Detailed information for compound 979457

Basic information

Technical information
  • TDR Targets ID: 979457
  • Name: (4E)-2-(4-nitrophenyl)-4-(thiophen-2-ylmethyl idene)-1,3-oxazol-5-one
  • MW: 300.289 | Formula: C14H8N2O4S
  • H donors: 0 H acceptors: 3 LogP: 3.11 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC(=N/C/1=C/c1cccs1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C14H8N2O4S/c17-14-12(8-11-2-1-7-21-11)15-13(20-14)9-3-5-10(6-4-9)16(18)19/h1-8H/b12-8+
  • InChiKey: RLTNIWJCLHLMDP-XYOKQWHBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4E)-2-(4-nitrophenyl)-4-(2-thienylmethylene)oxazol-5-one
  • (4E)-2-(4-nitrophenyl)-4-(2-thienylmethylene)-5-oxazolone
  • PHG 00799

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phospholipase C, gamma 2 (phosphatidylinositol-specific) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) variant SH3 domain-containing protein Get druggable targets OG5_131092 All targets in OG5_131092
Brugia malayi Variant SH3 domain containing protein Get druggable targets OG5_131092 All targets in OG5_131092
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0053 0.3326 1
Echinococcus multilocularis ryanodine receptor 44f 0.0053 0.3326 1
Echinococcus multilocularis transient receptor potential cation channel 0.0053 0.3326 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0006 0.0196 0.059
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0053 0.3326 1
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0053 0.3326 0.3192
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0053 0.3326 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0053 0.3326 1
Echinococcus multilocularis voltage gated potassium channel 0.0053 0.3326 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0053 0.3326 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0053 0.3326 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0006 0.0196 0.059
Echinococcus granulosus voltage dependent calcium channel 0.0053 0.3326 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0053 0.3326 1
Echinococcus granulosus voltage dependent calcium channel 0.0053 0.3326 1
Loa Loa (eye worm) voltage-gated calcium channel 0.0053 0.3326 0.3192
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0006 0.0196 0.059
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0053 0.3326 0.3192
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.3326 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Toxoplasma gondii transporter, cation channel family protein 0.0053 0.3326 1
Echinococcus multilocularis transient receptor potential cation channel 0.0053 0.3326 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0053 0.3326 1
Echinococcus multilocularis transient receptor potential cation channel 0.0053 0.3326 1
Echinococcus granulosus hypothetical protein 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus multilocularis growth factor receptor bound protein 2 0.0006 0.0196 0.059
Echinococcus granulosus TRP transient receptor potential channel 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Loa Loa (eye worm) voltage-gated potassium channel 0.0053 0.3326 0.3192
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Schistosoma mansoni voltage-gated ion channel 0.0053 0.3326 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0006 0.0196 0.059
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0053 0.3326 1
Onchocerca volvulus 0.0053 0.3326 1
Schistosoma mansoni growth factor receptor-bound protein 0.0006 0.0196 0.059
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0053 0.3326 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0196 0.059
Schistosoma mansoni transient receptor potential channel 0.0053 0.3326 1
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0022 0.1278 0.1104
Echinococcus granulosus tyrosine protein kinase Src64B 0.0006 0.0196 0.059
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0053 0.3326 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus granulosus sodium leak channel non selective protein 0.0053 0.3326 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0053 0.3326 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0053 0.3326 1
Toxoplasma gondii hypothetical protein 0.0053 0.3326 1
Leishmania major phospholipase c-like protein 0.0022 0.1278 0.3034
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1278 0.1104
Echinococcus granulosus voltage gated potassium channel 0.0053 0.3326 1
Echinococcus granulosus short transient receptor potential channel 6 0.0053 0.3326 1
Echinococcus granulosus intersectin 2 0.0004 0.0079 0.0237
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel protein 0.0053 0.3326 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0053 0.3326 0.3192
Schistosoma mansoni voltage-dependent calcium channel 0.0053 0.3326 1
Echinococcus granulosus two pore calcium channel protein 1 0.0053 0.3326 1
Brugia malayi Transient-receptor-potential like protein 0.0053 0.3326 0.3192
Brugia malayi phospholipase C homolog 0.0013 0.069 0.0504
Schistosoma mansoni tyrosine kinase 0.0006 0.0196 0.059
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0009 0.0386 0.0194
Echinococcus granulosus voltage gated potassium channel 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0053 0.3326 0.3192
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0006 0.0196 0.059
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0053 0.3326 1
Echinococcus multilocularis NCK adaptor protein 0.0006 0.0196 0.059
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0053 0.3326 0.3192
Schistosoma mansoni growth factor receptor-bound protein 0.0006 0.0196 0.059
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Toxoplasma gondii transporter, cation channel family protein 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Onchocerca volvulus 0.0022 0.1278 0.3034
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0053 0.3326 0.3192
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0053 0.3326 1
