Detailed information for compound 995381

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 436.29 | Formula: C23H15Cl2N3O2
  • H donors: 1 H acceptors: 2 LogP: 5.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1/C=c\1/nc(c2ccccc2)n([nH]c1=O)C(=O)c1ccccc1Cl
  • InChi: 1S/C23H15Cl2N3O2/c24-18-12-6-4-10-16(18)14-20-22(29)27-28(21(26-20)15-8-2-1-3-9-15)23(30)17-11-5-7-13-19(17)25/h1-14H,(H,27,29)/b20-14+
  • InChiKey: SZHGJYFCTVHTMR-XSFVSMFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Brugia malayi AKH receptor 0.0156 0.0214 0.0295
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0156 0.0214 0.0206
Schistosoma mansoni opsin-like receptor 0.0156 0.0214 0.0228
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.025 0.4149
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.025 0.4149
Echinococcus multilocularis SWI:SNF matrix associated 0.0122 0.0115 0.0106
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Echinococcus multilocularis enteropeptidase 0.0113 0.0091 0.0082
Echinococcus multilocularis somatostatin receptor 0.0156 0.0214 0.0206
Brugia malayi hypothetical protein 0.0567 0.1397 0.23
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0156 0.0214 0.0206
Schistosoma mansoni serine-type protease inhibitor 0.274 0.7651 1
Schistosoma mansoni apoptosis regulator bax 0.0358 0.0796 0.0992
Onchocerca volvulus 0.0156 0.0214 0.1134
Leishmania major C-8 sterol isomerase-like protein 0.0366 0.0819 0.4888
Onchocerca volvulus 0.0516 0.1248 0.7875
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0293 0.0607 0.0745
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1505 0.4098 0.6879
Echinococcus granulosus neuropeptides capa receptor 0.0156 0.0214 0.0206
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0127 0.013 0.0122
Toxoplasma gondii PAN domain-containing protein 0.0159 0.0221 0.02
Echinococcus granulosus enteropeptidase 0.0113 0.0091 0.0082
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0106 0.0069 0.0049
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Schistosoma mansoni hypothetical protein 0.0156 0.0214 0.0228
Brugia malayi Trypsin family protein 0.0113 0.0091 0.0085
Echinococcus granulosus somatostatin receptor 0.0156 0.0214 0.0206
Onchocerca volvulus 0.0113 0.0091 0.0327
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.025 0.4149
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) neuropeptide F receptor 0.0156 0.0214 0.0295
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.0091 0.0066
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0269 0.0539 0.0531
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0082 0 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0156 0.0214 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2145 0.5938 1
Schistosoma mansoni hypothetical protein 0.0156 0.0214 0.0228
Echinococcus granulosus g protein coupled receptor 0.0156 0.0214 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.025 0.4149
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Schistosoma mansoni protein kinase 0.0146 0.0186 0.0192
Brugia malayi Trypsin-like protease protein 5 0.0113 0.0091 0.0085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Loa Loa (eye worm) PAN domain-containing protein 0.0159 0.0221 0.0306
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0166 0.0244 0.0267
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0166 0.0244 0.0236
Schistosoma mansoni biogenic amine receptor 0.0156 0.0214 0.0228
Loa Loa (eye worm) G-protein coupled receptor 0.0156 0.0214 0.0295
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0358 0.0796 0.1281
Loa Loa (eye worm) hypothetical protein 0.0358 0.0796 0.1281
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0358 0.0796 0.0788
Onchocerca volvulus 0.0113 0.0091 0.0327
Loa Loa (eye worm) hypothetical protein 0.0159 0.0221 0.0306
Echinococcus multilocularis SWI:SNF matrix associated 0.0122 0.0115 0.0106
Echinococcus multilocularis ecdysone induced protein 78C 0.0096 0.004 0.0032
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0156 0.0214 0.0228
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Brugia malayi hypothetical protein 0.0113 0.0091 0.0085
Onchocerca volvulus Neuropeptide F receptor homolog 0.0156 0.0214 0.1134
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.0091 0.0066
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.004 0.0032
Schistosoma mansoni hypothetical protein 0.0156 0.0214 0.0228
