Detailed information for compound 991322

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.267 | Formula: C16H10FN3O3
  • H donors: 0 H acceptors: 3 LogP: 1.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(c2ccc(cc2)OC)[n+]([O-])c2c([n+]1[O-])cc(cc2)F
  • InChi: 1S/C16H10FN3O3/c1-23-12-5-2-10(3-6-12)16-15(9-18)19(21)14-8-11(17)4-7-13(14)20(16)22/h2-8H,1H3
  • InChiKey: PYAACZDOSIYREW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.00957178 0.0288211 0.0853295
Echinococcus multilocularis sex peptide receptor 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0036427 0.00162878 0.00162878
Echinococcus multilocularis g protein coupled receptor 0.00957178 0.0288211 0.0288211
Echinococcus granulosus neuroendocrine convertase 2 0.0174881 0.0651274 0.0651274
Brugia malayi EGF-like domain containing protein 0.00401685 0.00334474 0.00476011
Echinococcus granulosus furin 0.0280379 0.113512 0.113512
Schistosoma mansoni amine GPCR 0.00957178 0.0288211 0.0853295
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0036427 0.00162878 0.00162878
Giardia lamblia Heat shock protein HSP 90-alpha 0.00551031 0.0101942 0.228604
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Brugia malayi Dopamine receptor protein 1 0.00957178 0.0288211 0.0410171
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Echinococcus multilocularis adenylate cyclase type IX 0.00827285 0.0228639 0.0228639
Loa Loa (eye worm) adenylyl cyclase 3 0.0139398 0.0488541 0.0695271
Schistosoma mansoni tgf-beta family 0.00432837 0.00477347 0.0120902
Brugia malayi Melatonin receptor type 1A 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) PAN domain-containing protein 0.00767178 0.0201072 0.0286158
Loa Loa (eye worm) neuropeptide F receptor 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.0119238 0.0396083 0.056369
Schistosoma mansoni serine/threonine protein kinase 0.0134627 0.0466661 0.139678
Toxoplasma gondii heat shock protein HSP90 0.00551031 0.0101942 0.0130785
Echinococcus granulosus allatostatin A receptor 0.0417621 0.176455 0.176455
Loa Loa (eye worm) latrophilin receptor protein 2 0.0319254 0.131341 0.186919
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0134627 0.0466661 0.0664134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0319254 0.131341 0.131341
Echinococcus granulosus alpha 1A adrenergic receptor 0.00957178 0.0288211 0.0288211
Giardia lamblia Furin precursor putative serine protease 0.00549168 0.0101087 0.225752
Trichomonas vaginalis AGC family protein kinase 0.0134627 0.0466661 0.742069
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus granulosus tachykinin peptides receptor 99D 0.00957178 0.0288211 0.0288211
Brugia malayi Deoxyribonuclease II family protein 0.00930856 0.027614 0.0392991
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0142774 0.0504023 0.0504023
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00957178 0.0288211 0.0410171
Echinococcus granulosus neuropeptide FF receptor 2 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00767178 0.0201072 0.0286158
Brugia malayi celfurPC protein 0.0225462 0.0883254 0.125701
Echinococcus granulosus serotonin receptor 0.00957178 0.0288211 0.0288211
Brugia malayi Integrin beta pat-3 precursor 0.127527 0.569797 0.810911
Echinococcus granulosus endoplasmin 0.00420243 0.00419587 0.00419587
Toxoplasma gondii microneme protein, putative 0.00767178 0.0201072 0.0320067
Toxoplasma gondii 1,3(4)-beta-glucanase 0.00767178 0.0201072 0.0320067
Schistosoma mansoni biogenic amine (5HT) receptor 0.00957178 0.0288211 0.0853295
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0142774 0.0504023 0.0504023
Schistosoma mansoni alpha-1 adrenergic receptor 0.00957178 0.0288211 0.0853295
Onchocerca volvulus 0.00432837 0.00477347 0.00825328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Echinococcus granulosus g protein coupled receptor 0.00957178 0.0288211 0.0288211
Schistosoma mansoni hypothetical protein 0.0319254 0.131341 0.397562
Schistosoma mansoni tyrosine kinase 0.0036427 0.00162878 0.00251275
Toxoplasma gondii hypothetical protein 0.00767178 0.0201072 0.0320067
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni apoptosis regulator bax 0.0218253 0.0850193 0.256486
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00957178 0.0288211 0.0853295
Onchocerca volvulus 0.00432837 0.00477347 0.00825328
Echinococcus granulosus rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Brugia malayi G protein-coupled receptor F59B2.13 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) bone morphogenic protein 6 0.0137701 0.0480756 0.0684193
Echinococcus granulosus heat shock protein 0.00551031 0.0101942 0.0101942
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00635218 0.0140552 0.208802
