Detailed information for compound 974209

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.786 | Formula: C19H15ClN2O4
  • H donors: 1 H acceptors: 3 LogP: 2.94 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc2c(c1)[C@@H](n1oc3c(c1=O)ccc(c3)Cl)[C@@H](C(O2)(C)C)O
  • InChi: 1S/C19H15ClN2O4/c1-19(2)17(23)16(13-7-10(9-21)3-6-14(13)25-19)22-18(24)12-5-4-11(20)8-15(12)26-22/h3-8,16-17,23H,1-2H3/t16-,17+/m1/s1
  • InChiKey: LSWVRWFSRJQEKB-SJORKVTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica multidrug resistance protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi multidrug resistance related protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance protein E, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 7, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Canalicular multispecific organic anion transporter 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter, ATP-binding protein domain containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense multidrug resistance protein E,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia MRP-like ABC transporter Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ATP-binding cassette protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium hominis SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana multidrug resistance protein, copy 1-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance protein E Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) multidrug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance protein A Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense multidrug resistance-associated protein, putative,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cathepsin L homolog 0.005 0.1652 0.0757
Onchocerca volvulus 0.005 0.1652 0.0757
Schistosoma mansoni nAChR subunit 0.0036 0.0968 0.143
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0968 0.0962
Echinococcus granulosus glycine receptor subunit beta 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Entamoeba histolytica cysteine proteinase, putative 0.005 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0079 0.3097 0.3092
Schistosoma mansoni nAChR subunit 0.0079 0.3097 0.4595
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Giardia lamblia MRP-like ABC transporter 0.0017 0.0007 0.0034
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Echinococcus granulosus glycine receptor subunit beta 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0079 0.3097 0.3092
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.3097 0.3092
Schistosoma mansoni neurotransmitter gated ion channel 0.0042 0.1274 0.1885
Schistosoma mansoni nAChR subunit 0.0079 0.3097 0.4595
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0079 0.3097 0.3092
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.3097 0.3092
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.3097 0.3092
Toxoplasma gondii cathepsin CPL 0.005 0.1652 0.7961
Brugia malayi cathepsin L-like precursor 0.005 0.1652 0.1646
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0968 0.143
Schistosoma mansoni nAChR subunit 0.0036 0.0968 0.143
Entamoeba histolytica hypothetical protein 0.0042 0.1274 0.7705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Loa Loa (eye worm) ctsf protein 0.005 0.1652 0.1652
Onchocerca volvulus Cathepsin L homolog 0.005 0.1652 0.0757
Onchocerca volvulus 0.0042 0.1274 0.0339
Giardia lamblia ABC transporter, putative 0.0017 0.0007 0.0034
Schistosoma mansoni nAChR subunit 0.0079 0.3097 0.4595
Giardia lamblia Cathepsin B precursor 0.0058 0.2073 1
Brugia malayi Cation transporter family protein 0.0079 0.3097 0.3092
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.3097 0.4595
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0079 0.3097 0.3092
Echinococcus multilocularis cathepsin b 0.0151 0.6731 0.6729
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0079 0.3097 0.3097
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0216 1 1
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0036 0.0968 0.0962
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0079 0.3097 0.3092
Onchocerca volvulus Putative nachr subunit 0.0216 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3097 0.3092
Leishmania major cysteine peptidase A (CPA) 0.005 0.1652 0.7961
Entamoeba histolytica cysteine proteinase, putative 0.005 0.1652 1
Brugia malayi hypothetical protein 0.0036 0.0968 0.0962
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.1652 0.2446
Loa Loa (eye worm) cysteine protease 0.005 0.1652 0.1652
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.1652 0.2446
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.1652 0.1652
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0036 0.0968 0.0962
Echinococcus granulosus cathepsin b 0.0151 0.6731 0.6729
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.1652 0.2446
Brugia malayi Cathepsin L-like cysteine proteinase 0.005 0.1652 0.1646
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Onchocerca volvulus 0.005 0.1652 0.0757
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0147 0.6549 0.9728