Brugia malayi Trypsin family protein 0.0113 0.0091 0.0085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0633 0.1588 0.2033
Brugia malayi Dopamine receptor 0.0156 0.0214 0.0295
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0122 0.0115 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0156 0.0214 0.0295
Echinococcus multilocularis neuropeptide receptor 0.0156 0.0214 0.0206
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0156 0.0214 0.0206
Echinococcus granulosus neuropeptide Y receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.025 0.4149
Echinococcus multilocularis orexin receptor type 2 0.0156 0.0214 0.0206
Echinococcus granulosus glutamate NMDA receptor subunit 0.0269 0.0539 0.0531
Onchocerca volvulus 0.0159 0.0221 0.1178
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.0091 0.0066
Echinococcus granulosus neuropeptide Y receptor 0.0156 0.0214 0.0206
Echinococcus granulosus rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0122 0.0115 0.0043
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) trypsin family protein 0.0113 0.0091 0.0085
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0167 0.0245 0.1336
Brugia malayi GnHR receptor homolog 0.0156 0.0214 0.0295
Echinococcus granulosus neuropeptides capa receptor 0.0156 0.0214 0.0206
Echinococcus multilocularis neuropeptide receptor A26 0.0671 0.1697 0.169
Loa Loa (eye worm) hypothetical protein 0.0111 0.0085 0.0076
Onchocerca volvulus 0.0113 0.0091 0.0327
Schistosoma mansoni opsin-like receptor 0.0156 0.0214 0.0228
Schistosoma mansoni adenoreceptor 0.0156 0.0214 0.0228
Schistosoma mansoni neuropeptide f receptor 76f 0.0156 0.0214 0.0228
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Schistosoma mansoni neuropeptide F-like receptor 0.0156 0.0214 0.0228
Brugia malayi neuropeptide F receptor 0.0156 0.0214 0.0295
Loa Loa (eye worm) PAN domain-containing protein 0.0159 0.0221 0.0306
Echinococcus granulosus alpha 1A adrenergic receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0159 0.0221 0.0306
Brugia malayi Latrophilin receptor protein 2 0.0499 0.1202 0.1969
Toxoplasma gondii hypothetical protein 0.0159 0.0221 0.02
Brugia malayi Serotonin receptor 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0113 0.0091 0.0085
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Onchocerca volvulus 0.0156 0.0214 0.1134
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0166 0.0244 0.0236
Brugia malayi Protein kinase domain containing protein 0.0106 0.0069 0.0049
Onchocerca volvulus 0.0159 0.0221 0.1178
Onchocerca volvulus 0.0156 0.0214 0.1134
Echinococcus granulosus voltage dependent calcium channel 0.0166 0.0244 0.0236
Echinococcus multilocularis serotonin receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Echinococcus multilocularis transmembrane protease serine 3 0.0113 0.0091 0.0082
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0156 0.0214 0.0228
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0106 0.0069 0.0061
Echinococcus multilocularis Mastin 0.0113 0.0091 0.0082
Brugia malayi putative neuropeptide receptor 0.0156 0.0214 0.0295
Loa Loa (eye worm) PAN domain-containing protein 0.0159 0.0221 0.0306
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0122 0.0115 0.0126
Onchocerca volvulus 0.0156 0.0214 0.1134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0499 0.1202 0.1194
Echinococcus granulosus tm gpcr rhodopsin 0.0156 0.0214 0.0206
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0178 0.0278 0.0403
Echinococcus granulosus biogenic amine 5HT receptor 0.0156 0.0214 0.0206
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0166 0.0244 0.0345
Echinococcus granulosus rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Onchocerca volvulus 0.0156 0.0214 0.1134
Loa Loa (eye worm) neuropeptide F receptor 0.0156 0.0214 0.0295
Echinococcus granulosus peptide allatostatin:somatostatin 0.0156 0.0214 0.0206
Brugia malayi Dopamine receptor protein 2 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0113 0.0091 0.0085
Toxoplasma gondii microneme protein, putative 0.0159 0.0221 0.02
Toxoplasma gondii PAN domain-containing protein 0.0159 0.0221 0.02
Brugia malayi sulfakinin receptor protein 0.0567 0.1397 0.23
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0127 0.013 0.0122
Echinococcus multilocularis G protein coupled receptor 139 0.0156 0.0214 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0156 0.0214 0.0206
Brugia malayi Transforming growth factor beta like domain containing protein 0.0127 0.013 0.0152
Onchocerca volvulus 0.0156 0.0214 0.1134
