TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 365.389 | Formula: C18H19N7O2
H donors: 3 H acceptors: 6 LogP: 0.7 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OCCCn1cnc2c1nc(C#N)nc2NCc1cccc(c1)NC(=O)C
InChi: 1S/C18H19N7O2/c1-12(27)22-14-5-2-4-13(8-14)10-20-17-16-18(24-15(9-19)23-17)25(11-21-16)6-3-7-26/h2,4-5,8,11,26H,3,6-7,10H2,1H3,(H,22,27)(H,20,23,24)
InChiKey: DJDAKRQHQXZQIW-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.003	0.0597	1
Leishmania major	hypothetical protein, conserved	0.0041	0.0872	0.4182
Brugia malayi	Major Facilitator Superfamily protein	0.0041	0.0872	0.1242
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0041	0.0872	0.1242
Trypanosoma brucei	glucose transporter 2A	0.0091	0.2086	1
Treponema pallidum	prolyl-tRNA synthetase	0.001	0.0119	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	myo-inositol transporter, putative	0.0041	0.0872	0.1242
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Onchocerca volvulus		0.0041	0.0872	0.5
Toxoplasma gondii	facilitative glucose transporter GT1	0.0293	0.7024	1
Trypanosoma cruzi	sugar transporter, putative	0.0041	0.0872	0.4182
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.003	0.0597	0.0597
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0399	0.0568
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Echinococcus granulosus	solute carrier family 22	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0293	0.7024	1
Schistosoma mansoni	protein kinase	0.003	0.0597	0.085
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0091	0.2086	1
Giardia lamblia	Hexose transporter	0.0041	0.0872	1
Onchocerca volvulus		0.0041	0.0872	0.5
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0034	0.0701	0.336
Chlamydia trachomatis	lysine--tRNA ligase	0.0022	0.0399	1
Schistosoma mansoni	sugar transporter	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0293	0.7024	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0293	0.7024	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0872	0.1242
Trichomonas vaginalis	glucose transporter, putative	0.0091	0.2086	0.2969
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0034	0.0701	0.336
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0158	0.3724	0.3724
Plasmodium vivax	sugar transporter, putative	0.0041	0.0872	0.0872
Brugia malayi	Sugar transporter family protein	0.0041	0.0872	0.1242
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0293	0.7024	1
Leishmania major	myo-inositol/proton symporter (MIT)	0.0041	0.0872	0.4182
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0041	0.0872	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Plasmodium vivax	calcium-dependent protein kinase, putative	0.003	0.0597	0.0597
Trichomonas vaginalis	CAMK family protein kinase	0.003	0.0597	0.085
Plasmodium falciparum	protein kinase 7	0.0277	0.6612	0.6612
Trypanosoma cruzi	glucose transporter, putative	0.0041	0.0872	0.4182
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.003	0.0597	0.085
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Onchocerca volvulus		0.0041	0.0872	0.5
Plasmodium falciparum	calcium-dependent protein kinase 1	0.003	0.0597	0.0597
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0041	0.0872	0.4182
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.003	0.0597	0.085
Onchocerca volvulus	Putative transporter	0.0041	0.0872	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Plasmodium falciparum	calcium-dependent protein kinase 5	0.003	0.0597	0.0597
Onchocerca volvulus		0.0041	0.0872	0.5
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0034	0.0701	0.336
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0041	0.0872	0.1242
Trypanosoma cruzi	hexose transporter, putative	0.0091	0.2086	1
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0582	0.0829
Loa Loa (eye worm)	sugar transporter	0.0041	0.0872	0.1242
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0597	0.085
Onchocerca volvulus		0.0041	0.0872	0.5
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.003	0.0597	0.085
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.003	0.0597	0.085
Trichomonas vaginalis	sugar transporter, putative	0.0091	0.2086	0.2969
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0022	0.0399	0.1911
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0041	0.0872	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0034	0.0701	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.2086	0.2969
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.003	0.0597	0.085
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Echinococcus granulosus	solute carrier family 22	0.0041	0.0872	0.1242
Onchocerca volvulus		0.0041	0.0872	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0041	0.0872	1
Onchocerca volvulus		0.0041	0.0872	0.5
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0022	0.0399	0.6849
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0872	0.1242
Brugia malayi	Sugar transporter family protein	0.0041	0.0872	0.1242
Echinococcus granulosus	calcium dependent protein kinase	0.0028	0.0552	0.0785
Plasmodium falciparum	hexose transporter	0.0293	0.7024	0.7024
Echinococcus granulosus	synaptic vesicle 2 protein	0.0041	0.0872	0.1242