Echinococcus granulosus shaker cognate 0.0053 0.3326 1
Brugia malayi ion channel NompC 0.0053 0.3326 0.3192
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0053 0.3326 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0053 0.3326 1
Brugia malayi cation channel family protein 0.0053 0.3326 0.3192
Echinococcus granulosus transient receptor potential cation channel 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus multilocularis hyperpolarization activated cyclic 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel protein 0.0053 0.3326 1
Echinococcus multilocularis voltage dependent calcium channel 0.0053 0.3326 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0053 0.3326 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0053 0.3326 0.3192
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0053 0.3326 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0053 0.3326 0.3192
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel protein 0.0053 0.3326 1
Schistosoma mansoni calcium-activated potassium channel 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0053 0.3326 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0053 0.3326 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0053 0.3326 1
Echinococcus granulosus transient receptor potential cation channel 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Echinococcus granulosus two pore calcium channel protein 2 0.0053 0.3326 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0053 0.3326 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0006 0.0196 0.059
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0022 0.1278 0.3034
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0053 0.3326 0.3192
Schistosoma mansoni two-pore calcium channel 0.0053 0.3326 1
Schistosoma mansoni transient receptor potential channel 0.0053 0.3326 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0053 0.3326 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0053 0.3326 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0006 0.0196 0.059
Schistosoma mansoni nck2/grb4 0.0006 0.0196 0.059
Schistosoma mansoni tyrosine kinase 0.0006 0.0196 0.059
Echinococcus granulosus hyperpolarization activated cyclic 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0021 0.1194 0.2749
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0053 0.3326 0.3192
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0053 0.3326 1
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0021 0.1194 0.1018
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0053 0.3326 1
Echinococcus multilocularis voltage dependent calcium channel 0.0053 0.3326 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0053 0.3326 1
Echinococcus granulosus transient receptor potential gamma protein 0.0053 0.3326 1
Echinococcus granulosus transient receptor potential cation channel 0.0053 0.3326 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0053 0.3326 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0196 0.059
Loa Loa (eye worm) Plcb4 protein 0.0021 0.1194 0.1018
Echinococcus granulosus transient receptor potential cation channel 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0053 0.3326 0.3192
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0006 0.0196 0.059
Echinococcus granulosus potassium large conductance calcium activated 0.0053 0.3326 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0053 0.3326 0.3192
Schistosoma mansoni transient receptor potential channel 0.0053 0.3326 1
Echinococcus granulosus voltage gated hydrogen channel 1 0.0053 0.3326 1
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0022 0.1278 0.3844
Echinococcus multilocularis intersectin 2 0.0004 0.0079 0.0237
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0154 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0053 0.3326 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0053 0.3326 1
Echinococcus multilocularis transient receptor potential cation channel 0.0053 0.3326 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0022 0.1278 0.1104
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0021 0.1194 0.2749
Brugia malayi phospholipase C homolog 0.0009 0.0386 0.0194
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0006 0.0196 0.059
Toxoplasma gondii hypothetical protein 0.0053 0.3326 1
Loa Loa (eye worm) calcium channel 0.0053 0.3326 0.3192
Schistosoma mansoni 60S ribosomal protein L21 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Echinococcus multilocularis transfer RNA-Gly 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0053 0.3326 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0053 0.3326 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0053 0.3326 0.3192
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0196 0.059
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0006 0.0196 0.059
Toxoplasma gondii transporter, cation channel family protein 0.0053 0.3326 1
Schistosoma mansoni tyrosine kinase 0.0006 0.0196 0.059
Echinococcus multilocularis potassium voltage gated channel protein 0.0053 0.3326 1
Plasmodium vivax phospholipase C-like, putative 0.0021 0.1194 0.5
Schistosoma mansoni voltage-gated cation channel 0.0053 0.3326 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0053 0.3326 1
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0022 0.1278 0.3844
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.1278 0.1104
Echinococcus multilocularis sodium leak channel non selective protein 0.0053 0.3326 1
Echinococcus granulosus transient receptor potential cation channel 0.0053 0.3326 1
Schistosoma mansoni transient receptor potential channel 4 0.0053 0.3326 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0053 0.3326 0.3192
Echinococcus granulosus transient receptor potential cation channel 0.0053 0.3326 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0053 0.3326 0.3192
Echinococcus granulosus tyrosine protein kinase Fyn 0.0006 0.0196 0.059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0053 0.3326 1