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0166 0.0244 0.0236
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0127 0.0131 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Echinococcus granulosus g protein coupled receptor 0.0156 0.0214 0.0206
Schistosoma mansoni growth hormone secretagogue receptor 0.0156 0.0214 0.0228
Schistosoma mansoni biogenic amine receptor 0.0156 0.0214 0.0228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0156 0.0214 0.0228
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0629 0.1576 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0122 0.0115 0.0106
Toxoplasma gondii microneme protein MIC17B 0.0159 0.0221 0.02
Echinococcus multilocularis fmrfamide receptor 0.0156 0.0214 0.0206
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Onchocerca volvulus 0.0159 0.0221 0.1178
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0156 0.0214 0.0206
Echinococcus granulosus dro:myosuppressin receptor 0.0156 0.0214 0.0206
Brugia malayi brahma associated protein 60 kDa 0.0122 0.0115 0.0126
Brugia malayi larval opioid receptor 0.0156 0.0214 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.025 0.4149
Echinococcus granulosus GPCR family 2 0.0499 0.1202 0.1194
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0166 0.0244 0.0236
Schistosoma mansoni voltage-gated cation channel 0.0166 0.0244 0.0267
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Onchocerca volvulus 0.0159 0.0221 0.1178
Schistosoma mansoni hypothetical protein 0.0113 0.0091 0.0066
Echinococcus multilocularis serotonin receptor 0.0156 0.0214 0.0206
Brugia malayi Caveolin-1 0.0537 0.1311 0.2154
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0366 0.0819 1
Echinococcus granulosus G protein coupled receptor 139 0.0156 0.0214 0.0206
Onchocerca volvulus 0.0159 0.0221 0.1178
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0504 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Schistosoma mansoni alpha-1 adrenergic receptor 0.0156 0.0214 0.0228
Trypanosoma brucei C-8 sterol isomerase, putative 0.0366 0.0819 1
Echinococcus multilocularis sex peptide receptor 0.0156 0.0214 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0276 0.475
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0113 0.0091 0.0082
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis neuropeptide receptor 0.0156 0.0214 0.0206
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0156 0.0214 0.0295
Echinococcus granulosus hypothetical protein 0.0156 0.0214 0.0206
Echinococcus granulosus neuropeptide receptor 0.0156 0.0214 0.0206
Echinococcus multilocularis g protein coupled receptor 0.0156 0.0214 0.0206
Schistosoma mansoni histamine h1 receptor 0.0156 0.0214 0.0228
Brugia malayi phosphoinositide-dependent protein kinase I 0.0106 0.0069 0.0049
Brugia malayi brahma associated protein 60 kDa 0.0122 0.0115 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Echinococcus granulosus tachykinin peptides receptor 99D 0.0156 0.0214 0.0206
Schistosoma mansoni brg-1 associated factor 0.0122 0.0115 0.0098
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus 7tm_1 domain containing protein 0.0156 0.0214 0.0206
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Echinococcus multilocularis neuropeptide Y receptor 0.0156 0.0214 0.0206
Echinococcus granulosus SWI:SNF matrix associated 0.0122 0.0115 0.0106
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0113 0.0091 0.0085
Brugia malayi G-protein coupled receptor 0.0156 0.0214 0.0295
Schistosoma mansoni protein kinase 0.0146 0.0186 0.0192
Toxoplasma gondii microneme protein MIC17A 0.0159 0.0221 0.02
Schistosoma mansoni hypothetical protein 0.0113 0.0091 0.0066
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0156 0.0214 0.0206
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0504 0.0786
Loa Loa (eye worm) hypothetical protein 0.0159 0.0221 0.0306
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0122 0.0115 0.0106
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0122 0.0115 0.0043
Echinococcus multilocularis allatostatin A receptor 0.0293 0.0607 0.0599
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0629 0.1576 0.1569
Onchocerca volvulus 0.0156 0.0214 0.1134
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0156 0.0214 0.0206
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Toxoplasma gondii microneme protein MIC4 0.0159 0.0221 0.02
Brugia malayi ORL1-like opioid receptor 0.0156 0.0214 0.0295
