Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 2, subfamily D, polypeptide 6 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 19 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H4 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 2, subfamily D, polypeptide 6 | 497 aa | 425 aa | 32.0 % |
Leishmania major | cytochrome p450-like protein | cytochrome P450, family 2, subfamily C, polypeptide 19 | 490 aa | 411 aa | 23.1 % |
Brugia malayi | hypothetical protein | histamine receptor H2 | 397 aa | 333 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0962 | 0.0962 |
Loa Loa (eye worm) | hypothetical protein | 0.0702 | 1 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0517 | 0.7251 | 0.9012 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0054 | 0.0385 | 0.0478 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0278 | 0.3711 | 0.4613 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0146 | 0.1757 | 0.1757 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0093 | 0.0962 | 0.1196 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.0054 | 0.0385 | 0.0478 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0478 | 0.6673 | 0.654 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Schistosoma mansoni | amine GPCR | 0.0211 | 0.2724 | 0.2653 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Brugia malayi | Cytochrome P450 family protein | 0.004 | 0.0185 | 0.023 |
Leishmania major | extracellular receptor, putative | 0.0054 | 0.0385 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0054 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | glutamate receptor | 0.057 | 0.8046 | 0.8046 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0054 | 0.0385 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0054 | 0.0385 | 0.0478 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0649 | 0.9205 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0093 | 0.0962 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0702 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0224 | 0.2916 | 0.2916 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0093 | 0.0962 | 0.0601 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0278 | 0.3711 | 0.3772 |
Trypanosoma brucei | cytochrome P450, putative | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0054 | 0.0385 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1757 | 0.1757 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0478 | 0.6673 | 0.713 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0054 | 0.0385 | 0.0385 |
Schistosoma mansoni | hypothetical protein | 0.0093 | 0.0962 | 0.0655 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0385 | 0.0478 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.004 | 0.0185 | 0.0185 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0093 | 0.0962 | 0.0601 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0146 | 0.1757 | 0.2184 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0093 | 0.0962 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0146 | 0.1757 | 0.1757 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.057 | 0.8046 | 1 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0054 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0054 | 0.0385 | 0.0385 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0478 | 0.6673 | 0.654 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 140 nM | Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding | ChEMBL. | 20690643 |
IC50 (ADMET) | = 0.055 uM | Inhibition of CYP2C19 | ChEMBL. | 20690643 |
IC50 (ADMET) | = 0.35 uM | Inhibition of CYP3A4 | ChEMBL. | 20690643 |
IC50 (ADMET) | = 4.3 uM | Inhibition of CYP2D6 | ChEMBL. | 20690643 |
IC50 (ADMET) | = 8.6 uM | Inhibition of CYP1A2 | ChEMBL. | 20690643 |
Intrinsic activity (functional) | = 57 % | Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding relative to control | ChEMBL. | 20690643 |
Ki (binding) | = 17 nM | Binding affinity to human histamine H4 receptor | ChEMBL. | 20690643 |
Ki (binding) | = 200 nM | Displacement of [3H](R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation counting | ChEMBL. | 20690643 |
Ki (binding) | = 540 nM | Binding affinity to human histamine H1 receptor | ChEMBL. | 20690643 |
Ki (binding) | > 10000 nM | Binding affinity to human histamine H2 receptor | ChEMBL. | 20690643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.