Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0129 | 0 | 0.5 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0129 | 0 | 0.5 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0861 | 1 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0129 | 0 | 0.5 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0129 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0861 | 1 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0861 | 1 | 1 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0861 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0861 | 1 | 1 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0129 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0129 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0861 | 1 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0129 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0129 | 0 | 0.5 |
Onchocerca volvulus | 0.0129 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0129 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.12 uM | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation | ChEMBL. | 19110420 |
Inhibition (functional) | = 17 % | Inhibition of Bz-ATP-induced IL1-beta release in LPS/IFN-gamma-differentiated human THP1 cells at 1 uM by ELISA | ChEMBL. | 19110420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.