Plasmodium falciparum	calcium-dependent protein kinase 3	0.003	0.0597	0.0597
Brugia malayi	hypothetical protein	0.0041	0.0872	0.1242
Brugia malayi	Major Facilitator Superfamily protein	0.0041	0.0872	0.1242
Entamoeba histolytica	protein kinase, putative	0.003	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0582	0.0829
Schistosoma mansoni	sugar transporter	0.0041	0.0872	0.1242
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0029	0.0582	0.0829
Plasmodium vivax	hexose transporter	0.0293	0.7024	0.7024
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.003	0.0597	0.0597
Leishmania major	lysyl-tRNA synthetase, putative	0.0022	0.0399	0.1911
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0019	0.0333	0.0474
Plasmodium falciparum	lysine--tRNA ligase	0.0022	0.0399	0.0399
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0293	0.7024	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transport protein, putative	0.0041	0.0872	0.1242
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0415	1	1
Echinococcus granulosus	solute carrier family 22	0.0041	0.0872	0.1242
Plasmodium falciparum	calcium-dependent protein kinase 2	0.003	0.0597	0.0597
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0091	0.2086	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.003	0.0597	0.085
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0293	0.7024	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0022	0.0399	0.4571
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0029	0.0582	0.0829
Onchocerca volvulus		0.0041	0.0872	0.5
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0158	0.3724	0.3724
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0597	0.085
Echinococcus granulosus	General substrate transporter	0.0252	0.6017	0.8567
Onchocerca volvulus		0.0041	0.0872	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Schistosoma mansoni	protein kinase	0.003	0.0597	0.085
Trichomonas vaginalis	sugar transporter, putative	0.0091	0.2086	0.2969
Echinococcus granulosus	solute carrier family 22	0.0041	0.0872	0.1242
Giardia lamblia	Prolyl-tRNA synthetase	0.0029	0.0582	0.6673
Toxoplasma gondii	sugar transporter ST3	0.0041	0.0872	0.1242
Trichomonas vaginalis	glucose transporter, putative	0.0091	0.2086	0.2969
Onchocerca volvulus		0.0041	0.0872	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Onchocerca volvulus		0.0041	0.0872	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Echinococcus multilocularis	solute carrier family 22	0.0041	0.0872	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0041	0.0872	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Schistosoma mansoni	glucose transport protein	0.0293	0.7024	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0022	0.0399	0.0568
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0041	0.0872	0.1242
Echinococcus granulosus	lysyl tRNA synthetase	0.0022	0.0399	0.0568
Echinococcus multilocularis	solute carrier family 22	0.0041	0.0872	0.1242
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0041	0.0872	1
Entamoeba histolytica	hypothetical protein	0.0022	0.0399	0.6679
Toxoplasma gondii	transporter, major facilitator family protein	0.0041	0.0872	0.1242
Echinococcus multilocularis	General substrate transporter	0.0252	0.6017	0.8567
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0293	0.7024	1
Onchocerca volvulus		0.0041	0.0872	0.5
Toxoplasma gondii	sugar transporter ST1	0.0041	0.0872	0.1242
Leishmania major	glucose transporter, lmgt3	0.0091	0.2086	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Onchocerca volvulus		0.0041	0.0872	0.5
Brugia malayi	Major Facilitator Superfamily protein	0.0041	0.0872	0.1242
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0022	0.0399	0.1911
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Loa Loa (eye worm)	sugar transporter	0.0293	0.7024	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0029	0.0582	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.003	0.0597	0.085
Onchocerca volvulus		0.0041	0.0872	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Schistosoma mansoni	protein kinase	0.003	0.0597	0.085
Trypanosoma cruzi	hexose transporter, putative	0.0041	0.0872	0.4182
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0029	0.0582	0.0829
Echinococcus multilocularis	calcium dependent protein kinase	0.0028	0.0552	0.0785
Brugia malayi	major facilitator superfamily protein	0.0041	0.0872	0.1242
Brugia malayi	Sugar transporter family protein	0.0293	0.7024	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Echinococcus multilocularis	solute carrier family 22	0.0041	0.0872	0.1242
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.003	0.0597	0.085
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.003	0.0597	0.2862
Trypanosoma cruzi	hexose transporter	0.0091	0.2086	1
Trypanosoma cruzi	hexose transporter, putative	0.005	0.1079	0.5174
Leishmania major	glucose transporter, lmgt1	0.0091	0.2086	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0293	0.7024	1
Schistosoma mansoni	glucose transport protein	0.0293	0.7024	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0318	0.365
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.5469
