Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein kinase c iota type | 0.0786 | 0.3133 | 0.4695 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0083 | 0.0064 | 0.006 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0786 | 0.3133 | 0.4695 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0786 | 0.3133 | 0.3115 |
Trichomonas vaginalis | AGC family protein kinase | 0.236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0076 | 0.005 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0125 | 0.0249 | 0.0224 |
Trichomonas vaginalis | AGC family protein kinase | 0.236 | 1 | 1 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0786 | 0.3133 | 0.4695 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1508 | 0.6282 | 0.9454 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1591 | 0.6644 | 0.6622 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0125 | 0.0249 | 0.0375 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0786 | 0.3133 | 0.3115 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0074 | 0.0026 | 0.0039 |
Trichomonas vaginalis | AGC family protein kinase | 0.0786 | 0.3133 | 0.3089 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.1508 | 0.6282 | 0.9454 |
Toxoplasma gondii | AGC kinase | 0.2294 | 0.9713 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0086 | 0.0076 | 0.0114 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1591 | 0.6644 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.0786 | 0.3133 | 0.4695 |
Brugia malayi | protein kinase C II. | 0.0786 | 0.3133 | 0.3115 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0432 | 0.1589 | 0.1567 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0786 | 0.3133 | 0.4695 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0125 | 0.0249 | 0.0338 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0086 | 0.0076 | 0.005 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0086 | 0.0076 | 0.0076 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.1525 | 0.6356 | 0.9566 |
Trichomonas vaginalis | AGC family protein kinase | 0.236 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1591 | 0.6644 | 1 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0086 | 0.0076 | 0.0076 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1591 | 0.6644 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.236 | 1 | 1 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0083 | 0.0064 | 0.0039 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0786 | 0.3133 | 0.4716 |
Trichomonas vaginalis | AGC family protein kinase | 0.0786 | 0.3133 | 0.3089 |
Leishmania major | folate/biopterin transporter, putative | 0.0083 | 0.0064 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0786 | 0.3133 | 0.4716 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.236 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0786 | 0.3133 | 0.3115 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.2294 | 0.9713 | 0.9712 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.134 | 0.1317 |
Giardia lamblia | Kinase, AGC PKA | 0.1525 | 0.6356 | 0.5 |
Trypanosoma cruzi | Protein kinase B | 0.1591 | 0.6644 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0472 | 0.1762 | 0.2652 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0074 | 0.0026 | 0.0039 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0086 | 0.0076 | 0.0076 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0786 | 0.3133 | 0.4695 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0769 | 0.3059 | 0.3014 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1591 | 0.6644 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0786 | 0.3133 | 0.3115 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.0076 | 0.0114 |
Trichomonas vaginalis | AGC family protein kinase | 0.236 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0786 | 0.3133 | 0.4716 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0086 | 0.0076 | 0.0076 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.1525 | 0.6356 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0086 | 0.0076 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0249 | 0.0224 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0786 | 0.3133 | 0.3115 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0786 | 0.3133 | 0.4716 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0786 | 0.3133 | 0.4695 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0786 | 0.3133 | 0.4695 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0432 | 0.1589 | 0.2362 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0086 | 0.0076 | 0.0012 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0786 | 0.3133 | 0.4695 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0083 | 0.0064 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0786 | 0.3133 | 0.4695 |
Trichomonas vaginalis | AGC family protein kinase | 0.236 | 1 | 1 |
Echinococcus multilocularis | nervana 2 | 0.1508 | 0.6282 | 0.9454 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.1525 | 0.6356 | 0.9566 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0786 | 0.3133 | 0.4695 |
Entamoeba histolytica | protein kinase, putative | 0.236 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.1508 | 0.6282 | 0.9454 |
Echinococcus granulosus | protein kinase c iota type | 0.0786 | 0.3133 | 0.4695 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1591 | 0.6644 | 1 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0786 | 0.3133 | 0.4695 |
Echinococcus granulosus | voltage gated potassium channel | 0.0125 | 0.0249 | 0.0338 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0786 | 0.3133 | 0.3115 |
Entamoeba histolytica | protein kinase, putative | 0.2294 | 0.9713 | 0.9711 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0786 | 0.3133 | 0.4695 |
Echinococcus granulosus | protein kinase C gamma type | 0.0786 | 0.3133 | 0.4695 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0086 | 0.0076 | 0.0076 |
Brugia malayi | Protein kinase domain containing protein | 0.0786 | 0.3133 | 0.3115 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0086 | 0.0076 | 0.0076 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0083 | 0.0064 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0086 | 0.0076 | 0.0114 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0786 | 0.3133 | 0.4716 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0786 | 0.3133 | 0.3115 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0786 | 0.3133 | 0.4695 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0125 | 0.0249 | 0.0375 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0786 | 0.3133 | 0.4716 |
Leishmania major | protein kinase, putative | 0.0083 | 0.0064 | 1 |
Echinococcus granulosus | nervana 2 | 0.1508 | 0.6282 | 0.9454 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0086 | 0.0076 | 0.0076 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.1525 | 0.6356 | 0.9566 |
Schistosoma mansoni | atypical protein kinase C | 0.0786 | 0.3133 | 0.4716 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0786 | 0.3133 | 0.4695 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0083 | 0.0064 | 0.0039 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.236 | 1 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0786 | 0.3133 | 0.4716 |
Trichomonas vaginalis | AGC family protein kinase | 0.0786 | 0.3133 | 0.3089 |
Leishmania major | protein kinase, putative | 0.0083 | 0.0064 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0852 | 0.342 | 0.3378 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0404 | 0.1465 | 0.141 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0125 | 0.0249 | 0.0338 |
Brugia malayi | Hr1 repeat family protein | 0.0786 | 0.3133 | 0.3115 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0086 | 0.0076 | 0.0114 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0786 | 0.3133 | 0.4695 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1591 | 0.6644 | 0.6622 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0086 | 0.0076 | 0.005 |
Echinococcus multilocularis | nervana 2 | 0.1508 | 0.6282 | 0.9454 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0086 | 0.0076 | 0.0076 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0786 | 0.3133 | 0.4695 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.1525 | 0.6356 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0472 | 0.1762 | 0.2652 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0086 | 0.0076 | 0.0076 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0786 | 0.3133 | 0.4716 |
Trichomonas vaginalis | AGC family protein kinase | 0.236 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0404 | 0.1465 | 0.141 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1525 | 0.6356 | 0.9563 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0432 | 0.1589 | 0.2362 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0086 | 0.0076 | 0.0012 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0432 | 0.1589 | 0.1567 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0086 | 0.0076 | 0.0114 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0086 | 0.0076 | 0.0076 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0125 | 0.0249 | 0.0338 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1508 | 0.6282 | 0.9454 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0074 | 0.0026 | 0.0039 |
Entamoeba histolytica | protein kinase 2, putative | 0.1525 | 0.6356 | 0.6333 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0786 | 0.3133 | 0.3115 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.2294 | 0.9713 | 0.9712 |
Trichomonas vaginalis | AGC family protein kinase | 0.236 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.1508 | 0.6282 | 0.9454 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0086 | 0.0076 | 0.0076 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0086 | 0.0076 | 0.0114 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0083 | 0.0064 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0786 | 0.3133 | 0.3089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | Antimalarial activity as inhibition of schizont maturation against Plasmodium falciparum NF54 after 36 - 40 hrs | ChEMBL. | 19028410 | |
MIC (functional) | = 3.12 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 4 weeks by serial twofold dilution method | ChEMBL. | 19028410 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.