Detailed view for Rv3794

Basic information

TDR Targets ID: 980352
Mycobacterium tuberculosis, Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase)

Source Database / ID:  Tuberculist 

pI: 9.8964 | Length (AA): 1094 | MW (Da): 115692 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 13

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

Gene Ontology

Mouse over links to read term descriptions.
GO:0071766   GO:Actinobacterium-type cell wall biogenesis  

GO:0052636   GO:arabinosyltransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 194 3byw (A) 39 195 30.00 0 0.63 0.426282 0.12
353 470 2k3p (A) 6 135 31.00 0.43 0.09 0.0726611 2.44
717 1065 3pty (A) 735 1065 46.00 0 1 0.575813 0.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_166834)

Species Accession Gene Product
Mycobacterium leprae ML0106c   Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase)
Mycobacterium leprae ML0104c   Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase)
Mycobacterium leprae ML0105c   Probable integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase)
Mycobacterium tuberculosis Rv3795   Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase)
Mycobacterium tuberculosis Rv3793   Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase)
Mycobacterium tuberculosis Rv3794   Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase)
Mycobacterium ulcerans MUL_4974   integral membrane indolylacetylinositol arabinosyltransferase EmbB
Mycobacterium ulcerans MUL_4973   integral membrane indolylacetylinositol arabinosyltransferase EmbA
Mycobacterium ulcerans MUL_4972   integral membrane indolylacetylinositol arabinosyltransferase EmbC