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Brugia malayi hypothetical protein 0.00969615 0.0293915 0.0418288
Schistosoma mansoni opsin-like receptor 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.0218253 0.0850193 0.120996
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.00549168 0.0101087 0.144268
Echinococcus granulosus neuropeptides capa receptor 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus granulosus neuropeptide Y receptor 0.00957178 0.0288211 0.0288211
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.22133 1 1
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Echinococcus granulosus tyrosine protein kinase Src64B 0.0036427 0.00162878 0.00162878
Brugia malayi Dopamine receptor protein 2 0.00957178 0.0288211 0.0410171
Brugia malayi neuropeptide F receptor 0.00957178 0.0288211 0.0410171
Toxoplasma gondii microneme protein MIC4 0.00767178 0.0201072 0.0320067
Echinococcus granulosus 7tm_1 domain containing protein 0.00957178 0.0288211 0.0288211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00957178 0.0288211 0.0853295
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Brugia malayi ORL1-like opioid receptor 0.00957178 0.0288211 0.0410171
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Echinococcus granulosus neuropeptide Y receptor 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0134627 0.0466661 0.0466661
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Echinococcus granulosus adenylate cyclase type IX 0.00827285 0.0228639 0.0228639
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.00420243 0.00419587 0.5
Echinococcus multilocularis dro:myosuppressin receptor 0.00957178 0.0288211 0.0288211
Plasmodium vivax endoplasmin, putative 0.00551031 0.0101942 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.00957178 0.0288211 0.0288211
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Loa Loa (eye worm) SRC-1 0.0036427 0.00162878 0.00231801
Echinococcus multilocularis neuroendocrine convertase 2 0.0174881 0.0651274 0.0651274
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00635218 0.0140552 0.208802
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni hypothetical protein 0.0218253 0.0850193 0.256486
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0134627 0.0466661 0.0664134
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Echinococcus granulosus tyrosine protein kinase Lyn 0.00381969 0.00244051 0.00244051
Loa Loa (eye worm) endoplasmin 0.00551031 0.0101942 0.0145079
Loa Loa (eye worm) hypothetical protein 0.00401685 0.00334474 0.00476011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1104 0.491249 0.491249
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Echinococcus multilocularis fmrfamide receptor 0.00957178 0.0288211 0.0288211
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0121956 0.0408549 0.0408549
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0124137 0.0418551 0.0595665
Schistosoma mansoni growth hormone secretagogue receptor 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00957178 0.0288211 0.0853295
Brugia malayi EGF-like domain containing protein 0.00401685 0.00334474 0.00476011
Toxoplasma gondii PAN/Apple domain-containing protein 0.00767178 0.0201072 0.0320067
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0163592 0.0599499 0.326989
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis neuropeptide s receptor 0.0621862 0.270125 0.270125
Schistosoma mansoni biogenic amine receptor 0.00957178 0.0288211 0.0853295
Schistosoma mansoni endoplasmin 0.00551031 0.0101942 0.0285994
Echinococcus granulosus tm gpcr rhodopsin 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.0161508 0.0589945 0.0839585
Echinococcus granulosus fibrillin 2 0.00401685 0.00334474 0.00334474
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00957178 0.0288211 0.0288211
Echinococcus granulosus integrin beta 2 0.0944473 0.418083 0.418083
Schistosoma mansoni opsin-like receptor 0.00957178 0.0288211 0.0853295
Schistosoma mansoni hypothetical protein 0.00957178 0.0288211 0.0853295
Toxoplasma gondii PAN domain-containing protein 0.00767178 0.0201072 0.0320067
Schistosoma mansoni amine GPCR 0.00957178 0.0288211 0.0853295
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis neuropeptide receptor A26 0.0621862 0.270125 0.270125
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.00401685 0.00334474 0.00476011
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Toxoplasma gondii hypothetical protein 0.00767178 0.0201072 0.0320067
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Echinococcus multilocularis Furin 1 0.00635218 0.0140552 0.0140552
Loa Loa (eye worm) hypothetical protein 0.0111359 0.0359946 0.0512261
Loa Loa (eye worm) hypothetical protein 0.0112217 0.036388 0.0517859
