152 1
Trichomonas vaginalis set domain proteins, putative 0.0233 0.3347 0.805
Loa Loa (eye worm) hypothetical protein 0.0023 0.0203 0.044
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0317 0.3627
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0341 0.1295
Echinococcus granulosus protein quaking 0.0027 0.0255 0.0253
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.0836 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0023 0.0021
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.6696 0.6696
Trypanosoma brucei unspecified product 0.0019 0.0139 0.1121
Echinococcus multilocularis dna polymerase eta 0.0044 0.0513 0.0512
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0139 0.0137
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0023 0.0021
Echinococcus granulosus cpg binding protein 0.003 0.0301 0.03
Schistosoma mansoni pyruvate kinase 0.0034 0.0358 0.0338
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0303 0.3449
Echinococcus granulosus dna polymerase kappa 0.0019 0.0139 0.0137
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0046
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0023 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0097
Loa Loa (eye worm) hypothetical protein 0.0146 0.2051 0.4473
Echinococcus multilocularis chromobox protein 2 0.0011 0.0023 0.0021
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0047 0.0098
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0046 0.0045
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0139 0.0202
Echinococcus granulosus chromobox protein 1 0.0068 0.0879 0.0878
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Brugia malayi hypothetical protein 0.0016 0.0094 0.0205
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0786 0.0767
Plasmodium falciparum pyruvate kinase 0.0065 0.0836 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0118 0.0232
Loa Loa (eye worm) RNA binding protein 0.0062 0.0786 0.1712
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4152 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0671 0.7974
Loa Loa (eye worm) hypothetical protein 0.0026 0.0244 0.0529
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0251 0.0545
Plasmodium vivax SET domain protein, putative 0.003 0.0303 0.3449
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0398 0.0909
Trichomonas vaginalis glutaminase, putative 0.0268 0.3874 0.9327
Brugia malayi Muscleblind-like protein 0.0146 0.2051 0.4475
Echinococcus granulosus chromobox protein 1 0.0068 0.0879 0.0878
Schistosoma mansoni chromobox protein 0.0011 0.0023 0.0001
Echinococcus granulosus dna polymerase eta 0.0044 0.0513 0.0512
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0139 0.0118
Giardia lamblia Pyruvate kinase 0.0034 0.0358 0.0547
Brugia malayi chromobox protein homolog 3 0.0038 0.0429 0.0936
Loa Loa (eye worm) tumor suppressor 0.0315 0.4583 1
Schistosoma mansoni hypothetical protein 0.0011 0.0023 0.0001
Brugia malayi Inositol-1 0.0036 0.0398 0.0868
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0225 0.2228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0067 0.0107
Echinococcus granulosus neuropeptide s receptor 0.0456 0.6696 0.6696
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0225 0.2495
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.6696 0.6696
Echinococcus multilocularis lamin dm0 0.0026 0.0251 0.025
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0225 0.2495
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0836 0.1821
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0139 0.0299
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0203 0.0438
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0398 0.4616
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0398 0.3719
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0836 0.1821
Echinococcus granulosus lamin 0.0026 0.0251 0.025
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0358 0.4129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0081
Schistosoma mansoni apoptosis regulator bax 0.0081 0.1072 0.1053
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0139 0.0302
Onchocerca volvulus 0.0233 0.3347 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0398 0.0378
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Echinococcus granulosus pyruvate kinase 0.0034 0.0358 0.0357
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.1072 0.1053
Schistosoma mansoni chromobox protein 0.0068 0.0879 0.086
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0836 0.2446
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0203 0.093
Loa Loa (eye worm) glutaminase 2 0.0268 0.3874 0.8452
Brugia malayi glutaminase DH11.1 0.0268 0.3874 0.8453
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0118 0.0232
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0118 0.0232
Loa Loa (eye worm) hypothetical protein 0.0065 0.0836 0.1821
Echinococcus multilocularis pyruvate kinase 0.0034 0.0358 0.0357
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0398 0.0909
Chlamydia trachomatis pyruvate kinase 0.0065 0.0836 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.1121
Onchocerca volvulus 0.0026 0.0251 0.0688
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0358 0.4129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0786 0.1712
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0398 0.0396
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0513 0.5372
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0023 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0046
Leishmania major DNA polymerase eta, putative 0.0031 0.0317 0.2565
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0115 0.1141
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0879 0.1915
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0139 0.0137
Schistosoma mansoni hypothetical protein 0.0027 0.0255 0.0234
Echinococcus multilocularis chromobox protein 1 0.0068 0.0879 0.0878
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.1072 0.1071
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0513 0.112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0767 0.0747
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0786 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.1072 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0047 0.0026
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0398 0.3719
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0836 0.1821
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0203 0.0234
Schistosoma mansoni hypothetical protein 0.0401 0.5868 0.5859
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0021 0.0019
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0115 0.1141
Schistosoma mansoni cpg binding protein 0.003 0.0301 0.0281
Schistosoma mansoni cpg binding protein 0.003 0.0301 0.0281
Loa Loa (eye worm) hypothetical protein 0.0025 0.0225 0.0489
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0203 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0074 0.0124
Trypanosoma brucei pyruvate kinase 1 0.0065 0.0836 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0139 0.0281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0248
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.1072 0.2337
Schistosoma mansoni microtubule-associated protein tau 0.0676 1 1
Schistosoma mansoni pyruvate kinase 0.0065 0.0836 0.0816
Schistosoma mansoni lamin 0.0026 0.0251 0.0231
Brugia malayi hypothetical protein 0.0027 0.0255 0.0556
Schistosoma mansoni lamin 0.0026 0.0251 0.0231
Echinococcus granulosus tar DNA binding protein 0.0062 0.0786 0.0785
Schistosoma mansoni chromobox protein 0.0068 0.0879 0.086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0473 0.109