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0036 0.0968 0.0962
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0079 0.3097 0.3092
Loa Loa (eye worm) ACC-1 protein 0.0079 0.3097 0.3097
Onchocerca volvulus 0.0147 0.6549 0.6179
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3097 0.3092
Loa Loa (eye worm) GABA receptor subunit 0.0042 0.1274 0.1274
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Echinococcus multilocularis glycine receptor subunit beta 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0151 0.6731 0.6731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.3097 0.3092
Echinococcus granulosus nAChR subunit 0.0042 0.1274 0.1268
Onchocerca volvulus 0.0079 0.3097 0.2357
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0058 0.2073 0.3073
Loa Loa (eye worm) fibroinase 0.005 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0079 0.3097 0.3097
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Schistosoma mansoni acetylcholine receptor-related 0.0036 0.0968 0.143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Toxoplasma gondii cathepsin B 0.0058 0.2073 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.6731 1
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Loa Loa (eye worm) ACC-1 protein 0.0079 0.3097 0.3097
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.1652 0.1646
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.1652 0.2446
Giardia lamblia Cathepsin B precursor 0.0058 0.2073 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0042 0.1274 0.1885
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0079 0.3097 0.3092
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Brugia malayi Cation transporter family protein 0.0079 0.3097 0.3092
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0007 0.0034
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0079 0.3097 0.3097
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.3097 0.3092
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0216 1 1
Schistosoma mansoni nAChR subunit 0.0079 0.3097 0.4595
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0216 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.005 0.1652 0.1646
Loa Loa (eye worm) acetylcholine receptor protein 0.0036 0.0968 0.0968
Loa Loa (eye worm) LGC-31 protein 0.0079 0.3097 0.3097
Echinococcus multilocularis cysteine protease 0.005 0.1652 0.1646
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.1652 0.2446
Brugia malayi hypothetical protein 0.0036 0.0968 0.0962
Onchocerca volvulus 0.005 0.1652 0.0757
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Onchocerca volvulus 0.0147 0.6549 0.6179
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Onchocerca volvulus 0.005 0.1652 0.0757
Echinococcus granulosus cathepsin b 0.0151 0.6731 0.6729
Entamoeba histolytica cysteine protease, putative 0.005 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0968 0.0962
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Plasmodium vivax vivapain-2 0.005 0.1652 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0968 0.0962
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0079 0.3097 0.3092
Brugia malayi Papain family cysteine protease containing protein 0.005 0.1652 0.1646
Plasmodium falciparum cysteine proteinase falcipain 2b 0.005 0.1652 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0216 1 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0079 0.3097 0.3092
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.6731 1
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0042 0.1274 0.1885
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Echinococcus granulosus cathepsin l cysteine peptidase 0.005 0.1652 0.1646
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0968 0.143
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.1652 0.1646
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0036 0.0968 0.0962
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0079 0.3097 0.3097
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0216 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0079 0.3097 0.3097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0042 0.1274 0.1268
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3097 0.3092
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.1652 0.2446
Loa Loa (eye worm) hypothetical protein 0.0111 0.4726 0.4726
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Brugia malayi hypothetical protein 0.0036 0.0968 0.0962
Loa Loa (eye worm) hypothetical protein 0.0147 0.6549 0.6549
Onchocerca volvulus Cathepsin F homolog 0.005 0.1652 0.0757
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0042 0.1274 0.1268
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Onchocerca volvulus 0.0042 0.1274 0.0339
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.1652 0.1646
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0036 0.0968 0.0962
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Onchocerca volvulus 0.005 0.1652 0.0757
Schistosoma mansoni acetylcholine receptor subunit beta 0.0036 0.0968 0.143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0151 0.6731 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0036 0.0968 0.0962
