Detailed information for compound 951509

Basic information

Technical information
  • TDR Targets ID: 951509
  • Name: N-[2-[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-y l)amino]-2-oxoethyl]benzamide
  • MW: 364.398 | Formula: C20H20N4O3
  • H donors: 2 H acceptors: 3 LogP: 2.38 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1c(=O)n(n(c1C)C)c1ccccc1)CNC(=O)c1ccccc1
  • InChi: 1S/C20H20N4O3/c1-14-18(20(27)24(23(14)2)16-11-7-4-8-12-16)22-17(25)13-21-19(26)15-9-5-3-6-10-15/h3-12H,13H2,1-2H3,(H,21,26)(H,22,25)
  • InChiKey: URWSDMBJVGVIQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)amino]-2-oxo-ethyl]benzamide
  • N-[2-[(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)amino]-2-oxoethyl]benzamide
  • N-[2-keto-2-[(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)amino]ethyl]benzamide
  • 81216-96-8
  • BENZAMIDE, N-((ANTIPYRINYLCARBAMOYL)METHYL)-
  • BRN 5146962
  • Benzamide, N-(2-((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amino)-2-oxoethyl)-
  • N-((Antipyrinylcarbamoyl)methyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.1984 0.5495
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0021 0.009 0.0227
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0223 0.0404
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0214 0.054
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0044 0.0385 1
Schistosoma mansoni glucose transport protein 0.0102 0.1155 0.2911
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0111 0.0961
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0021 0.009 0.0227
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.0385 1
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0281 0.051
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0223 0.0561
Schistosoma mansoni ran 0.0022 0.0098 0.0246
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0228 0.0228
Plasmodium vivax hexose transporter 0.0102 0.1155 0.2094
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1155 0.3201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0111 0.028
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0307 0.3847 0.9881
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0228 0.0228
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.009 0.078
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.02 0.02
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0021 0.009 0.009
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.009 0.078
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0021 0.009 0.0163
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0223 0.0404
Plasmodium falciparum importin beta, putative 0.003 0.02 0.0363
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0307 0.3847 0.9693
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0349
Entamoeba histolytica hypothetical protein 0.0024 0.0127 0.1245
Trypanosoma cruzi lanosterol synthase, putative 0.0774 1 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0111 0.0114
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.1984 0.3595
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.009 0.0227
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0111 0.2886
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0111 0.2886
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0098 0.0098
Giardia lamblia Alanyl dipeptidyl peptidase 0.0044 0.0385 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0044 0.0385 0.0605
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0281 0.0779
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0111 0.1418
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0044 0.0385 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0111 0.5
Entamoeba histolytica prolyl oligopeptidase family protein 0.0044 0.0385 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0228 0.0228
Leishmania major geranylgeranyltransferase, putative 0.0021 0.009 0.0093
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0214 0.055
Brugia malayi hypothetical protein 0.031 0.3893 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0185 0.2245 0.622
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0223 0.0617
Leishmania major importin beta-1 subunit, putative 0.0024 0.0127 0.013
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.1984 0.3595
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.009 0.009
Plasmodium falciparum geranylgeranyltransferase, putative 0.0021 0.009 0.0163
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0098 0.0246
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0228 0.1973
Toxoplasma gondii prolyl endopeptidase 0.0044 0.0385 0.1066
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0303 0.3796 0.3905
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0021 0.009 0.0227
Echinococcus granulosus prolyl endopeptidase 0.0044 0.0385 0.0969
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0228 0.1973
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0021 0.009 0.009
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0 0.5
Entamoeba histolytica protein kinase, putative 0.0031 0.0223 0.4498
Brugia malayi Importin beta-1 subunit 0.003 0.02 0.0515
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0098 0.0177
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0197 0.0497
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0141 0.1671 0.4211
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.054
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.009 0.0231
Schistosoma mansoni glucose transport protein 0.0102 0.1155 0.2911
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0044 0.0385 1
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0197 0.0497
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0223 0.0561
Leishmania major oligopeptidase b 0.0044 0.0385 0.0396
Leishmania major glucose transporter, lmgt1 0.0032 0.0228 0.0234
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0098 0.0251
Schistosoma mansoni protein kinase 0.0031 0.0223 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0228 0.1973
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0228 0.0228
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0497 0.6358 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0303 0.3796 0.9563
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0111 0.2886
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.009 0.009
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0111 0.0308
Trypanosoma brucei prolyl oligopeptidase, putative 0.0044 0.0385 0.0385
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.009 0.2342
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0385 0.333
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0385 0.0385
