TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 493.789 | Formula: C23H20Cl3FN4O
H donors: 0 H acceptors: 3 LogP: 7.22 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1c(C(F)C)c(nn1c1ccc(cc1Cl)Cl)c1nnc(o1)C(C)(C)C
InChi: 1S/C23H20Cl3FN4O/c1-12(27)18-19(21-28-29-22(32-21)23(2,3)4)30-31(17-10-9-15(25)11-16(17)26)20(18)13-5-7-14(24)8-6-13/h5-12H,1-4H3
InChiKey: YGBNDLCEKRHJGG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 2 (macrophage)	Starlite/ChEMBL	References
Rattus norvegicus	Cannabinoid CB1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Papain family cysteine protease containing protein	0.0479	0.1066	0.1045
Entamoeba histolytica	hypothetical protein	0.0479	0.1066	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1066	0.1045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Echinococcus multilocularis	cysteine protease	0.1817	0.4373	0.4516
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0048	0.0001	0.0001
Trypanosoma cruzi	cysteine protease, putative	0.1021	0.2407	0.2406
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0479	0.1066	0.2437
Giardia lamblia	Cathepsin B precursor	0.0479	0.1066	0.1968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0542	0.1224	0.1209
Onchocerca volvulus	Cathepsin L homolog	0.1817	0.4373	1
Giardia lamblia	Cathepsin L precursor	0.0479	0.1066	0.1968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1817	0.4373	1
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1066	0.1045
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.3551	0.866	0.8659
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Brugia malayi	Papain family cysteine protease containing protein	0.1817	0.4373	0.4481
Onchocerca volvulus	Cathepsin F homolog	0.1817	0.4373	1
Plasmodium falciparum	serine repeat antigen 8	0.0479	0.1066	0.2437
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1817	0.4373	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3965	0.9683	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1817	0.4373	0.4516
Entamoeba histolytica	cysteine protease, putative	0.0479	0.1066	0.2437
Trypanosoma cruzi	cysteine peptidase, putative	0.1021	0.2407	0.2406
Echinococcus granulosus	serine/threonine protein kinase	0.0052	0.0013	0.0013
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1274	0.3032	0.3088
Giardia lamblia	Cathepsin B precursor	0.0479	0.1066	0.1968
Trypanosoma cruzi	cruzipain precursor, putative	0.0542	0.1224	0.1223
Giardia lamblia	Cysteine protease	0.0479	0.1066	0.1968
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1021	0.2407	0.5503
Entamoeba histolytica	cysteine proteinase, putative	0.1021	0.2407	0.5503
Schistosoma mansoni	cathepsin F (C01 family)	0.1817	0.4373	0.4509
Plasmodium vivax	unspecified product	0.1021	0.2407	0.5503
Toxoplasma gondii	cathepsin CPC1	0.0479	0.1066	0.1879
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1817	0.4373	1
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Giardia lamblia	Cathepsin L precursor	0.0479	0.1066	0.1968
Brugia malayi	Cathepsin L-like precursor	0.0542	0.1224	0.1209
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0479	0.1066	0.1861
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0479	0.1066	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0479	0.1066	0.1861
Trypanosoma cruzi	cruzipain precursor, putative	0.4093	1	1
Giardia lamblia	Cathepsin B precursor	0.0479	0.1066	0.1968
Echinococcus granulosus	cathepsin l1	0.1817	0.4373	0.4516
Entamoeba histolytica	cysteine proteinase 2	0.1021	0.2407	0.5503
Entamoeba histolytica	cysteine protease, putative	0.0479	0.1066	0.2437
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0479	0.1066	0.2437
Echinococcus granulosus	cathepsin l1	0.1274	0.3032	0.3132
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0479	0.1066	0.1045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Trypanosoma cruzi	cysteine peptidase, putative	0.4093	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0479	0.1066	0.1045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2238	0.5414	0.5585
Giardia lamblia	Cathepsin L-like protease	0.0479	0.1066	0.1968
Loa Loa (eye worm)	cathepsin B	0.2238	0.5414	0.5563
Brugia malayi	Cathepsin L-like precursor	0.1817	0.4373	0.4481
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0479	0.1066	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Giardia lamblia	Cathepsin L precursor	0.0479	0.1066	0.1968
Plasmodium vivax	serine-repeat antigen (SERA)	0.0479	0.1066	0.2437
Trypanosoma cruzi	cysteine peptidase, putative	0.0542	0.1224	0.1223
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1817	0.4373	0.4481
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0479	0.1066	0.2437
