Detailed information for compound 936226

Basic information

Technical information
  • TDR Targets ID: 936226
  • Name: 5-imino-6-[[1-(phenylmethyl)indol-3-yl]methyl idene]-2-(phenylmethylsulfanyl)-[1,3,4]thiadi azolo[3,2-a]pyrimidin-7-one
  • MW: 507.629 | Formula: C28H21N5OS2
  • H donors: 0 H acceptors: 1 LogP: 6.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1N=c2sc(nn2C(=N)/C/1=C/c1cn(c2c1cccc2)Cc1ccccc1)SCc1ccccc1
  • InChi: 1S/C28H21N5OS2/c29-25-23(26(34)30-27-33(25)31-28(36-27)35-18-20-11-5-2-6-12-20)15-21-17-32(16-19-9-3-1-4-10-19)24-14-8-7-13-22(21)24/h1-15,17,29H,16,18H2/b23-15-,29-25?
  • InChiKey: VQKQKOYWKROUCM-HGNJXLJLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (6Z)-5-imino-6-[[1-(phenylmethyl)indol-3-yl]methylidene]-2-(phenylmethylsulfanyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • 5-imino-6-[[1-(phenylmethyl)indol-3-yl]methylene]-2-(phenylmethylsulfanyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6Z)-5-imino-6-[[1-(phenylmethyl)indol-3-yl]methylene]-2-(phenylmethylsulfanyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6Z)-5-imino-6-[[1-(phenylmethyl)-3-indolyl]methylene]-2-(phenylmethylthio)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • 5-imino-6-[[1-(phenylmethyl)-3-indolyl]methylene]-2-(phenylmethylthio)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • (6Z)-6-[[1-(benzyl)indol-3-yl]methylene]-2-(benzylthio)-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • 6-[[1-(benzyl)indol-3-yl]methylene]-2-(benzylthio)-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
  • AM-900/41331994

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Dengue virus 2 Genome polyprotein Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei 2'-O-ribose RNA methyltransferase SPB1 homolog Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium knowlesi ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum expressed protein Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania infantum FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Theileria parva ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium falciparum large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium berghei ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Entamoeba histolytica ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans similar to S. cerevisiae MRM2 (YGL136C) mitochondrial rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Onchocerca volvulus Putative ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania donovani FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium vivax FtsJ-like methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma congolense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Trichomonas vaginalis ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Brugia malayi ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Babesia bovis ribosomal RNA large subunit methyltransferase J protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Cryptosporidium hominis FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium falciparum ribosomal RNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni cell division protein ftsj Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania braziliensis FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Giardia lamblia FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Cryptosporidium parvum Spb1p-like, FtsJ methylase Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus multilocularis rrna methyltransferase 3 Get druggable targets OG5_126871 All targets in OG5_126871
Trypanosoma brucei gambiense FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Leishmania mexicana FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum Putative rRNA methyltransferase 3, putative Get druggable targets OG5_126871 All targets in OG5_126871
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein Get druggable targets OG5_126871 All targets in OG5_126871
Treponema pallidum cell division protein (ftsJ) Get druggable targets OG5_126871 All targets in OG5_126871
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein Get druggable targets OG5_126871 All targets in OG5_126871
Neospora caninum ftsJ-like methyltransferase domain-containing protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii FtsJ cell division protein, putative Get druggable targets OG5_126871 All targets in OG5_126871
Candida albicans potential FtsJ-like methyltransferase similar to S. cerevisiae SPB1 (YCL054W) putative rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Theileria parva rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma mansoni ribosomal RNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium berghei large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
Neospora caninum ribosomal RNA large subunit methyltransferase J, putative Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium yoelii FtsJ cell division protein Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum ko:K02427 cell division protein methyltransferase FtsJ, putative Get druggable targets OG5_126871 All targets in OG5_126871
Brugia malayi rRNA methyltransferase Get druggable targets OG5_126871 All targets in OG5_126871
Schistosoma japonicum ko:K00599 rRNA methyltransferase Spb1 [EC:2.1.1.-], putative Get druggable targets OG5_126871 All targets in OG5_126871
