TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 499.571 | Formula: C27H32F3N5O
H donors: 3 H acceptors: 2 LogP: 4.26 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#CCNC(=O)C1(CCCCC1)N[C@H](C(F)(F)F)c1ccc(cc1)c1ccc(cc1)N1CCNCC1
InChi: 1S/C27H32F3N5O/c28-27(29,30)24(34-26(12-2-1-3-13-26)25(36)33-15-14-31)22-6-4-20(5-7-22)21-8-10-23(11-9-21)35-18-16-32-17-19-35/h4-11,24,32,34H,1-3,12-13,15-19H2,(H,33,36)/t24-/m0/s1
InChiKey: BWTADDUGYRQSQU-DEOSSOPVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0312	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.1055	0.1971
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1055	0.362
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.5354	0.5354
Entamoeba histolytica	cysteine protease, putative	0.0086	0.2	1
Toxoplasma gondii	cathepsin B	0.007	0.1428	0.7138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Echinococcus granulosus	cathepsin l1	0.0059	0.1055	0.1055
Schistosoma mansoni	calcium-activated potassium channel	0.0145	0.4075	0.4075
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2	0.3736
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0567	0.0567
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Trypanosoma brucei	RNA helicase, putative	0.0165	0.4789	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0753	0.0753
Echinococcus granulosus	cysteine protease	0.0047	0.0614	0.0614
Echinococcus granulosus	geminin	0.0172	0.504	0.504
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.1428	0.1879
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0614	0.0197
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0567	0.0567
Brugia malayi	RNase H family protein	0.0044	0.0519	0.097
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.2	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1055	0.1055
Schistosoma mansoni	hypothetical protein	0.0312	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Echinococcus multilocularis	small conductance calcium activated potassium	0.0152	0.4337	0.4337
Echinococcus multilocularis	snurportin 1	0.0312	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.2	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2	0.3736
Onchocerca volvulus		0.0086	0.2	1
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0614	0.1148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0614	0.0643
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2	1
Plasmodium vivax	unspecified product	0.0047	0.0614	0.3072
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.2	0.3063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0567	0.0567
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0567	0.1059
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.1428	0.1428
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.1055	0.1109
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1055	0.1971
Trypanosoma brucei	ingi protein (ORF1)	0.0048	0.0651	0.136
Treponema pallidum	ribonuclease H (rnhA)	0.0044	0.0519	0.5
Schistosoma mansoni	hypothetical protein	0.0165	0.4789	0.4789
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1659	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2	0.2
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.1428	0.6134
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0614	0.1148
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2	0.3736
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Echinococcus granulosus	cathepsin l1	0.0086	0.2	0.2
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2	0.3063
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2	0.2
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2	1
Brugia malayi	RNase H family protein	0.0044	0.0519	0.097
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2	0.2
Schistosoma mansoni	hypothetical protein	0.0035	0.0188	0.0188
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2	0.3063
Onchocerca volvulus		0.0086	0.2	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0567	0.0567
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Giardia lamblia	Cathepsin B precursor	0.007	0.1428	1
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Brugia malayi	RNA, U transporter 1	0.0083	0.1906	0.3559
Giardia lamblia	Cathepsin B precursor	0.007	0.1428	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2	0.2
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.5354	0.5354
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2	0.3736
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0614	0.0614
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0188	0.0351
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.2	0.2
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Onchocerca volvulus		0.0086	0.2	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0567	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1383	0.1383
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.1428	0.6134
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Schistosoma mansoni	phosphoglucomutase	0.0044	0.0519	0.0519
Echinococcus multilocularis	geminin	0.0172	0.504	0.504
Echinococcus multilocularis	cysteine protease	0.0086	0.2	0.2
Echinococcus multilocularis	cathepsin L	0.0047	0.0614	0.0614
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2	0.3063
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0614	0.0197
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0614	0.1283
Schistosoma mansoni	phosphoglucomutase	0.0044	0.0519	0.0519
