Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.01 | 0.0043 | 1 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0319 | 0.036 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0173 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.007 | 0 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.6977 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.01 | 0.0043 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0906 | 0.121 | 0.5 |
Echinococcus granulosus | geminin | 0.019 | 0.0173 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.6977 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.6977 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0906 | 0.121 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.6977 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.01 | 0.0043 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0906 | 0.121 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.6977 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6977 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0043 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.01 | 0.0043 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6977 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.019 | 0.0173 | 1 |
Treponema pallidum | hypothetical protein | 0.0319 | 0.036 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0906 | 0.121 | 0.5 |
Echinococcus multilocularis | geminin | 0.019 | 0.0173 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0906 | 0.121 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 11 % | Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP at 10 uM after 20 mins by scintillation proximity assay | ChEMBL. | 25264825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.