Babesia bovis ribosomal RNA large subunit methyltransferase J family protein Get druggable targets OG5_126871 All targets in OG5_126871
Plasmodium knowlesi large subunit rRNA methyltransferase, putative Get druggable targets OG5_126871 All targets in OG5_126871
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0084 0.0079 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0084 0.0079 0.0467
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0105
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.001 0.0012
Brugia malayi hypothetical protein 0.0039 0.001 0.0062
Loa Loa (eye worm) hypothetical protein 0.1125 0.1685 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0018 0.002
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.001 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0109 0.0647
Brugia malayi Nuclear hormone receptor E75 0.0039 0.001 0.0062
Loa Loa (eye worm) hypothetical protein 0.0575 0.0837 0.4965
Schistosoma mansoni hypothetical protein 0.0352 0.0492 0.0566
Loa Loa (eye worm) steroid hormone receptor 0.0084 0.0079 0.0467
Loa Loa (eye worm) hypothetical protein 0.0103 0.0109 0.0647
Echinococcus multilocularis kinesin family 1 0.6515 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Schistosoma mansoni thyroid hormone receptor 0.0084 0.0079 0.009
Schistosoma mansoni kinesin eg-5 0.0846 0.1255 0.1444
Schistosoma mansoni nuclear hormone receptor 0.0039 0.001 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0084 0.0079 0.0079
Brugia malayi ecdysone receptor 0.0039 0.001 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0084 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Schistosoma mansoni hypothetical protein 0.0352 0.0492 0.0566
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Brugia malayi Steroid receptor seven-up type 2 0.0084 0.0079 0.0467
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Brugia malayi nuclear hormone receptor 0.0084 0.0079 0.0467
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0152 0.0175
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0105
Schistosoma mansoni nuclear receptor 0.0039 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0152 0.0175
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0084 0.0079 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.001 0.001
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.001 0.0062
Brugia malayi nuclear receptor RXR 0.0044 0.0018 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0084 0.0079 0.0467
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0084 0.0079 0.0467
Brugia malayi conserved hypotetical protein 0.0039 0.001 0.0062
Plasmodium vivax kinesin-5 0.0846 0.1255 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0972 0.1449 0.1449
Schistosoma mansoni thyroid hormone receptor 0.0084 0.0079 0.009
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.001 0.001
Brugia malayi hypothetical protein 0.0044 0.0018 0.0105
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0105
Brugia malayi hypothetical protein 0.0039 0.001 0.0062
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0084 0.0079 0.0079
Leishmania major C-8 sterol isomerase-like protein 0.1125 0.1685 0.5
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.001 0.0062
Schistosoma mansoni hypothetical protein 0.5669 0.8694 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0972 0.1449 0.1449
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0079 0.0079
Echinococcus multilocularis geminin 0.0352 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.0079 0.0467
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0152 0.0175
Trypanosoma brucei C-8 sterol isomerase, putative 0.1125 0.1685 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0084 0.0079 0.0467
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0152 0.0904
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0084 0.0079 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0084 0.0079 0.0079
Schistosoma mansoni retinoic acid receptor RXR 0.0084 0.0079 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.0079 0.0467
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1125 0.1685 0.5
Echinococcus granulosus FTZ F1 alpha 0.0084 0.0079 0.0079
Echinococcus granulosus tar DNA binding protein 0.0131 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Plasmodium falciparum kinesin-5 0.0846 0.1255 0.5
Brugia malayi TAR-binding protein 0.0131 0.0152 0.0904
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0972 0.1449 0.86
Loa Loa (eye worm) DR-78 0.0039 0.001 0.0062
Brugia malayi nuclear receptor NHR-67 0.0039 0.001 0.0062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0084 0.0079 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0084 0.0079 0.0079
Brugia malayi Kinesin motor domain containing protein 0.0846 0.1255 0.7447
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0084 0.0079 0.0467
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.001 0.0062
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Brugia malayi hypothetical protein 0.0044 0.0018 0.0105
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.0079 0.0467
Echinococcus granulosus geminin 0.0352 0.0492 0.0492
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.001 0.0062
