Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0131 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.3207 | 0.3207 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0132 | 0.0021 | 0.023 |
Echinococcus granulosus | glutamate receptor 2 | 0.033 | 0.7025 | 0.803 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0131 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0131 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0196 | 0.2296 | 0.2296 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0132 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0414 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0131 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0196 | 0.2296 | 0.2296 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0132 | 0.0021 | 0.023 |
Leishmania major | cytochrome p450-like protein | 0.0196 | 0.2296 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0196 | 0.2296 | 0.2296 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0131 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0131 | 0 | 0.5 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0132 | 0.0021 | 0.023 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0354 | 0.7865 | 0.7865 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0271 | 0.4931 | 0.5636 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0131 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0132 | 0.0021 | 0.023 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0131 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0131 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0131 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0131 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0157 | 0.0904 | 0.1034 |
Trypanosoma brucei | cytochrome P450, putative | 0.0196 | 0.2296 | 1 |
Echinococcus granulosus | glutamate receptor 4 | 0.0222 | 0.3207 | 0.3666 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0271 | 0.4931 | 0.5636 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0131 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0157 | 0.0904 | 0.1034 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0157 | 0.0904 | 0.1034 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0132 | 0.0021 | 0.023 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0131 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0379 | 0.8748 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0157 | 0.0904 | 0.1034 |
Schistosoma mansoni | glutamate receptor kainate | 0.0132 | 0.0021 | 0.023 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0132 | 0.0021 | 0.0024 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0131 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0157 | 0.0904 | 0.1034 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0131 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0132 | 0.0021 | 0.023 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0196 | 0.2296 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0157 | 0.0904 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0379 | 0.8748 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0379 | 0.8748 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0131 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0379 | 0.8748 | 1 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0354 | 0.7865 | 0.7865 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0131 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0222 | 0.3207 | 0.3666 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0354 | 0.7865 | 0.7865 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0131 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0196 | 0.2296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.3207 | 0.3207 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0354 | 0.7865 | 0.899 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0196 | 0.2296 | 0.2296 |
Echinococcus granulosus | glutamate receptor 1 | 0.0222 | 0.3207 | 0.3666 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0131 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0131 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0157 | 0.0904 | 0.1034 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0131 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0131 | 0 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0132 | 0.0021 | 0.0024 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0196 | 0.2296 | 0.2296 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0131 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.033 | 0.7025 | 0.803 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0196 | 0.2296 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.3207 | 0.3207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.