Detailed information for compound 1158240

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.519 | Formula: C27H26N4O5
  • H donors: 2 H acceptors: 3 LogP: 3.26 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C(C(=O)Nc1ccc2c(c1)OCC(=O)N2Cc1ccc(cc1)C(=N)N)Cc1ccccc1
  • InChi: 1S/C27H26N4O5/c1-35-27(34)21(13-17-5-3-2-4-6-17)26(33)30-20-11-12-22-23(14-20)36-16-24(32)31(22)15-18-7-9-19(10-8-18)25(28)29/h2-12,14,21H,13,15-16H2,1H3,(H3,28,29)(H,30,33)
  • InChiKey: NXJQSTSGZAVTTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transcription factor SMAD2 0.0722 0.1581 0.2484
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.055 0.1188 0.1171
Echinococcus multilocularis ferritin 0.0093 0.015 0.0131
Mycobacterium tuberculosis Probable hydrolase 0.0583 0.1263 0.1489
Schistosoma mansoni thyroid hormone receptor 0.0553 0.1195 0.2522
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Trypanosoma cruzi cysteine peptidase, putative 0.01 0.0166 0.124
Schistosoma mansoni ubiquitin ligase sina (ec 6.3.2.-) (seven in absentia homolog)(smsina) 0.1382 0.3081 0.6539
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0063 0.0044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.016 0.0302 0.0475
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0045 0.007
Schistosoma mansoni hypothetical protein 0.024 0.0485 0.1009
Schistosoma mansoni transcription factor LCR-F1 0.055 0.1188 0.2506
Echinococcus multilocularis expressed protein 0.0093 0.015 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0179
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0052 0.0055 0.0358
Leishmania major hypothetical protein, conserved 0.0103 0.0173 0.1293
Trypanosoma cruzi cysteine peptidase, putative 0.0382 0.0806 0.6348
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0583 0.1263 0.1985
Entamoeba histolytica hypothetical protein 0.055 0.1188 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Onchocerca volvulus 0.0151 0.0281 0.0345
Echinococcus granulosus expressed protein 0.0093 0.015 0.0131
Brugia malayi Integrin alpha pat-2 precursor 0.0185 0.0358 0.0563
Loa Loa (eye worm) hypothetical protein 0.0147 0.0273 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.01 0.0166 0.0261
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0027 0.0042
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.039 0.0826 0.0808
Onchocerca volvulus 0.016 0.0302 0.0375
Brugia malayi hypothetical protein 0.055 0.1188 0.1867
Brugia malayi cytoplasmic intermediate filament protein 0.0086 0.0133 0.0209
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0262 0.0535 0.1116
Leishmania major cathepsin L-like protease 0.0382 0.0806 0.6348
Loa Loa (eye worm) hypothetical protein 0.008 0.012 0.0188
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0032 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0032 0.005
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0039 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.2825 0.6363 1
Entamoeba histolytica hypothetical protein 0.055 0.1188 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0045 0.0217
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0045 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0055 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.0166 0.0224
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.005 0.0084
Loa Loa (eye worm) hypothetical protein 0.1382 0.3081 0.4843
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.024 0.0485 0.0467
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0032 0.005
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0032 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.024 0.0485 0.0467
Trichomonas vaginalis penicillin-binding protein, putative 0.0583 0.1263 0.1738
Toxoplasma gondii ABC1 family protein 0.0583 0.1263 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0032 0.0045
Echinococcus granulosus intermediate filament protein 0.016 0.0302 0.0284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0045 0.0037
Brugia malayi Intermediate filament tail domain containing protein 0.016 0.0302 0.0475
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0032 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0055 0.0244
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.005 0.0031
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0055 0.0087
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Schistosoma mansoni integrin alpha-ps 0.0083 0.0126 0.0247
Schistosoma mansoni integrin alpha 0.0185 0.0358 0.074
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0042
Brugia malayi Pre-SET motif family protein 0.2825 0.6363 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0032 0.005
Onchocerca volvulus 0.0047 0.0045 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Onchocerca volvulus 0.3216 0.725 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0262 0.0535 0.0841
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0055 0.0358
Trypanosoma cruzi cysteine peptidase, putative 0.0382 0.0806 0.6348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0091 0.012
Onchocerca volvulus 0.0583 0.1263 0.1706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0013 0.0013