Echinococcus multilocularis tgf beta family 0.00432837 0.00477347 0.00477347
Schistosoma mansoni tyrosine kinase 0.0036427 0.00162878 0.00251275
Schistosoma mansoni amine GPCR 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) integrin alpha pat-2 0.0242484 0.0961321 0.136811
Echinococcus granulosus hypothetical protein 0.00957178 0.0288211 0.0288211
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036427 0.00162878 0.00162878
Echinococcus multilocularis heat shock protein 90 0.00551031 0.0101942 0.0101942
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0417621 0.176455 0.534961
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0036427 0.00162878 0.00162878
Schistosoma mansoni hypothetical protein 0.0218253 0.0850193 0.256486
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Brugia malayi endoprotease bli-4 precursor 0.0280379 0.113512 0.161545
Echinococcus granulosus rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis jun protein 0.0121956 0.0408549 0.0408549
Loa Loa (eye worm) endoprotease bli-4 0.0280379 0.113512 0.161545
Loa Loa (eye worm) LjBmp2/4b 0.00432837 0.00477347 0.00679341
Schistosoma mansoni integrin alpha 0.0162147 0.0592874 0.178117
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.016902 0.0624394 1
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Trichomonas vaginalis hypothetical protein 0.00401685 0.00334474 0.0336609
Brugia malayi AKH receptor 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Echinococcus granulosus fibrillin 1 0.00401685 0.00334474 0.00334474
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Echinococcus granulosus neuropeptide s receptor 0.0621862 0.270125 0.270125
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00957178 0.0288211 0.0853295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00957178 0.0288211 0.0288211
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Toxoplasma gondii microneme protein MIC17A 0.00767178 0.0201072 0.0320067
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.0291489 0.118607 0.168797
Echinococcus granulosus somatostatin receptor 0.00957178 0.0288211 0.0288211
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112217 0.036388 0.0517859
Echinococcus multilocularis neuropeptide Y receptor 0.00957178 0.0288211 0.0288211
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00957178 0.0288211 0.0853295
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.00401685 0.00334474 0.0336609
Echinococcus granulosus dro:myosuppressin receptor 0.00957178 0.0288211 0.0288211
Brugia malayi Kelch motif family protein 0.0193917 0.0738579 0.105112
Schistosoma mansoni hypothetical protein 0.0319254 0.131341 0.397562
Brugia malayi proprotein convertase 2 0.0174881 0.0651274 0.0926867
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00957178 0.0288211 0.0410171
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Schistosoma mansoni heat shock protein 0.00551031 0.0101942 0.0285994
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0218253 0.0850193 0.0850193
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0319254 0.131341 0.131341
Brugia malayi SRC-1 0.0036427 0.00162878 0.00231801
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Brugia malayi larval opioid receptor 0.00957178 0.0288211 0.0410171
Schistosoma mansoni heat shock protein 0.00551031 0.0101942 0.0285994
Echinococcus multilocularis 0.0225462 0.0883254 0.0883254
Schistosoma mansoni neuropeptide F-like receptor 0.00957178 0.0288211 0.0853295
Toxoplasma gondii PAN domain-containing protein 0.00767178 0.0201072 0.0320067
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.156497 0.702662 1
Schistosoma mansoni hypothetical protein 0.00957178 0.0288211 0.0853295
Echinococcus granulosus sex peptide receptor 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036427 0.00162878 0.00162878
Loa Loa (eye worm) hypothetical protein 0.00767178 0.0201072 0.0286158
Schistosoma mansoni protein kinase 0.0142774 0.0504023 0.151057
Schistosoma mansoni hypothetical protein 0.00957178 0.0288211 0.0853295
Echinococcus granulosus sodium channel protein 0.0124452 0.0419996 0.0419996
Loa Loa (eye worm) proprotein convertase 2 0.00635218 0.0140552 0.0200028
Toxoplasma gondii subtilisin SUB12 0.00853228 0.0240537 0.0395422
Echinococcus multilocularis serotonin receptor 0.00957178 0.0288211 0.0288211
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.00420243 0.00419587 0.5
Echinococcus multilocularis G-protein coupled receptor, putative 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0036427 0.00162878 0.00162878
Echinococcus granulosus g protein coupled receptor 0.00957178 0.0288211 0.0288211
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.00420243 0.00419587 0.5
Echinococcus multilocularis heat shock protein 0.00551031 0.0101942 0.0101942
