Detailed information for compound 946191

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 548.753 | Formula: C35H48O5
  • H donors: 0 H acceptors: 3 LogP: 6.83 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)CC[C@@H]([C@@H]1CC[C@]2([C@@]1(C)CCC1=C2CC[C@@H]2[C@]1(C)CCC(=O)C2(C)C)C)C(=O)OCc1ccccc1
  • InChi: 1S/C35H48O5/c1-32(2)28-14-13-27-26(33(28,3)19-18-29(32)36)17-21-34(4)25(16-20-35(27,34)5)24(12-15-30(37)39-6)31(38)40-22-23-10-8-7-9-11-23/h7-11,24-25,28H,12-22H2,1-6H3/t24-,25-,28-,33+,34-,35+/m0/s1
  • InChiKey: RYVPHYGDJJEMAV-WZEOZWDXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0018 0.0089 0.0087
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0175 0.2154 0.2152
Echinococcus multilocularis tyrosine kinase 0.0018 0.0089 0.0087
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1703 0.1701
Schistosoma mansoni hypothetical protein 0.0015 0.0054 0.0144
Brugia malayi hypothetical protein 0.0018 0.0089 0.0239
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0429 0.118
Entamoeba histolytica hypothetical protein 0.0034 0.0307 0.8194
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0061 0.0654 0.0652
Onchocerca volvulus 0.0011 0.0002 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0429 0.1188
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0022 0.0144 0.0395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0429 0.1188
Schistosoma mansoni adapter molecule crk 0.0022 0.0144 0.0395
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0054 0.0142
Brugia malayi Protein kinase domain containing protein 0.0018 0.0089 0.0239
Brugia malayi hypothetical protein 0.0031 0.0265 0.0724
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0178 0.2188 0.6017
Echinococcus granulosus expressed protein 0.004 0.0387 0.107
Echinococcus granulosus mitogen activated protein kinase 14 0.0141 0.1703 0.4736
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0018 0.0089 0.0242
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0654 0.0652
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0018 0.0089 0.2336
Loa Loa (eye worm) hypothetical protein 0.0031 0.0265 0.073
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0144 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0387 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1703 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0178 0.2188 0.6017
Onchocerca volvulus 0.0031 0.0265 0.1213
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0141 0.1703 1
Echinococcus granulosus tyrosine protein kinase Srms 0.0018 0.0089 0.0242
Entamoeba histolytica hypothetical protein 0.0034 0.0307 0.8194
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0178 0.2188 0.6087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0366 0.1014
Brugia malayi Protein kinase domain containing protein 0.0018 0.0089 0.0239
Echinococcus granulosus NCK adaptor protein 0.0022 0.0144 0.0395
Echinococcus granulosus c src tyrosine kinase 0.0029 0.0231 0.0637
Echinococcus granulosus protein tyrosine kinase 0.0285 0.3593 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0022 0.0144 0.0397
Schistosoma mansoni tyrosine kinase 0.0285 0.3593 1
Onchocerca volvulus 0.0011 0.0002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.005 0.0512 0.1419
Schistosoma mansoni nck2/grb4 0.0022 0.0144 0.0395
Loa Loa (eye worm) TK/FAK protein kinase 0.0288 0.3636 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0429 0.0427
Echinococcus multilocularis GPCR, family 2 0.0015 0.0054 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.2188 0.6087
Entamoeba histolytica protein kinase, putative 0.0013 0.0029 0.0719
Brugia malayi Protein kinase domain containing protein 0.0288 0.3636 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0179 0.2212 0.221
Schistosoma mansoni hypothetical protein 0.0031 0.0265 0.0732
Brugia malayi Protein kinase domain containing protein 0.0018 0.0089 0.0239
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Schistosoma mansoni hypothetical protein 0.0015 0.0054 0.0144
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0061 0.0654 0.0652
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1703 0.1701
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0307 0.0848
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0012 0.0019 0.0045
Schistosoma mansoni tyrosine kinase 0.0029 0.0231 0.0637
Echinococcus granulosus MAM 0.0031 0.0265 0.0732
Echinococcus granulosus tyrosine protein kinase Src64B 0.0061 0.0654 0.1815
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0146 0.1774 0.488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0429 0.1188
Brugia malayi hypothetical protein 0.021 0.2612 0.7183
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.1774 0.4935
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0654 0.0652
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0374 0.2114
Echinococcus multilocularis tyrosine protein kinase Srms 0.005 0.0512 0.051
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0018 0.0089 0.0087
Echinococcus multilocularis expressed protein 0.004 0.0387 0.0384
Echinococcus granulosus GPCR family 2 0.0015 0.0054 0.0144
Onchocerca volvulus 0.0018 0.0089 0.0408
Echinococcus multilocularis tyrosine protein kinase shark 0.0018 0.0089 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0086 0.0232