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0048 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0018 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0583 0.1263 0.2667
Loa Loa (eye worm) hypothetical protein 0.0047 0.0045 0.007
Loa Loa (eye worm) hypothetical protein 0.0048 0.0048 0.0075
Brugia malayi MH2 domain containing protein 0.0722 0.1581 0.2484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0151 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Leishmania major hypothetical protein, conserved 0.0583 0.1263 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0045 0.0273
Onchocerca volvulus 0.0648 0.1411 0.1911
Loa Loa (eye worm) intermediate filament protein 0.016 0.0302 0.0475
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0027 0.0035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0032 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0583 0.1263 0.1738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0055 0.0358
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Trichomonas vaginalis ferritin, putative 0.0093 0.015 0.0202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0405 0.086 0.1808
Schistosoma mansoni ferritin light chain 0.0093 0.015 0.0297
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0045 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0032 0.0045
Schistosoma mansoni DNA polymerase eta 0.0039 0.0027 0.0035
Trypanosoma cruzi cysteine protease, putative 0.0052 0.0055 0.0358
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0018 0.0062
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0063 0.0044
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0032 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0032 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Echinococcus granulosus e3 ubiquitin protein ligase siah1 0.1382 0.3081 0.3068
Brugia malayi Smad1 0.0049 0.005 0.0079
Brugia malayi steroid hormone receptor 0.0041 0.0032 0.005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0032 0.0045
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0033 0.0013 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.024 0.0485 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0583 0.1263 0.1985
Mycobacterium tuberculosis Probable lipase LipD 0.0583 0.1263 0.1489
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0151 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0151 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0013 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0045 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0039 0.0049
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0027 0.0032
Echinococcus granulosus beta LACTamase domain containing family member 0.0583 0.1263 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Mycobacterium tuberculosis Conserved protein 0.0583 0.1263 0.1489
Loa Loa (eye worm) hypothetical protein 0.0519 0.1119 0.1758
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0048 0.0079
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0039 0.0226
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Echinococcus multilocularis geminin 0.0176 0.0339 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Entamoeba histolytica cysteine proteinase, putative 0.0067 0.0091 0.0547
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0173 0.1293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0032 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.024 0.0485 0.0467
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0019 0.0018
Onchocerca volvulus 0.01 0.0166 0.0186
Mycobacterium tuberculosis Possible penicillin-binding protein 0.3723 0.8404 1
Mycobacterium leprae Probable lipase LipE 0.0583 0.1263 1
Trypanosoma cruzi cysteine proteinase, putative 0.0052 0.0055 0.0358
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0032 0.0013
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0048 0.0029
Schistosoma mansoni cathepsin s 0.0033 0.0013 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0583 0.1263 0.1489
Plasmodium vivax vivapain-2 0.01 0.0166 0.122
Loa Loa (eye worm) fibroinase 0.01 0.0166 0.0261
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.01 0.0166 0.0224
Echinococcus multilocularis e3 ubiquitin protein ligase siah1 0.1382 0.3081 0.3068
Echinococcus multilocularis cathepsin L 0.0052 0.0055 0.0037
Loa Loa (eye worm) hypothetical protein 0.0157 0.0296 0.0465
Onchocerca volvulus Cathepsin F homolog 0.01 0.0166 0.0186
Schistosoma mansoni apoferritin-2 0.0093 0.015 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0032 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0048 0.0079
Echinococcus granulosus Smad4 0.0049 0.005 0.0031
Brugia malayi beta-lactamase 0.0583 0.1263 0.1985
Echinococcus granulosus cathepsin l cysteine peptidase 0.01 0.0166 0.0147
Brugia malayi Ubiquitin ligase sia-1 0.1382 0.3081 0.4843
Schistosoma mansoni zinc finger protein 0.0041 0.0031 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0045 0.0217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0032 0.0013
Brugia malayi Cathepsin L-like precursor 0.01 0.0166 0.0261
Loa Loa (eye worm) pigment dispersing factor receptor c 0.076 0.1665 0.2617