Brugia malayi EGF-like domain containing protein 0.00401685 0.00334474 0.00476011
Echinococcus granulosus heat shock protein 90 0.00420243 0.00419587 0.00419587
Loa Loa (eye worm) hypothetical protein 0.00767178 0.0201072 0.0286158
Echinococcus granulosus jun protein 0.0121956 0.0408549 0.0408549
Brugia malayi neuropeptide F receptor 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036427 0.00162878 0.00162878
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0121956 0.0408549 0.0408549
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Brugia malayi neuroendocrine convertase 1 precursor 0.0174881 0.0651274 0.0926867
Echinococcus granulosus rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Schistosoma mansoni hypothetical protein 0.00957178 0.0288211 0.0853295
Schistosoma mansoni adenoreceptor 0.00957178 0.0288211 0.0853295
Brugia malayi Integrin alpha pat-2 precursor 0.0162147 0.0592874 0.0843754
Schistosoma mansoni neuropeptide receptor 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.0617536 0.268141 0.381607
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036427 0.00162878 0.00162878
Loa Loa (eye worm) G-protein coupled receptor 0.00957178 0.0288211 0.0410171
Trypanosoma cruzi heat shock protein 85, putative 0.00551031 0.0101942 0.0415208
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00957178 0.0288211 0.0853295
Toxoplasma gondii PAN domain-containing protein 0.00767178 0.0201072 0.0320067
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0217132 0.0845052 0.0845052
Brugia malayi Protein kinase domain containing protein 0.0134627 0.0466661 0.0664134
Trichomonas vaginalis hypothetical protein 0.00549168 0.0101087 0.144268
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Brugia malayi Transforming growth factor beta like domain containing protein 0.00432837 0.00477347 0.00679341
Schistosoma mansoni protein kinase 0.0142774 0.0504023 0.151057
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Schistosoma mansoni amine GPCR 0.00957178 0.0288211 0.0853295
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0217132 0.0845052 0.0845052
Treponema pallidum heat shock protein 90 0.00420243 0.00419587 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.1104 0.491249 0.491249
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00635218 0.0140552 0.208802
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036427 0.00162878 0.00162878
Schistosoma mansoni integrin alpha-ps 0.00665078 0.0154247 0.0445293
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Leishmania major C-8 sterol isomerase-like protein 0.0357018 0.148661 1
Loa Loa (eye worm) hypothetical protein 0.0357018 0.148661 0.211568
Echinococcus granulosus rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis endoplasmin 0.00420243 0.00419587 0.00419587
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis fmrfamide receptor 0.00957178 0.0288211 0.0288211
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357018 0.148661 1
Loa Loa (eye worm) hypothetical protein 0.0417621 0.176455 0.251123
Echinococcus granulosus peptide allatostatin:somatostatin 0.00957178 0.0288211 0.0288211
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Brugia malayi Deoxyribonuclease II family protein 0.00930856 0.027614 0.0392991
Echinococcus granulosus neuropeptide receptor 0.00957178 0.0288211 0.0288211
Trichomonas vaginalis heat shock protein, putative 0.00551031 0.0101942 0.145665
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00957178 0.0288211 0.0288211
Schistosoma mansoni endoplasmin 0.00551031 0.0101942 0.0285994
Echinococcus multilocularis serotonin receptor 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00957178 0.0288211 0.0288211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Brugia malayi Endoplasmin precursor 0.00551031 0.0101942 0.0145079
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0218253 0.0850193 0.256486
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0036427 0.00162878 0.00162878
Loa Loa (eye worm) hypothetical protein 0.00767178 0.0201072 0.0286158
Echinococcus granulosus neuropeptide receptor 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) PAN domain-containing protein 0.00767178 0.0201072 0.0286158
Schistosoma mansoni serine/threonine protein kinase 0.0217132 0.0845052 0.25492
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Brugia malayi Transforming growth factor beta like domain containing protein 0.00432837 0.00477347 0.00679341
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Trichomonas vaginalis deoxyribonuclease II precursor, putative 0.00930856 0.027614 0.430521
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00957178 0.0288211 0.0410171
Brugia malayi bZIP transcription factor family protein 0.0121956 0.0408549 0.058143
