Detailed information for compound 935901

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.57 | Formula: C27H26N2O6S
  • H donors: 1 H acceptors: 3 LogP: 5.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)C(=O)c1sc2c(c1N)c(c1cc(OC)c(c(c1)OC)OC)c(c(n2)C)C(=O)C
  • InChi: 1S/C27H26N2O6S/c1-13-20(14(2)30)21(16-11-18(33-4)25(35-6)19(12-16)34-5)22-23(28)26(36-27(22)29-13)24(31)15-7-9-17(32-3)10-8-15/h7-12H,28H2,1-6H3
  • InChiKey: ILTHGBCIUFBFBA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Starlite/ChEMBL References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter, ATP-binding protein domain containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium hominis ABC transporter protein Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium hominis SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia MRP-like ABC transporter Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense multidrug resistance-associated protein, putative,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum Canalicular multispecific organic anion transporter 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance protein E, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Brugia malayi ABC transporter family protein Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana multidrug resistance protein, copy 1-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 7, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium vivax ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ATP-binding cassette sub-family G member 1, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium falciparum ABC transporter G family member 2 Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ABC transporter, AAA domain Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense multidrug resistance protein A Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei multidrug resistance protein E Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi multidrug resistance related protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana p-glycoprotein-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium berghei ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium parvum ATP-binding cassette protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium knowlesi ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense multidrug resistance protein E,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) multidrug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica multidrug resistance protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei ABC transporter, putative ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 611 aa 557 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus multidrug resistance associated protein 4 0.0013 0.011 0.011
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0004 0 0.5
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.016 0.1277
Brugia malayi Kinesin motor domain containing protein 0.0107 0.1255 1
Entamoeba histolytica ABC transporter, putative 0.0017 0.016 0.1277
Brugia malayi ABC transporter transmembrane region family protein 0.0017 0.016 0.1277
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Loa Loa (eye worm) multidrug resistance-associated protein 0.0013 0.0114 0.0904
Trypanosoma brucei ABC transporter, putative 0.0012 0.0096 0.5999
Trypanosoma cruzi multidrug resistance protein E, putative 0.0017 0.016 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Leishmania major pentamidine resistance protein 1 0.0017 0.016 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.016 1
Brugia malayi ABC transporter family protein 0.001 0.0074 0.0591
Echinococcus multilocularis multidrug resistance associated protein 1 0.0017 0.016 0.016
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0004 0 0.5
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0096 0.0096
Giardia lamblia MRP-like ABC transporter 0.0017 0.016 0.0581
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0 0.5
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.001 0.0071 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0017 0.016 0.016
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0004 0 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.016 0.0581
Giardia lamblia Kinesin-5 0.0107 0.1255 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0 0.5
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0017 0.016 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0012 0.0096 0.0766
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0004 0 0.5
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.016 0.1277
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0017 0.016 1
Plasmodium falciparum kinesin-5 0.0107 0.1255 1
Schistosoma mansoni ABC transporter 0.001 0.0074 0.0085
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.016 1
Trichomonas vaginalis ABC transporter, putative 0.0004 0 0.5
Toxoplasma gondii kinesin motor domain-containing protein 0.0107 0.1255 1
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0017 0.016 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0157 0.0552
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0004 0 0.5
Entamoeba histolytica hypothetical protein 0.0017 0.016 0.1277
Trichomonas vaginalis ABC transporter, putative 0.0004 0 0.5
Trypanosoma brucei ATP-binding cassette protein, putative 0.0012 0.0096 0.5999
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0096 0.0096
Trichomonas vaginalis taga, putative 0.0004 0 0.5
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0096 0.0096
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0096 0.0096
Schistosoma mansoni kinesin eg-5 0.0107 0.1255 0.1444
Trypanosoma cruzi hypothetical protein 0.0013 0.011 0.6871
Plasmodium vivax kinesin-5 0.0107 0.1255 1
Schistosoma mansoni hypothetical protein 0.0719 0.8694 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0017 0.016 0.016
Schistosoma mansoni multidrug resistance protein 0.0017 0.016 0.0184
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0004 0 0.5
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0017 0.016 1
Loa Loa (eye worm) kinesin-like protein KLP2 0.0107 0.1255 1
Schistosoma mansoni multidrug resistance protein 0.0017 0.016 0.0184
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0017 0.016 1
Trichomonas vaginalis ABC transporter, putative 0.0004 0 0.5
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.016 0.1277
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0004 0 0.5
Schistosoma mansoni hypothetical protein 0.001 0.0071 0.0081
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0012 0.0096 0.5999
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0017 0.016 0.1277
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0096 1
Leishmania major p-glycoprotein e 0.0017 0.016 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0004 0 0.5
Schistosoma mansoni multidrug resistance protein 0.0017 0.016 0.0184
Trichomonas vaginalis abcb9, putative 0.0004 0 0.5
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.016 0.1277
Trichomonas vaginalis abcb9, putative 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, putative 0.0004 0 0.5
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0004 0 0.5
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0012 0.0096 0.5999
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0096 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0 0.5
Entamoeba histolytica ABC transporter, putative 0.0012 0.0096 0.0766
Echinococcus multilocularis multidrug resistance associated protein 7 0.0017 0.016 0.016
Brugia malayi multidrug resistance related protein 1 0.0017 0.016 0.1277
Giardia lamblia ABC transporter, putative 0.0017 0.016 0.0581
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.016 0.1277
Schistosoma mansoni multidrug resistance protein 0.0017 0.016 0.0184
Loa Loa (eye worm) hypothetical protein 0.0017 0.016 0.1277
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0012 0.0096 0.5999
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Trypanosoma cruzi ABC transporter, putative 0.0012 0.0096 0.5999
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0 0.5
Trypanosoma brucei multidrug resistance protein E 0.0017 0.016 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0017 0.016 0.1277
Entamoeba histolytica multidrug resistance protein, putative 0.0017 0.016 0.1277
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.016 0.0581
Loa Loa (eye worm) ABC transporter 0.001 0.0074 0.0591
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0017 0.016 1
Echinococcus multilocularis multidrug resistance associated protein 4 0.0013 0.011 0.011
Plasmodium falciparum ABC transporter G family member 2 0.0012 0.0096 0.0766
Trichomonas vaginalis abcb9, putative 0.0004 0 0.5
Leishmania major ABC-thiol transporter 0.0017 0.016 1
Echinococcus multilocularis kinesin family 1 0.0826 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0 0.5
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0012 0.0096 1
Entamoeba histolytica kinesin, putative 0.0107 0.1255 1
Onchocerca volvulus 0.0004 0 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0 0.5
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0096 0.0096
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0004 0 0.5
Trypanosoma brucei p-glycoprotein 0.0017 0.016 1
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0096 0.0111
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0096 0.0096
Plasmodium vivax ABC transporter G family member 2, putative 0.0012 0.0096 0.0766
Loa Loa (eye worm) hypothetical protein 0.0017 0.0157 0.125

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 2.6 uM Modulation of BCRP1 mediated drug efflux in mitoxantrone-resistant human MES-SA cells assessed as accumulation of hoechst 33342 incubated for 15 mins prior to rhodamine-123 addition measured after 90 mins by fluorescence analysis ChEMBL. 25311564
EC50 (binding) = 6.6 uM Modulation of MRP1 mediated drug efflux in doxorubicin-resistant human H69 cells assessed as accumulation of calcein AM incubated for 15 mins prior to calcein AM addition measured after 30 mins by fluorescence analysis ChEMBL. 25311564

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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