Schistosoma mansoni hypothetical protein 0.0358 0.0796 0.0992
Schistosoma mansoni hypothetical protein 0.0499 0.1202 0.1526
Onchocerca volvulus 0.0113 0.0091 0.0327
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0159 0.0221 0.0306
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0082 0 0.5
Brugia malayi SWIB/MDM2 domain containing protein 0.0122 0.0115 0.0126
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Onchocerca volvulus 0.0156 0.0214 0.1134
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Schistosoma mansoni neuropeptide receptor 0.0156 0.0214 0.0228
Onchocerca volvulus 0.0293 0.0607 0.3694
Onchocerca volvulus 0.0156 0.0214 0.1134
Schistosoma mansoni hypothetical protein 0.0122 0.0115 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0069 0.0038
Echinococcus multilocularis G-protein coupled receptor, putative 0.0156 0.0214 0.0206
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0156 0.0214 0.0228
Schistosoma mansoni neuropeptide F-like receptor 0.0156 0.0214 0.0228
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0156 0.0214 0.0295
Chlamydia trachomatis DNA topoisomerase I 0.0122 0.0115 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.1505 0.4098 0.6879
Loa Loa (eye worm) PAN domain-containing protein 0.0159 0.0221 0.0306
Schistosoma mansoni hypothetical protein 0.0156 0.0214 0.0228
Echinococcus granulosus orexin receptor type 2 0.0156 0.0214 0.0206
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0156 0.0214 0.0295
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0156 0.0214 0.0206
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0114 0.0092 0.0083
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0113 0.0091 0.0082
Brugia malayi Serotonin receptor 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0159 0.0221 0.0306
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0096 0.004 0.0032
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0166 0.0244 0.0236
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus neuropeptide s receptor 0.0671 0.1697 0.169
Echinococcus multilocularis g-protein coupled receptor 0.0156 0.0214 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0156 0.0214 0.0206
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0499 0.1202 0.1194
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0156 0.0214 0.0295
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0156 0.0214 0.0206
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0159 0.0221 0.02
Brugia malayi G protein-coupled receptor 0.0156 0.0214 0.0295
Onchocerca volvulus 0.0156 0.0214 0.1134
Schistosoma mansoni amine GPCR 0.0156 0.0214 0.0228
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus ecdysone induced protein 78C 0.0096 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis FTZ F1 alpha 0.0096 0.004 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0156 0.0214 0.0206
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0096 0.004 0.0032
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0096 0.004 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0156 0.0214 0.0206
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0156 0.0214 0.0206
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus g protein coupled receptor 0.0156 0.0214 0.0206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0156 0.0214 0.0228
Schistosoma mansoni amine GPCR 0.0156 0.0214 0.0228
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Mycobacterium ulcerans hypothetical protein 0.0113 0.0091 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Loa Loa (eye worm) hypothetical protein 0.0567 0.1397 0.23
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0127 0.0131 0.0154
Echinococcus granulosus sex peptide receptor 0.0156 0.0214 0.0206
Schistosoma mansoni hypothetical protein 0.0499 0.1202 0.1526
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0178 0.0278 0.027
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.025 0.4149
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0166 0.0244 0.0236
Onchocerca volvulus 0.0159 0.0221 0.1178
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0096 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0293 0.0607 0.0961
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Schistosoma mansoni neuropeptide receptor 0.0156 0.0214 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0504 1
Loa Loa (eye worm) bone morphogenic protein 6 0.0127 0.013 0.0152
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.0091 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0366 0.0819 0.1319