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0479	0.1066	0.1089
Giardia lamblia	Cathepsin L precursor	0.0479	0.1066	0.1968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Schistosoma mansoni	cathepsin C	0.0479	0.1066	0.1089
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3965	0.9683	1
Leishmania major	cathepsin L-like protease	0.4093	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Schistosoma mansoni	cathepsin s	0.0542	0.1224	0.1252
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0479	0.1066	0.1968
Trypanosoma cruzi	Protein kinase B	0.0052	0.0013	0.0012
Toxoplasma gondii	cathepsin CPL	0.1817	0.4373	0.8055
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0479	0.1066	0.2437
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0479	0.1066	0.1089
Onchocerca volvulus		0.1817	0.4373	1
Toxoplasma gondii	cathepsin CPC2	0.0479	0.1066	0.1879
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0076	0.0072	0.0012
Onchocerca volvulus		0.1817	0.4373	1
Plasmodium vivax	unspecified product	0.0479	0.1066	0.2437
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0479	0.1066	0.1968
Echinococcus multilocularis	cathepsin L	0.1021	0.2407	0.2486
Plasmodium vivax	vivapain-2	0.1817	0.4373	1
Entamoeba histolytica	cysteine proteinase, putative	0.1021	0.2407	0.5503
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3965	0.9683	0.9683
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0479	0.1066	0.1089
Brugia malayi	Papain family cysteine protease containing protein	0.1021	0.2407	0.2438
Entamoeba histolytica	cysteine proteinase, putative	0.1021	0.2407	0.5503
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0479	0.1066	0.2437
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1817	0.4373	0.4516
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Trypanosoma cruzi	major cysteine proteinase, putative	0.0479	0.1066	0.1065
Loa Loa (eye worm)	hypothetical protein	0.3965	0.9683	1
Plasmodium falciparum	serine repeat antigen 5	0.0479	0.1066	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0542	0.1224	0.1209
Giardia lamblia	Cathepsin L precursor	0.0479	0.1066	0.1968
Brugia malayi	Protein kinase domain containing protein	0.0076	0.0072	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Onchocerca volvulus		0.1817	0.4373	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1817	0.4373	0.8051
Plasmodium falciparum	serine repeat antigen 9	0.0479	0.1066	0.2437
Entamoeba histolytica	cysteine protease, putative	0.0479	0.1066	0.2437
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1021	0.2407	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0542	0.1224	0.1209
Trypanosoma cruzi	cysteine proteinase, putative	0.1021	0.2407	0.2406
Giardia lamblia	Cysteine protease	0.0479	0.1066	0.1968
Giardia lamblia	Hypothetical protein	0.0479	0.1066	0.1968
Giardia lamblia	Cysteine protease	0.0479	0.1066	0.1968
Trypanosoma cruzi	cysteine proteinase, putative	0.1021	0.2407	0.2406
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.1066	0.1861
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0479	0.1066	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1066	0.1045
Echinococcus granulosus	cathepsin L	0.1021	0.2407	0.2486
Loa Loa (eye worm)	hypothetical protein	0.0542	0.1224	0.1209
Loa Loa (eye worm)	cysteine protease	0.1817	0.4373	0.4481
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1817	0.4373	0.4516
Plasmodium vivax	vivapain-2	0.1817	0.4373	1
Giardia lamblia	Cathepsin B precursor	0.2238	0.5414	1
Trypanosoma cruzi	cysteine peptidase, putative	0.4093	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1817	0.4373	0.4481
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0479	0.1066	0.1045
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1021	0.2407	0.5503
Plasmodium falciparum	serine repeat antigen 4	0.0479	0.1066	0.2437
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1066	0.1045
Brugia malayi	cathepsin L-like precursor	0.1274	0.3032	0.3088
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0479	0.1066	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.1066	0.1861
Echinococcus multilocularis	cathepsin L cysteine protease	0.1817	0.4373	0.4516
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0479	0.1066	0.2437
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0013	0.0027
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0479	0.1066	0.1879
Trypanosoma cruzi	major cysteine proteinase, putative	0.2755	0.6694	0.6693
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0479	0.1066	0.1861
Plasmodium falciparum	serine repeat antigen 1	0.0479	0.1066	0.2437
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.1066	0.1861
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1066	0.1045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1021	0.2407	0.4371
