Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1721 | 0.8596 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1642 | 0.82 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0214 | 0.0237 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.157 | 0.7832 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0716 | 0.3508 | 0.4074 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1721 | 0.8596 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1721 | 0.8596 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0084 | 0.0086 |
Echinococcus granulosus | carbonic anhydrase II | 0.1721 | 0.8596 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0035 | 0.0013 |
Schistosoma mansoni | lamin | 0.0029 | 0.0035 | 0.004 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0035 | 0.0028 |
Echinococcus granulosus | lamin | 0.0029 | 0.0035 | 0.0028 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0716 | 0.3508 | 0.4082 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0716 | 0.3508 | 0.4065 |
Echinococcus multilocularis | carbonic anhydrase | 0.0716 | 0.3508 | 0.4074 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1721 | 0.8596 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0221 | 0.1008 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1721 | 0.8596 | 0.8596 |
Onchocerca volvulus | 0.0221 | 0.1008 | 1 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0716 | 0.3508 | 0.4065 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0035 | 0.0013 |
Toxoplasma gondii | hypothetical protein | 0.0716 | 0.3508 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.1721 | 0.8596 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0716 | 0.3508 | 0.4065 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.157 | 0.7832 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1055 | 0.5225 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0035 | 0.0035 |
Echinococcus multilocularis | carbonic anhydrase | 0.0716 | 0.3508 | 0.4074 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0214 | 0.0237 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0716 | 0.3508 | 0.4065 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.0234 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0121 | 0.0121 |
Schistosoma mansoni | carbonic anhydrase | 0.157 | 0.7832 | 0.9111 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1721 | 0.8596 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0716 | 0.3508 | 0.4074 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.011 | 0.011 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0035 | 0.0028 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1642 | 0.82 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0035 | 0.0028 |
Schistosoma mansoni | lamin | 0.0029 | 0.0035 | 0.004 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0716 | 0.3508 | 0.4082 |
Chlamydia trachomatis | sulfate transporter | 0.0035 | 0.0065 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1721 | 0.8596 | 1 |
Plasmodium vivax | sulfate transporter, putative | 0.0035 | 0.0065 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1721 | 0.8596 | 0.8596 |
Echinococcus multilocularis | carbonic anhydrase | 0.0716 | 0.3508 | 0.4074 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0035 | 0.0028 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0097 | 0.0086 |
Schistosoma mansoni | hypothetical protein | 0.0716 | 0.3508 | 0.4082 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0844 | 0.4157 | 0.7358 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0716 | 0.3508 | 0.4082 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 0.3508 | 0.3508 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0982 | 0.4857 | 0.9089 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0035 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0275 | 0.0275 |
Echinococcus granulosus | carbonic anhydrase | 0.0716 | 0.3508 | 0.4074 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1721 | 0.8596 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.157 | 0.7832 | 0.9547 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.0298 | 0.0321 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.001 | 0.0012 |
Plasmodium falciparum | carbonic anhydrase | 0.0716 | 0.3508 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0084 | 0.0086 |
Schistosoma mansoni | carbonic anhydrase | 0.0716 | 0.3508 | 0.4082 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1721 | 0.8596 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0716 | 0.3508 | 0.3508 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0035 | 0.004 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0716 | 0.3508 | 0.4065 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 0.3508 | 0.3508 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1642 | 0.82 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 39 % | In vitro inhibition of [3H]-spiperone binding to dopamine receptor D2 from rat brain limbic tissue at 1 microM. | ChEMBL. | 2898533 |
Inhibition (binding) | = 47 % | In vitro inhibition of [3H]-spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue at 1 uM | ChEMBL. | 2898533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.