Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.2474 | 0.1758 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.504 | 0.9752 |
Echinococcus multilocularis | GPCR, family 2 | 0.0037 | 0.1716 | 0.3015 |
Brugia malayi | Protein kinase domain containing protein | 0.0069 | 0.5032 | 0.456 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0037 | 0.1716 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.5162 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.5162 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.5032 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0037 | 0.1716 | 0.1716 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0356 | 0.0356 |
Giardia lamblia | Kinase, CDC7 | 0.0069 | 0.5032 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1716 | 0.1716 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2482 | 0.2482 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.8309 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.5032 | 0.8091 |
Echinococcus granulosus | GPCR family 2 | 0.0037 | 0.1716 | 0.3015 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.5032 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.5162 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.5032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2766 | 0.2766 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0069 | 0.5032 | 0.9737 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0069 | 0.5032 | 0.5032 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0037 | 0.1716 | 0.3015 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0037 | 0.1716 | 0.0928 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0585 | 0.0599 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0356 | 0.0213 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 1 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0585 | 0.0721 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.5469 | 0.8826 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.6166 | 0.6166 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.6166 | 0.5801 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.6166 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.219 | 0.3975 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.6874 | 0.6577 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0037 | 0.1716 | 0.3015 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.504 | 0.9752 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.219 | 0.3975 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.6361 | 0.6361 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0037 | 0.1716 | 0.3015 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0585 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2995 | 0.2995 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0037 | 0.1716 | 0.3015 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0069 | 0.5032 | 0.9737 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.5032 | 0.5 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.8309 |
Onchocerca volvulus | 0.0069 | 0.5032 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Inhibition of Cdc7-mediated phosphorylation of Mcm2 | ChEMBL. | 19555113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.