Entamoeba histolytica	protein kinase, putative	0.0076	0.0072	0.0163
Loa Loa (eye worm)	hypothetical protein	0.1274	0.3032	0.3088
Loa Loa (eye worm)	fibroinase	0.1817	0.4373	0.4481
Giardia lamblia	Cathepsin L precursor	0.0479	0.1066	0.1968
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1817	0.4373	1
Giardia lamblia	Cysteine protease	0.0479	0.1066	0.1968
Brugia malayi	Cathepsin L-like precursor	0.1817	0.4373	0.4481
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Onchocerca volvulus		0.1817	0.4373	1
Brugia malayi	Cathepsin L-like precursor	0.1817	0.4373	0.4481
Onchocerca volvulus	Cathepsin L homolog	0.1817	0.4373	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.1066	0.1861
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1817	0.4373	0.4516
Echinococcus multilocularis	cathepsin L	0.0479	0.1066	0.1101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0479	0.1066	0.1861
Entamoeba histolytica	cysteine proteinase, putative	0.1817	0.4373	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0479	0.1066	0.1045
Giardia lamblia	Cathepsin B precursor	0.2238	0.5414	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0479	0.1066	0.1045
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.2238	0.5414	0.185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1021	0.2407	0.4371
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Brugia malayi	Cathepsin L-like precursor	0.1817	0.4373	0.4481
Echinococcus granulosus	serine threonine protein kinase nrc	0.0048	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.1066	0.1861
Onchocerca volvulus		0.1817	0.4373	1
Entamoeba histolytica	cysteine proteinase, putative	0.1274	0.3032	0.6934
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0479	0.1066	0.1861
Brugia malayi	Papain family cysteine protease containing protein	0.0479	0.1066	0.1045
Entamoeba histolytica	protein kinase, putative	0.0076	0.0072	0.0163
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0048	0.0001	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0479	0.1066	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Entamoeba histolytica	cysteine protease, putative	0.0479	0.1066	0.2437
Trichomonas vaginalis	conserved hypothetical protein	0.0479	0.1066	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0479	0.1066	0.1861
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0479	0.1066	0.1968
Entamoeba histolytica	cysteine protease, putative	0.0479	0.1066	0.2437
Plasmodium falciparum	serine repeat antigen 2	0.0479	0.1066	0.2437
Giardia lamblia	Cathepsin B precursor	0.2238	0.5414	1
Entamoeba histolytica	cysteine protease, putative	0.0479	0.1066	0.2437
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1817	0.4373	0.4372
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1021	0.2407	0.2476
Brugia malayi	Cathepsin L-like precursor	0.1274	0.3032	0.3088
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0479	0.1066	0.2437
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0479	0.1066	0.2437
Echinococcus granulosus	cathepsin b	0.3965	0.9683	1
Leishmania major	cathepsin L-like protease	0.4093	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0479	0.1066	0.2437
Giardia lamblia	Cathepsin B precursor	0.0479	0.1066	0.1968
Plasmodium vivax	vivapain-1	0.1021	0.2407	0.5503
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0052	0.0013	0.0012
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3965	0.9683	1
Plasmodium vivax	vivapain-3	0.1021	0.2407	0.5503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1021	0.2407	0.2352
Echinococcus multilocularis	cysteine protease	0.1817	0.4373	0.4516
Plasmodium vivax	serine-repeat antigen (SERA)	0.0479	0.1066	0.2437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Schistosoma mansoni	cathepsin F (C01 family)	0.1274	0.3032	0.3123
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1021	0.2407	0.2476
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0542	0.1224	0.1209
Echinococcus granulosus	cathepsin L cysteine protease	0.1021	0.2407	0.2486
Giardia lamblia	Cathepsin L-like protease	0.0479	0.1066	0.1968
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0479	0.1066	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0479	0.1066	0.1861
Brugia malayi	fibroinase precursor	0.0479	0.1066	0.1045
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0479	0.1066	0.2437
Trichomonas vaginalis	conserved hypothetical protein	0.0479	0.1066	0.1861
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0479	0.1066	0.1089
Loa Loa (eye worm)	hypothetical protein	0.1817	0.4373	0.4481
Brugia malayi	Cathepsin L-like precursor	0.1274	0.3032	0.3088
