Detailed information for compound 955264

Basic information

Technical information
  • TDR Targets ID: 955264
  • Name: 1-(3,4,5-trihydroxyphenyl)heptan-1-one
  • MW: 238.28 | Formula: C13H18O4
  • H donors: 3 H acceptors: 4 LogP: 2.99 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCC(=O)c1cc(O)c(c(c1)O)O
  • InChi: 1S/C13H18O4/c1-2-3-4-5-6-10(14)9-7-11(15)13(17)12(16)8-9/h7-8,15-17H,2-6H2,1H3
  • InChiKey: LJPMCPHSTVMALD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 100079-25-2
  • 1-Heptanone, 1-(3,4,5-trihydroxyphenyl)-
  • 1,2,3-Benzenetriol, 4-(hexylcarbonyl)-
  • 1-(3,4,5-Trihydroxyphenyl)-1-heptanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0004 0.0529
Entamoeba histolytica hypothetical protein 0.0045 0.0016 0.5817
Echinococcus multilocularis serotonin receptor 0.004 0.0013 0.4583
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0011 0.3886
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0013 0.4583
Echinococcus multilocularis g protein coupled receptor 0.004 0.0013 0.4583
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0004 0.0214
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0013 0.5102
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0014 0.4891
Echinococcus granulosus tyrosine protein kinase Lyn 0.0041 0.0014 0.4891
Echinococcus multilocularis g protein coupled receptor 0.004 0.0013 0.4583
Schistosoma mansoni multidrug resistance protein 0.0061 0.0026 0.1936
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.0014 0.4891
Schistosoma mansoni multidrug resistance protein 0.0045 0.0016 0.1126
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0013 0.4583
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0013 0.4583
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.0014 0.4891
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0013 0.0852
Schistosoma mansoni neuropeptide receptor 0.004 0.0013 0.0852
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0045 0.0016 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0004 0.0529
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni myosin xvIII 0.004 0.0013 0.0852
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0061 0.0026 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0014 0.4891
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0013 0.4583
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0011 0.3596
Echinococcus multilocularis 0.0024 0.0004 0.0529
Brugia malayi GnHR receptor homolog 0.004 0.0013 0.4403
Giardia lamblia ABC transporter, putative 0.0045 0.0016 1
Echinococcus multilocularis fmrfamide receptor 0.004 0.0013 0.4583
Schistosoma mansoni smdr2 0.0061 0.0026 0.1936
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Brugia malayi sulfakinin receptor protein 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0011 0.3886
Leishmania major p-glycoprotein 0.0061 0.0026 1
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0013 0.4583
Giardia lamblia Multidrug resistance-associated protein 1 0.0045 0.0016 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0013 0.0852
Brugia malayi RE15519p 0.004 0.0013 0.4403
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0013 0.4583
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0004 0.0214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.0014 0.4891
Echinococcus multilocularis neuropeptide receptor 0.004 0.0013 0.4583
Entamoeba histolytica P-glycoprotein-2 0.0061 0.0026 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0061 0.0026 1
Schistosoma mansoni tyrosine kinase 0.0041 0.0014 0.0914
Schistosoma mansoni biogenic amine receptor 0.004 0.0013 0.0852
Echinococcus granulosus g protein coupled receptor 0.004 0.0013 0.4583
Entamoeba histolytica P-glycoprotein-1 0.0061 0.0026 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0013 0.0852
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0061 0.0026 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0045 0.0016 0.5817
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0045 0.0016 1
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0013 0.4583
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0045 0.0016 0.5725
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Brugia malayi multidrug resistance related protein 1 0.0045 0.0016 0.5817
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Entamoeba histolytica P-glyco protein 6, putative 0.0061 0.0026 1
Trichomonas vaginalis abcb9, putative 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0013 0.4583
Echinococcus multilocularis orexin receptor type 2 0.004 0.0013 0.4583
Trypanosoma brucei p-glycoprotein 0.0045 0.0016 1
Entamoeba histolytica ABC transporter, putative 0.0045 0.0016 0.5817
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0014 0.4891
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Schistosoma mansoni hypothetical protein 0.004 0.0013 0.0852
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0014 0.4891
Brugia malayi Dopamine receptor protein 1 0.004 0.0013 0.4403
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0013 0.5102
Mycobacterium ulcerans histidinol dehydrogenase 1.7115 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0013 0.5102
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Loa Loa (eye worm) TK protein kinase 0.0037 0.0011 0.4471
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.0014 0.4891
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0061 0.0026 1
Echinococcus granulosus neuropeptide receptor 0.004 0.0013 0.4583
Echinococcus granulosus orexin receptor type 2 0.004 0.0013 0.4583
Schistosoma mansoni biogenic amine receptor 0.004 0.0013 0.0852
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus multilocularis allatostatin A receptor 0.004 0.0013 0.4583
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0013 0.0852
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Trichomonas vaginalis abcb9, putative 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0011 0.3596
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0013 0.4403
Brugia malayi Serotonin receptor 0.004 0.0013 0.4403
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Brugia malayi Cytochrome P450 family protein 0.0024 0.0004 0.0394
