pI: 7.8366 |
Length (AA): 1862 |
MW (Da): 204457 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 1430 | 3h0g (A) | 46 | 1459 | 54.00 | 0 | 1 | 1.17865 | 1.17 |
5 | 1432 | 4by7 (A) | 47 | 1455 | 52.00 | 0 | 1 | 1.20522 | 0.14 |
5 | 1423 | 5x51 (A) | 47 | 1449 | 55.00 | 0 | 1 | 1.17438 | 0.5 |
5 | 312 | 3qqc (A) | 97 | 425 | 37.00 | 0 | 1 | 0.383614 | 0.46 |
1556 | 1771 | 5b5h (A) | 1 | 213 | 12.00 | 0 | 0.01 | 0.179204 | -0.42 |
1608 | 1852 | 3wp9 (A) | 2 | 224 | 13.00 | 0 | 0.02 | 0.113779 | -0.56 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126637)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthCp013 | RNA polymerase beta' chain |
Arabidopsis thaliana | AT4G35800 | DNA-directed RNA polymerase II subunit RPB1 |
Arabidopsis thaliana | AT5G60040 | nuclear RNA polymerase C1 |
Babesia bovis | BBOV_I003360 | DNA-directed RNA polymerase II largest subunit, putative |
Babesia bovis | BBOV_V000120 | rpoC1 |
Babesia bovis | BBOV_III007400 | RNA polymerase Rpb1, domain containing protein |
Brugia malayi | Bm1_27995 | RNA polymerase Rpb1, domain 1 family protein |
Brugia malayi | Bm1_34315 | DNA-directed RNA polymerase II largest subunit, putative |
Candida albicans | CaO19.10615 | RNA polymerase 3 large subunit |
Candida albicans | CaO19.7655 | RNA polymerase II large subunit |
Candida albicans | CaO19.3103 | RNA polymerase 3 large subunit |
Caenorhabditis elegans | CELE_F36A4.7 | Protein AMA-1 |
Caenorhabditis elegans | CELE_C42D4.8 | Protein RPC-1 |
Cryptosporidium hominis | Chro.30301 | DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain |
Cryptosporidium hominis | Chro.60382 | DNA-directed RNA polymerase II/III subunit |
Cryptosporidium parvum | cgd6_3290 | DNA-directed RNA polymerase III C1 subunit |
Cryptosporidium parvum | cgd3_2620 | putative DNA-directed RNA polymerase,possible RNA polymerase A/beta/A subunit, long PHYSPTS repeat at C-terminus |
Chlamydia trachomatis | CT_314 | DNA-directed RNA polymerase subunit beta' |
Dictyostelium discoideum | DDB_G0277199 | RNA polymerase III, largest subunit |
Dictyostelium discoideum | DDB_G0279193 | RNA polymerase II core subunit |
Drosophila melanogaster | Dmel_CG17209 | CG17209 gene product from transcript CG17209-RC |
Drosophila melanogaster | Dmel_CG1554 | RNA polymerase II 215kD subunit |
Escherichia coli | b3988 | RNA polymerase, beta prime subunit |
Echinococcus granulosus | EgrG_000811400 | DNA directed RNA polymerase II subunit |
Echinococcus granulosus | EgrG_000428100 | DNA directed RNA polymerase III subunit RPC1 |
Entamoeba histolytica | EHI_125350 | DNA-directed RNA polymerase III largest subunit, putative |
Entamoeba histolytica | EHI_121760 | DNA-directed RNA polymerase II large subunit, putative |
Echinococcus multilocularis | EmuJ_000006100 | DNA directed RNA polymerase II subunit RPB1 |
Echinococcus multilocularis | EmuJ_000811400 | DNA directed RNA polymerase II subunit |
Echinococcus multilocularis | EmuJ_000428100 | DNA directed RNA polymerase III subunit RPC1 |
Giardia lamblia | GL50803_16223 | DNA-directed RNA polymerase subunit A |
Giardia lamblia | GL50803_89347 | DNA-directed RNA polymerase II largest subunit RPB1 |
Homo sapiens | ENSG00000181222 | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
Homo sapiens | ENSG00000148606 | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa |
Leishmania braziliensis | LbrM.20.0330 | DNA-directed RNA polymerase III largest subunit , putative |
Leishmania braziliensis | LbrM.31.2950 | RNA polymerase ii largest subunit |
Leishmania donovani | LdBPK_340380.1 | DNA-directed RNA polymerase III subunit C1, putative |
Leishmania donovani | LdBPK_312680.1 | RNA polymerase ii largest subunit |
Leishmania infantum | LinJ.31.2680 | RNA polymerase ii largest subunit |
Leishmania infantum | LinJ.34.0380 | DNA-directed RNA polymerase III largest subunit , putative |
Leishmania major | LmjF.31.2610 | RNA polymerase ii largest subunit |
