Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | choline O acetyltransferase | 0.0341 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0051 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0051 | 0 | 0.5 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0051 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0051 | 0 | 0.5 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0341 | 1 | 1 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0051 | 0 | 0.5 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0051 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0051 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0341 | 1 | 1 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0051 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0341 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0341 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0051 | 0 | 0.5 |
Onchocerca volvulus | 0.0051 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0051 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0051 | 0 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0051 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 78 nM | Agonist activity at human cloned CB2 receptor assessed as stimulation of [35S]GTPgammaS binding | ChEMBL. | 19091565 |
Ki (binding) | = 82 nM | Displacement of [3H]CP-55940 from human cloned CB2 receptor by scintillation spectrometry | ChEMBL. | 19091565 |
Ki (binding) | = 560 nM | Displacement of [3H]CP-55940 from human cloned CB1 receptor by scintillation spectrometry | ChEMBL. | 19091565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.