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0055 0.0072
Loa Loa (eye worm) hypothetical protein 0.0067 0.0091 0.0142
Echinococcus granulosus ferritin 0.0093 0.015 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0028
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0077 0.0114 0.0095
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0405 0.086 0.6772
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0027 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0151 0.03
Onchocerca volvulus 0.01 0.0166 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0032 0.005
Brugia malayi nuclear receptor NHR-88 0.0041 0.0032 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.0173 0.1276
Echinococcus multilocularis integrin alpha ps 0.004 0.0028 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0032 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0027 0.0132
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0032 0.005
Entamoeba histolytica cysteine proteinase 2 0.0052 0.0055 0.0244
Plasmodium falciparum cysteine proteinase falcipain 3 0.01 0.0166 0.9565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0151 0.03
Brugia malayi Cathepsin L-like precursor 0.0067 0.0091 0.0142
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0052 0.0055 0.0096
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0027 0.0042
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0027 0.0132
Loa Loa (eye worm) hypothetical protein 0.0583 0.1263 0.1985
Loa Loa (eye worm) hypothetical protein 0.0074 0.0107 0.0168
Onchocerca volvulus 0.0048 0.0048 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0583 0.1263 0.2667
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0032 0.0045
Schistosoma mansoni coup transcription factor 0.0041 0.0032 0.0045
Brugia malayi cathepsin F-like cysteine proteinase 0.0033 0.0013 0.0021
Onchocerca volvulus 0.01 0.0166 0.0186
Trypanosoma cruzi major cysteine proteinase, putative 0.03 0.062 0.4865
Schistosoma mansoni hypothetical protein 0.0512 0.1102 0.2323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Schistosoma mansoni hypothetical protein 0.0519 0.1119 0.236
Echinococcus granulosus smad 0.0049 0.005 0.0031
Brugia malayi beta-lactamase family protein 0.0583 0.1263 0.1985
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0032 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0018 0.002
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0018 0.0035
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0013 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0055 0.0244
Trypanosoma cruzi cysteine proteinase, putative 0.0052 0.0055 0.0358
Onchocerca volvulus 0.0583 0.1263 0.1706
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Echinococcus multilocularis tumor protein p63 0.4425 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Brugia malayi MH2 domain containing protein 0.0049 0.005 0.0079
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0145 0.0268 0.0421
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0032 0.0013
Schistosoma mansoni thyroid hormone receptor 0.0553 0.1195 0.2522
Onchocerca volvulus 0.01 0.0166 0.0186
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.024 0.0485 0.0467
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0052 0.0055 0.0096
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0086 0.0133 0.0209
Onchocerca volvulus 0.01 0.0166 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Toxoplasma gondii cathepsin CPL 0.01 0.0166 0.1222
Loa Loa (eye worm) hypothetical protein 0.0648 0.1411 0.2217
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0032 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Entamoeba histolytica cysteine protease, putative 0.01 0.0166 0.1196
Brugia malayi Papain family cysteine protease containing protein 0.01 0.0166 0.0261
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0173 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0032 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0262 0.0535 0.1116
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0043 0.0024
Onchocerca volvulus 0.01 0.0166 0.0186
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0027 0.0016
Echinococcus granulosus integrin alpha ps 0.0083 0.0126 0.0108
Loa Loa (eye worm) hypothetical protein 0.0583 0.1263 0.1985
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.0166 0.0331
Echinococcus granulosus microtubule associated protein 2 0.2097 0.4707 0.4697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0032 0.005
Brugia malayi Cathepsin L-like precursor 0.01 0.0166 0.0261
Echinococcus multilocularis lamin 0.016 0.0302 0.0284
Echinococcus multilocularis zinc finger protein 0.0041 0.0031 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Echinococcus granulosus lamin 0.016 0.0302 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0039 0.0049
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0055 0.0087
Schistosoma mansoni hypothetical protein 0.024 0.0485 0.1009
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0093 0.015 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.0166 0.0147
Mycobacterium tuberculosis Probable lipase LipE 0.0583 0.1263 0.1489
Mycobacterium ulcerans beta-lactamase 0.0583 0.1263 1