Trypanosoma cruzi	cysteine peptidase, putative	0.4093	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.1021	0.2407	0.2438
Schistosoma mansoni	cathepsin S (C01 family)	0.0479	0.1066	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1817	0.4373	0.8051
Plasmodium falciparum	serine repeat antigen 3	0.0479	0.1066	0.2437
Entamoeba histolytica	cysteine protease, putative	0.1817	0.4373	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0479	0.1066	0.1045
Loa Loa (eye worm)	ctsf protein	0.1817	0.4373	0.4481
Loa Loa (eye worm)	hypothetical protein	0.1274	0.3032	0.3088
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0479	0.1066	0.2437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1817	0.4373	0.8051
Entamoeba histolytica	protein kinase, putative	0.0072	0.0061	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1274	0.3032	0.5542
Echinococcus granulosus	cysteine protease	0.1021	0.2407	0.2486
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2238	0.5414	0.5413
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0479	0.1066	0.2437
Brugia malayi	cathepsin F-like cysteine proteinase	0.0542	0.1224	0.1209
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Onchocerca volvulus		0.1274	0.3032	0.5946
Schistosoma mansoni	cathepsin B (C01 family)	0.0479	0.1066	0.1089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Loa Loa (eye worm)	hypothetical protein	0.0479	0.1066	0.1045
Echinococcus multilocularis	cathepsin b	0.3965	0.9683	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1021	0.2407	0.2406
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0479	0.1066	0.1089
Giardia lamblia	Encystation-specific protease	0.0479	0.1066	0.1968
Brugia malayi	Papain family cysteine protease containing protein	0.0479	0.1066	0.1045
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4093	1	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0479	0.1066	0.2437
Brugia malayi	cathepsin B-like cysteine proteinase	0.3965	0.9683	1
Brugia malayi	Cathepsin L-like precursor	0.1817	0.4373	0.4481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0479	0.1066	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1274	0.3032	0.5542
Echinococcus multilocularis	rac serine:threonine kinase	0.0052	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0479	0.1066	0.1861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Onchocerca volvulus		0.1817	0.4373	1
Echinococcus granulosus	cathepsin b	0.3965	0.9683	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.2238	0.5414	0.5381
Schistosoma mansoni	cathepsin F (C01 family)	0.1817	0.4373	0.4509
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3965	0.9683	1
Plasmodium falciparum	serine repeat antigen 7	0.0479	0.1066	0.2437
Loa Loa (eye worm)	hypothetical protein	0.1274	0.3032	0.3088
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0479	0.1066	0.1045
Plasmodium falciparum	serine repeat antigen 6	0.0479	0.1066	0.2437
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0479	0.1066	0.2437
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1021	0.2407	0.2476
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0479	0.1066	0.2437
Onchocerca volvulus		0.1817	0.4373	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.2238	0.5414	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1817	0.4373	0.8051
Brugia malayi	cathepsin L precursor	0.0479	0.1066	0.1045
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1817	0.4373	0.4516
Giardia lamblia	Hypothetical protein	0.0479	0.1066	0.1968
Plasmodium vivax	unspecified product	0.0542	0.1224	0.2797
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0013	0.0027
Entamoeba histolytica	cysteine proteinase 1, putative	0.1021	0.2407	0.5503
Echinococcus multilocularis	cathepsin b	0.3965	0.9683	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0479	0.1066	0.1089
Giardia lamblia	Cathepsin B precursor	0.0479	0.1066	0.1968
Echinococcus granulosus	cathepsin L	0.0479	0.1066	0.1101
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0479	0.1066	0.1968
Toxoplasma gondii	cathepsin B	0.2238	0.5414	1
Brugia malayi	Cathepsin L-like precursor	0.1817	0.4373	0.4481
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Entamoeba histolytica	cysteine protease, putative	0.1021	0.2407	0.5503
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0479	0.1066	0.1089

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 14.1 nM	Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometry	ChEMBL.	18954042
IC50 (binding)	= 924 nM	Displacement of [3H]WIN-55212-2 from human CB2 receptor expressed in CHOK1 cells by liquid scintillation spectrometry	ChEMBL.	18954042

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL486562

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 992867