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0021 0.009 0.025
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0111 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1155 1
Brugia malayi prolyl oligopeptidase family protein 0.0307 0.3847 0.9881
Schistosoma mansoni hypothetical protein 0.0316 0.3969 1
Schistosoma mansoni glucose transport protein 0.0102 0.1155 0.2911
Mycobacterium tuberculosis Probable peptidase 0.0044 0.0385 0.0605
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0223 0.0561
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.009 0.0231
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0223 0.0561
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.3969 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0098 0.027
Echinococcus multilocularis prolyl endopeptidase 0.0044 0.0385 0.0969
Loa Loa (eye worm) hypothetical protein 0.0021 0.009 0.0227
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0281 0.0289
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0223 0.0404
Brugia malayi prolyl oligopeptidase family protein 0.0044 0.0385 0.0988
Schistosoma mansoni ran 0.0022 0.0098 0.0246
Echinococcus granulosus acylamino acid releasing enzyme 0.0044 0.0385 0.0969
Trypanosoma cruzi prolyl endopeptidase 0.0044 0.0385 0.0385
Entamoeba histolytica prolyl oligopeptidase family protein 0.0044 0.0385 1
Echinococcus granulosus General substrate transporter 0.0088 0.0966 0.2435
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0281 0.0281
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0098 0.0177
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0021 0.009 0.009
Onchocerca volvulus Prolyl endopeptidase homolog 0.0044 0.0385 0.0988
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0044 0.0385 0.333
Toxoplasma gondii hypothetical protein 0.0044 0.0385 0.1066
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0307 0.3847 0.9693
Trichomonas vaginalis ran, putative 0.0022 0.0098 0.0845
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0385 0.0385
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0098 0.2537
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1155 0.2911
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0127 0.1097
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0214 0.055
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0044 0.0385 0.0396
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.009 0.078
Plasmodium vivax CDK-related protein kinase 6, putative 0.0434 0.5517 1
Brugia malayi Cam kinase protein 1 0.0031 0.0223 0.0572
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0214 0.4215
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0021 0.009 0.078
Plasmodium falciparum peptidase, putative 0.0044 0.0385 0.0697
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0044 0.0385 0.0969
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0223 0.0561
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0021 0.009 0.0227
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0021 0.009 0.078
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0214 0.1855
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0303 0.3796 0.3796
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0044 0.0385 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0098 0.0098
Trypanosoma cruzi oligopeptidase b 0.0044 0.0385 0.0385
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0127 0.1097
Brugia malayi prolyl oligopeptidase family protein 0.0303 0.3796 0.9749
Brugia malayi prolyl oligopeptidase family protein 0.0044 0.0385 0.0988
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0214 0.054
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0021 0.009 0.0227
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0223 0.0561
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.009 0.078
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0223 0.0223
Brugia malayi prolyl oligopeptidase family protein 0.0044 0.0385 0.0988
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0111 0.0201
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0214 0.054
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.009 0.0227
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1155 0.2911
Loa Loa (eye worm) hypothetical protein 0.0044 0.0385 0.0969
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0044 0.0385 0.333
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0127 0.0127
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0303 0.3796 0.3796
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0044 0.0385 0.0385
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0111 0.0201
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0303 0.3796 0.9563
Loa Loa (eye worm) sugar transporter 0.0102 0.1155 0.2911
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0228 0.0228
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1155 0.2911
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0044 0.0385 0.1066
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0044 0.0385 0.0969
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0223 0.0404
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0223 0.0404
Trypanosoma brucei glucose transporter 2A 0.0032 0.0228 0.0228
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.009 0.025
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.009 0.009
Entamoeba histolytica protein kinase, putative 0.0031 0.0223 0.4498
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0281 0.051
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0385 0.0697
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.009 0.025
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0111 0.0111
Echinococcus multilocularis General substrate transporter 0.0088 0.0966 0.2435
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.054
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0307 0.3847 0.9693
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0021 0.009 0.0227
Trypanosoma brucei oligopeptidase b 0.0044 0.0385 0.0385
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0223 0.0404
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0021 0.009 0.0227
Echinococcus granulosus Dipeptidyl peptidase 9 0.0303 0.3796 0.9563
Echinococcus multilocularis acylamino acid releasing enzyme 0.0044 0.0385 0.0969
Plasmodium falciparum protein kinase 7 0.0289 0.361 0.6542
Onchocerca volvulus 0.031 0.3893 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0281 0.0289
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0223 0.0572
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0303 0.3796 0.3796
Trypanosoma brucei glucose transporter 1E 0.0032 0.0228 0.0228
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0111 0.028
