Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0037 | 0.1716 | 0.3015 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.5032 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.8309 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0037 | 0.1716 | 0.3015 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0037 | 0.1716 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1716 | 0.1716 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.8309 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.5162 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0037 | 0.1716 | 0.0928 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.5032 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.219 | 0.3975 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.6166 | 0.6166 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0037 | 0.1716 | 0.1716 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0585 | 0.0721 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0069 | 0.5032 | 0.9737 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0069 | 0.5032 | 0.5032 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.5469 | 0.8826 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2995 | 0.2995 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.2474 | 0.1758 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0356 | 0.0213 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0585 | 0.0721 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.5032 | 0.8091 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2482 | 0.2482 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.6166 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 0.5032 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0069 | 0.5032 | 0.456 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.5032 | 0.5 | |
Giardia lamblia | Kinase, CDC7 | 0.0069 | 0.5032 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.504 | 0.9752 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2766 | 0.2766 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0069 | 0.5032 | 0.9737 |
Echinococcus granulosus | GPCR family 2 | 0.0037 | 0.1716 | 0.3015 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.5162 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.504 | 0.9752 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.5162 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0585 | 0.0599 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.5162 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0037 | 0.1716 | 0.0928 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1716 | 0.2505 |
Onchocerca volvulus | 0.0069 | 0.5032 | 0.5 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0037 | 0.1716 | 0.3015 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.219 | 0.3975 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0037 | 0.1716 | 0.3015 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.6361 | 0.6361 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.6166 | 0.5801 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.6874 | 0.6577 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 uM | Inhibition of Cdc7-mediated phosphorylation of Mcm2 | ChEMBL. | 19555113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.