Onchocerca volvulus 0.0011 0.0002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0012 0.0019 0.0045
Schistosoma mansoni hypothetical protein 0.0032 0.0283 0.0782
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0654 0.1815
Schistosoma mansoni protein kinase 0.0179 0.2212 0.6156
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0054 0.0144
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0141 0.1703 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0061 0.0654 0.1815
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1703 1
Echinococcus granulosus tyrosine kinase 0.0018 0.0089 0.0242
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0425 0.1178
Loa Loa (eye worm) hypothetical protein 0.0015 0.0054 0.0149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0654 0.0652
Brugia malayi Guanylate kinase family protein 0.0013 0.0028 0.007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0054 0.0052
Onchocerca volvulus 0.0031 0.0265 0.1213
Echinococcus multilocularis tyrosine protein kinase Fyn 0.005 0.0512 0.051
Loa Loa (eye worm) TK protein kinase 0.0039 0.0366 0.1008
Loa Loa (eye worm) TK/ABL protein kinase 0.0018 0.0089 0.0245
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1703 0.1701
Loa Loa (eye worm) TK protein kinase 0.005 0.0512 0.1408
Trichomonas vaginalis rotamase, putative 0.004 0.0387 1
Schistosoma mansoni rotamase 0.004 0.0387 0.107
Echinococcus multilocularis cyclin dependent kinase 19 0.0146 0.1774 0.1772
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0374 0.2114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0011 0.0002 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0047 0.048 0.1316
Echinococcus multilocularis MAM 0.0031 0.0265 0.0263
Loa Loa (eye worm) hypothetical protein 0.0032 0.0283 0.0779
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0012 0.0019 0.0016
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0011 0.0002 0.0007
Entamoeba histolytica hypothetical protein 0.0012 0.0019 0.0436
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0054 0.0149
Echinococcus granulosus cyclin dependent kinase 19 0.0146 0.1774 0.4935
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Loa Loa (eye worm) SRC-1 0.0061 0.0654 0.1798
Onchocerca volvulus 0.0011 0.0002 0.0011
Schistosoma mansoni hypothetical protein 0.0031 0.0265 0.0732
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0175 0.2154 0.5994
Schistosoma mansoni tyrosine kinase 0.0061 0.0654 0.1815
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0054 0.0052
Brugia malayi Protein kinase domain containing protein 0.0266 0.3355 0.9226
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0374 0.2114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0047 0.048 0.1316
Schistosoma mansoni tyrosine kinase 0.0164 0.2012 0.5599
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0144 0.0391
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0054 0.0142
Schistosoma mansoni vav2 0.0013 0.0022 0.0055
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0387 0.1063
Loa Loa (eye worm) hypothetical protein 0.0047 0.048 0.1321
Brugia malayi protein-tyrosine kinase 0.005 0.0512 0.1402
Echinococcus granulosus mitogen activated protein kinase 11 0.0141 0.1703 0.4736
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0061 0.0654 0.1815
Onchocerca volvulus 0.0018 0.0089 0.0408
Onchocerca volvulus 0.0015 0.0055 0.025
Schistosoma mansoni hypothetical protein 0.0015 0.0054 0.0144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0307 0.0305
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus granulosus growth factor receptor bound protein 2 0.0022 0.0144 0.0395
Echinococcus granulosus tyrosine protein kinase Blk 0.005 0.0512 0.1419
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0374 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0061 0.0654 0.0652
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0022 0.0061
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0179 0.2212 0.6156
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.0231 0.0637
Echinococcus granulosus tyrosine protein kinase ABL1 0.0018 0.0089 0.0242
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1703 0.1701
Loa Loa (eye worm) SH2 domain-containing protein 0.0011 0.0002 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0061 0.0654 0.0652
Loa Loa (eye worm) STAT protein 0.0011 0.0002 0.0007
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0011 0.0002 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Brugia malayi Serine/threonine-protein kinase SULU 0.021 0.2612 0.7183
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0011 0.0002 0.0007
Brugia malayi SH2 domain containing protein 0.0018 0.0089 0.0239
Entamoeba histolytica protein kinase, putative 0.0039 0.0366 0.9797
Echinococcus multilocularis protein tyrosine kinase 0.0285 0.3593 0.3591
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0374 1
Schistosoma mansoni tyrosine kinase 0.0029 0.0231 0.0637
Loa Loa (eye worm) hypothetical protein 0.0229 0.2858 0.7861
Brugia malayi Protein kinase domain containing protein 0.0018 0.0089 0.0239
Echinococcus multilocularis tyrosine protein kinase Abl 0.0029 0.0231 0.0229