Echinococcus granulosus multidrug resistance protein 1 0.0061 0.0026 1
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0004 0.032
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni amine GPCR 0.004 0.0013 0.0852
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni biogenic amine receptor 0.004 0.0013 0.0852
Loa Loa (eye worm) hypothetical protein 0.0045 0.0016 0.6339
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0024 0.0004 0.089
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Loa Loa (eye worm) multidrug resistance protein 3 0.0061 0.0026 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0045 0.0016 1
Echinococcus multilocularis neuropeptide receptor 0.004 0.0013 0.4583
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Loa Loa (eye worm) hypothetical protein 0.0061 0.0026 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0013 0.0852
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0013 0.4583
Trypanosoma brucei multidrug resistance protein E 0.0045 0.0016 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0013 0.0852
Brugia malayi G-protein coupled receptor 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0013 0.5102
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0013 0.4583
Brugia malayi ABC transporter family protein 0.0024 0.0004 0.0214
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0013 0.0852
Schistosoma mansoni neuropeptide receptor 0.004 0.0013 0.0852
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0013 0.5102
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus granulosus somatostatin receptor 0.004 0.0013 0.4583
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0013 0.4583
Echinococcus multilocularis multidrug resistance associated protein 7 0.0045 0.0016 0.5952
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0013 0.4583
Brugia malayi G protein-coupled receptor 0.004 0.0013 0.4403
Echinococcus multilocularis multidrug resistance protein 1 0.0061 0.0026 1
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0004 0.1593
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0013 0.4583
Leishmania major cytochrome p450-like protein 0.0024 0.0004 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0013 0.4583
Trichomonas vaginalis ABC transporter, putative 0.0061 0.0026 1
Trichomonas vaginalis taga, putative 0.0061 0.0026 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0013 0.0852
Brugia malayi putative neuropeptide receptor 0.004 0.0013 0.4403
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.0014 0.4891
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0004 0.0529
Leishmania major p-glycoprotein e 0.0045 0.0016 0.5725
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0016 0.6339
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0013 0.4583
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0013 0.4403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Schistosoma mansoni hypothetical protein 0.004 0.0013 0.0852
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0045 0.0016 0.6339
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Brugia malayi Dopamine receptor protein 2 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni opsin-like receptor 0.004 0.0013 0.0852
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0013 0.4403
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0061 0.0026 1
Echinococcus granulosus sex peptide receptor 0.004 0.0013 0.4583
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0013 0.4583
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.1436
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0024 0.0004 0.0214
Brugia malayi Serotonin receptor 0.004 0.0013 0.4403
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0061 0.0026 1
Echinococcus multilocularis sex peptide receptor 0.004 0.0013 0.4583
Brugia malayi P-glycoprotein-like protein 0.0024 0.0004 0.0214
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 1.7115 1 1
Brugia malayi Cytochrome P450 family protein 0.0024 0.0004 0.0394
Echinococcus multilocularis serotonin receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0013 0.4583
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0061 0.0026 1
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Loa Loa (eye worm) hypothetical protein 0.0061 0.0026 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Schistosoma mansoni multidrug resistance protein 0.0061 0.0026 0.1936
Schistosoma mansoni hypothetical protein 0.004 0.0013 0.0852
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Loa Loa (eye worm) ABC transporter 0.0024 0.0004 0.1436
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0061 0.0026 1
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0013 0.4583
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.0044 0.0016 0.6152
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0061 0.0026 1
Leishmania major ABC-thiol transporter 0.0045 0.0016 0.5725
Echinococcus multilocularis somatostatin receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) TK protein kinase 0.0033 0.0009 0.3539
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0013 0.4403
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0013 0.4583
Entamoeba histolytica ATP-binding cassette protein, putative 0.0045 0.0016 0.5817
Echinococcus granulosus tyrosine kinase 0.0037 0.0011 0.3886
Echinococcus granulosus multidrug resistance protein 1 0.0061 0.0026 1
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0013 0.4583
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.0014 0.4891
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0013 0.4403
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0045 0.0016 0.5725
Brugia malayi SRC-1 0.0041 0.0014 0.4721
Echinococcus granulosus serotonin receptor 0.004 0.0013 0.4583
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0061 0.0026 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0013 0.0852
Trichomonas vaginalis abcb9, putative 0.0061 0.0026 1
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0004 0.1181
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0013 0.5102
