Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1054 | 1 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.042 | 0.1096 | 0.1096 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1054 | 1 | 1 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0424 | 0.1153 | 0.1153 |
Loa Loa (eye worm) | cysteine protease | 0.1054 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1054 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.042 | 0.1096 | 0.1096 |
Echinococcus granulosus | cathepsin L | 0.0553 | 0.2968 | 0.2052 |
Trypanosoma cruzi | cysteine protease, putative | 0.0553 | 0.2968 | 0.2968 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0885 | 0.7623 | 0.7623 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1054 | 1 | 1 |
Onchocerca volvulus | 0.1054 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0553 | 0.2968 | 0.2968 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0553 | 0.2968 | 0.2968 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0553 | 0.2968 | 0.2968 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0553 | 0.2968 | 0.2968 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0553 | 0.2968 | 0.2968 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0885 | 0.7623 | 0.7623 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1054 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0885 | 0.7623 | 0.7623 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0712 | 0.5206 | 0.5206 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.5206 | 0.5206 |
Plasmodium vivax | unspecified product | 0.0553 | 0.2968 | 0.2968 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0885 | 0.7623 | 0.7623 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.5206 | 0.5206 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0424 | 0.1153 | 0.1153 |
Echinococcus granulosus | cathepsin b | 0.0885 | 0.7623 | 0.7313 |
Loa Loa (eye worm) | hypothetical protein | 0.0885 | 0.7623 | 0.7623 |
Brugia malayi | Cathepsin L-like precursor | 0.0712 | 0.5206 | 0.5206 |
Leishmania major | cysteine peptidase A (CPA) | 0.1054 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0712 | 0.5206 | 0.5206 |
Echinococcus granulosus | cathepsin b | 0.0885 | 0.7623 | 0.7313 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0885 | 0.7623 | 0.7623 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1054 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1054 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1054 | 1 | 1 |
Onchocerca volvulus | 0.1054 | 1 | 1 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.042 | 0.1096 | 0.0024 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0553 | 0.2968 | 0.2103 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1054 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0553 | 0.2968 | 0.2968 |
Brugia malayi | Cathepsin L-like precursor | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1054 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0712 | 0.5206 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0437 | 0.1345 | 0.1345 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0437 | 0.1345 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0712 | 0.5206 | 0.5206 |
Loa Loa (eye worm) | ctsf protein | 0.1054 | 1 | 1 |
Schistosoma mansoni | FFA transport protein | 0.0424 | 0.1153 | 0.1153 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0885 | 0.7623 | 0.7313 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0418 | 0.1075 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.1054 | 1 | 1 |
Onchocerca volvulus | 0.1054 | 1 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0553 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0712 | 0.5206 | 0.5206 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1054 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.042 | 0.1096 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.0553 | 0.2968 | 0.2968 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0712 | 0.5206 | 0.5206 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Onchocerca volvulus | 0.1054 | 1 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0553 | 0.2968 | 0.2052 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0553 | 0.2968 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1054 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.042 | 0.1096 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0553 | 0.2968 | 0.2052 |
Onchocerca volvulus | 0.1054 | 1 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.042 | 0.1096 | 0.1096 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0553 | 0.2968 | 0.2103 |
Loa Loa (eye worm) | hypothetical protein | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1054 | 1 | 1 |
Onchocerca volvulus | 0.1054 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0553 | 0.2968 | 0.2103 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0712 | 0.5206 | 0.4615 |
Leishmania major | cathepsin L-like protease | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1054 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0712 | 0.5206 | 0.5206 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0437 | 0.1345 | 0.1345 |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0418 | 0.1075 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1054 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0553 | 0.2968 | 0.2968 |
Plasmodium vivax | vivapain-3 | 0.0553 | 0.2968 | 0.2968 |
Onchocerca volvulus | Cathepsin L homolog | 0.1054 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1054 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1054 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.042 | 0.1096 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1054 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1054 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0885 | 0.7623 | 0.7623 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0553 | 0.2968 | 0.2103 |
Echinococcus granulosus | cysteine protease | 0.0553 | 0.2968 | 0.2052 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1054 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0712 | 0.5206 | 0.4581 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0712 | 0.5206 | 0.4615 |
Brugia malayi | Cathepsin L-like precursor | 0.1054 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0885 | 0.7623 | 0.7313 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1054 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1054 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Antiproliferative activity against human A549 cells after 3 days by alamar blue assay | ChEMBL. | 10217715 |
IC50 (functional) | > 40 uM | Antiproliferative activity against mouse B16 cells after 3 days by alamar blue assay | ChEMBL. | 10217715 |
IC50 (functional) | > 40 uM | Antiproliferative activity against human CCRF-HSB-2 cells after 3 days by alamar blue assay | ChEMBL. | 10217715 |
IC50 (functional) | > 40 uM | Antiproliferative activity against human TGBC11TKB cells after 3 days by alamar blue assay | ChEMBL. | 10217715 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.