Echinococcus granulosus rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00957178 0.0288211 0.0410171
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Brugia malayi Tachykinin-like peptides receptor 99D 0.00957178 0.0288211 0.0410171
Brugia malayi G-protein coupled receptor 0.00957178 0.0288211 0.0410171
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0218253 0.0850193 0.0850193
Trichomonas vaginalis heat shock protein, putative 0.00420243 0.00419587 0.0475788
Loa Loa (eye worm) hypothetical protein 0.00767178 0.0201072 0.0286158
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00957178 0.0288211 0.0288211
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.016902 0.0624394 1
Loa Loa (eye worm) hypothetical protein 0.0280379 0.113512 0.161545
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0036427 0.00162878 0.00162878
Loa Loa (eye worm) hypothetical protein 0.0183325 0.0690002 0.0981982
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0036427 0.00162878 0.00162878
Loa Loa (eye worm) hypothetical protein 0.156497 0.702662 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) deoxyribonuclease II family protein 0.00930856 0.027614 0.0392991
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis adenylate cyclase 9 0.00587528 0.011868 0.011868
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis orexin receptor type 2 0.00957178 0.0288211 0.0288211
Echinococcus granulosus 7TM GPCR rhodopsin 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.093679 0.414559 0.589984
Echinococcus multilocularis neuropeptides capa receptor 0.00957178 0.0288211 0.0288211
Brugia malayi phosphoinositide-dependent protein kinase I 0.0134627 0.0466661 0.0664134
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.016902 0.0624394 0.0624394
Echinococcus multilocularis sodium channel protein 0.0124452 0.0419996 0.0419996
Echinococcus granulosus rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Brugia malayi EGF-like domain containing protein 0.00401685 0.00334474 0.00476011
Trichomonas vaginalis heat shock protein, putative 0.00420243 0.00419587 0.0475788
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni hypothetical protein 0.0319254 0.131341 0.397562
Loa Loa (eye worm) G-protein coupled receptor 0.00957178 0.0288211 0.0410171
Schistosoma mansoni jun-related protein 0.00996795 0.0306381 0.0908632
Schistosoma mansoni hypothetical protein 0.00549168 0.0101087 0.0283391
Schistosoma mansoni biogenic amine receptor 0.00957178 0.0288211 0.0853295
Schistosoma mansoni amine GPCR 0.00957178 0.0288211 0.0853295
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0137701 0.0480756 0.0480756
Brugia malayi Latrophilin receptor protein 2 0.0319254 0.131341 0.186919
Trichomonas vaginalis DNAse2-prov protein, putative 0.00930856 0.027614 0.430521
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus granulosus rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Schistosoma mansoni integrin beta subunit 0.0750556 0.329148 1
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Brugia malayi hypothetical protein 0.00432837 0.00477347 0.00679341
Trypanosoma cruzi heat shock protein 85, putative 0.00551031 0.0101942 0.0415208
Loa Loa (eye worm) hypothetical protein 0.00767178 0.0201072 0.0286158
Echinococcus granulosus g protein coupled receptor 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis integrin alpha 3 0.0127519 0.0434061 0.0434061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00957178 0.0288211 0.0288211
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Echinococcus multilocularis allatostatin A receptor 0.0417621 0.176455 0.176455
Echinococcus granulosus GPCR family 2 0.0319254 0.131341 0.131341
Entamoeba histolytica protein kinase, putative 0.0134627 0.0466661 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0193917 0.0738579 0.105112
Echinococcus granulosus fmrfamide receptor 0.00957178 0.0288211 0.0288211
Echinococcus granulosus neuropeptide receptor A26 0.0621862 0.270125 0.270125
Schistosoma mansoni biogenic amine (5HT) receptor 0.00957178 0.0288211 0.0853295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00957178 0.0288211 0.0288211
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Loa Loa (eye worm) TYRA-2 protein 0.00957178 0.0288211 0.0410171
Plasmodium falciparum heat shock protein 90 0.00551031 0.0101942 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0124452 0.0419996 0.0419996
Brugia malayi G protein-coupled receptor 0.00957178 0.0288211 0.0410171
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0217132 0.0845052 0.120264
Trichomonas vaginalis AGC family protein kinase 0.0134627 0.0466661 0.742069
Echinococcus multilocularis neuropeptide FF receptor 2 0.00957178 0.0288211 0.0288211