Schistosoma mansoni serine-type protease inhibitor 0.274 0.7651 1
Onchocerca volvulus 0.0156 0.0214 0.1134
Echinococcus multilocularis neuropeptide Y receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) adenylyl cyclase 3 0.0142 0.0175 0.0227
Brugia malayi neuropeptide F receptor 0.0156 0.0214 0.0295
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0096 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Schistosoma mansoni amine GPCR 0.0156 0.0214 0.0228
Brugia malayi latrophilin 2 splice variant baaae 0.1006 0.2661 0.4443
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0146 0.0186 0.0178
Echinococcus multilocularis nmda type glutamate receptor 0.0114 0.0092 0.0083
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0096 0.004 0.0032
Schistosoma mansoni hypothetical protein 0.1006 0.2661 0.3443
Onchocerca volvulus 0.0156 0.0214 0.1134
Echinococcus multilocularis GPCR, family 2 0.0499 0.1202 0.1194
Echinococcus granulosus voltage dependent calcium channel 0.0166 0.0244 0.0236
Echinococcus granulosus neuropeptide receptor A26 0.0671 0.1697 0.169
Onchocerca volvulus 0.0156 0.0214 0.1134
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Echinococcus granulosus 7TM GPCR rhodopsin 0.0156 0.0214 0.0206
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Schistosoma mansoni myosin xvIII 0.0156 0.0214 0.0228
Loa Loa (eye worm) hypothetical protein 0.0164 0.0238 0.0335
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0166 0.0244 0.2061
Loa Loa (eye worm) hypothetical protein 0.0166 0.0244 0.0345
Brugia malayi Dopamine receptor protein 1 0.0156 0.0214 0.0295
Echinococcus granulosus FTZ F1 alpha 0.0096 0.004 0.0032
Schistosoma mansoni neuropeptide receptor 0.0156 0.0214 0.0228
Loa Loa (eye worm) hypothetical protein 0.0113 0.0091 0.0085
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Echinococcus multilocularis neuropeptide FF receptor 2 0.0156 0.0214 0.0206
Schistosoma mansoni hypothetical protein 0.0358 0.0796 0.0992
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Brugia malayi follicle stimulating hormone receptor 0.0156 0.0214 0.0295
Toxoplasma gondii PAN domain-containing protein 0.0159 0.0221 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0504 1
Loa Loa (eye worm) hypothetical protein 0.0499 0.1202 0.1969
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0504 0.0786
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.025 0.1364
Echinococcus multilocularis neuropeptide s receptor 0.0671 0.1697 0.169
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1689 0.4626 0.4621
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0276 0.475
Echinococcus granulosus nmda type glutamate receptor 0.0114 0.0092 0.0083
Echinococcus granulosus biogenic amine 5HT receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) calcium channel 0.0166 0.0244 0.0345
Loa Loa (eye worm) latrophilin receptor protein 2 0.0499 0.1202 0.1969
Loa Loa (eye worm) PAN domain-containing protein 0.0159 0.0221 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Loa Loa (eye worm) melatonin receptor type 1A 0.0156 0.0214 0.0295
Echinococcus multilocularis dro:myosuppressin receptor 0.0156 0.0214 0.0206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0499 0.1202 0.1969
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0156 0.0214 0.0295
Echinococcus granulosus transmembrane protease serine 3 0.0113 0.0091 0.0082
Loa Loa (eye worm) TYRA-2 protein 0.0156 0.0214 0.0295
Onchocerca volvulus 0.0159 0.0221 0.1178
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0156 0.0214 0.0228
Schistosoma mansoni hypothetical protein 0.0499 0.1202 0.1526
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0504 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0113 0.0091 0.0066
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3556 1 1
Echinococcus multilocularis g protein coupled receptor 0.0156 0.0214 0.0206
Schistosoma mansoni opsin-like receptor 0.0156 0.0214 0.0228
Onchocerca volvulus 0.0159 0.0221 0.1178
Schistosoma mansoni amine GPCR 0.0156 0.0214 0.0228
Brugia malayi putative neuropeptide receptor NPR1 0.0156 0.0214 0.0295
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0113 0.0091 0.0082
Loa Loa (eye worm) hypothetical protein 0.0629 0.1574 0.2601
Brugia malayi G protein-coupled receptor F59B2.13 0.0156 0.0214 0.0295
Echinococcus multilocularis voltage dependent calcium channel 0.0166 0.0244 0.0236
Echinococcus multilocularis neuropeptides capa receptor 0.0156 0.0214 0.0206
