Detailed information for compound 987921

Basic information

Technical information
  • TDR Targets ID: 987921
  • Name: 2-[(5Z)-5-[(4-hydroxyphenyl)methylidene]-2,4- dioxo-1,3-thiazolidin-3-yl]acetic acid
  • MW: 279.269 | Formula: C12H9NO5S
  • H donors: 2 H acceptors: 5 LogP: 1.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CN1C(=O)S/C(=C\c2ccc(cc2)O)/C1=O
  • InChi: 1S/C12H9NO5S/c14-8-3-1-7(2-4-8)5-9-11(17)13(6-10(15)16)12(18)19-9/h1-5,14H,6H2,(H,15,16)/b9-5-
  • InChiKey: LDSAGOKBOKCGGG-UITAMQMPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-[(4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
  • 2-[(5Z)-5-[(4-hydroxyphenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetic acid
  • 2-[5-[(4-hydroxyphenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetic acid
  • 2-[(5Z)-5-[(4-hydroxyphenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetic acid
  • 2-[5-[(4-hydroxyphenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetic acid
  • 2-[5-(4-hydroxybenzylidene)-2,4-diketo-thiazolidin-3-yl]acetic acid
  • 2-[(5Z)-5-(4-hydroxybenzylidene)-2,4-diketo-thiazolidin-3-yl]acetic acid
  • 2-[5-[(4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanoic acid
  • 2-[(5Z)-5-[(4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanoic acid
  • 5874-34-0
  • MLS-0146313.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Conserved protein aldo-keto reductase family 1, member B1 (aldose reductase) 316 aa 325 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.032 0.3088 0.3818
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0152 0.6545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Brugia malayi Cathepsin L-like cysteine proteinase 0.0031 0.0074 0.0074
Brugia malayi cathepsin L-like precursor 0.0031 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0232 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Onchocerca volvulus 0.0046 0.0232 0.0198
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0799 0.8086 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.0232 0.0287
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0232 1
Onchocerca volvulus 0.0314 0.3027 0.3686
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0046 0.0232 1
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0152 0.0188
Loa Loa (eye worm) ctsf protein 0.0046 0.0232 0.016
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0046 0.0232 1
Loa Loa (eye worm) fibroinase 0.0046 0.0232 0.016
Toxoplasma gondii cathepsin CPL 0.0046 0.0232 1
Brugia malayi Cathepsin L-like precursor 0.0046 0.0232 0.0232
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 0.0232 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Onchocerca volvulus 0.0046 0.0232 0.0198
Plasmodium vivax vivapain-2 0.0046 0.0232 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0074 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Onchocerca volvulus Cathepsin F homolog 0.0046 0.0232 0.0198
Echinococcus granulosus aldehyde reductase 0.0027 0.0037 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Onchocerca volvulus 0.0038 0.0152 0.0098
Echinococcus granulosus rho-associated protein kinase 1 0.032 0.3088 0.3818
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0232 0.0198
Brugia malayi Cathepsin L-like precursor 0.0046 0.0232 0.0232
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Loa Loa (eye worm) oxidoreductase 0.0038 0.0152 0.0079
Onchocerca volvulus 0.0038 0.0152 0.0098
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0152 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0799 0.8086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Entamoeba histolytica aldose reductase, putative 0.0038 0.0152 0.6545
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Echinococcus multilocularis cysteine protease 0.0046 0.0232 0.0287
Plasmodium falciparum cysteine proteinase falcipain 3 0.0046 0.0232 1
Echinococcus granulosus cathepsin l1 0.0046 0.0232 0.0287
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0232 1
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.0232 1
Echinococcus granulosus hypothetical protein 0.0038 0.0152 0.0188
Onchocerca volvulus 0.0046 0.0232 0.0198
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Echinococcus granulosus aldo keto reductase 0.0038 0.0152 0.0188
Giardia lamblia Kinase, TTK 0.0799 0.8086 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0799 0.8086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0074 0.3182
Brugia malayi Cathepsin L-like precursor 0.0046 0.0232 0.0232
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Loa Loa (eye worm) hypothetical protein 0.0046 0.0232 0.016
Echinococcus granulosus aldo keto reductase 0.0038 0.0152 0.0188
Loa Loa (eye worm) oxidoreductase 0.0038 0.0152 0.0079
Loa Loa (eye worm) oxidoreductase 0.0038 0.0152 0.0079
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0152 0.6545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0074 0.0091
Echinococcus granulosus cathepsin L cysteine proteinase 0.0046 0.0232 0.0287
Brugia malayi Cathepsin L-like precursor 0.0031 0.0074 0.0074
