Detailed information for compound 994254

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 374.867 | Formula: C18H16ClD6FN2O3
  • H donors: 0 H acceptors: 1 LogP: 2.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1c(cnn(c1=O)C(C)(C)C)OC(c1ccc(cc1)COC(C(F)([2H])[2H])([2H])[2H])([2H])[2H]
  • InChi: 1S/C18H22ClFN2O3/c1-18(2,3)22-17(23)16(19)15(10-21-22)25-12-14-6-4-13(5-7-14)11-24-9-8-20/h4-7,10H,8-9,11-12H2,1-3H3/i8D2,9D2,12D2
  • InChiKey: RMXZKEPDYBTFOS-BERGFZKVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica DNA topoisomerase III, putative 0.0115 0.0163 0.0984
Toxoplasma gondii DNA topoisomerase family protein 0.0115 0.0163 0.0735
Toxoplasma gondii heat shock protein 75, putative 0.0054 0.0029 0.0076
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0085 0.0098 0.0046
Toxoplasma gondii heat shock protein 90, putative 0.0191 0.0332 0.1564
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0555 0.1137 0.4612
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0115 0.0163 0.0662
Giardia lamblia DNA topoisomerase II 0.0584 0.1203 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0106 0.0143 0.0276
Entamoeba histolytica heat shock protein 90, putative 0.0191 0.0332 0.2222
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0098 0.0206
Trypanosoma brucei DNA topoisomerase ii 0.1155 0.2466 1
Echinococcus granulosus endoplasmin 0.0106 0.0143 0.0835
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0065 0.0051 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.0367 0.2477
Loa Loa (eye worm) hypothetical protein 0.0226 0.0409 0.2791
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Mycobacterium tuberculosis Conserved protein 0.0085 0.0098 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.0478 0.0429
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0085 0.0098 0.0396
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0085 0.0098 0.0046
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0065 0.0051 0.0165
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.056 0.227
Leishmania major hypothetical protein, conserved 0.0085 0.0098 0.0281
Loa Loa (eye worm) glutaminase 2 0.0271 0.0508 0.3515
Onchocerca volvulus 0.0066 0.0055 0.0227
Loa Loa (eye worm) endoplasmin 0.0191 0.0332 0.2222
Leishmania major DNA topoisomerase ii 0.0555 0.1137 0.4548
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0055 0.0068
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0115 0.0163 0.0338
Trypanosoma cruzi heat shock protein 90, putative 0.0106 0.0143 0.0579
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Echinococcus granulosus heat shock protein 90 0.0191 0.0332 0.2222
Mycobacterium ulcerans DNA gyrase subunit A 0.0434 0.0869 0.0822
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0463 0.0933 0.6636
Schistosoma mansoni ap endonuclease 0.0065 0.0051 0.0165
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0085 0.0098 0.0413
Plasmodium vivax endoplasmin, putative 0.0191 0.0332 0.091
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0106 0.0143 0.0046
Plasmodium falciparum DNA topoisomerase 3, putative 0.0115 0.0163 0.0403
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0115 0.0163 0.0984
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0115 0.0163 0.0984
Treponema pallidum heat shock protein 90 0.0106 0.0143 0.0276
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0217 0.077
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0055 0.0194
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0106 0.0143 0.0467
Schistosoma mansoni heat shock protein 0.0191 0.0332 0.2222
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0065 0.0051 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0055 0.0194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0065 0.0051 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0055 0.0194
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0207 0.0367 0.2477
Brugia malayi GRF zinc finger family protein 0.0115 0.0163 0.0984
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0434 0.0869 0.2472
Onchocerca volvulus DNA topoisomerase 2 homolog 0.058 0.1193 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0085 0.0098 0.0503
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0085 0.0098 0.0046
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.0079
Echinococcus multilocularis endoplasmin 0.0106 0.0143 0.0292
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.056 0.2178
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trichomonas vaginalis heat shock protein, putative 0.0106 0.0143 0.0835
Loa Loa (eye worm) hypothetical protein 0.0367 0.0721 0.5074
Trypanosoma cruzi DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Trypanosoma cruzi heat shock protein 85, putative 0.0106 0.0143 0.0579
Chlamydia trachomatis DNA gyrase subunit A 0.0098 0.0126 0.0088
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0085 0.0098 0.0046
Mycobacterium tuberculosis Possible two component sensor kinase 0.0085 0.0098 0.0046