Echinococcus granulosus glycoprotein Antigen 5 0.0113 0.0091 0.0082
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0156 0.0214 0.0206
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis glycoprotein Antigen 5 0.0113 0.0091 0.0082
Loa Loa (eye worm) hypothetical protein 0.0159 0.0221 0.0306
Entamoeba histolytica protein kinase, putative 0.0106 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0629 0.1574 0.2601
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0156 0.0214 0.1134
Echinococcus granulosus tm gpcr rhodopsin 0.1689 0.4626 0.4621
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0122 0.0115 0.5
Schistosoma mansoni hypothetical protein 0.0209 0.0366 0.0428
Toxoplasma gondii PAN domain-containing protein 0.2464 0.6857 1
Onchocerca volvulus 0.0156 0.0214 0.1134
Schistosoma mansoni cercarial elastase (S01 family) 0.0113 0.0091 0.0066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0096 0.004 0.0032
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0156 0.0214 0.0228
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0156 0.0214 0.0228
Onchocerca volvulus 0.0122 0.0115 0.0484
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0106 0.0069 0.0061
Loa Loa (eye worm) hypothetical protein 0.0159 0.0221 0.0306
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1139 0.3042 0.3037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.004 0.0032
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0358 0.0796 0.0788
Onchocerca volvulus 0.0159 0.0221 0.1178
Loa Loa (eye worm) apoptosis regulator protein 0.0358 0.0796 0.1281
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0115 0.1041
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0 0.5
Toxoplasma gondii subtilisin SUB12 0.0159 0.0221 0.02
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0156 0.0214 0.0228
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.004 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0096 0.004 0.0032
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0156 0.0214 0.0228
Echinococcus multilocularis thyroid hormone receptor alpha 0.0096 0.004 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0504 1
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0187 0.0303 0.0446
Echinococcus multilocularis sodium channel protein 0.0629 0.1576 0.1569
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1139 0.3042 0.3037
Echinococcus granulosus serotonin receptor 0.0156 0.0214 0.0206
Brugia malayi G-protein coupled receptor 0.0156 0.0214 0.0295
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0156 0.0214 0.0228
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0504 1
Toxoplasma gondii transporter, cation channel family protein 0.0166 0.0244 0.0234
Onchocerca volvulus 0.0156 0.0214 0.1134
Brugia malayi RE15519p 0.0156 0.0214 0.0295
Toxoplasma gondii PAN/Apple domain-containing protein 0.0159 0.0221 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.0278 0.0313
Plasmodium vivax hypothetical protein, conserved 0.0122 0.0115 0.5
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Brugia malayi map kinase activated protein kinase protein 2 0.0178 0.0278 0.0403
Schistosoma mansoni hypothetical protein 0.0499 0.1202 0.1526
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0166 0.0244 0.0267
Schistosoma mansoni neuropeptide receptor 0.0156 0.0214 0.0228
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus neuropeptide receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Toxoplasma gondii PAN domain-containing protein 0.0159 0.0221 0.02
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Trypanosoma brucei RNA helicase, putative 0.0209 0.0366 0.3754
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus multilocularis voltage dependent calcium channel 0.0166 0.0244 0.0236
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0156 0.0214 0.0295
Echinococcus granulosus rhodopsin orphan GPCR 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0166 0.0244 0.0345
Toxoplasma gondii hypothetical protein 0.0159 0.0221 0.02
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.1006 0.2661 0.4443
Loa Loa (eye worm) hypothetical protein 0.0113 0.0091 0.0085
Brugia malayi Melatonin receptor type 1A 0.0156 0.0214 0.0295
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0106 0.0069 0.0049
Toxoplasma gondii microneme protein MIC17C 0.0159 0.0221 0.02
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.004 0.0032
