Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0023 | 0.0415 | 0.0415 |
Mycobacterium leprae | Probable lipase LipE | 0.0023 | 0.0415 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0023 | 0.0415 | 0.0541 |
Leishmania major | phenylalanine-4-hydroxylase,phenylalanine-4-hydroxylase, putative | 0.0048 | 0.1332 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0415 | 0.3113 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0023 | 0.0415 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0279 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0023 | 0.0415 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0415 |
Mycobacterium tuberculosis | Conserved protein | 0.0023 | 0.0415 | 0.0814 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0169 | 0.5862 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0023 | 0.0415 | 0.0814 |
Brugia malayi | Kelch motif family protein | 0.0042 | 0.1135 | 0.1135 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0023 | 0.0415 | 0.0415 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.0207 | 0.729 | 0.9507 |
Onchocerca volvulus | 0.0023 | 0.0415 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.7668 | 0.7668 |
Onchocerca volvulus | 0.0023 | 0.0415 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1135 | 0.1135 |
Brugia malayi | Biopterin-dependent aromatic amino acid hydroxylase family protein | 0.0048 | 0.1332 | 0.1332 |
Mycobacterium ulcerans | beta-lactamase | 0.0023 | 0.0415 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0023 | 0.0415 | 0.0814 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0023 | 0.0415 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0023 | 0.0415 | 0.0415 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0023 | 0.0415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0415 |
Loa Loa (eye worm) | beta-lactamase | 0.0023 | 0.0415 | 0.0415 |
Brugia malayi | beta-lactamase family protein | 0.0023 | 0.0415 | 0.0415 |
Toxoplasma gondii | phenylalanine-4-hydroxylase | 0.0048 | 0.1332 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0207 | 0.729 | 0.9507 |
Toxoplasma gondii | ABC1 family protein | 0.0023 | 0.0415 | 0.3113 |
Schistosoma mansoni | tyrosine/tryptophan monooxygenase | 0.0048 | 0.1332 | 0.2273 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0012 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0023 | 0.0415 | 0.0814 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0023 | 0.0415 | 0.0814 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0023 | 0.0415 | 0.0708 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0023 | 0.0415 | 0.0708 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0415 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0023 | 0.0415 | 0.0541 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0023 | 0.0415 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0023 | 0.0415 | 0.0814 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0023 | 0.0415 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0164 | 0.5702 | 0.9727 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0415 |
Toxoplasma gondii | aromatic amino acid hydrolase AAH1 | 0.0048 | 0.1332 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0023 | 0.0415 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0023 | 0.0415 | 0.0814 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0023 | 0.0415 | 1 |
Echinococcus granulosus | tryptophan hydroxylase | 0.0217 | 0.7668 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0415 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0023 | 0.0415 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0023 | 0.0415 | 0.0814 |
Toxoplasma gondii | aromatic amino acid hydrolase AAH2 | 0.0048 | 0.1332 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0023 | 0.0415 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0415 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.0415 | 1 |
Echinococcus multilocularis | tryptophan hydroxylase | 0.0217 | 0.7668 | 1 |
Schistosoma mansoni | tyrosine 3-monooxygenase | 0.0048 | 0.1332 | 0.2273 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0042 | 0.1135 | 0.1135 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0148 | 0.5095 | 1 |
Brugia malayi | beta-lactamase | 0.0023 | 0.0415 | 0.0415 |
Mycobacterium ulcerans | lipase LipD | 0.0023 | 0.0415 | 1 |
Loa Loa (eye worm) | tryptophan hydroxylase 1 | 0.0048 | 0.1332 | 0.1332 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0415 | 0.0415 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0012 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0415 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.0415 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0023 | 0.0415 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1135 | 0.1135 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0023 | 0.0415 | 1 |
Onchocerca volvulus | 0.0023 | 0.0415 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.