Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.06 | 0.0575 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0154 | 0.0127 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0008 | 0.0012 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0154 | 0.0127 |
Echinococcus multilocularis | sodium channel protein | 0.0074 | 0.1086 | 0.1075 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Onchocerca volvulus | 0.0047 | 0.0636 | 0.2036 | |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.074 | 0.0715 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0027 | 0.0027 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0008 | 0.0012 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0154 | 0.0127 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.06 | 0.0589 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.06 | 0.0589 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0154 | 0.0142 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0009 | 0.0035 | 0.0035 |
Schistosoma mansoni | dep domain containing protein | 0.0009 | 0.0035 | 0.0035 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0012 | 0.0012 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0469 | 0.0442 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0047 | 0.0636 | 0.0636 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0012 | 0.0012 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0008 | 0.0012 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.074 | 0.0715 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0972 | 0.0961 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0008 | 0.0012 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.074 | 0.0715 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.06 | 0.0589 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0035 | 0.0008 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0008 | 0.0012 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0469 | 0.0442 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0.0035 | 0.5 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0012 | 0.0012 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.06 | 0.06 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0469 | 0.0469 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0972 | 0.0961 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0009 | 0.0027 | 1 |
Schistosoma mansoni | regulator of G protein signaling | 0.0009 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0972 | 0.0947 |
Brugia malayi | Serine/threonine-protein kinase SULU | 0.0624 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase TAO1 | 0.0624 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase TAO1 | 0.0624 | 1 | 1 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0009 | 0.0027 | 0.0016 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0972 | 0.0947 |
Loa Loa (eye worm) | STE/STE20/TAO protein kinase | 0.0624 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0009 | 0.0035 | 0.0024 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0009 | 0.0027 | 0.0016 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0154 | 0.0142 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0009 | 0.0035 | 0.0008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.06 | 0.06 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.06 | 0.0589 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0192 | 0.2987 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0972 | 0.0947 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0012 | 0.0012 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0009 | 0.0035 | 0.0008 |
Echinococcus granulosus | sodium channel protein | 0.0074 | 0.1086 | 0.1075 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0009 | 0.0027 | 0.0016 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0972 | 0.0947 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0009 | 0.0027 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.06 | 0.0575 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0154 | 0.0142 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0027 | 0.0027 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0074 | 0.1086 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0009 | 0.0027 | 0.0016 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0009 | 0.0035 | 0.0024 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0008 | 0.0012 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0009 | 0.0035 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0035 | 0.0008 |
Echinococcus granulosus | voltage gated potassium channel | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0074 | 0.1086 | 0.1075 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0009 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0972 | 0.0947 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0009 | 0.0027 | 0.0016 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0154 | 0.0142 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0008 | 0.0012 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Echinococcus granulosus | tumor protein p63 | 0.0318 | 0.5033 | 0.5028 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0009 | 0.0035 | 0.0024 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.074 | 0.0715 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Brugia malayi | DIX domain containing protein | 0.0009 | 0.0035 | 0.0008 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0154 | 0.0142 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0154 | 0.0142 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0009 | 0.0035 | 0.0008 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0009 | 0.0035 | 0.0024 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0972 | 0.0947 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.06 | 0.06 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.2987 | 0.2968 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0027 | 0.0027 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0624 | 1 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0192 | 0.2987 | 0.2968 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0009 | 0.0027 | 0.0016 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0154 | 0.0127 |
Echinococcus multilocularis | tumor protein p63 | 0.0318 | 0.5033 | 0.5028 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0009 | 0.0027 | 0.0016 |
Schistosoma mansoni | dishevelled | 0.0009 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0636 | 0.0611 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0972 | 0.0972 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.