Loa Loa (eye worm) beta-lactamase 0.0583 0.1263 0.1985
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0027 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.055 0.1188 0.1171
Schistosoma mansoni lamin 0.016 0.0302 0.0621
Mycobacterium ulcerans hypothetical protein 0.0047 0.0045 0.0217
Entamoeba histolytica hypothetical protein 0.055 0.1188 1
Echinococcus multilocularis microtubule associated protein 2 0.2097 0.4707 0.4697
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.076 0.1665 0.2617
Loa Loa (eye worm) hypothetical protein 0.0441 0.094 0.1478
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Brugia malayi TAR-binding protein 0.0262 0.0535 0.0841
Mycobacterium ulcerans lipase LipD 0.0583 0.1263 1
Leishmania major cathepsin L-like protease 0.0382 0.0806 0.6348
Brugia malayi Cathepsin L-like cysteine proteinase 0.0067 0.0091 0.0142
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0027 0.0016
Trypanosoma cruzi cruzipain precursor, putative 0.0382 0.0806 0.6348
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0151 0.0133
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0032 0.0013
Brugia malayi hypothetical protein 0.0151 0.0281 0.0441
Treponema pallidum bacterioferrin (TpF1) 0.0093 0.015 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0583 0.1263 0.1738
Echinococcus multilocularis cysteine protease 0.01 0.0166 0.0147
Echinococcus granulosus cathepsin L cysteine proteinase 0.01 0.0166 0.0147
Loa Loa (eye worm) integrin alpha pat-2 0.0285 0.0585 0.092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Onchocerca volvulus Cathepsin L homolog 0.01 0.0166 0.0186
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0405 0.086 0.0842
Brugia malayi beta-lactamase family protein 0.0583 0.1263 0.1985
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0027 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0553 0.1195 0.1179
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0348 0.073 0.5747
Schistosoma mansoni smad1 5 8 and 0.0049 0.005 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0583 0.1263 0.1247
Trichomonas vaginalis esterase, putative 0.0583 0.1263 0.1738
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0036 0.0056
Schistosoma mansoni cathepsin F (C01 family) 0.01 0.0166 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Trypanosoma brucei hypothetical protein, conserved 0.0583 0.1263 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0077 0.0114 0.0095
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0039 0.0226
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0055 0.0244
Schistosoma mansoni Smad4 0.0049 0.005 0.0084
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0093 0.015 0.0163
Schistosoma mansoni ferritin 0.0093 0.015 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Mycobacterium ulcerans bacterioferritin BfrB 0.0093 0.015 0.1061
Schistosoma mansoni integrin alpha-ps 0.0043 0.0036 0.0055
Schistosoma mansoni hypothetical protein 0.055 0.1188 0.2506
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Plasmodium vivax unspecified product 0.0052 0.0055 0.0336
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0093 0.015 0.0863
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0039 0.0049
Brugia malayi Integrin alpha cytoplasmic region family protein 0.014 0.0256 0.0402
Schistosoma mansoni hypothetical protein 0.0176 0.0339 0.0699
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.0173 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0045 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.01 0.0166 0.1196
Loa Loa (eye worm) hypothetical protein 0.0074 0.0107 0.0168
Schistosoma mansoni smad1 5 8 and 0.0049 0.005 0.0084
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0039 0.0061
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0045 0.0153
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0027 0.0008
Echinococcus multilocularis cysteine protease 0.01 0.0166 0.0147
Loa Loa (eye worm) MBCTL1 0.0055 0.0063 0.0099
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0045 0.0026
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0048 0.0029
Plasmodium falciparum cysteine proteinase falcipain 2a 0.01 0.0166 0.9565
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0221 0.0202
Loa Loa (eye worm) hypothetical protein 0.016 0.0302 0.0475
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0027 0.0132
Brugia malayi hypothetical protein 0.0067 0.0089 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Brugia malayi MH1 domain containing protein 0.0049 0.005 0.0079
Leishmania major cathepsin L-like protease 0.01 0.0166 0.124
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0027 0.0042
Echinococcus granulosus dna polymerase kappa 0.0039 0.0027 0.0008
Loa Loa (eye worm) hypothetical protein 0.0067 0.0091 0.0142
Brugia malayi mbt repeat family protein 0.0048 0.0048 0.0075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0583 0.1263 0.1489
Schistosoma mansoni hypothetical protein 0.0176 0.0339 0.0699
Echinococcus granulosus lamin dm0 0.016 0.0302 0.0284
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0039 0.0061
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0027 0.0132