Leishmania major hypothetical protein, unknown function 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0053 0.3326 1
Brugia malayi hypothetical protein 0.0053 0.3326 0.3192
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Brugia malayi olfactory channel protein osm-9 0.0053 0.3326 0.3192
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0006 0.0196 0.059
Echinococcus multilocularis two pore calcium channel protein 1 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0053 0.3326 1
Echinococcus multilocularis c src tyrosine kinase 0.0006 0.0196 0.059
Echinococcus multilocularis transient receptor potential gamma protein 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus granulosus NCK adaptor protein 0.0006 0.0196 0.059
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Schistosoma mansoni phospholipase C beta 0.0009 0.0386 0.1162
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0053 0.3326 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0053 0.3326 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0053 0.3326 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel protein 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0053 0.3326 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0053 0.3326 0.3192
Echinococcus granulosus sodium channel protein 0.0053 0.3326 1
Brugia malayi cation channel family protein 0.0053 0.3326 0.3192
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0013 0.069 0.2076
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Echinococcus multilocularis sodium channel protein 0.0053 0.3326 1
Schistosoma mansoni hypothetical protein 0.0053 0.3326 1
Loa Loa (eye worm) ion channel NompC 0.0053 0.3326 0.3192
Schistosoma mansoni ryanodine receptor related 0.0053 0.3326 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0053 0.3326 1
Schistosoma mansoni adapter molecule crk 0.0006 0.0196 0.059
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0006 0.0196 0.059
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0053 0.3326 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0053 0.3326 1
Schistosoma mansoni tyrosine kinase 0.0006 0.0196 0.059
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0009 0.0386 0.0194
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0009 0.0386 0.1162
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0053 0.3326 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0053 0.3326 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0053 0.3326 1
Schistosoma mansoni phospholipase C beta 0.0021 0.1194 0.3591
Brugia malayi voltage-dependent calcium channel 0.0053 0.3326 0.3192
Echinococcus granulosus growth factor receptor bound protein 2 0.0006 0.0196 0.059
Echinococcus granulosus short transient receptor potential channel 6 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0053 0.3326 1
Echinococcus multilocularis calcium activated potassium channel 0.0053 0.3326 1
Echinococcus multilocularis transient receptor potential cation channel 0.0053 0.3326 1
Echinococcus multilocularis two pore calcium channel protein 2 0.0053 0.3326 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0053 0.3326 0.3192
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0021 0.1194 0.1018
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Loa Loa (eye worm) ryanodine receptor 0.0053 0.3326 0.3192
Echinococcus multilocularis voltage gated potassium channel 0.0053 0.3326 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0053 0.3326 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0006 0.0196 0.059
Echinococcus multilocularis potassium voltage gated channel protein 0.0053 0.3326 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0053 0.3326 0.3192
Echinococcus multilocularis shaker cognate 0.0053 0.3326 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0006 0.0196 0.059
Echinococcus granulosus hyperpolarization activated cyclic 0.0053 0.3326 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0021 0.1194 0.5
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0053 0.3326 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0053 0.3326 1
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.3326 1
Schistosoma mansoni vesicular amine transporter 0.0053 0.3326 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0053 0.3326 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0053 0.3326 0.3192
Echinococcus granulosus c src tyrosine kinase 0.0006 0.0196 0.059
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0053 0.3326 0.3192
Echinococcus granulosus calcium activated potassium channel 0.0053 0.3326 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0006 0.0196 0.059
Echinococcus multilocularis transient receptor potential cation channel 0.0053 0.3326 1
Echinococcus granulosus ryanodine receptor 44f 0.0053 0.3326 1
Onchocerca volvulus 0.0022 0.1278 0.3034
Loa Loa (eye worm) hypothetical protein 0.0053 0.3326 0.3192
Echinococcus multilocularis conserved hypothetical protein 0.0053 0.3326 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0006 0.0196 0.059
Echinococcus multilocularis tyrosine protein kinase Abl 0.0006 0.0196 0.059
Leishmania major hypothetical protein, conserved 0.0053 0.3326 1
Echinococcus granulosus potassium voltage gated channel protein 0.0053 0.3326 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0053 0.3326 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0053 0.3326 0.3192
Loa Loa (eye worm) hypothetical protein 0.0021 0.1194 0.1018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0053 0.3326 1

Activities

Activity type Activity value Assay description Source Reference
GC50 (binding) Inhibition of phospholipase C gamma2 in human A431 cells assessed as reduction of calcium release at 50 uM after 45 mins by FLIPR assay ChEMBL. 19303309
IC50 (binding) = 12 uM Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemical assay ChEMBL. 19303309

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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