Leishmania major | LmjF.34.0360 | DNA-directed RNA polymerase III largest subunit , putative |
Leishmania mexicana | LmxM.30.2610 | RNA polymerase ii largest subunit |
Leishmania mexicana | LmxM.33.0360 | DNA-directed RNA polymerase III largest subunit , putative |
Loa Loa (eye worm) | LOAG_05313 | DNA-directed RNA polymerase II largest subunit |
Loa Loa (eye worm) | LOAG_03832 | RNA polymerase Rpb1 |
Mycobacterium leprae | ML1890c | DNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). |
Mus musculus | ENSMUSG00000025280 | polymerase (RNA) III (DNA directed) polypeptide A |
Mus musculus | ENSMUSG00000005198 | polymerase (RNA) II (DNA directed) polypeptide A |
Mycobacterium tuberculosis | Rv0668 | DNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit). |
Mycobacterium ulcerans | MUL_0747 | DNA-directed RNA polymerase subunit beta' |
Neospora caninum | NCLIV_047440 | DNA-directed RNA polymerase II largest subunit, putative |
Neospora caninum | NCLIV_044520 | DNA-directed RNA polymerase III largest subunit, putative |
Oryza sativa | 4336254 | Os04g0492300 |
Oryza sativa | 9267835 | Os08g0155700 |
Oryza sativa | 3131433 | RNA polymerase beta' chain |
Oryza sativa | 4337831 | Os05g0151000 |
Oryza sativa | 9271945 | Os01g0111900 |
Plasmodium berghei | PBANKA_API00160 | RNA polymerase beta subunit, putative |
Plasmodium berghei | PBANKA_1344000 | DNA-directed RNA polymerase III subunit RPC1, putative |
Plasmodium berghei | PBANKA_0807000 | DNA-directed RNA polymerase II subunit RPB1, putative |
Plasmodium falciparum | PF3D7_API04300 | RNA polymerase beta subunit, putative |
Plasmodium falciparum | PF3D7_1329000 | DNA-directed RNA polymerase III subunit RPC1, putative |
Plasmodium falciparum | PF3D7_0318200 | DNA-directed RNA polymerase II subunit RPB1 |
Plasmodium knowlesi | PKNH_API05200 | RNA polymerase beta subunit, putative |
Plasmodium knowlesi | PKNH_0823500 | DNA-directed RNA polymerase II subunit RPB1, putative |
Plasmodium knowlesi | PKNH_1271400 | DNA-directed RNA polymerase III subunit RPC1, putative |
Plasmodium vivax | PVX_082395 | DNA-directed RNA polymerase III largest subunit, putative |
Plasmodium vivax | PVX_095320 | DNA-directed RNA polymerase II subunit RPB1, putative |
Plasmodium yoelii | PY04439 | DNA-directed RNA polymerase beta' chain |
Plasmodium yoelii | PY01037 | RNA polymerase A/beta'/A'' subunit, putative |
Plasmodium yoelii | PY03187 | RNA polymerase A/beta'/A'' subunit, putative |
Saccharomyces cerevisiae | YDL140C | DNA-directed RNA polymerase II core subunit RPO21 |
Saccharomyces cerevisiae | YOR116C | DNA-directed RNA polymerase III core subunit RPO31 |
Schistosoma japonicum | Sjp_0073320 | DNA-directed RNA polymerase III subunit RPC1, putative |
Schistosoma japonicum | Sjp_0130240 | DNA-directed RNA polymerase III subunit RPC1, putative |
Schistosoma japonicum | Sjp_0048890 | expressed protein |
Schistosoma japonicum | Sjp_0108190 | DNA-directed RNA polymerase III subunit RPC1, putative |
Schistosoma japonicum | Sjp_0309240 | DNA-directed RNA polymerase II subunit RPB1, putative |
Schistosoma japonicum | Sjp_0131980 | DNA-directed RNA polymerase III subunit RPC1, putative |
Schistosoma japonicum | Sjp_0130250 | DNA-directed RNA polymerase III subunit RPC1, putative |
Schistosoma japonicum | Sjp_0128360 | DNA-directed RNA polymerase II subunit RPB1, putative |
Schistosoma japonicum | Sjp_0086530 | ko:K03006 DNA-directed RNA polymerase II subunit A, putative |
Schistosoma mansoni | Smp_157740 | RNA polymerase Rpb1 |
Schistosoma mansoni | Smp_002890 | DNA-directed RNA polymerase III largest subunit |
Schistosoma mansoni | Smp_156670 | DNA-directed RNA polymerase II largest subunit |
Schmidtea mediterranea | mk4.004362.02 | DNA-directed RNA polymerase III subunit RPC1 |
Schmidtea mediterranea | mk4.004768.00 | DNA-directed RNA polymerase III subunit RPC1 |
Schmidtea mediterranea | mk4.004362.01 | DNA-directed RNA polymerase II subunit RPB1 |