Mycobacterium ulcerans bacterioferritin BfrA 0.0093 0.015 0.1061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Brugia malayi mbt repeat family protein 0.0048 0.0048 0.0075
Loa Loa (eye worm) hypothetical protein 0.0067 0.0091 0.0142
Loa Loa (eye worm) papain family cysteine protease containing protein 0.01 0.0166 0.0261
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0021
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0048 0.0075
Brugia malayi Pre-SET motif family protein 0.0405 0.086 0.1351
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0006 0.0003
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0052 0.0055 0.0358
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0052 0.0055 0.0096
Echinococcus granulosus cathepsin L cysteine protease 0.0052 0.0055 0.0037
Echinococcus multilocularis integrin alpha ps 0.0083 0.0126 0.0108
Schistosoma mansoni intermediate filament proteins 0.016 0.0302 0.0621
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0027 0.0074
Echinococcus granulosus GPCR family 2 0.024 0.0485 0.0467
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0045 0.007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0151 0.0238
Schistosoma mansoni hypothetical protein 0.004 0.0028 0.0038
Trypanosoma cruzi cruzipain precursor, putative 0.0033 0.0013 0.0023
Onchocerca volvulus 0.0583 0.1263 0.1706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0441 0.094 0.198
Loa Loa (eye worm) hypothetical protein 0.0103 0.0173 0.0271
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0048 0.0029
Echinococcus granulosus cathepsin l1 0.0067 0.0091 0.0072
Brugia malayi MH1 domain containing protein 0.0049 0.005 0.0079
Schistosoma mansoni hypothetical protein 0.0293 0.0605 0.1266
Echinococcus granulosus cysteine protease 0.0052 0.0055 0.0037
Schistosoma mansoni apoferritin-2 0.0093 0.015 0.0297
Onchocerca volvulus Cathepsin L homolog 0.01 0.0166 0.0186
Plasmodium vivax vivapain-1 0.0052 0.0055 0.0336
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0027 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0045 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0032 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0032 0.005
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.005 0.0031
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0063 0.0099
Brugia malayi cathepsin L-like precursor 0.0067 0.0091 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0262 0.0535 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0018 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.1674 0.3745 0.3733
Loa Loa (eye worm) hypothetical protein 0.0047 0.0045 0.007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0045 0.007
Brugia malayi Cathepsin L-like precursor 0.01 0.0166 0.0261
Schistosoma mansoni hypothetical protein 0.024 0.0485 0.1009
Leishmania major DNA polymerase eta, putative 0.0039 0.0027 0.0132
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0018 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.0166 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Echinococcus granulosus dna polymerase eta 0.0039 0.0027 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0032 0.0045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0019 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0262 0.0535 0.1116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0039 0.0102
Echinococcus multilocularis cathepsin L cysteine protease 0.01 0.0166 0.0147
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0027 0.0008
Brugia malayi Calcitonin receptor-like protein seb-1 0.076 0.1665 0.2617
Loa Loa (eye worm) hypothetical protein 0.0055 0.0063 0.0099
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0583 0.1263 1
Echinococcus granulosus integrin alpha ps 0.004 0.0028 0.001
Schistosoma mansoni ferritin 0.0093 0.015 0.0297
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0028
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0063 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Brugia malayi Bromodomain containing protein 0.0156 0.0293 0.0461
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.037 0.0352
Loa Loa (eye worm) hypothetical protein 0.0089 0.014 0.022
Echinococcus granulosus cathepsin L 0.0052 0.0055 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.037 0.0352
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0032 0.0045
Entamoeba histolytica hypothetical protein 0.055 0.1188 1
Mycobacterium tuberculosis Conserved protein 0.0583 0.1263 0.1489
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0045 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0045 0.0153
Loa Loa (eye worm) RNA binding protein 0.0262 0.0535 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Leishmania major cysteine peptidase A (CPA) 0.01 0.0166 0.124
Schistosoma mansoni cellular tumor antigen P53 0.0648 0.1411 0.2982
Brugia malayi MH2 domain containing protein 0.0049 0.005 0.0079
Schistosoma mansoni hypothetical protein 0.0046 0.0043 0.007
Loa Loa (eye worm) hypothetical protein 0.024 0.0485 0.0762
Brugia malayi nuclear hormone receptor 0.0041 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0131 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0583 0.1263 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0045 0.0037
