TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 478.606 | Formula: C26H30N4O3S
H donors: 1 H acceptors: 2 LogP: 5.23 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1c(NCCC2CCCN2C)n(c2ccccc2)c(=S)n(c1=O)c1ccccc1
InChi: 1S/C26H30N4O3S/c1-3-33-25(32)22-23(27-17-16-19-15-10-18-28(19)2)29(20-11-6-4-7-12-20)26(34)30(24(22)31)21-13-8-5-9-14-21/h4-9,11-14,19,27H,3,10,15-18H2,1-2H3
InChiKey: SFSVPKUSQYRTIX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	bone morphogenic protein 6	0.0122	0.0178	0.0274
Echinococcus granulosus	sodium channel protein	0.02	0.0459	0.0459
Echinococcus granulosus	orexin receptor type 2	0.0175	0.0369	0.0369
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0116	0.0155	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0311	0.0477
Echinococcus multilocularis	neuropeptide receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0382	0.1118	0.1715
Onchocerca volvulus		0.0451	0.1366	1
Schistosoma mansoni	neuropeptide receptor	0.0175	0.0369	0.0803
Echinococcus multilocularis	dro:myosuppressin receptor	0.0175	0.0369	0.0369
Schistosoma mansoni	apoptosis regulator bax	0.0301	0.0825	0.1796
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	protein kinase	0.0145	0.0262	0.0572
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0079	0.0022	0.5
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Schistosoma mansoni	amine GPCR	0.0175	0.0369	0.0803
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0175	0.0369	0.0369
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0175	0.0369	0.27
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus multilocularis	SWI:SNF matrix associated	0.0087	0.0053	0.0053
Echinococcus multilocularis	neuropeptide Y receptor	0.0175	0.0369	0.0369
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Onchocerca volvulus		0.0116	0.0155	0.1135
Brugia malayi	Latrophilin receptor protein 2	0.0411	0.1221	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	G-protein coupled receptor	0.0175	0.0369	0.0566
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0175	0.0369	0.0803
Schistosoma mansoni	hypothetical protein	0.0076	0.0013	0.0029
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0175	0.0369	0.0803
Echinococcus granulosus	7TM GPCR rhodopsin	0.0175	0.0369	0.0369
Onchocerca volvulus		0.0116	0.0155	0.1135
Onchocerca volvulus		0.0087	0.0053	0.0389
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0175	0.0369	0.0369
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0104	0.0112	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0175	0.0369	0.0803
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.0104	0.0112	0.0112
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0175	0.0369	0.0803
Schistosoma mansoni	protein kinase	0.0145	0.0262	0.0572
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0175	0.0369	0.0369
Brugia malayi	GnHR receptor homolog	0.0175	0.0369	0.0566
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0175	0.0369	0.0369
Schistosoma mansoni	neuropeptide receptor	0.0175	0.0369	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	Serotonin receptor	0.0175	0.0369	0.0566
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	anti dorsalizing morphogenetic protein 1a	0.0122	0.0178	0.0178
Echinococcus granulosus	biogenic amine 5HT receptor	0.0175	0.0369	0.0369
Trypanosoma brucei	calpain, putative	0.0115	0.0151	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.1028	0.3452	0.3452
Schistosoma mansoni	amine GPCR	0.0175	0.0369	0.0803
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0094	0.0077	0.0077
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.0112	0.0243
Schistosoma mansoni	hypothetical protein	0.0411	0.1221	0.266
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0175	0.0369	0.0369
Schistosoma mansoni	opsin-like receptor	0.0175	0.0369	0.0803
Echinococcus granulosus	g protein coupled receptor	0.0175	0.0369	0.0369
Schistosoma mansoni	hypothetical protein	0.0411	0.1221	0.266
Echinococcus multilocularis	GPCR, family 2	0.0411	0.1221	0.1221
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0175	0.0369	0.0369
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0151	0.3295
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0175	0.0369	0.0566
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0175	0.0369	0.0369
Onchocerca volvulus		0.0175	0.0369	0.27
Toxoplasma gondii	hypothetical protein	0.0116	0.0155	0.0249
Onchocerca volvulus		0.0175	0.0369	0.27
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Trypanosoma brucei	hypothetical protein	0.0115	0.0151	1
Schistosoma mansoni	hypothetical protein	0.0175	0.0369	0.0803
Loa Loa (eye worm)	PAN domain-containing protein	0.0116	0.0155	0.0238
Schistosoma mansoni	neuropeptide F-like receptor	0.0175	0.0369	0.0803
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0411	0.1221	0.1873
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0411	0.1221	0.1221
Echinococcus multilocularis	nmda type glutamate receptor	0.0109	0.0133	0.0133