Echinococcus granulosus neuropeptide FF receptor 2 0.0156 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0111 0.0085 0.0076
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0156 0.0214 0.0206
Echinococcus multilocularis fmrfamide receptor 0.0156 0.0214 0.0206
Schistosoma mansoni glutamate receptor NMDA 0.0269 0.0539 0.0655
Onchocerca volvulus 0.0629 0.1574 1
Onchocerca volvulus 0.0113 0.0091 0.0327
Loa Loa (eye worm) brahma associated protein 0.0122 0.0115 0.0126
Loa Loa (eye worm) hypothetical protein 0.0366 0.0819 0.1319
Schistosoma mansoni amine GPCR 0.0156 0.0214 0.0228
Onchocerca volvulus 0.0156 0.0214 0.1134
Brugia malayi Trypsin family protein 0.0629 0.1574 0.2601
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Schistosoma mansoni biogenic amine (5HT) receptor 0.0156 0.0214 0.0228
Brugia malayi PAN domain containing protein 0.0159 0.0221 0.0306
Loa Loa (eye worm) hypothetical protein 0.0113 0.0091 0.0085
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0146 0.0186 0.0178
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0178 0.0278 0.027
Brugia malayi hypothetical protein 0.0156 0.0214 0.0295
Onchocerca volvulus 0.0159 0.0221 0.1178
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Brugia malayi Trypsin family protein 0.0113 0.0091 0.0085
Echinococcus granulosus fmrfamide receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) G-protein coupled receptor 0.0156 0.0214 0.0295
Toxoplasma gondii PAN domain-containing protein 0.2464 0.6857 1
Schistosoma mansoni hypothetical protein 0.0122 0.0115 0.0098
Echinococcus granulosus Mastin 0.0113 0.0091 0.0082
Loa Loa (eye worm) hypothetical protein 0.2145 0.5938 1
Onchocerca volvulus 0.0159 0.0221 0.1178
Schistosoma mansoni hypothetical protein 0.0122 0.0115 0.0098
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0358 0.0796 0.0992
Echinococcus granulosus g-protein coupled receptor 0.0156 0.0214 0.0206
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0166 0.0244 0.0236
Schistosoma mansoni biogenic amine receptor 0.0156 0.0214 0.0228
Schistosoma mansoni protein kinase 0.0146 0.0186 0.0192
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0122 0.0115 0.5
Loa Loa (eye worm) hypothetical protein 0.0537 0.1311 0.2154
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0113 0.0091 0.0082
Loa Loa (eye worm) hypothetical protein 0.0156 0.0214 0.0295
Echinococcus granulosus sodium channel protein 0.0629 0.1576 0.1569
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0122 0.0115 0.0106
Echinococcus granulosus allatostatin A receptor 0.0293 0.0607 0.0599
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0629 0.1574 0.2016
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0156 0.0214 0.0206
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0166 0.0244 0.2061
Echinococcus multilocularis neuropeptides capa receptor 0.0156 0.0214 0.0206
Loa Loa (eye worm) voltage-dependent calcium channel 0.0166 0.0244 0.0345
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0156 0.0214 0.0228
Schistosoma mansoni biogenic amine (5HT) receptor 0.0156 0.0214 0.0228
Schistosoma mansoni hypothetical protein 0.0358 0.0796 0.0992
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0113 0.0091 0.0066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0096 0.004 0.0032
Chlamydia trachomatis SWIB complex protein 0.0122 0.0115 1
Echinococcus multilocularis g protein coupled receptor 0.0156 0.0214 0.0206
Echinococcus granulosus tm gpcr rhodopsin 0.0156 0.0214 0.0206
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0156 0.0214 0.0228

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 30 mg kg-1 Anticonvulsant activity in ip dosed albino mouse assessed as protection against MES-induced seizures after 0.5 hrs ChEMBL. 20573424
ED50 (functional) = 30 mg kg-1 Anticonvulsant activity in ip dosed albino mouse assessed as protection against MES-induced seizures after 4 hrs ChEMBL. 20573424
ED50 (functional) = 30 mg kg-1 Anticonvulsant activity in ip dosed albino mouse assessed as protection against scPTZ-induced seizures after 0.5 hrs ChEMBL. 20573424
ED50 (functional) = 100 mg kg-1 Anticonvulsant activity in ip dosed albino mouse assessed as protection against scPTZ-induced seizures after 4 hrs ChEMBL. 20573424
Time (functional) = 148.17 s Reduction of immobility time in albino Swiss mouse at 100 mg/kg, ip pretreated for 1 hrs by forced swimming test ChEMBL. 20573424

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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