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0398 0.0909
Leishmania major pyruvate kinase 0.0065 0.0836 1
Mycobacterium ulcerans pyruvate kinase 0.0065 0.0836 0.1917
Echinococcus multilocularis pyruvate kinase 0.0052 0.0629 0.0628
Brugia malayi Pre-SET motif family protein 0.0205 0.2924 0.638
Brugia malayi tumor suppressor. 0.0315 0.4583 1
Brugia malayi Protein cec-1. 0.0011 0.0023 0.0049
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0023 0.0001
Schistosoma mansoni hypothetical protein 0.0081 0.1072 0.1053
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0225 0.2495
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0836 0.2446
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0203 0.0234
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0046 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Loa Loa (eye worm) hypothetical protein 0.0081 0.1072 0.2337
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0118 0.0232
Echinococcus granulosus muscleblind protein 0.0146 0.2051 0.205
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0118 0.0232
Brugia malayi Heterochromatin protein 1 0.0068 0.0879 0.1918
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0139 0.1121
Echinococcus multilocularis Chromo domain 0.0011 0.0023 0.0021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2924 0.6379
Echinococcus multilocularis musashi 0.0026 0.0251 0.025
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.6696 0.6696
Echinococcus multilocularis pyruvate kinase 0.0065 0.0836 0.0834
Brugia malayi hypothetical protein 0.0025 0.0225 0.0492
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0118 0.0232
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.0836 0.1824
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0225 0.1246
Echinococcus multilocularis lamin 0.0026 0.0251 0.025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5868 0.5867
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1954 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0225 0.1246
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0021 0.0019
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0836 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.1121
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0139 0.0137
Mycobacterium ulcerans glutaminase 0.0268 0.3874 1
Brugia malayi pyruvate kinase 0.0014 0.0062 0.0134
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0398 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0039 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0429 0.0984
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0225 0.2495
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0139 0.0281
Loa Loa (eye worm) hypothetical protein 0.0027 0.0255 0.0553
Loa Loa (eye worm) hypothetical protein 0.0023 0.0203 0.044
Echinococcus granulosus Chromo domain 0.0011 0.0023 0.0021
Echinococcus multilocularis protein quaking 0.0027 0.0255 0.0253
Brugia malayi TAR-binding protein 0.0062 0.0786 0.1716
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0118 0.0232
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.1173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0118 0.0232
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0139 0.1121
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0786 0.0767
Loa Loa (eye worm) hypothetical protein 0.0038 0.0429 0.0933
Schistosoma mansoni glutaminase 0.0268 0.3874 0.3861
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0139 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0203 0.0552
Loa Loa (eye worm) inositol-1 0.0036 0.0398 0.0865
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0398 0.5
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0203 0.0444
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0139 0.0281
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0251 0.0545
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0047 0.0045
Schistosoma mansoni hypothetical protein 0.0081 0.1072 0.1053
Echinococcus multilocularis pyruvate kinase 0.0034 0.0358 0.0357
Leishmania major hypothetical protein, conserved 0.0025 0.0225 0.1246
Echinococcus multilocularis microtubule associated protein 2 0.0676 1 1
Echinococcus multilocularis pyruvate kinase 0.0065 0.0836 0.0834
Schistosoma mansoni cpg binding protein 0.0028 0.0277 0.0257
Echinococcus granulosus hypothetical protein 0.0027 0.0255 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0471 0.045
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0429 0.1223
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.1072 0.234
Echinococcus granulosus lamin dm0 0.0026 0.0251 0.025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0303 0.0282
Loa Loa (eye worm) hypothetical protein 0.0044 0.0513 0.1116
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0277 0.0601
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0203 0.0444
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0248
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1954 0.4892
Onchocerca volvulus 0.0026 0.0251 0.0688
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0248
Onchocerca volvulus 0.0028 0.0277 0.0766
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0023 0.0021
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0786 0.0785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.2051 0.4473
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0398 0.3719
Loa Loa (eye worm) helicase 0.0011 0.0023 0.0046
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0251 0.0548
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0786 0.1716
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0303 0.0282
Echinococcus granulosus pyruvate kinase 0.0065 0.0836 0.0834
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5868 0.5867
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.4152 0.5
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.0836 0.1824
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.0836 0.3612
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0303 0.0301
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1954 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0398 0.0752
Plasmodium vivax pyruvate kinase, putative 0.0065 0.0836 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0203 0.093
Schistosoma mansoni pyruvate kinase 0.0065 0.0836 0.0816
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0203 0.093
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0203 0.0234
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0023 0.0049
Brugia malayi intermediate filament protein 0.0026 0.0251 0.0548
Echinococcus granulosus pyruvate kinase 0.0065 0.0836 0.0834
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0047 0.0045
Echinococcus multilocularis pyruvate kinase 0.0034 0.0358 0.0357
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4152 1
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0879 0.2075
Loa Loa (eye worm) hypothetical protein 0.003 0.0303 0.0658
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0152 0.0331
Schistosoma mansoni hypothetical protein 0.0027 0.0255 0.0234
Loa Loa (eye worm) hypothetical protein 0.0026 0.0251 0.0545
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0317 0.2565
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0203 0.0438
Brugia malayi Pre-SET motif family protein 0.003 0.0303 0.0661
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.0539 0.1173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0303 0.0282
Mycobacterium ulcerans hypothetical protein 0.0023 0.0203 0.0234

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 6.13 Binding affinity to human SST3 receptor ChEMBL. 20137944

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.