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Echinococcus multilocularis ATP binding cassette sub family B 0.006 0.0025 0.9793
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0013 0.0852
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0061 0.0026 0.0022
Echinococcus granulosus g protein coupled receptor 0.004 0.0013 0.4583
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0013 0.4583
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0061 0.0026 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0061 0.0026 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0004 0.0529
Entamoeba histolytica P-glycoprotein 5, putative 0.0061 0.0026 1
Brugia malayi ABC transporter transmembrane region family protein 0.0045 0.0016 0.5817
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni multidrug resistance protein 0.0045 0.0016 0.1126
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0013 0.4583
Echinococcus multilocularis multidrug resistance associated protein 1 0.0045 0.0016 0.5952
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0013 0.4583
Entamoeba histolytica P-glycoprotein-5 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Brugia malayi Dopamine receptor 0.004 0.0013 0.4403
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.0013 0.5102
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus g protein coupled receptor 0.004 0.0013 0.4583
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.006 0.0025 0.9793
Schistosoma mansoni amine GPCR 0.004 0.0013 0.0852
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0013 0.4583
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0013 0.0852
Schistosoma mansoni amine GPCR 0.0221 0.0119 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0061 0.0026 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.0014 0.4891
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni opsin-like receptor 0.004 0.0013 0.0852
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0013 0.4583
Entamoeba histolytica ATP-binding cassette protein, putative 0.0045 0.0016 0.5817
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0013 0.4403
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0013 0.4583
Brugia malayi Melatonin receptor type 1A 0.004 0.0013 0.4403
Brugia malayi ABC transporter 0.0024 0.0004 0.0214
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0013 0.4583
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0013 0.0852
Schistosoma mansoni multidrug resistance protein 0.0061 0.0026 0.1936
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Echinococcus granulosus ATP binding cassette sub family B 0.0023 0.0003 0.0322
Brugia malayi AKH receptor 0.004 0.0013 0.4403
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0045 0.0016 0.5725
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0013 0.4583
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0013 0.0852
Brugia malayi larval opioid receptor 0.004 0.0013 0.4403
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Entamoeba histolytica P-glycoprotein-2 0.0061 0.0026 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0013 0.4583
Echinococcus granulosus hypothetical protein 0.004 0.0013 0.4583
Giardia lamblia MRP-like ABC transporter 0.0045 0.0016 1
Echinococcus granulosus fmrfamide receptor 0.004 0.0013 0.4583
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0004 0.0214
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0061 0.0026 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.0014 0.4891
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0014 0.4891
Brugia malayi neuropeptide F receptor 0.004 0.0013 0.4403
Brugia malayi G-protein coupled receptor 0.004 0.0013 0.4403
Schistosoma mansoni multidrug resistance protein 0.0045 0.0016 0.1126
Schistosoma mansoni hypothetical protein 0.004 0.0013 0.0852
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0013 0.4583
Entamoeba histolytica protein kinase, putative 0.0033 0.0009 0.2617
Schistosoma mansoni amine GPCR 0.004 0.0013 0.0852
Echinococcus granulosus neuropeptide s receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Brugia malayi ABC transporter family protein 0.0061 0.0026 1
Brugia malayi follicle stimulating hormone receptor 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0061 0.0026 1
Trichomonas vaginalis ABC transporter, putative 0.0061 0.0026 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0045 0.0016 0.5725
Trichomonas vaginalis ABC transporter, putative 0.0061 0.0026 1
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0013 0.4583
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0013 0.5102
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0004 0.1181
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0013 0.4583
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0061 0.0026 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0013 0.0852
Echinococcus multilocularis g protein coupled receptor 0.004 0.0013 0.4583
Brugia malayi neuropeptide F receptor 0.004 0.0013 0.4403
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0024 0.0004 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0013 0.4583
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Brugia malayi multidrug resistance protein 3 0.0061 0.0026 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0013 0.4583
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0011 0.3886
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.1249
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0013 0.0852
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0013 0.4583
Schistosoma mansoni tyrosine kinase 0.0041 0.0014 0.0914
Trypanosoma cruzi multidrug resistance protein E, putative 0.0045 0.0016 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0013 0.4583
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0011 0.3886
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0013 0.4583
Entamoeba histolytica P-glycoprotein-2, putative 0.0061 0.0026 1
Schistosoma mansoni smdr1 0.0024 0.0004 0.0042
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0024 0.0004 0.089
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0014 0.4891