Brugia malayi nuclear hormone receptor 0.0039 0.001 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.0084 0.0079 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.0079 0.0467
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0109 0.0647
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.001 0.001
Giardia lamblia Kinesin-5 0.0846 0.1255 0.5
Brugia malayi nuclear receptor NHR-88 0.0084 0.0079 0.0467
Schistosoma mansoni hypothetical protein 0.0071 0.0059 0.0067
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0084 0.0079 0.0079
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.001 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0152 0.0175
Onchocerca volvulus 0.0084 0.0079 1
Schistosoma mansoni nuclear hormone receptor 0.0084 0.0079 0.009
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0152 0.0175
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0084 0.0079 0.0467
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0018 0.0105
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.001 0.0062
Brugia malayi photoreceptor-specific nuclear receptor 0.0084 0.0079 0.0467
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0972 0.1449 0.86
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0018 0.0105
Onchocerca volvulus Protein ultraspiracle homolog 0.0084 0.0079 1
Brugia malayi nuclear receptor NHR-88 0.0039 0.001 0.0062
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0084 0.0079 0.0467
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0059 0.0348
Onchocerca volvulus Bile acid receptor homolog 0.0084 0.0079 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0084 0.0079 0.0467
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0928 0.1381 0.1589
Brugia malayi ecdysteroid receptor 0.0084 0.0079 0.0467
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0084 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0084 0.0079 0.009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0018 0.002
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0152 0.0904
Loa Loa (eye worm) kinesin-like protein KLP2 0.0846 0.1255 0.7447
Schistosoma mansoni steroid hormone receptor ad4bp 0.0084 0.0079 0.009
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0152 0.0152
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0059 0.0348
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0152 0.0904
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0084 0.0079 0.0467
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.001 0.001
Toxoplasma gondii kinesin motor domain-containing protein 0.0846 0.1255 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0018 0.0105
Echinococcus granulosus ecdysone induced protein 78C 0.0084 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0084 0.0079 1
Schistosoma mansoni nuclear receptor 0.0039 0.001 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0084 0.0079 0.009
Schistosoma mansoni zinc finger protein 0.0039 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.001 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0084 0.0079 0.0467
Brugia malayi RNA binding protein 0.0131 0.0152 0.0904
Brugia malayi tailless protein 0.0039 0.001 0.0062
Brugia malayi nuclear receptor RXR 0.0039 0.001 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0084 0.0079 0.0467
Loa Loa (eye worm) hypothetical protein 0.0039 0.001 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0084 0.0079 0.0467
Brugia malayi Nuclear hormone receptor E75 0.0039 0.001 0.0062
Echinococcus multilocularis ecdysone induced protein 78C 0.0084 0.0079 0.0079
Schistosoma mansoni RAR-like nuclear receptor 0.0084 0.0079 0.009
Schistosoma mansoni nuclear hormone receptor 0.0039 0.001 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0109 0.0647
Loa Loa (eye worm) hypothetical protein 0.0084 0.0079 0.0467
Echinococcus multilocularis thyroid hormone receptor alpha 0.0084 0.0079 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0084 0.0079 0.0467
Schistosoma mansoni coup transcription factor 0.0084 0.0079 0.009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0084 0.0079 0.009
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.001 0.001
Brugia malayi steroid hormone receptor 0.0084 0.0079 0.0467
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.001 0.001
Loa Loa (eye worm) RNA binding protein 0.0131 0.0152 0.0904
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.001 0.0062
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0084 0.0079 0.0079
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1125 0.1685 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0084 0.0079 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0084 0.0079 0.0467
Entamoeba histolytica kinesin, putative 0.0846 0.1255 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.09 uM Inhibition of Dengue virus 2 NS2B/NS3 protease using Bz-Nle-Lys-Arg-Arg-AMC as substrate preincubated for 30 mins before substrate addition by fluorescence assay ChEMBL. 25438757
Inhibition (binding) = 72.01 % Inhibition of Dengue virus 2 NS2B/NS3 protease using Bz-Nle-Lys-Arg-Arg-AMC as substrate preincubated at 20 uM for 30 mins before substrate addition by fluorescence assay ChEMBL. 25438757

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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