Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.2295 | 0.275 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0202 | 0.8345 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0064 | 0.2295 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.2295 | 0.275 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0038 | 0.1118 | 0.4873 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.1151 | 0.5015 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1118 | 0.4873 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0038 | 0.1118 | 0.134 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0038 | 0.1118 | 0.134 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Echinococcus granulosus | serine:threonine protein kinase PAK 1 | 0.0026 | 0.0608 | 0.0728 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.2295 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1118 | 0.4873 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.2295 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0064 | 0.2295 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2262 | 0.2262 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0027 | 0.064 | 0.5 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0038 | 0.1118 | 0.1118 |
Schistosoma mansoni | tyrosine kinase | 0.0045 | 0.1444 | 0.6291 |
Echinococcus multilocularis | neural Wiskott Aldrich syndrome protein | 0.0038 | 0.1118 | 0.134 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0038 | 0.1151 | 0.1379 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0038 | 0.1118 | 0.1118 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.2295 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.024 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0038 | 0.1118 | 0.4873 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.2295 | 1 |
Schistosoma mansoni | protein kinase | 0.0064 | 0.2295 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0202 | 0.8345 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0038 | 0.1151 | 0.3086 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0013 | 0.0033 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1118 | 0.4873 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.1151 | 0.5015 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0038 | 0.1118 | 0.134 |
Trichomonas vaginalis | STE family protein kinase | 0.0064 | 0.2295 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0038 | 0.1118 | 0.1118 |
Entamoeba histolytica | protein kinase, putative | 0.0064 | 0.2295 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Brugia malayi | WH1 domain containing protein | 0.0038 | 0.1118 | 0.1118 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0027 | 0.064 | 0.064 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0038 | 0.1118 | 0.134 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Schistosoma mansoni | protein kinase | 0.0038 | 0.1151 | 0.5015 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0064 | 0.2295 | 0.275 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0064 | 0.2262 | 0.9803 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0027 | 0.064 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1118 | 0.4873 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1118 | 0.4873 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.2295 | 0.275 |
Entamoeba histolytica | protein kinase, putative | 0.0038 | 0.1151 | 0.5015 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0027 | 0.064 | 0.279 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0027 | 0.064 | 0.064 |
Brugia malayi | Protein kinase domain | 0.0064 | 0.2295 | 0.2295 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.1444 | 0.6291 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0064 | 0.2295 | 0.275 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0027 | 0.064 | 0.279 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0064 | 0.2295 | 0.275 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0027 | 0.064 | 0.064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0053 uM | Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assay | ChEMBL. | 25589921 |
IC50 (binding) | > 4.5 uM | Inhibition of human recombinant PAK1 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assay | ChEMBL. | 25589921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.