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0583 0.1263 0.1985
Leishmania major cathepsin L-like protease 0.01 0.0166 0.124
Brugia malayi Latrophilin receptor protein 2 0.024 0.0485 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0024 0.0028
Echinococcus multilocularis GPCR, family 2 0.024 0.0485 0.0467
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0045 0.0153
Brugia malayi Cathepsin L-like precursor 0.01 0.0166 0.0261
Loa Loa (eye worm) hypothetical protein 0.0583 0.1263 0.1985
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0055 0.0072
Plasmodium falciparum cysteine proteinase falcipain 2b 0.01 0.0166 0.9565
Brugia malayi Cathepsin L-like precursor 0.01 0.0166 0.0261
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.014 0.0256 0.0402
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.0173 0.1293
Mycobacterium tuberculosis Conserved protein 0.0583 0.1263 0.1489
Schistosoma mansoni ferritin 0.0093 0.015 0.0297
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0032 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0028
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0018 0.0062
Brugia malayi intermediate filament protein 0.016 0.0302 0.0475
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0151 0.0133
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0032 0.005
Echinococcus multilocularis Smad4 0.0049 0.005 0.0031
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0512 0.1102 0.1085
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0032 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0032 0.005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0075 0.0108 0.009
Schistosoma mansoni microtubule-associated protein tau 0.2097 0.4707 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0063 0.0044
Plasmodium vivax SET domain protein, putative 0.0405 0.086 0.6771
Brugia malayi RNA binding protein 0.0262 0.0535 0.0841
Brugia malayi Cathepsin L-like precursor 0.0033 0.0013 0.0021
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0093 0.015 0.5
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0032 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0583 0.1263 0.1738
Mycobacterium leprae conserved hypothetical protein 0.0583 0.1263 1
Schistosoma mansoni bromodomain containing protein 0.0132 0.0238 0.0484
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0382 0.0806 0.6348
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0027 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0032 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0583 0.1263 1
Schistosoma mansoni lamin 0.016 0.0302 0.0621
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0032 0.0013
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0045 0.0217
Loa Loa (eye worm) TAR-binding protein 0.0262 0.0535 0.0841
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0512 0.1102 0.1085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0018 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.005 0.0079
Brugia malayi Bromodomain containing protein 0.008 0.0119 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Plasmodium vivax vivapain-3 0.0052 0.0055 0.0336
Leishmania major DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0032 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0039 0.006
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0032 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0048 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0441 0.094 0.198
Trichomonas vaginalis D-aminoacylase, putative 0.0583 0.1263 0.1738
Onchocerca volvulus 0.01 0.0166 0.0186
Trichomonas vaginalis set domain proteins, putative 0.3216 0.725 1
Loa Loa (eye worm) hypothetical protein 0.0583 0.1263 0.1985
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0013 0.0023
Leishmania major cathepsin L-like protease 0.01 0.0166 0.124
Schistosoma mansoni ferritin light chain 0.0093 0.015 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.01 0.0166 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.0583 0.1263 1
Plasmodium vivax vivapain-2 0.01 0.0166 0.122
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0583 0.1263 0.1489
Leishmania major cathepsin L-like protease 0.01 0.0166 0.124
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0048 0.0029
Brugia malayi Cathepsin L-like precursor 0.0067 0.0091 0.0142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1674 0.3745 0.3733
Mycobacterium tuberculosis Probable esterase LipL 0.0583 0.1263 0.1489
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0032 0.005
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0018 0.0062
Brugia malayi ecdysteroid receptor 0.0041 0.0032 0.005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.024 0.0485 0.0762
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0039 0.0102
Loa Loa (eye worm) Smad1 0.0049 0.005 0.0079
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0039 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0067 0.0091 0.012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0039 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0441 0.094 0.0923