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	TYRA-2 protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus granulosus	hypothetical protein	0.0175	0.0369	0.0369
Echinococcus multilocularis	fmrfamide receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	adenylyl cyclase 3	0.0137	0.0234	0.0359
Loa Loa (eye worm)	PAN domain-containing protein	0.0116	0.0155	0.0238
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.1028	0.3452	0.3452
Toxoplasma gondii	PAN domain-containing protein	0.0116	0.0155	0.0249
Schistosoma mansoni	biogenic amine receptor	0.0175	0.0369	0.0803
Loa Loa (eye worm)	PAN domain-containing protein	0.0116	0.0155	0.0238
Onchocerca volvulus	Adenylate cyclase type 3 homolog	0.0161	0.032	0.2341
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0079	0.0022	0.5
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	biogenic amine receptor	0.0175	0.0369	0.0803
Echinococcus granulosus	neuropeptide receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0461	0.1401	0.1401
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Toxoplasma gondii	microneme protein MIC17C	0.0116	0.0155	0.0249
Schistosoma mansoni	histamine h1 receptor	0.0175	0.0369	0.0803
Onchocerca volvulus		0.0175	0.0369	0.27
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0451	0.1366	0.2095
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus multilocularis	serotonin receptor	0.0175	0.0369	0.0369
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0175	0.0369	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Onchocerca volvulus		0.0175	0.0369	0.27
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0175	0.0369	0.0369
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0451	0.1366	0.2975
Onchocerca volvulus		0.0175	0.0369	0.27
Schistosoma mansoni	serine/threonine protein kinase	0.0185	0.0406	0.0885
Echinococcus granulosus	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0301	0.0825	0.0825
Echinococcus multilocularis	SWI:SNF matrix associated	0.0087	0.0053	0.0053
Brugia malayi	Dopamine receptor protein 1	0.0175	0.0369	0.0566
Schistosoma mansoni	hypothetical protein	0.0301	0.0825	0.1796
Echinococcus multilocularis	neuropeptides capa receptor	0.0175	0.0369	0.0369
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Onchocerca volvulus		0.0175	0.0369	0.27
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.2841	1	1
Brugia malayi	putative neuropeptide receptor	0.0175	0.0369	0.0566
Brugia malayi	follicle stimulating hormone receptor	0.0175	0.0369	0.0566
Brugia malayi	G protein-coupled receptor	0.0175	0.0369	0.0566
Schistosoma mansoni	hypothetical protein	0.0087	0.0053	0.0116
Echinococcus granulosus	g protein coupled receptor	0.0175	0.0369	0.0369
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0079	0.0022	0.5
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Schistosoma mansoni	amine GPCR	0.0175	0.0369	0.0803
Echinococcus granulosus	g protein coupled receptor	0.0175	0.0369	0.0369
Echinococcus multilocularis	serotonin receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	neuropeptide s receptor	0.0692	0.2235	0.2235
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0104	0.0112	0.0171
Toxoplasma gondii	PAN domain-containing protein	0.0116	0.0155	0.0249
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0087	0.0053	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0259	0.0673	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0155	0.0238
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0411	0.1221	0.1221
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0175	0.0369	0.0566
Schistosoma mansoni	hypothetical protein	0.0175	0.0369	0.0803
Schistosoma mansoni	serine-type protease inhibitor	0.1344	0.4592	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0259	0.0673	0.0673
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0087	0.0053	0.0085
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Echinococcus granulosus	SWI:SNF matrix associated	0.0087	0.0053	0.0053
Loa Loa (eye worm)	PAN domain-containing protein	0.0116	0.0155	0.0238
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.1878	0.652	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0068	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Onchocerca volvulus		0.0175	0.0369	0.27
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0112	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0175	0.0369	0.0803
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.02	0.0459	0.0459
Schistosoma mansoni	hypothetical protein	0.0411	0.1221	0.266
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0175	0.0369	0.0566
Brugia malayi	Melatonin receptor type 1A	0.0175	0.0369	0.0566
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0175	0.0369	0.0566
Schistosoma mansoni	myosin xvIII	0.0175	0.0369	0.0803
Onchocerca volvulus		0.0175	0.0369	0.27
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus multilocularis	orexin receptor type 2	0.0175	0.0369	0.0369
Toxoplasma gondii	PAN domain-containing protein	0.1796	0.6224	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Onchocerca volvulus		0.0116	0.0155	0.1135