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Brugia malayi	Cam kinase protein 1	0.003	0.0597	0.085
Schistosoma mansoni	hypothetical protein	0.0293	0.7024	1
Toxoplasma gondii	protein kinase, putative	0.0277	0.6612	0.9413
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0091	0.2086	0.2969
Plasmodium falciparum	proline--tRNA ligase	0.0034	0.0701	0.0701
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0012	0.016	0.0227
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0029	0.0582	0.0829
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.2086	0.2969
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Brugia malayi	lysyl-tRNA synthetase	0.0022	0.0399	0.0568
Schistosoma mansoni	glucose transport protein	0.0293	0.7024	1
Mycobacterium ulcerans	sugar transporter	0.0041	0.0872	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	conserved hypothetical protein	0.0293	0.7024	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Brugia malayi	hypothetical protein	0.0041	0.0872	0.1242
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0029	0.0582	0.9752
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0041	0.0872	0.1242
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0597	0.085
Schistosoma mansoni	sugar transporter	0.0041	0.0872	0.1242
Schistosoma mansoni	glucose transporter	0.0041	0.0872	0.1242
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0029	0.0582	0.0829
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0034	0.0701	0.336
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0597	0.085
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.003	0.0597	0.085
Chlamydia trachomatis	proline--tRNA ligase	0.001	0.0119	0.2978
Echinococcus multilocularis	solute carrier family 22	0.0041	0.0872	0.1242
Schistosoma mansoni	sugar transporter	0.0041	0.0872	0.1242
Onchocerca volvulus		0.0041	0.0872	0.5
Schistosoma mansoni	lysyl-tRNA synthetase	0.0022	0.0399	0.0568
Leishmania major	glucose transporter, lmgt2	0.0091	0.2086	1
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0041	0.0872	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0399	0.0568
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Plasmodium falciparum	calcium-dependent protein kinase 4	0.003	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0022	0.0399	0.4571
Trypanosoma brucei	sugar transporter, putative	0.0041	0.0872	0.4182
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0041	0.0872	0.1242
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0872	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Mycobacterium ulcerans	integral membrane transport protein	0.0041	0.0872	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0158	0.3724	0.5302
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0091	0.2086	1
Trypanosoma cruzi	hexose transporter, putative	0.0091	0.2086	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0091	0.2086	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0034	0.0701	0.0998
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.003	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0029	0.0582	0.0829
Toxoplasma gondii	sugar transporter ST2	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.365
Brugia malayi	major facilitator superfamily protein	0.0041	0.0872	0.1242
Brugia malayi	hypothetical protein	0.0041	0.0872	0.1242
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0041	0.0872	0.0872
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0022	0.0399	0.4571
Toxoplasma gondii	lysine-tRNA ligase	0.0022	0.0399	0.0568
Schistosoma mansoni	lysyl-tRNA synthetase	0.0022	0.0399	0.0568
Trypanosoma cruzi	hexose transporter, putative	0.0091	0.2086	1
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0029	0.0582	0.0829
Giardia lamblia	Sugar-proton symporter	0.0041	0.0872	1
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0597	0.085
Trypanosoma brucei	glucose transporter 1E	0.0091	0.2086	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.003	0.0597	0.085
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.001	0.0119	0.1361
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Leishmania major	protein kinase, putative	0.003	0.0597	0.2862
Trichomonas vaginalis	sugar transporter, putative	0.0041	0.0872	0.1242
Onchocerca volvulus		0.0041	0.0872	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.0597	0.085
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0034	0.0701	0.336
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0872	0.1242
Trypanosoma brucei	glucose transporter, putative	0.0091	0.2086	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0022	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0448	0.0637

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 6 uM	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human O+ erythrocytes by DNA stain with pepstatin	ChEMBL.	19447616
EC50 (functional)	= 15 uM	Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human O+ erythrocytes by DNA stain without pepstatin	ChEMBL.	19447616

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	19447616

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL497008

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 998961