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Loa Loa (eye worm) hypothetical protein 0.0193917 0.0738579 0.105112
Loa Loa (eye worm) deoxyribonuclease II family protein 0.00930856 0.027614 0.0392991
Echinococcus multilocularis g protein coupled receptor 0.00957178 0.0288211 0.0288211
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00957178 0.0288211 0.0853295
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Brugia malayi hypothetical protein 0.0291489 0.118607 0.168797
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Echinococcus multilocularis integrin alpha ps 0.00665078 0.0154247 0.0154247
Schistosoma mansoni hypothetical protein 0.00996795 0.0306381 0.0908632
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00957178 0.0288211 0.0288211
Schistosoma mansoni hypothetical protein 0.0218253 0.0850193 0.256486
Loa Loa (eye worm) hypothetical protein 0.0034628 0.000803731 0.00114384
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0947439 0.419443 0.419443
Brugia malayi Transforming growth factor beta like domain containing protein 0.0137701 0.0480756 0.0684193
Trypanosoma cruzi heat shock protein 90, putative 0.00551031 0.0101942 0.0415208
Toxoplasma gondii PAN domain-containing protein 0.00767178 0.0201072 0.0320067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00956393 0.0287851 0.0409658
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Brugia malayi RE15519p 0.00957178 0.0288211 0.0410171
Echinococcus granulosus integrin alpha ps 0.00665078 0.0154247 0.0154247
Loa Loa (eye worm) hypothetical protein 0.00401685 0.00334474 0.00476011
Toxoplasma gondii heat shock protein 90, putative 0.00551031 0.0101942 0.0130785
Echinococcus multilocularis G protein coupled receptor 139 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Loa Loa (eye worm) heat shock protein 90 0.00551031 0.0101942 0.0145079
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00957178 0.0288211 0.0288211
Echinococcus granulosus neuropeptides capa receptor 0.00957178 0.0288211 0.0288211
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00957178 0.0288211 0.0853295
Giardia lamblia Grp94/Hsp90 0.00420243 0.00419587 0.0284069
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Toxoplasma gondii PAN domain-containing protein 0.118209 0.527063 1
Loa Loa (eye worm) hypothetical protein 0.00587528 0.011868 0.0168901
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Echinococcus granulosus Furin 1 0.00635218 0.0140552 0.0140552
Echinococcus granulosus deoxyribonuclease ii 0.00930856 0.027614 0.027614
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00957178 0.0288211 0.0853295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni biogenic amine receptor 0.00957178 0.0288211 0.0853295
Echinococcus multilocularis integrin beta 2 0.0944473 0.418083 0.418083
Echinococcus granulosus heat shock protein 90 0.00551031 0.0101942 0.0101942
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00635218 0.0140552 0.208802
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.00587528 0.011868 0.0492362
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00957178 0.0288211 0.0288211
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.00549168 0.0101087 0.144268
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Onchocerca volvulus 0.0417621 0.176455 1
Brugia malayi Serotonin receptor 0.00957178 0.0288211 0.0410171
Brugia malayi putative neuropeptide receptor NPR1 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis protein jagged 2 0.00401685 0.00334474 0.00334474
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis fibrillin 2 0.00401685 0.00334474 0.00334474
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00957178 0.0288211 0.0853295
Brugia malayi sulfakinin receptor protein 0.0291489 0.118607 0.168797
Loa Loa (eye worm) hypothetical protein 0.0319254 0.131341 0.186919
Echinococcus multilocularis heat shock protein 90 0.00420243 0.00419587 0.00419587
Onchocerca volvulus 0.00969615 0.0293915 0.150464
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0280379 0.113512 0.343262
Plasmodium vivax heat shock protein 86, putative 0.00551031 0.0101942 0.5
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Schistosoma mansoni myosin xvIII 0.00957178 0.0288211 0.0853295
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0137701 0.0480756 0.0480756
Brugia malayi hypothetical protein 0.0193917 0.0738579 0.105112
Brugia malayi hypothetical protein 0.00432837 0.00477347 0.00679341
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Loa Loa (eye worm) PAN domain-containing protein 0.00767178 0.0201072 0.0286158
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis neuropeptide Y receptor 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) hypothetical protein 0.00432837 0.00477347 0.00679341