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0055 0.0068
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0085 0.0098 0.0046
Schistosoma mansoni heat shock protein 0.0191 0.0332 0.2222
Trichomonas vaginalis endoplasmin, putative 0.014 0.0218 0.1388
Trypanosoma cruzi Heat shock protein 83, putative 0.0191 0.0332 0.1346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Leishmania major DNA topoisomerase 1A 0.0115 0.0163 0.055
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0115 0.0163 0.0662
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0434 0.0869 0.0822
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0085 0.0098 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Loa Loa (eye worm) hypothetical protein 0.0066 0.0055 0.0194
Trypanosoma cruzi DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Toxoplasma gondii heat shock protein HSP90 0.0191 0.0332 0.1564
Plasmodium vivax heat shock protein 86, putative 0.0191 0.0332 0.091
Chlamydia trachomatis DNA gyrase subunit A 0.0434 0.0869 0.2366
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0115 0.0163 0.0984
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0065 0.0051 0.0165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0367 0.2477
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.0367 0.0867
Trichomonas vaginalis set domain proteins, putative 0.0527 0.1075 0.7675
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Trypanosoma cruzi DNA topoisomerase II, putative 0.0555 0.1137 0.4612
Trichomonas vaginalis glutaminase, putative 0.0271 0.0508 0.3515
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Brugia malayi Endoplasmin precursor 0.0191 0.0332 0.2222
Trypanosoma brucei DNA topoisomerase IA, putative 0.0115 0.0163 0.0662
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.0367 0.0867
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Echinococcus multilocularis geminin 0.0198 0.0348 0.0818
Plasmodium vivax DNA topoisomerase 3, putative 0.0115 0.0163 0.0403
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Plasmodium vivax DNA topoisomerase II, putative 0.067 0.1392 0.4095
Leishmania major mitochondrial DNA topoisomerase II 0.1155 0.2466 1
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.0196
Brugia malayi DNA topoisomerase III 0.0115 0.0163 0.0984
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0085 0.0098 0.0139
Plasmodium vivax DNA gyrase subunit A, putative 0.0434 0.0869 0.2523
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0085 0.0098 0.0046
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.056 0.227
Echinococcus granulosus heat shock protein 0.0191 0.0332 0.2222
Brugia malayi exodeoxyribonuclease III family protein 0.0065 0.0051 0.0165
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.0367 0.2477
Chlamydia trachomatis DNA gyrase subunit B 0.1072 0.2284 0.6706
Giardia lamblia DNA topoisomerase III 0.0115 0.0163 0.097
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0178 0.0303 0.0208
Plasmodium falciparum endoplasmin, putative 0.014 0.0218 0.0568
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0036 0.0147
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0085 0.0098 0.0046
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0085 0.0098 0.0046
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0085 0.0098 0.0176
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0434 0.0869 0.4202
Brugia malayi hypothetical protein 0.0071 0.0065 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0367 0.2477
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0085 0.0098 0.0046
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0065 0.0051 0.0165
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Plasmodium falciparum heat shock protein 90 0.0191 0.0332 0.091
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbB 0.4557 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0252 0.0201
Onchocerca volvulus DNA topoisomerase 2 homolog 0.058 0.1193 1
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0085 0.0098 0.0139
Loa Loa (eye worm) heat shock protein 90 0.0191 0.0332 0.2222
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0085 0.0098 0.0176
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0085 0.0098 0.0413
Treponema pallidum DNA topoisomerase I (topA) 0.0115 0.0163 0.0338
Trypanosoma brucei Heat shock protein 83, putative 0.0191 0.0332 0.1346
Trypanosoma cruzi heat shock protein 85, putative 0.0191 0.0332 0.1346
Loa Loa (eye worm) hypothetical protein 0.0367 0.0721 0.5074
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0967 0.2049 1
Mycobacterium ulcerans DNA topoisomerase I 0.0115 0.0163 0.0112
Plasmodium vivax SET domain protein, putative 0.0066 0.0055 0.0079
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1155 0.2466 1
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0065 0.0261
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.002 0.0081
Mycobacterium ulcerans two component regulator - sensor kinase 0.0085 0.0098 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0055 0.0194