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0232 0.016
Schistosoma mansoni aldo-keto reductase 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0074 0.0091
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Entamoeba histolytica cysteine protease, putative 0.0046 0.0232 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0152 0.6545
Onchocerca volvulus 0.0046 0.0232 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Echinococcus granulosus aldo keto reductase 0.0038 0.0152 0.0188
Loa Loa (eye worm) TTK protein kinase 0.0799 0.8086 0.8072
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0152 0.6545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Brugia malayi Cathepsin L-like precursor 0.0046 0.0232 0.0232
Echinococcus multilocularis cysteine protease 0.0046 0.0232 0.0287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0152 0.0188
Brugia malayi Cathepsin L-like precursor 0.0046 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 0.0232 0.0287
Echinococcus granulosus cathepsin l cysteine peptidase 0.0046 0.0232 0.0287
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0046 0.0232 0.016
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Onchocerca volvulus 0.0046 0.0232 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 0.0232 0.0287
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Echinococcus multilocularis aldo keto reductase 0.0038 0.0152 0.0188
Echinococcus multilocularis aldehyde reductase 0.0027 0.0037 0.0045
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 0.0232 0.0287
Onchocerca volvulus 0.0038 0.0152 0.0098
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Loa Loa (eye worm) oxidoreductase 0.0038 0.0152 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0152 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Onchocerca volvulus 0.0038 0.0152 0.0098
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0152 0.0188
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0982 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0152 0.0188
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0152 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0031 0.0074 0.3182
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.0232 1
Echinococcus granulosus cathepsin l1 0.0031 0.0074 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Brugia malayi Cathepsin L-like precursor 0.0046 0.0232 0.0232
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 0.0232 0.0287
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0152 0.5
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0799 0.8086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Brugia malayi Protein kinase domain containing protein 0.0799 0.8086 0.8086
Plasmodium vivax vivapain-2 0.0046 0.0232 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.0152 0.0079
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0232 1
Onchocerca volvulus Cathepsin L homolog 0.0046 0.0232 0.0198
Schistosoma mansoni aldo-keto reductase 0.0038 0.0152 0.0188
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0232 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.0152 0.0188
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0799 0.8086 1
Echinococcus multilocularis aldo keto reductase 0.0038 0.0152 0.0188
Entamoeba histolytica aldose reductase, putative 0.0038 0.0152 0.6545
Echinococcus multilocularis aldo keto reductase 0.0038 0.0152 0.0188
Onchocerca volvulus 0.0046 0.0232 0.0198
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 0.0232 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0152 0.0188
Onchocerca volvulus 0.0038 0.0152 0.0098
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0232 1
Schistosoma mansoni pol-related 0.0038 0.0152 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Mycobacterium ulcerans oxidoreductase 0.0038 0.0152 0.5
Entamoeba histolytica aldose reductase, putative 0.0038 0.0152 0.6545
Leishmania major cysteine peptidase A (CPA) 0.0046 0.0232 1
Trichomonas vaginalis CAMK family protein kinase 0.0799 0.8086 1
Onchocerca volvulus 0.0046 0.0232 0.0198
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.0232 0.0232
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0152 0.0152
Onchocerca volvulus 0.0038 0.0152 0.0098
Onchocerca volvulus 0.032 0.3088 0.3761
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.0232 0.0287
Brugia malayi Cathepsin L-like precursor 0.0031 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.0232 0.0287
Loa Loa (eye worm) cysteine protease 0.0046 0.0232 0.016
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.0232 0.0287
Leishmania major cathepsin L-like protease 0.0046 0.0232 1
Echinococcus multilocularis rho associated protein kinase 0.032 0.3088 0.3818
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0152 0.0188
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0152 0.0188
Loa Loa (eye worm) hypothetical protein 0.0038 0.0152 0.0079

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.15 uM Inhibition of ALR2 ChEMBL. 18492610
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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