Brugia malayi Dopamine receptor 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00957178 0.0288211 0.0288211
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.22133 1 1
Brugia malayi G-protein coupled receptor 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) PAN domain-containing protein 0.00767178 0.0201072 0.0286158
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00957178 0.0288211 0.0410171
Schistosoma mansoni neuropeptide receptor 0.00957178 0.0288211 0.0853295
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0124452 0.0419996 0.261681
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Schistosoma mansoni neuropeptide f receptor 76f 0.00957178 0.0288211 0.0853295
Echinococcus granulosus tgf beta family 0.00432837 0.00477347 0.00477347
Brugia malayi Calcitonin receptor-like protein seb-1 0.093679 0.414559 0.589984
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0319254 0.131341 0.186919
Echinococcus multilocularis somatostatin receptor 0.00957178 0.0288211 0.0288211
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Echinococcus multilocularis bone morphogenetic protein 2 0.00432837 0.00477347 0.00477347
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Echinococcus multilocularis g-protein coupled receptor 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00957178 0.0288211 0.0288211
Schistosoma mansoni hypothetical protein 0.0617536 0.268141 0.814199
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00957178 0.0288211 0.0410171
Echinococcus granulosus integrin alpha 3 0.0127519 0.0434061 0.0434061
Mycobacterium ulcerans heat shock protein 90 0.00420243 0.00419587 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036427 0.00162878 0.00162878
Echinococcus multilocularis fibrillin 1 0.00401685 0.00334474 0.00334474
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.00549168 0.0101087 0.144268
Loa Loa (eye worm) PAN domain-containing protein 0.00767178 0.0201072 0.0286158
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus granulosus g-protein coupled receptor 0.00957178 0.0288211 0.0288211
Brugia malayi Serotonin receptor 0.00957178 0.0288211 0.0410171
Onchocerca volvulus 0.00566696 0.0109126 0.043717
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Trypanosoma cruzi Heat shock protein 83, putative 0.00551031 0.0101942 0.0415208
Echinococcus multilocularis neuropeptides capa receptor 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0124137 0.0418551 0.0595665
Brugia malayi latrophilin 2 splice variant baaae 0.0617536 0.268141 0.381607
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Loa Loa (eye worm) hypothetical protein 0.00767178 0.0201072 0.0286158
Echinococcus granulosus tm gpcr rhodopsin 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) integrin beta-2 0.127527 0.569797 0.810911
Toxoplasma gondii microneme protein MIC17B 0.00767178 0.0201072 0.0320067
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.00420243 0.00419587 0.00419587
Loa Loa (eye worm) melatonin receptor type 1A 0.00957178 0.0288211 0.0410171
Giardia lamblia High cysteine membrane protein Group 2 0.0105498 0.0333066 1
Onchocerca volvulus 0.00957178 0.0288211 0.147169
Loa Loa (eye worm) apoptosis regulator protein 0.0218253 0.0850193 0.120996
Loa Loa (eye worm) growth/differentiation factor 10 0.00432837 0.00477347 0.00679341
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Echinococcus granulosus orexin receptor type 2 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis neuropeptide receptor 0.00957178 0.0288211 0.0288211
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00635218 0.0140552 0.208802
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00957178 0.0288211 0.0288211
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00957178 0.0288211 0.0288211
Giardia lamblia Heat shock protein HSP 90-alpha 0.00420243 0.00419587 0.0284069
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis neuropeptide receptor 0.00957178 0.0288211 0.0288211
Toxoplasma gondii PAN domain-containing protein 0.118209 0.527063 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.00635218 0.0140552 0.208802
Schistosoma mansoni furin-1 (S08 family) 0.0119964 0.0399411 0.119196
Trypanosoma cruzi heat shock protein 85, putative 0.00551031 0.0101942 0.0415208
Echinococcus multilocularis rhodopsin orphan GPCR 0.00957178 0.0288211 0.0288211
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Onchocerca volvulus 0.00767178 0.0201072 0.0968314
Brugia malayi map kinase activated protein kinase protein 2 0.0217132 0.0845052 0.120264
Toxoplasma gondii microneme protein MIC17C 0.00767178 0.0201072 0.0320067
Schistosoma mansoni neuropeptide F-like receptor 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus multilocularis adam 0.00401685 0.00334474 0.00334474
