Detailed information for compound 935762

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 416.855 | Formula: C21H21ClN2O5
  • H donors: 3 H acceptors: 4 LogP: 4.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1c(onc1c1cc(Cl)c(cc1O)O)NC(=O)C(C)(C)C
  • InChi: 1S/C21H21ClN2O5/c1-21(2,3)20(27)23-19-17(11-5-7-12(28-4)8-6-11)18(24-29-19)13-9-14(22)16(26)10-15(13)25/h5-10,25-26H,1-4H3,(H,23,27)
  • InChiKey: DXGLAMIYOFRRGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0221 0.1004 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.199 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0221 0.1004 0.093
Trypanosoma cruzi oligopeptidase b 0.0221 0.1004 0.1523
Echinococcus multilocularis prolyl endopeptidase 0.0221 0.1004 0.0967
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.132 0.6593 0.6565
Echinococcus multilocularis heat shock protein 0.0039 0.0082 0.0041
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0221 0.1004 0.093
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Toxoplasma gondii prolyl endopeptidase 0.0221 0.1004 0.2023
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0221 0.1004 0.1523
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0082 0.0124
Brugia malayi prolyl oligopeptidase family protein 0.0221 0.1004 0.093
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.132 0.6593 1
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0041 0.0062
Echinococcus granulosus Dipeptidyl peptidase 9 0.132 0.6593 0.6579
Entamoeba histolytica hypothetical protein, conserved 0.0221 0.1004 1
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0221 0.1004 1
Brugia malayi hypothetical protein 0.0715 0.3519 0.3465
Echinococcus granulosus heat shock protein 90 0.0039 0.0082 0.0041
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0221 0.1004 0.093
Trypanosoma cruzi prolyl endopeptidase 0.0221 0.1004 0.1523
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0221 0.1004 0.093
Echinococcus granulosus acylamino acid releasing enzyme 0.0221 0.1004 0.0967
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Plasmodium falciparum heat shock protein 90 0.0039 0.0082 0.0772
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Brugia malayi prolyl oligopeptidase family protein 0.0221 0.1004 0.093
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0221 0.1004 0.2023
Mycobacterium tuberculosis Probable peptidase 0.0221 0.1004 1
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.199 1 1
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0082 0.0772
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0041 0.0365
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0082 0.0124
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0221 0.1004 1
Loa Loa (eye worm) hypothetical protein 0.0605 0.2956 0.2898
Brugia malayi prolyl oligopeptidase family protein 0.132 0.6593 0.6565
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.132 0.6593 1
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Giardia lamblia Alanyl dipeptidyl peptidase 0.0221 0.1004 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0041 0.5
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0041 0.0365
Loa Loa (eye worm) prolyl oligopeptidase 0.0221 0.1004 0.093
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Toxoplasma gondii hypothetical protein 0.0221 0.1004 0.2023
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.132 0.6593 1
Echinococcus granulosus heat shock protein 0.0039 0.0082 0.0041
Trypanosoma brucei oligopeptidase b 0.0221 0.1004 0.1416
Echinococcus granulosus prolyl endopeptidase 0.0221 0.1004 0.0967
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0221 0.1004 0.147
Loa Loa (eye worm) prolyl oligopeptidase 0.199 1 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0041 0.0365
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0221 0.1004 0.1416
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0082 0.0124
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.199 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.1004 1
Treponema pallidum heat shock protein 90 0.0031 0.0041 0.5
Entamoeba histolytica prolyl oligopeptidase family protein 0.0221 0.1004 1
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.132 0.6593 1
Plasmodium vivax hypothetical protein, conserved 0.0221 0.1004 1
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.1004 0.1523
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0082 0.0124
Brugia malayi Cytochrome P450 family protein 0.0049 0.013 0.0049
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.132 0.6593 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0221 0.1004 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.1004 0.093
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0221 0.1004 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0221 0.1004 0.1523
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0936 0.464 1
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0082 0.0124
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0221 0.1004 0.1416
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.1004 0.1523
Trypanosoma cruzi oligopeptidase b 0.0221 0.1004 0.1523
Echinococcus multilocularis acylamino acid releasing enzyme 0.0221 0.1004 0.0967
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Entamoeba histolytica prolyl oligopeptidase family protein 0.0221 0.1004 1
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Trypanosoma brucei prolyl endopeptidase 0.0221 0.1004 0.1416
Entamoeba histolytica prolyl oligopeptidase family protein 0.0221 0.1004 1
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0041 0.0062
Echinococcus multilocularis Dipeptidyl peptidase 9 0.132 0.6593 0.6579
Echinococcus multilocularis heat shock protein 90 0.0039 0.0082 0.0041
Trypanosoma brucei prolyl oligopeptidase, putative 0.0221 0.1004 0.1416
Leishmania major oligopeptidase b 0.0221 0.1004 0.147
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0082 0.0422
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0221 0.1004 1
Plasmodium falciparum peptidase, putative 0.0221 0.1004 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.013 0.0049
Loa Loa (eye worm) hypothetical protein 0.0221 0.1004 0.093
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0221 0.1004 0.093
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0221 0.1004 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.199 1 1
Loa Loa (eye worm) hypothetical protein 0.0715 0.3519 0.3465
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0221 0.1004 0.147
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Leishmania major heat shock protein 83-1 0.0039 0.0082 0.0062
Giardia lamblia Alanyl dipeptidyl peptidase 0.0221 0.1004 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 2.301 uM Growth inhibition of human A549 cells after 72 hrs by SRB assay ChEMBL. 25313505
IC50 (binding) = 0.042 uM Inhibition of HSP90alpha (unknown origin) after 16 hrs by FP enzymatic assay ChEMBL. 25313505

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.