Schistosoma mansoni	phosphoglucomutase	0.0044	0.0519	0.0519
Echinococcus granulosus	cathepsin b	0.0181	0.5354	0.5354
Loa Loa (eye worm)	hypothetical protein	0.0181	0.5354	0.5354
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1055	0.3182
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2	0.3736
Plasmodium vivax	vivapain-1	0.0047	0.0614	0.3072
Trypanosoma brucei	unspecified product	0.0048	0.0651	0.136
Onchocerca volvulus		0.0086	0.2	1
Echinococcus granulosus	cathepsin b	0.0181	0.5354	0.5354
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0567	0.0567
Toxoplasma gondii	cathepsin CPL	0.0086	0.2	1
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0044	0.0519	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0614	0.1283
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Onchocerca volvulus		0.0059	0.1055	0.362
Loa Loa (eye worm)	fibroinase	0.0086	0.2	0.2
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Loa Loa (eye worm)	hypothetical protein	0.0152	0.4337	0.4337
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1055	0.1055
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0753	0.1407
Plasmodium vivax	vivapain-3	0.0047	0.0614	0.3072
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.5354	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0753	0.0753
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Echinococcus multilocularis	ribonuclease H1	0.0044	0.0519	0.0519
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2	0.3736
Onchocerca volvulus		0.0086	0.2	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0188	0.0188
Echinococcus multilocularis	cathepsin b	0.0181	0.5354	0.5354
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1055	0.1971
Plasmodium vivax	vivapain-2	0.0086	0.2	1
Trypanosoma brucei	ribonuclease H1	0.0044	0.0519	0.1084
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.2	0.2
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.2	1
Schistosoma mansoni	hypothetical protein	0.0172	0.504	0.504
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0567	0.0567
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2	0.2
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1055	0.1055
Loa Loa (eye worm)	cysteine protease	0.0086	0.2	0.2
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Echinococcus granulosus	ribonuclease H1	0.0044	0.0519	0.0519
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0614	0.0614
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2	0.2
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0614	0.0197
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.2	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0614	0.0614
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.2	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1055	0.1055
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.5354	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1055	0.362
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.2	0.2
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.1428	0.2981
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0614	0.0643
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0614	0.3072
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0048	0.0651	0.136
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2	0.2
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0614	0.0197
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0614	0.0614
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.5354	0.5354
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0567	0.0567
Schistosoma mansoni	hypothetical protein	0.0152	0.4337	0.4337
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.2	0.3736
Brugia malayi	RNase H family protein	0.0044	0.0519	0.097
Toxoplasma gondii	ribonuclease HI protein	0.0044	0.0519	0.2596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Echinococcus multilocularis	cathepsin b	0.0181	0.5354	0.5354
Brugia malayi	cathepsin L-like precursor	0.0059	0.1055	0.1971
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0753	0.1407
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2	0.3063
Onchocerca volvulus		0.0086	0.2	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0614	0.0197
Loa Loa (eye worm)	ctsf protein	0.0086	0.2	0.2
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2	0.4176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.5354	0.5354
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Schistosoma mansoni	calcium-activated potassium channel	0.0152	0.4337	0.4337
Plasmodium vivax	vivapain-2	0.0086	0.2	1
Loa Loa (eye worm)	cathepsin B	0.007	0.1428	0.1428
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.2	0.2
Leishmania major	cathepsin L-like protease	0.0086	0.2	1
Echinococcus multilocularis	cysteine protease	0.0086	0.2	0.2
Echinococcus granulosus	cathepsin L	0.0047	0.0614	0.0614
Schistosoma mansoni	hypothetical protein	0.0172	0.504	0.504
Trypanosoma brucei	ingi protein (ORF1)	0.0048	0.0651	0.136
Echinococcus granulosus	small conductance calcium activated potassium	0.0152	0.4337	0.4337
Giardia lamblia	Cathepsin B precursor	0.007	0.1428	1
Onchocerca volvulus		0.0086	0.2	1
Trypanosoma brucei	hypothetical protein, conserved	0.0048	0.0651	0.136

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5 nM	Inhibition of cathepsin K	ChEMBL.	18570365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL479755

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 978345