Trichomonas vaginalis receptor histidine kinase, putative 0.0085 0.0098 0.0503
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.067 0.1392 1
Trypanosoma brucei DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0065 0.0051 0.0068
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0085 0.0098 0.0503
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1155 0.2466 1
Brugia malayi Pre-SET motif family protein 0.0463 0.0933 0.6636
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0065 0.0051 0.0209
Onchocerca volvulus 0.0527 0.1075 0.8985
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0085 0.0098 0.0503
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0115 0.0163 0.0984
Giardia lamblia Grp94/Hsp90 0.0106 0.0143 0.0793
Trypanosoma brucei heat shock protein 90, putative 0.0191 0.0332 0.1346
Toxoplasma gondii Hsp90 domain-containing protein 0.0054 0.0029 0.0076
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbA 0.4557 1 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.067 0.1392 1
Brugia malayi Probable DNA topoisomerase II 0.067 0.1392 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0085 0.0098 0.0046
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0523 0.1066 0.0978
Leishmania major developmentally regulated phosphoprotein-like protein 0.0085 0.0098 0.0281
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.056 0.227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0085 0.0098 0.0046
Brugia malayi glutaminase DH11.1 0.0271 0.0508 0.3515
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0115 0.0163 0.0984
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0115 0.0163 0.0984
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.0196
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0085 0.0098 0.0503
Echinococcus multilocularis rho GTPase activating protein 20 0.0115 0.0163 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0048 0.0196
Chlamydia trachomatis DNA gyrase subunit B 0.1557 0.3357 1
Mycobacterium ulcerans DNA gyrase subunit B 0.1557 0.3357 0.3323
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0065 0.0051 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0065 0.0051 0.0209
Schistosoma mansoni endoplasmin 0.0191 0.0332 0.2222
Loa Loa (eye worm) TOPoisomerase family member 0.067 0.1392 1
Trichomonas vaginalis heat shock protein, putative 0.0191 0.0332 0.2222
Trichomonas vaginalis receptor histidine kinase, putative 0.0085 0.0098 0.0503
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0106 0.0143 0.0835
Schistosoma mansoni DNA topoisomerase II 0.067 0.1392 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0085 0.0098 0.0046
Entamoeba histolytica DNA topoisomerase II, putative 0.067 0.1392 1
Echinococcus multilocularis heat shock protein 0.0191 0.0332 0.0778
Mycobacterium ulcerans integral membrane indolylacetylinositol arabinosyltransferase EmbC 0.4557 1 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0085 0.0098 0.0046
Plasmodium falciparum DNA topoisomerase 2 0.067 0.1392 0.4095
Giardia lamblia Heat shock protein HSP 90-alpha 0.0106 0.0143 0.0793
Giardia lamblia Pms1-like protein 0.0085 0.0098 0.04
Trypanosoma cruzi heat shock protein 85, putative 0.0191 0.0332 0.1346
Brugia malayi DNA topoisomerase III beta-1 0.0115 0.0163 0.0984
Trypanosoma cruzi heat shock protein 90, putative 0.0137 0.0211 0.0857
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Plasmodium falciparum DNA gyrase subunit B 0.1557 0.3357 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0085 0.0098 0.0046
Trichomonas vaginalis heat shock protein, putative 0.0106 0.0143 0.0835
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0055 0.0206
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0115 0.0163 0.0735
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.058 0.1193 1
Loa Loa (eye worm) DNA topoisomerase III 0.0115 0.0163 0.0984
Trypanosoma cruzi heat shock protein 90, putative 0.0191 0.0332 0.1346
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0555 0.1137 0.4612
Trypanosoma cruzi DNA topoisomerase II, putative 0.0555 0.1137 0.4612
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Trichomonas vaginalis ap endonuclease, putative 0.0065 0.0051 0.0165
Loa Loa (eye worm) glutaminase 0.0271 0.0508 0.3515
Brugia malayi Pre-SET motif family protein 0.0066 0.0055 0.0194
Leishmania major DNA topoisomerase III, putative 0.0115 0.0163 0.055
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0085 0.0098 0.0046
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0115 0.0163 0.0344
Entamoeba histolytica hypothetical protein 0.0071 0.0065 0.0261
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0085 0.0098 0.0396
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1813 0.3924 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.1557 0.3357 1
Trypanosoma cruzi DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.067 0.1392 0.3499
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0085 0.0098 0.0046