Brugia malayi	brahma associated protein 60 kDa	0.0087	0.0053	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Loa Loa (eye worm)	neuropeptide F receptor	0.0175	0.0369	0.0566
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0175	0.0369	0.0369
Brugia malayi	hypothetical protein	0.0382	0.1118	0.1715
Loa Loa (eye worm)	neuropeptide F receptor	0.0175	0.0369	0.0566
Echinococcus granulosus	serotonin receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0175	0.0369	0.0566
Echinococcus multilocularis	sodium channel protein	0.02	0.0459	0.0459
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0175	0.0369	0.0803
Echinococcus multilocularis	adenylate cyclase type IX	0.0082	0.0033	0.0033
Echinococcus granulosus	fmrfamide receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	PAN domain-containing protein	0.0116	0.0155	0.0238
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0175	0.0369	0.0369
Schistosoma mansoni	growth hormone secretagogue receptor	0.0175	0.0369	0.0803
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0087	0.0053	0.0053
Echinococcus granulosus	allatostatin A receptor	0.0451	0.1366	0.1366
Onchocerca volvulus		0.0175	0.0369	0.27
Schistosoma mansoni	hypothetical protein	0.0301	0.0825	0.1796
Echinococcus granulosus	jun protein	0.0094	0.0077	0.0077
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0175	0.0369	0.0566
Echinococcus multilocularis	fmrfamide receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	dro:myosuppressin receptor	0.0175	0.0369	0.0369
Schistosoma mansoni	protein kinase	0.0145	0.0262	0.0572
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0185	0.0406	0.0406
Echinococcus multilocularis	somatostatin receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0155	0.0238
Onchocerca volvulus		0.0116	0.0155	0.1135
Echinococcus granulosus	sex peptide receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0094	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0175	0.0369	0.0803
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.126	0.429	0.658
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	G protein-coupled receptor F59B2.13	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0155	0.0238
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0175	0.0369	0.0369
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0087	0.0053	0.0053
Entamoeba histolytica	protein kinase, putative	0.0104	0.0112	0.5
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0112	1
Brugia malayi	hypothetical protein	0.0074	0.0004	0.0006
Onchocerca volvulus		0.0116	0.0155	0.1135
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0175	0.0369	0.0803
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Echinococcus granulosus	g-protein coupled receptor	0.0175	0.0369	0.0369
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0175	0.0369	0.27
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.085	0.2806	0.4304
Brugia malayi	map kinase activated protein kinase protein 2	0.0185	0.0406	0.0623
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0175	0.0369	0.0803
Brugia malayi	putative neuropeptide receptor NPR1	0.0175	0.0369	0.0566
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0175	0.0369	0.0566
Onchocerca volvulus		0.0116	0.0155	0.1135
Schistosoma mansoni	hypothetical protein	0.0087	0.0053	0.0116
Schistosoma mansoni	brg-1 associated factor	0.0087	0.0053	0.0116
Loa Loa (eye worm)	brahma associated protein	0.0087	0.0053	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Brugia malayi	neuropeptide F receptor	0.0175	0.0369	0.0566
Echinococcus granulosus	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Trypanosoma brucei	calpain-like protein, putative	0.0115	0.0151	1
Onchocerca volvulus		0.0116	0.0155	0.1135
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	opsin-like receptor	0.0175	0.0369	0.0803
Onchocerca volvulus		0.0175	0.0369	0.27
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0185	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0301	0.0825	0.1265
Echinococcus granulosus	tm gpcr rhodopsin	0.0175	0.0369	0.0369
Echinococcus multilocularis	neuropeptide receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	neuropeptides capa receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.1878	0.652	1
Onchocerca volvulus		0.0074	0.0004	0.003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0112	1
Brugia malayi	brahma associated protein 60 kDa	0.0087	0.0053	0.0081
Toxoplasma gondii	microneme protein MIC17A	0.0116	0.0155	0.0249
Echinococcus granulosus	neuropeptide receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus granulosus	G protein coupled receptor 139	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0155	0.0238
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0461	0.1401	0.1401
Brugia malayi	bZIP transcription factor family protein	0.0094	0.0077	0.0118
Brugia malayi	Serotonin receptor	0.0175	0.0369	0.0566
Brugia malayi	Dopamine receptor protein 2	0.0175	0.0369	0.0566
Echinococcus multilocularis	anti dorsalizing morphogenetic protein 1a	0.0122	0.0178	0.0178