Essentiality

Rv3794 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3862 Mycobacterium tuberculosis essential nmpdr
mtu3860 Mycobacterium tuberculosis essential nmpdr
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) Compounds References
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) Compounds References
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) Compounds References
Mycobacterium tuberculosis Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) Compounds References
Mycobacterium leprae Probable integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
1.4267 1 1
1.0782 0.8751 1
0.4541 1 1
0.448306 0.440879 0.440729
0.1688 0.3446 1
0.5434 1 1
1.6159 1 1
1.3973 1 1
0.4776 0.8196 1
0.2053 0.3341 0.9721
0.4776 0.8196 1
1.531 1 1
0.4676 0.6677 1
1.5681 1 1
0.4676 0.6677 1
0.427 0.3518 1
0.2214 0.3545 1
0.2052 0.3349 0.3767
0.2214 0.2816 0.3749
0.4338 1 1
0.458 1 1
0.2416 1 1
1.4267 1 1
0.1682 0.4499 1
0.3333 0.2722 1
1.3843 1 1
1.443 1 1
1.4897 0.4987 0.4982
0.4776 0.8196 1
0.4776 0.8196 1
1.3973 1 1
0.239 0.5006 1
0.1553 0.3021 0.7426
0.5223 1 1
1.3973 1 1
0.524 1 1
0.4557 1 1
0.239 0.4539 1
0.2579 1 1
0.7455 1 1
1.4647 1 1
0.3567 1 1
0.4776 0.8196 1
1.5477 1 1
0.4676 0.6677 1
0.4198 1 1
1.4612 1 1
0.5556 1 1
0.5206 1 1
1.4064 1 1
0.4776 0.8196 1
0.4776 0.8196 1
1.0681 1 1
0.4751 0.2729 1
0.3205 1 0.5
0.2051 0.694 0.694
0.4198 1 1
0.4776 0.8196 1
0.5363 1 1
0.3333 0.2722 1
1.0782 0.8751 1
1.4897 0.4987 0.4982
0.4776 0.8196 1
0.2066 0.3262 0.9675
0.2052 0.5367 1
0.22 0.4051 1
0.156 0.2792 0.2999
0.1364 0.302 0.7426
1.0607 1 1
1.6159 1 1
0.6911 1 1
0.3333 0.2722 1
0.4776 0.8196 1
0.4676 0.6677 1
0.7157 1 1
0.2322 0.6259 1
0.2778 0.332 1
0.348 0.2535 0.815
0.5556 0.3989 1
0.3205 1 1
0.4751 0.2729 1
1.4267 1 1
0.4776 0.8196 1
0.5184 1 1
0.2778 0.332 1
0.1376 0.2626 1
0.5556 1 1
1.4897 0.4987 0.4982
0.458 1 1
0.2214 0.2816 0.3749
0.2579 0.4675 1
0.1148 0.7667 1
0.1919 0.6561 0.891
1.0787 1 1
1.0721 1 1
1.49 1 1
0.2667 1 0.5
0.5556 0.3989 1
0.3333 0.2722 1
0.4796 0.6642 1
1.0721 1 1
1.3747 1 1
1.0888 1 1
1.4267 1 1
1.531 1 1
0.4776 0.8196 1
0.4198 1 1
1.5727 1 1
0.5556 0.3989 1
1.0884 1 1
1.4897 0.4987 0.4982
1.0006 1 1
0.4776 0.8196 1
0.3901 0.3894 0.782
1.47131 1 1
1.5727 1 1
1.3973 1 1
0.3444 0.8852 0.8845
0.4097 1 1
0.101632 0.509307 0.736895
1.5681 1 1
0.2241 0.3692 0.369
0.4751 0.2729 1
0.18051 0.785363 0.784379
0.4796 0.6642 1
0.3901 0.3894 0.782
1.4301 1 1
0.1971 0.7483 1
0.4676 0.6677 1
0.3333 0.2722 1
0.4776 0.8196 1
0.5556 0.3989 1
0.101632 0.509307 0.736895
0.2363 1 1
0.1682 0.2789 0.2992
0.4751 0.2729 1
0.4676 0.6677 1
1.0175 1 1
0.22 1 1
0.5206 1 1
0.5206 1 1
0.4776 0.8196 1
0.2241 0.6979 0.8811
0.3205 1 0.5
0.4776 0.8196 1
0.1215 0.9721 0.9721
0.4651 1 1
0.3205 1 1
0.4751 0.2729 1
1.0531 1 1
0.1542 1 1
0.4776 0.8196 1
0.4776 0.8196 1
0.1682 0.4499 1
1.5727 1 1
1.0688 1 1
1.0721 1 1
0.7455 1 1
0.3333 0.2722 1
0.4776 0.8196 1
1.4273 1 1
1.5149 1 1
0.468 1 1
1.0537 1 1
0.4198 1 1
0.5556 1 1
0.996 1 1
1.0447 1 1
0.4776 0.8196 1
0.1809 0.8514 0.9721
0.348 0.2547 0.8186
0.4776 0.8196 1
0.9752 1 1
0.1148 0.5059 0.7309
0.4776 0.8196 1
0.3851 1 1
0.348 0.2547 0.8186
1.3948 1 1
0.5556 0.3989 1
0.1919 0.6561 0.891
0.348 0.2535 0.815
0.9835 1 1
1.3948 1 1
0.4751 0.2729 1
0.9723 1 1
0.4776 0.8196 1
0.9835 1 1
0.4751 0.2729 1
0.3333 0.2722 1
0.3444 0.8852 0.8845
0.4751 0.2729 1
0.3333 0.2722 1
0.4776 0.8196 1
0.4776 0.8196 1
0.2768 1 1
1.4718 0.4052 1
0.239 1 1
0.1682 0.4499 1
0.5556 1 1
0.4776 0.8196 1
0.425 1 1
0.3333 0.2722 1
1.4273 1 1
1.4718 0.4052 1
0.45 1 1
0.5556 0.6567 1
0.17961 1 1
1.0721 1 1
1.4267 1 1
1.0006 1 1
0.2404 0.6775 1
1.5149 1 1
0.0358 1 1
0.2052 0.3349 0.3767
1.5727 1 1
0.3112 1 1
0.4846 1 1
1.4647 1 1
0.4557 1 1
0.458 1 1
0.4557 1 1
0.3086 1 0.5
0.101632 0.509307 0.736895
0.2984 0.3382 1
0.2025 0.8514 0.9721
0.2579 0.4675 1
0.4776 0.8196 1
1.0787 1 1
0.3228 0.9722 0.9722

Assayability

Assay information

  • Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation at 3.6 mM ChEMBL
  • Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation at 3.6 mM
  • Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation ChEMBL
  • Inhibition of Mycobacterium smegmatis arabinosyl transferase assessed as [14C]arabinofuranose incorporation

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv3794 (Mycobacterium tuberculosis), Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase)
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