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0079 0.3097 0.3092
Echinococcus granulosus glycine receptor subunit alpha 1 0.0079 0.3097 0.3092
Echinococcus multilocularis nAChR subunit 0.0079 0.3097 0.3092
Giardia lamblia Multidrug resistance-associated protein 1 0.0017 0.0007 0.0034
Brugia malayi Cation transporter family protein 0.0147 0.6549 0.6546
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0042 0.1274 0.1268
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.1652 0.1652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Loa Loa (eye worm) hypothetical protein 0.005 0.1652 0.1652
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0042 0.1274 0.1268
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.6731 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0079 0.3097 0.3092
Brugia malayi cathepsin B-like cysteine proteinase 0.0151 0.6731 0.6729
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0079 0.3097 0.4595
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0147 0.6549 0.6549
Schistosoma mansoni nAChR subunit 0.0079 0.3097 0.4595
Plasmodium falciparum cysteine proteinase falcipain 2a 0.005 0.1652 0.5
Giardia lamblia Cathepsin B precursor 0.0058 0.2073 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0216 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0216 1 1
Brugia malayi hypothetical protein 0.0036 0.0968 0.0962
Loa Loa (eye worm) hypothetical protein 0.005 0.1652 0.1652
Onchocerca volvulus 0.005 0.1652 0.0757
Onchocerca volvulus 0.0079 0.3097 0.2357
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Echinococcus granulosus nAChR subunit 0.0079 0.3097 0.3092
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Plasmodium vivax vivapain-2 0.005 0.1652 0.5
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Onchocerca volvulus 0.0079 0.3097 0.2357
Brugia malayi hypothetical protein 0.0036 0.0968 0.0962
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0058 0.2073 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.005 0.1652 0.5
Echinococcus granulosus cathepsin l1 0.005 0.1652 0.1646
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.1652 0.7961
Brugia malayi Cathepsin L-like precursor 0.005 0.1652 0.1646
Onchocerca volvulus 0.005 0.1652 0.0757
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Leishmania major cathepsin L-like protease 0.005 0.1652 0.7961
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0058 0.2073 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.005 0.1652 0.1652
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0036 0.0968 0.0962
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.1652 0.1646
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.6731 1
Entamoeba histolytica cysteine proteinase, putative 0.005 0.1652 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.005 0.1652 0.2446
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Onchocerca volvulus 0.0147 0.6549 0.6179
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.3097 0.4595
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0058 0.2073 0.3073
Loa Loa (eye worm) hypothetical protein 0.0079 0.3097 0.3097
Echinococcus multilocularis cathepsin b 0.0151 0.6731 0.6729
Echinococcus multilocularis glycine receptor subunit beta 0.0079 0.3097 0.3092
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0147 0.6549 0.9728
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0036 0.0968 0.0968
Onchocerca volvulus 0.005 0.1652 0.0757
Schistosoma mansoni nAChR subunit 0.0079 0.3097 0.4595
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0079 0.3097 0.3092
Loa Loa (eye worm) hypothetical protein 0.005 0.1652 0.1652
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.1652 0.2446
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0036 0.0968 0.0962
Schistosoma mansoni nAChR subunit 0.0079 0.3097 0.4595
Brugia malayi excitatory GABA receptor EXP-1A 0.0079 0.3097 0.3092
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.1652 0.2446
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0216 1 1
Echinococcus multilocularis nAChR subunit 0.0042 0.1274 0.1268
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0036 0.0968 0.0968
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0079 0.3097 0.4595
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0079 0.3097 0.3092
Echinococcus multilocularis cysteine protease 0.005 0.1652 0.1646
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0079 0.3097 0.3092
Loa Loa (eye worm) cathepsin B 0.0058 0.2073 0.2073
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Trypanosoma brucei cysteine peptidase C (CPC) 0.0058 0.2073 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0042 0.1274 0.1274
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0017 0.0007 0.0007
Echinococcus granulosus cathepsin l1 0.005 0.1652 0.1646

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.67 uM Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR ChEMBL. 19101153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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