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Schistosoma mansoni	hypothetical protein	0.0301	0.0825	0.1796
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.0115	0.0151	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1221	0.1873
Loa Loa (eye worm)	apoptosis regulator protein	0.0301	0.0825	0.1265
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus granulosus	biogenic amine 5HT receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0126	0.0194	0.0298
Schistosoma mansoni	hypothetical protein	0.085	0.2806	0.6111
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	Transforming growth factor beta like domain containing protein	0.0122	0.0178	0.0274
Toxoplasma gondii	PAN domain-containing protein	0.0116	0.0155	0.0249
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0175	0.0369	0.0803
Schistosoma mansoni	hypothetical protein	0.0411	0.1221	0.266
Chlamydia trachomatis	SWIB complex protein	0.0087	0.0053	1
Brugia malayi	Protein kinase domain containing protein	0.0104	0.0112	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus granulosus	adenylate cyclase type IX	0.0082	0.0033	0.0033
Schistosoma mansoni	amine GPCR	0.0175	0.0369	0.0803
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0175	0.0369	0.0369
Echinococcus multilocularis	SWI:SNF matrix associated	0.0087	0.0053	0.0053
Onchocerca volvulus		0.0116	0.0155	0.1135
Echinococcus multilocularis	g protein coupled receptor	0.0175	0.0369	0.0369
Echinococcus multilocularis	neuropeptide s receptor	0.0692	0.2235	0.2235
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0175	0.0369	0.0803
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0151	0.3295
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0126	0.0194	0.0298
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Brugia malayi	Calcitonin receptor-like protein seb-1	0.126	0.429	0.658
Schistosoma mansoni	hypothetical protein	0.0175	0.0369	0.0803
Toxoplasma gondii	microneme protein MIC17B	0.0116	0.0155	0.0249
Toxoplasma gondii	subtilisin SUB12	0.0116	0.0155	0.0249
Brugia malayi	latrophilin 2 splice variant baaae	0.085	0.2806	0.4304
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Toxoplasma gondii	PAN domain-containing protein	0.0116	0.0155	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Onchocerca volvulus		0.0175	0.0369	0.27
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	neuropeptide F-like receptor	0.0175	0.0369	0.0803
Schistosoma mansoni	hypothetical protein	0.0175	0.0369	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus granulosus	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Schistosoma mansoni	biogenic amine receptor	0.0175	0.0369	0.0803
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0301	0.0825	0.1796
Loa Loa (eye worm)	hypothetical protein	0.0395	0.1163	0.1784
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	neuropeptide receptor	0.0175	0.0369	0.0803
Echinococcus multilocularis	g protein coupled receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	tm gpcr rhodopsin	0.0175	0.0369	0.0369
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0175	0.0369	0.0803
Toxoplasma gondii	microneme protein, putative	0.0116	0.0155	0.0249
Schistosoma mansoni	hypothetical protein	0.0108	0.0129	0.0281
Echinococcus granulosus	neuropeptide Y receptor	0.0175	0.0369	0.0369
Onchocerca volvulus		0.0175	0.0369	0.27
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0151	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0395	0.1163	0.1163
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0175	0.0369	0.0369
Brugia malayi	Dopamine receptor	0.0175	0.0369	0.0566
Schistosoma mansoni	opsin-like receptor	0.0175	0.0369	0.0803
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0079	0.0022	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0175	0.0369	0.0803
Echinococcus granulosus	neuropeptides capa receptor	0.0175	0.0369	0.0369
Echinococcus multilocularis	sex peptide receptor	0.0175	0.0369	0.0369
Brugia malayi	SWIB/MDM2 domain containing protein	0.0087	0.0053	0.0081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus multilocularis	neuropeptide receptor A26	0.0692	0.2235	0.2235
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0411	0.1221	0.1873
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	AKH receptor	0.0175	0.0369	0.0566
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0145	0.0262	0.0262
Onchocerca volvulus		0.0116	0.0155	0.1135
Brugia malayi	sulfakinin receptor protein	0.0382	0.1118	0.1715
Echinococcus granulosus	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus granulosus	somatostatin receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	neuropeptide Y receptor	0.0175	0.0369	0.0369
Onchocerca volvulus		0.0116	0.0155	0.1135
Echinococcus multilocularis	neuropeptide Y receptor	0.0175	0.0369	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0301	0.0825	0.1265
Echinococcus granulosus	tm gpcr rhodopsin	0.0175	0.0369	0.0369