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0061 0.0654 0.0652
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0144 0.0391
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Loa Loa (eye worm) TK/ALK protein kinase 0.0266 0.3354 0.9224
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Loa Loa (eye worm) SH2 domain-containing protein 0.0011 0.0002 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0307 0.0848
Brugia malayi SRC-1 0.0061 0.0654 0.1793
Schistosoma mansoni growth factor receptor-bound protein 0.0022 0.0144 0.0395
Loa Loa (eye worm) SH2 domain-containing protein 0.0011 0.0002 0.0007
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0178 0.2188 0.6014
Brugia malayi Protein kinase domain containing protein 0.0146 0.1774 0.4876
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0429 0.1188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0429 0.0427
Echinococcus granulosus tyrosine protein kinase Lyn 0.0063 0.0681 0.1889
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0061 0.0654 0.0652
Onchocerca volvulus 0.0018 0.0089 0.0408
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0387 0.1057
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0011 0.0002 0.0011
Loa Loa (eye worm) guanylate kinase 0.0013 0.0028 0.0077
Schistosoma mansoni tyrosine kinase 0.0061 0.0654 0.1815
Schistosoma mansoni hypothetical protein 0.0015 0.0054 0.0144
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0366 0.0364
Loa Loa (eye worm) gastrulation defective protein 1 0.0144 0.1748 0.4806
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0141 0.1703 0.4683
Schistosoma mansoni serine/threonine protein kinase 0.021 0.2612 0.727
Brugia malayi Sex muscle abnormal protein 5 0.0022 0.0144 0.0391
Echinococcus multilocularis growth factor receptor bound protein 2 0.0022 0.0144 0.0142
Onchocerca volvulus 0.0018 0.0089 0.0408
Brugia malayi Protein kinase domain containing protein 0.0178 0.2188 0.6014
Schistosoma mansoni protein kinase 0.0179 0.2212 0.6156
Echinococcus granulosus tyrosine protein kinase Src42A 0.0061 0.0654 0.1815
Loa Loa (eye worm) hypothetical protein 0.0031 0.0265 0.073
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0397
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0013 0.0029 0.0719
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0018 0.5
Echinococcus granulosus serine:threonine protein kinase TAO1 0.021 0.2612 0.727
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0429 0.1174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0265 0.073
Brugia malayi hypothetical protein 0.0034 0.0307 0.0838
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0178 0.2188 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Brugia malayi P38 map kinase family protein 2 0.0141 0.1703 0.4679
Brugia malayi Protein kinase domain containing protein 0.0018 0.0089 0.0239
Entamoeba histolytica hypothetical protein 0.0034 0.0307 0.8194
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0654 0.1815
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0022 0.0144 0.0397
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0374 0.2114
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.021 0.2612 0.7185
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.0231 0.0229
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0047 0.048 0.1321
Schistosoma mansoni hypothetical protein 0.0034 0.0307 0.0848
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0022 0.0055
Echinococcus multilocularis tyrosine protein kinase Blk 0.005 0.0512 0.051
Onchocerca volvulus 0.0011 0.0002 0.0011
Brugia malayi Tyrosine-protein kinase abl-1 0.0029 0.0231 0.063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus granulosus tyrosine kinase 0.005 0.0512 0.1419
Onchocerca volvulus 0.0011 0.0002 0.0011
Entamoeba histolytica hypothetical protein 0.0034 0.0307 0.8194
Loa Loa (eye worm) hypothetical protein 0.0018 0.0089 0.0245
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Brugia malayi SH2 domain containing protein 0.0018 0.0089 0.0239
Schistosoma mansoni tyrosine kinase 0.0018 0.0089 0.0242
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.021 0.2612 0.261
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0425 0.0423
Brugia malayi Peripheral plasma membrane protein CASK 0.0013 0.0028 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0429 0.1188
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0178 0.2188 0.2186
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0054 0.0144
Echinococcus granulosus tyrosine protein kinase shark 0.0018 0.0089 0.0242
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0089 0.0245
Echinococcus multilocularis NCK adaptor protein 0.0022 0.0144 0.0142
Onchocerca volvulus 0.0018 0.0089 0.0408
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0654 0.1815
Brugia malayi latrophilin 2 splice variant baaae 0.0032 0.0283 0.0773
Onchocerca volvulus 0.0018 0.0089 0.0408

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 40 uM Inhibition of Pin1 (unknown origin) using Suc-Ala-Glu-Pro-Phe-4-nitroanilide as substrate after 30 mins by protease-coupled assay ChEMBL. 25466185

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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