Schmidtea mediterranea | mk4.001978.00 | DNA-directed RNA polymerase III subunit RPC1 |
Schmidtea mediterranea | mk4.001789.00 | |
Trypanosoma brucei gambiense | Tbg972.4.5210 | RNA polymerase IIA largest subunit, putative |
Trypanosoma brucei gambiense | Tbg972.8.7660 | |
Trypanosoma brucei gambiense | Tbg972.10.3460 | DNA-directed RNA polymerase iii largest subunit,RNA polymerase III largest subunit, putative |
Trypanosoma brucei | Tb927.8.7400 | RNA polymerase IIA largest subunit |
Trypanosoma brucei | Tb927.10.2780 | DNA-directed RNA polymerase III subunit C1 |
Trypanosoma brucei | Tb11.v5.0609 | DNA-directed RNA polymerase III largest subunit, putative |
Trypanosoma brucei | Tb927.4.5020 | DNA-directed RNA polymerase II subunit RPB1 |
Trypanosoma brucei | Tb11.v5.0608 | DNA-directed RNA polymerase III largest subunit, putative |
Trypanosoma brucei | Tb11.v5.0504 | RNA polymerase IIA largest subunit, putative |
Trypanosoma congolense | TcIL3000_10_2390 | DNA-directed RNA polymerase III subunit C1, putative |
Trypanosoma congolense | TcIL3000_4_4270 | RNA polymerase IIA largest subunit, putative |
Trypanosoma cruzi | TcCLB.510685.30 | RNA polymerase IIA largest subunit, putative |
Trypanosoma cruzi | TcCLB.509011.20 | RNA polymerase IIA largest subunit, putative |
Trypanosoma cruzi | TcCLB.504105.30 | DNA-directed RNA polymerase III subunit C1, putative |
Toxoplasma gondii | TGME49_306290 | DNA-directed RNA polymerase III RPC1 |
Toxoplasma gondii | TGME49_326700 | DNA-directed RNA polymerase, putative |
Toxoplasma gondii | TGME49_225260 | DNA-directed RNA polymerase II RPB1 |
Treponema pallidum | TP0242 | DNA-directed RNA polymerase subunit beta' |
Theileria parva | TP04_0648 | DNA-directed RNA polymerase III largest subunit, putative |
Theileria parva | TP03_0185 | DNA-directed RNA polymerase II largest subunit, putative |
Theileria parva | TP05_0029 | DNA-directed RNA polymerase beta' chain, putative |
Trichomonas vaginalis | TVAG_172240 | DNA-directed RNA polymerase I largest subunit, putative |
Trichomonas vaginalis | TVAG_247430 | DNA-directed RNA polymerase I largest subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2780 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2780 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.2780 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.5020 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.5020 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.5020 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.5020 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.8.7400 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.7400 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.7400 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.7400 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3988 | Escherichia coli | essential | goodall |
CELE_F36A4.7 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F36A4.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F36A4.7 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F36A4.7 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F36A4.7 | Caenorhabditis elegans | sterile | wormbase |
CELE_C42D4.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C42D4.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C42D4.8 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C42D4.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C42D4.8 | Caenorhabditis elegans | sterile | wormbase |
YDL140C | Saccharomyces cerevisiae | inviable | yeastgenome |
YOR116C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0807000 | Plasmodium berghei | Essential | plasmo |
PBANKA_1344000 | Plasmodium berghei | Essential | plasmo |
TGME49_225260 | Toxoplasma gondii | Probably essential | sidik |
TGME49_306290 | Toxoplasma gondii | Probably essential | sidik |
TGME49_326700 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.