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Toxoplasma gondii	PAN domain-containing protein	0.1796	0.6224	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Brugia malayi	ORL1-like opioid receptor	0.0175	0.0369	0.0566
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.0104	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0151	0.3295
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	G-protein coupled receptor	0.0175	0.0369	0.0566
Echinococcus granulosus	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus granulosus	nmda type glutamate receptor	0.0109	0.0133	0.0133
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Toxoplasma gondii	microneme protein MIC4	0.0116	0.0155	0.0249
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0175	0.0369	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	neuropeptide f receptor 76f	0.0175	0.0369	0.0803
Echinococcus multilocularis	g-protein coupled receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0175	0.0369	0.0369
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0175	0.0369	0.0566
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	G-protein coupled receptor	0.0175	0.0369	0.0566
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.02	0.0459	1
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0301	0.0825	0.0825
Brugia malayi	larval opioid receptor	0.0175	0.0369	0.0566
Plasmodium vivax	hypothetical protein, conserved	0.0087	0.0053	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus granulosus	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0109	0.0133	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0155	0.0238
Chlamydia trachomatis	DNA topoisomerase I	0.0087	0.0053	1
Brugia malayi	phosphoinositide-dependent protein kinase I	0.0104	0.0112	0.0171
Brugia malayi	G-protein coupled receptor	0.0175	0.0369	0.0566
Echinococcus multilocularis	G protein coupled receptor 139	0.0175	0.0369	0.0369
Schistosoma mansoni	hypothetical protein	0.0087	0.0053	0.0116
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0115	0.0151	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0155	0.0238
Brugia malayi	PAN domain containing protein	0.0116	0.0155	0.0238
Echinococcus granulosus	7tm_1 domain containing protein	0.0175	0.0369	0.0369
Schistosoma mansoni	amine GPCR	0.0175	0.0369	0.0803
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0087	0.0053	0.0085
Echinococcus granulosus	neuropeptide FF receptor 2	0.0395	0.1163	0.1163
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0185	0.0406	0.0623
Schistosoma mansoni	adenoreceptor	0.0175	0.0369	0.0803
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0115	0.0151	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0175	0.0369	0.0369
Brugia malayi	neuropeptide F receptor	0.0175	0.0369	0.0566
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0175	0.0369	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Brugia malayi	hypothetical protein	0.0175	0.0369	0.0566
Schistosoma mansoni	jun-related protein	0.0076	0.0013	0.0029
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0395	0.1163	0.1784
Echinococcus granulosus	GPCR family 2	0.0411	0.1221	0.1221
Echinococcus granulosus	rhodopsin orphan GPCR	0.0175	0.0369	0.0369
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0145	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus multilocularis	jun protein	0.0094	0.0077	0.0077
Brugia malayi	RE15519p	0.0175	0.0369	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Echinococcus multilocularis	allatostatin A receptor	0.0451	0.1366	0.1366
Onchocerca volvulus		0.0175	0.0369	0.27
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0115	0.0151	1
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0116	0.0155	0.0249
Toxoplasma gondii	hypothetical protein	0.0116	0.0155	0.0249
Onchocerca volvulus		0.0175	0.0369	0.27
Onchocerca volvulus		0.0175	0.0369	0.27
Schistosoma mansoni	neuropeptide receptor	0.0175	0.0369	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0155	0.0238
Echinococcus multilocularis	neuropeptides capa receptor	0.0175	0.0369	0.0369
Echinococcus granulosus	neuropeptide receptor A26	0.0692	0.2235	0.2235
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0087	0.0053	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0175	0.0369	0.0369
Schistosoma mansoni	glutamate receptor NMDA	0.0259	0.0673	0.1465
Schistosoma mansoni	serine-type protease inhibitor	0.1344	0.4592	1
Echinococcus multilocularis	g protein coupled receptor	0.0175	0.0369	0.0369
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0087	0.0053	1
Onchocerca volvulus		0.0116	0.0155	0.1135
Loa Loa (eye worm)	hypothetical protein	0.0175	0.0369	0.0566
Loa Loa (eye worm)	melatonin receptor type 1A	0.0175	0.0369	0.0566
Onchocerca volvulus		0.0175	0.0369	0.27
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0087	0.0053	0.0081

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Binding affinity to CXCR2	ChEMBL.	19394230
Activity (binding)		Binding affinity to CXCR1	ChEMBL.	19394230

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL480666

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 984052