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0044 0.0385 0.0969
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0021 0.009 0.0163
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.009 0.0163
Schistosoma mansoni hypothetical protein 0.0102 0.1155 0.2911
Loa Loa (eye worm) prolyl oligopeptidase 0.0044 0.0385 0.0969
Leishmania major lanosterol synthase, putative 0.0753 0.9721 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0281 0.0281
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1155 0.2911
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.02 0.0555
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.009 0.078
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0044 0.0385 0.0385
Trypanosoma cruzi oligopeptidase b 0.0044 0.0385 0.0385
Trypanosoma brucei prolyl endopeptidase 0.0044 0.0385 0.0385
Entamoeba histolytica prolyl oligopeptidase family protein 0.0044 0.0385 1
Plasmodium falciparum protein kinase 6 0.0434 0.5517 1
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0021 0.009 0.0231
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0044 0.0385 0.0385
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1155 0.2911
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0111 0.028
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0044 0.0385 0.0396
Loa Loa (eye worm) hypothetical protein 0.0161 0.1935 0.4876
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0223 0.0561
Giardia lamblia Alanyl dipeptidyl peptidase 0.0044 0.0385 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0223 0.0617
Leishmania major farnesyltransferase beta subunit 0.0021 0.009 0.0093
Leishmania major glucose transporter, lmgt3 0.0032 0.0228 0.0234
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0223 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0228 0.1973
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0214 0.4655
Entamoeba histolytica hypothetical protein 0.0023 0.0111 0.0711
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.009 0.0227
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0223 0.0561
Trypanosoma cruzi hexose transporter 0.0032 0.0228 0.0228
Plasmodium vivax geranylgeranyltransferase, putative 0.0021 0.009 0.0163
Toxoplasma gondii protein kinase, putative 0.0289 0.361 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0223 0.0561
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.009 0.0163
Trypanosoma cruzi lanosterol synthase, putative 0.0774 1 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.009 0.078
Echinococcus granulosus snurportin 1 0.0316 0.3969 1
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0223 0.0561
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0223 0.0561
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0228 0.1973
Loa Loa (eye worm) hypothetical protein 0.0044 0.0385 0.0969
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0228 0.1973
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0228 0.0234
Leishmania major protein kinase, putative 0.0031 0.0223 0.0229
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0111 0.0111
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0098 0.0098
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0111 0.028
Schistosoma mansoni protein kinase 0.0031 0.0223 0.0561
Plasmodium falciparum hexose transporter 0.0102 0.1155 0.2094
Loa Loa (eye worm) hypothetical protein 0.031 0.3893 0.9809
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0098 0.0246
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.009 0.078
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0214 0.557
Loa Loa (eye worm) hypothetical protein 0.0031 0.0223 0.0561
Echinococcus granulosus importin subunit beta 1 0.003 0.02 0.0505
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0223 0.0404
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Brugia malayi Sugar transporter family protein 0.0102 0.1155 0.2968
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1155 0.2911
Plasmodium vivax importin-beta 2, putative 0.003 0.02 0.0363
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0214 0.054
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0074 0.0641
Echinococcus multilocularis snurportin 1 0.0316 0.3969 1
Loa Loa (eye worm) hypothetical protein 0.003 0.02 0.0505
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0281 0.0281
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1155 0.2911
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1155 0.2911
Loa Loa (eye worm) prolyl oligopeptidase 0.0307 0.3847 0.9693
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0044 0.0385 0.0385
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.02 0.02
Schistosoma mansoni importin beta-1 0.003 0.02 0.0505
Schistosoma mansoni protein kinase 0.0031 0.0223 0.0561
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0127 0.1097
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0223 0.1927
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.009 0.009
Giardia lamblia Prenyltransferase 0.0021 0.009 0.2342
Echinococcus multilocularis importin subunit beta 1 0.003 0.02 0.0505
Entamoeba histolytica Ran family GTPase 0.0022 0.0098 0.0255
Brugia malayi hypothetical protein 0.0141 0.1671 0.4293
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0228 0.1973
Loa Loa (eye worm) hypothetical protein 0.0021 0.009 0.0227
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0111 0.028
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.009 0.0227
Trypanosoma brucei glucose transporter, putative 0.0032 0.0228 0.0228
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0044 0.0385 0.0969
Brugia malayi RNA, U transporter 1 0.0084 0.0919 0.2359
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0223 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0228 0.0228
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0066 0.0104
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0223 0.0617
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0039 0.0039
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0098 0.0246
Leishmania major glucose transporter, lmgt2 0.0032 0.0228 0.0234
Leishmania major GTP-binding protein, putative 0.0022 0.0098 0.01
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0066 0.0104
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0303 0.3796 0.3796

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 5000 nM OSM: Inhibition of Plasmodium falciparum 3D7 growth using a SYBR green I fluorescence based assay. GSK Tres Cantos. ChEMBL. No reference
Inhibition (functional) = 0 % OSM: Percent inhibition of Plasmodium falciparum 3D7 growth at 80 uM. Avery Group Griffith. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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