Loa Loa (eye worm) hypothetical protein 0.0102 0.017 0.0267
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Giardia lamblia GTOR 0.0044 0.0039 1
Schistosoma mansoni smad 0.0049 0.005 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0132
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0027 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Echinococcus multilocularis dna polymerase eta 0.0039 0.0027 0.0008
Echinococcus granulosus geminin 0.0176 0.0339 0.032
Echinococcus granulosus cathepsin l1 0.01 0.0166 0.0147
Mycobacterium ulcerans esterase/lipase LipP 0.0583 0.1263 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.005
Echinococcus granulosus tar DNA binding protein 0.0262 0.0535 0.0517
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0221 0.0202
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.005 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0382 0.0806 0.6348
Loa Loa (eye worm) ctsf protein 0.01 0.0166 0.0261
Echinococcus granulosus zinc finger protein 0.0041 0.0031 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0262 0.0535 0.0517
Loa Loa (eye worm) cysteine protease 0.01 0.0166 0.0261
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.0173 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0018 0.002
Brugia malayi RNA recognition motif domain containing protein 0.0262 0.0535 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0032 0.0013
Onchocerca volvulus 0.0405 0.086 0.1147
Echinococcus multilocularis integrin alpha ps 0.0083 0.0126 0.0108
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.0173 0.1293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0151 0.03
Leishmania major cathepsin L-like protease 0.0382 0.0806 0.6348
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0032 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0018 0.002
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0063 0.0044
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0032 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0262 0.0535 0.1116
Schistosoma mansoni ferritin 0.0093 0.015 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0032 0.005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0032 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.0519 0.1119 0.1758
Schistosoma mansoni cathepsin F (C01 family) 0.0067 0.0091 0.017
Mycobacterium ulcerans hypothetical protein 0.0583 0.1263 1
Leishmania major cathepsin L-like protease 0.01 0.0166 0.124
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0045 0.0073
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0039 0.0226
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0032 0.0013
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.01 0.0166 0.0261
Schistosoma mansoni hypothetical protein 0.0043 0.0036 0.0054
Schistosoma mansoni smad1 5 8 and 0.0049 0.005 0.0084
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0022 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0032 0.005
Echinococcus multilocularis lamin dm0 0.016 0.0302 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0032 0.005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0441 0.094 0.0923
Entamoeba histolytica cysteine proteinase, putative 0.01 0.0166 0.1196
Loa Loa (eye worm) hypothetical protein 0.0035 0.0018 0.0028
Onchocerca volvulus 0.0067 0.0091 0.0082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.01 0.0166 0.0147
Loa Loa (eye worm) hypothetical protein 0.01 0.0166 0.0261
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0045 0.0273
Echinococcus multilocularis integrin alpha 3 0.0142 0.026 0.0242
Brugia malayi PHD-finger family protein 0.0052 0.0056 0.0088
Loa Loa (eye worm) MH2 domain-containing protein 0.0722 0.1581 0.2484
Echinococcus multilocularis musashi 0.016 0.0302 0.0284
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0039 0.0226
Schistosoma mansoni hypothetical protein 0.024 0.0485 0.1009
Loa Loa (eye worm) hypothetical protein 0.0583 0.1263 0.1985
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0039 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.01 0.0166 0.0224
Entamoeba histolytica cysteine protease, putative 0.0052 0.0055 0.0244
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.005 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0032 0.005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0405 0.086 0.1808
Onchocerca volvulus 0.016 0.0302 0.0375
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0045 0.0217
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0032 0.0013
Brugia malayi hypothetical protein 0.0103 0.0173 0.0271
Entamoeba histolytica cysteine proteinase 1, putative 0.0052 0.0055 0.0244
Plasmodium falciparum cysteine proteinase falcipain 1 0.0052 0.0055 0.243
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0043 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.076 0.1665 0.2617
Echinococcus multilocularis smad 0.0049 0.005 0.0031
Echinococcus granulosus integrin alpha 3 0.0142 0.026 0.0242
Loa Loa (eye worm) hypothetical protein 0.0151 0.0281 0.0441
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0075 0.0108 0.009
Trypanosoma brucei unspecified product 0.0039 0.0027 0.0132

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.