Brugia malayi heat shock protein 90 0.00551031 0.0101942 0.0145079
Echinococcus granulosus biogenic amine 5HT receptor 0.00957178 0.0288211 0.0288211
Brugia malayi hypothetical protein 0.00957178 0.0288211 0.0410171
Onchocerca volvulus 0.00587528 0.011868 0.0492362
Echinococcus granulosus G protein coupled receptor 139 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00957178 0.0288211 0.0410171
Brugia malayi follicle stimulating hormone receptor 0.00957178 0.0288211 0.0410171
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00957178 0.0288211 0.147169
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.00635218 0.0140552 0.0403585
Schistosoma mansoni deoxyribonuclease II-related 0.00930856 0.027614 0.0816529
Brugia malayi PAN domain containing protein 0.00767178 0.0201072 0.0286158
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0134627 0.0466661 0.0466661
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036427 0.00162878 0.00162878
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357018 0.148661 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.016902 0.0624394 0.0624394
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0218253 0.0850193 0.120996
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036427 0.00162878 0.00162878
Echinococcus multilocularis g protein coupled receptor 0.00957178 0.0288211 0.0288211
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00957178 0.0288211 0.0410171
Schistosoma mansoni hypothetical protein 0.0319254 0.131341 0.397562
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Onchocerca volvulus Neuropeptide F receptor homolog 0.00957178 0.0288211 0.147169
Echinococcus multilocularis GPCR, family 2 0.0319254 0.131341 0.131341
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Echinococcus granulosus adenylate cyclase 9 0.00587528 0.011868 0.011868
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00957178 0.0288211 0.0853295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00957178 0.0288211 0.0853295
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Schistosoma mansoni opsin-like receptor 0.00957178 0.0288211 0.0853295
Schistosoma mansoni tgf-beta family 0.00432837 0.00477347 0.0120902
Echinococcus granulosus adam 0.00401685 0.00334474 0.00334474
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Trichomonas vaginalis conserved hypothetical protein 0.00549168 0.0101087 0.144268
Loa Loa (eye worm) neuropeptide F receptor 0.00957178 0.0288211 0.0410171
Brugia malayi Adenylyl cyclase protein 0.00587528 0.011868 0.0168901
Trichomonas vaginalis heat shock protein, putative 0.00420243 0.00419587 0.0475788
Echinococcus multilocularis deoxyribonuclease ii 0.00930856 0.027614 0.027614
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00957178 0.0288211 0.0853295
Trichomonas vaginalis deoxyribonuclease II, putative 0.00930856 0.027614 0.430521
Schistosoma mansoni protein kinase 0.0142774 0.0504023 0.151057
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357018 0.148661 0.211568
Echinococcus granulosus bone morphogenetic protein 2 0.00432837 0.00477347 0.00477347
Loa Loa (eye worm) hypothetical protein 0.00401685 0.00334474 0.00476011
Leishmania major heat shock protein 83-1 0.00551031 0.0101942 0.0415208
Schistosoma mansoni histamine h1 receptor 0.00957178 0.0288211 0.0853295
Brugia malayi putative neuropeptide receptor 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.00432837 0.00477347 0.00679341
Loa Loa (eye worm) hypothetical protein 0.00957178 0.0288211 0.0410171
Brugia malayi GnHR receptor homolog 0.00957178 0.0288211 0.0410171
Loa Loa (eye worm) hypothetical protein 0.0130267 0.0446665 0.0635675
Echinococcus multilocularis integrin alpha ps 0.00665078 0.0154247 0.0154247
Trichomonas vaginalis AGC family protein kinase 0.0134627 0.0466661 0.742069
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0947439 0.419443 0.419443
Schistosoma mansoni neuropeptide receptor 0.00957178 0.0288211 0.0853295

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 92.2 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as inhibition of parasite growth at 25 uM relative to control ChEMBL. 20634064
IC50 (functional) = 14.3 uM Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes ChEMBL. 20634064
IC50 (functional) > 20 uM Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake ChEMBL. 18215443
Inhibition (functional) = 90 % Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml by microplate alamar blue assay ChEMBL. 19058970
MIC (functional) < 0.2 ug ml-1 Antimicrobial activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay ChEMBL. 19058970

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma cruzi ChEMBL23 20634064

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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