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus granulosus multidrug resistance associated protein 1 0.0045 0.0016 0.5952
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus multidrug resistance associated protein 7 0.0045 0.0016 0.5952
Loa Loa (eye worm) SRC-1 0.0041 0.0014 0.5381
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0004 0.0529
Loa Loa (eye worm) multidrug resistance-associated protein 0.0022 0.0003 0.1145
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0061 0.0026 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0013 0.4583
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Echinococcus multilocularis fmrfamide receptor 0.004 0.0013 0.4583
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0013 0.4583
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0014 0.4891
Schistosoma mansoni multidrug resistance protein 0.0045 0.0016 0.1126
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0045 0.0016 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0013 0.4583
Echinococcus granulosus neuropeptide receptor 0.004 0.0013 0.4583
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0061 0.0026 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0061 0.0026 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0013 0.4403
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0004 0.1593
Loa Loa (eye worm) ABC transporter 0.0024 0.0004 0.1436
Loa Loa (eye worm) ABC transporter 0.0024 0.0004 0.1436
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0004 0.0529
Schistosoma mansoni opsin-like receptor 0.004 0.0013 0.0852
Onchocerca volvulus 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus multidrug resistance protein 1 0.0038 0.0012 0.4256
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0004 0.1593
Brugia malayi ABC transporter family protein 0.0024 0.0004 0.0214
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0013 0.0852
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0013 0.5102
Echinococcus granulosus multidrug resistance protein 1 0.0038 0.0012 0.4256
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0009 0.2855
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0045 0.0016 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0025 0.9812
Schistosoma mansoni histamine h1 receptor 0.004 0.0013 0.0852
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0013 0.0852
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0045 0.0016 0.5725
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0061 0.0026 1
Brugia malayi protein-tyrosine kinase 0.0037 0.0011 0.3682
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0013 0.4583
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0061 0.0026 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Schistosoma mansoni multidrug resistance protein 0.0024 0.0004 0.0042
Brugia malayi ABC transporter family protein 0.0024 0.0004 0.0214
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0061 0.0026 1
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0013 0.4583
Brugia malayi hypothetical protein 0.0024 0.0004 0.0214
Schistosoma mansoni neuropeptide receptor 0.004 0.0013 0.0852
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Entamoeba histolytica ATP-binding cassette protein, putative 0.0045 0.0016 0.5817
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0061 0.0026 1
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0013 0.5102
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0013 0.0852
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0061 0.0026 1
Brugia malayi hypothetical protein 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0004 0.0214
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0013 0.4583
Schistosoma mansoni neuropeptide receptor 0.004 0.0013 0.0852
Schistosoma mansoni adenoreceptor 0.004 0.0013 0.0852
Schistosoma mansoni amine GPCR 0.004 0.0013 0.0852
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Giardia lamblia Multidrug resistance-associated protein 1 0.0044 0.0016 0.9631
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0061 0.0026 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0013 0.4583
Echinococcus granulosus allatostatin A receptor 0.004 0.0013 0.4583
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0013 0.4583
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0013 0.0852
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0013 0.0852
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0024 0.0004 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0061 0.0026 1
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0013 0.4583
Trichomonas vaginalis ABC transporter, putative 0.0061 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0038 0.0012 0.4065
Leishmania major pentamidine resistance protein 1 0.0045 0.0016 0.5725
Echinococcus multilocularis multidrug resistance protein 1 0.0061 0.0026 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0009 0.2855
Plasmodium falciparum multidrug resistance protein 1 0.0061 0.0026 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0013 0.4583
Brugia malayi ORL1-like opioid receptor 0.004 0.0013 0.4403
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Echinococcus granulosus multidrug resistance protein 1 0.0061 0.0026 1
Echinococcus multilocularis multidrug resistance protein 1 0.0038 0.0012 0.4256
Echinococcus granulosus g-protein coupled receptor 0.004 0.0013 0.4583
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0011 0.3886
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.5102
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0024 0.0004 0.0042
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0013 0.5102
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0014 0.4891
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0013 0.0852
Entamoeba histolytica multidrug resistance protein, putative 0.0045 0.0016 0.5817

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 75 % Decrease in cytoplasmic glutathione level in mouse L1210 cells at 100 uM ChEMBL. 18295493

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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