TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 350.454 | Formula: C22H26N2O2
H donors: 2 H acceptors: 2 LogP: 2.86 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H]1Cc2ccccc2C[C@H]1N1CCC(CC1)C(=O)c1ccc(cc1)N
InChi: 1S/C22H26N2O2/c23-19-7-5-15(6-8-19)22(26)16-9-11-24(12-10-16)20-13-17-3-1-2-4-18(17)14-21(20)25/h1-8,16,20-21,25H,9-14,23H2/t20-,21-/m1/s1
InChiKey: YCMBHNGPEVEVOO-NHCUHLMSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 18 (vesicular acetylcholine transporter), member 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	vesicular acetylcholine transporter unc-17	Get druggable targets OG5_133283	All targets in OG5_133283
Schistosoma mansoni	vesicular acetylcholine transporter	Get druggable targets OG5_133283	All targets in OG5_133283
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	Get druggable targets OG5_133283	All targets in OG5_133283
Echinococcus granulosus	vesicular acetylcholine transporter	Get druggable targets OG5_133283	All targets in OG5_133283
Echinococcus multilocularis	vesicular acetylcholine transporter	Get druggable targets OG5_133283	All targets in OG5_133283
Schistosoma japonicum	ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative	Get druggable targets OG5_133283	All targets in OG5_133283
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	Get druggable targets OG5_133283	All targets in OG5_133283

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Abnormal catecholamine distribution protein 1	solute carrier family 18 (vesicular acetylcholine transporter), member 3	532 aa	504 aa	34.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0863	0.0336
Onchocerca volvulus		0.0038	0.0863	0.0336
Onchocerca volvulus		0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0863	0.0863
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0863	0.0336
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0863	0.0336
Brugia malayi	GnHR receptor homolog	0.0038	0.0863	0.0863
Brugia malayi	Serotonin receptor	0.0038	0.0863	0.0863
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0863	0.0863
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0863	0.0336
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0863	0.0863
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	G-protein coupled receptor	0.0038	0.0863	0.0863
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0863	0.0336
Brugia malayi	putative neuropeptide receptor	0.0038	0.0863	0.0863
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0863	0.0336
Onchocerca volvulus		0.0038	0.0863	0.0336
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0863	0.0863
Brugia malayi	G-protein coupled receptor	0.0038	0.0863	0.0863
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0863	0.0336
Brugia malayi	neuropeptide F receptor	0.0038	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0863	0.0863
Schistosoma mansoni	amine GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0863	0.0336
Brugia malayi	larval opioid receptor	0.0038	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Trypanosoma brucei	Enriched in surface-labeled proteome protein 12	0.0217	0.8023	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0267	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0863	0.0336
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0863	0.0336
Brugia malayi	Serotonin receptor	0.0038	0.0863	0.0863
Schistosoma mansoni	amine GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0863	0.0336
Brugia malayi	AKH receptor	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0863	0.0336
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	amine GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0863	0.0336
Brugia malayi	G protein-coupled receptor	0.0038	0.0863	0.0863
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0863	0.0336
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0863	0.0336
Echinococcus granulosus	somatostatin receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0863	0.0336
Brugia malayi	intermediate filament protein	0.003	0.0546	0.0546
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0863	0.0863
Echinococcus multilocularis	serotonin receptor	0.0038	0.0863	0.0336
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	myosin xvIII	0.0038	0.0863	0.0336
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0863	0.0336
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0267	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0863	0.0336
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0863	0.0863
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0863	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Onchocerca volvulus		0.0038	0.0863	0.0336
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0863	0.0336
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0863	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0863	0.0336
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	hypothetical protein	0.0038	0.0863	0.0336
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0267	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0863	0.0863
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0863	0.0336
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0217	0.8023	0.5
Brugia malayi	sulfakinin receptor protein	0.0038	0.0863	0.0863
Brugia malayi	Dopamine receptor	0.0038	0.0863	0.0863
Trypanosoma brucei	hypothetical protein, conserved	0.0217	0.8023	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.003	0.0546	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0863	0.0863
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0863	0.0336
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0217	0.8023	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0546	0.0546
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	opsin-like receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0217	0.8023	0.5
Onchocerca volvulus		0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	opsin-like receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0863	0.0863
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0863	0.0336
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0863	0.0863
Schistosoma mansoni	hypothetical protein	0.0038	0.0863	0.0336
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0863	0.0336
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0863	0.0336
Brugia malayi	RE15519p	0.0038	0.0863	0.0863
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0863	0.0336
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0863	0.0336
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0863	0.0863
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Echinococcus granulosus	vesicular acetylcholine transporter	0.0267	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0863	0.0336
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0863	0.0336
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0863	0.0336
Schistosoma mansoni	amine GPCR	0.0038	0.0863	0.0336
Brugia malayi	neuropeptide F receptor	0.0038	0.0863	0.0863
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0863	0.0336
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0217	0.8023	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0863	0.0336
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0863	0.0863
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0863	0.0336
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	hypothetical protein	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0546	0.0546
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0863	0.0336
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	serotonin receptor	0.0038	0.0863	0.0336
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0863	0.0336
Schistosoma mansoni	hypothetical protein	0.0038	0.0863	0.0336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	adenoreceptor	0.0038	0.0863	0.0336
Schistosoma mansoni	amine GPCR	0.0038	0.0863	0.0336
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0863	0.0336
Onchocerca volvulus		0.0038	0.0863	0.0336
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0863	0.0336
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0863	0.0336
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0524	0.0524
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0863	0.0336
Onchocerca volvulus		0.0038	0.0863	0.0336
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0863	0.0863
Echinococcus granulosus	serotonin receptor	0.0038	0.0863	0.0336
Trypanosoma brucei	hypothetical protein, conserved	0.0217	0.8023	0.5
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	vesicular acetylcholine transporter	0.0267	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0863	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0863	0.0336
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0863	0.0863
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0863	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	hypothetical protein	0.0038	0.0863	0.0336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0863	0.0336
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0863	0.0336
Schistosoma mansoni	hypothetical protein	0.0057	0.1624	0.1141
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0217	0.8023	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0863	0.0336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0863	0.0336
Echinococcus granulosus	sex peptide receptor	0.0038	0.0863	0.0336
Schistosoma mansoni	opsin-like receptor	0.0038	0.0863	0.0336
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0863	0.0863
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0863	0.0863
Brugia malayi	hypothetical protein	0.0038	0.0863	0.0863
Onchocerca volvulus		0.0038	0.0863	0.0336

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)		Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membrane by liquid scintillation counting	ChEMBL.	19203271
Ki (binding)	= 1.68 nM	Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometry	ChEMBL.	19203271
Ki (binding)	= 1.68 nM	Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrs	ChEMBL.	23802889

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL473548

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 974689