Entamoeba histolytica DNA topoisomerase III, putative 0.0115 0.0163 0.0984
Mycobacterium ulcerans hypothetical protein 0.0155 0.0252 0.0201
Schistosoma mansoni ap endonuclease 0.0065 0.0051 0.0165
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0085 0.0098 0.0503
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0115 0.0163 0.0066
Giardia lamblia Heat shock protein HSP 90-alpha 0.0191 0.0332 0.2435
Loa Loa (eye worm) hypothetical protein 0.0085 0.0098 0.0503
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0065 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Schistosoma mansoni hypothetical protein 0.0071 0.0065 0.0261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0367 0.2477
Entamoeba histolytica heat shock protein 90, putative 0.0191 0.0332 0.2222
Trypanosoma brucei heat shock protein, putative 0.0191 0.0332 0.1346
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Leishmania major cathepsin L-like protease 0.0063 0.0048 0.0079
Trypanosoma brucei heat shock protein 90, putative 0.0191 0.0332 0.1346
Brugia malayi heat shock protein 90 0.0191 0.0332 0.2222
Trypanosoma cruzi heat shock protein, putative 0.0054 0.0029 0.0118
Giardia lamblia DNA topoisomerase III 0.0115 0.0163 0.097
Mycobacterium ulcerans glutaminase 0.0271 0.0508 0.0459
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0085 0.0098 0.0503
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0085 0.0098 0.0396
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0065 0.0091
Echinococcus granulosus geminin 0.0198 0.0348 0.2337
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0434 0.0869 0.2472
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0055 0.0194
Trypanosoma cruzi heat shock protein 85, putative 0.0191 0.0332 0.1346
Leishmania major heat shock protein 83-1 0.0191 0.0332 0.1243
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1557 0.3357 0.3323
Trichomonas vaginalis heat shock protein, putative 0.014 0.0218 0.1388
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0085 0.0098 0.0206
Mycobacterium ulcerans putative regultory protein 0.0085 0.0098 0.0046
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.005 0.0154
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0217 0.0879
Trichomonas vaginalis heat shock protein, putative 0.0106 0.0143 0.0835
Schistosoma mansoni hypothetical protein 0.0198 0.0348 0.2337
Brugia malayi DNA topoisomerase II, alpha isozyme 0.067 0.1392 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0085 0.0098 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0207 0.0367 0.2477
Schistosoma mansoni glutaminase 0.0271 0.0508 0.3515
Schistosoma mansoni pyruvate dehydrogenase 0.0085 0.0098 0.0503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Toxoplasma gondii DNA topoisomerase 2, putative 0.067 0.1392 0.6772
Schistosoma mansoni hypothetical protein 0.0198 0.0348 0.2337
Leishmania major DNA topoisomerase III, putative 0.0115 0.0163 0.055
Loa Loa (eye worm) hypothetical protein 0.0226 0.0409 0.2791
Trypanosoma brucei heat shock protein 84, putative 0.0054 0.0029 0.0118
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0106 0.0143 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Brugia malayi kinase, mitochondrial precursor 0.0085 0.0098 0.0503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0048 0.0196
Onchocerca volvulus 0.0115 0.0163 0.1152
Trypanosoma brucei DNA topoisomerase III, putative 0.0115 0.0163 0.0662
Mycobacterium ulcerans heat shock protein 90 0.0106 0.0143 0.0092
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0018 0.0075
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0085 0.0098 0.0046
Echinococcus multilocularis heat shock protein 90 0.0191 0.0332 0.0778
Plasmodium falciparum DNA gyrase subunit A 0.0434 0.0869 0.2523
Schistosoma mansoni endoplasmin 0.0191 0.0332 0.2222
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0085 0.0098 0.0139
Chlamydia trachomatis DNA topoisomerase I 0.0115 0.0163 0.0201
Echinococcus granulosus DNA topoisomerase 2 alpha 0.067 0.1392 1
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0115 0.0163 0.0984
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.1557 0.3357 1
Plasmodium vivax DNA gyrase subunit B, putative 0.1557 0.3357 1
Toxoplasma gondii exonuclease III APE 0.0065 0.0051 0.0187
Mycobacterium ulcerans two component sensor kinase MprB 0.0085 0.0098 0.0046
Trichomonas vaginalis sensor histidine kinase, putative 0.0085 0.0098 0.0503
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0065 0.0051 0.0068
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0048 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0217 0.0879
Echinococcus granulosus heat shock protein 90 0.0106 0.0143 0.0835
Trypanosoma brucei developmentally regulated phosphoprotein 0.0085 0.0098 0.0396
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) 0.4557 1 1
Echinococcus multilocularis heat shock protein 90 0.0106 0.0143 0.0292

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.