TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.486 | Formula: C24H24N6O2
H donors: 4 H acceptors: 5 LogP: 0.86 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CC(c1ccc(cc1)c1nc(nc(n1)N)N[C@@H](c1ccc2c(c1)cccc2)C)N
InChi: 1S/C24H24N6O2/c1-14(18-11-6-15-4-2-3-5-19(15)12-18)27-24-29-22(28-23(26)30-24)17-9-7-16(8-10-17)20(25)13-21(31)32/h2-12,14,20H,13,25H2,1H3,(H,31,32)(H3,26,27,28,29,30)/t14-,20?/m1/s1
InChiKey: LOCFHKGLFJWAJO-QMRFKDRMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tryptophan hydroxylase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tryptophan hydroxylase	Get druggable targets OG5_132520	All targets in OG5_132520
Echinococcus granulosus	tryptophan hydroxylase	Get druggable targets OG5_132520	All targets in OG5_132520
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132520	All targets in OG5_132520

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	phenylalanine-4-hydroxylase,phenylalanine-4-hydroxylase, putative	tryptophan hydroxylase 1	444 aa	404 aa	43.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0042	0.1032
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0072	0.0066
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0014	0.0048	0.0618
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0042	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0026	0.0308
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0069	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0026	0.0308
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0114	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0026	0.0064
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0026	0.0064
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0074	0.0215
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0026	0.0308
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0114	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0114	0.1641
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.005	0.0044
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0026	0.0322
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.057	0.7937
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0026	0.0308
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0042	0.1032
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0026	0.002
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0072	0.0208
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0114	0.1641
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0026	0.0308
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0101	0.057	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0074	0.9775
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0042	0.1032
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0074	0.6277
Toxoplasma gondii	aromatic amino acid hydrolase AAH1	0.0116	0.0663	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0074	0.5
Brugia malayi	hypothetical protein	0.0038	0.0193	0.2843
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0026	0.0322
Toxoplasma gondii	melibiase subfamily protein	0.0101	0.057	0.8588
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0026	0.0064
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0074	0.0215
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0026	0.0649
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0006	0.0546
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0026	0.0322
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0114	0.1641
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0074	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.022
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0075	0.6421
Entamoeba histolytica	hypothetical protein	0.0038	0.0193	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0114	0.1641
Schistosoma mansoni	tyrosine 3-monooxygenase	0.0116	0.0663	0.9236
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0074	0.3715
Loa Loa (eye worm)	hypothetical protein	0.0529	0.3152	1
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0067	0.0367	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0114	0.5833
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0026	0.0308
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0026	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0074	0.1905
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0193	0.0187
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0074	0.1905
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0072	0.0208
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0026	0.0308
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0074	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0074	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0026	0.0064
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0026	0.002
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0042	0.1032
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0026	0.002
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0026	0.0064
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0026	0.0322
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0114	1
Echinococcus granulosus	cpg binding protein	0.0062	0.0338	0.1055
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0042	0.1032
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0026	0.0322
Toxoplasma gondii	exonuclease III APE	0.0019	0.0074	0.103
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.005	0.0044
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0074	1
Brugia malayi	ecdysteroid receptor	0.0011	0.0026	0.0308
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0114	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0026	0.0064
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0114	1
Brugia malayi	CXXC zinc finger family protein	0.0059	0.0318	0.4746
Toxoplasma gondii	phenylalanine-4-hydroxylase	0.0116	0.0663	1
Onchocerca volvulus		0.0025	0.0114	0.3457
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0075	1
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0006	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0114	0.0343
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0006	0.0546
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0114	0.5833
Schistosoma mansoni	hypothetical protein	0.0038	0.0193	0.2653
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0112	0.0637	0.9601
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0026	0.0649
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0114	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0059	0.0318	0.0991
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0013	0.0127
Echinococcus multilocularis	tryptophan hydroxylase	0.0529	0.3152	0.3148
Onchocerca volvulus		0.0059	0.0318	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0026	0.0064
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0026	0.0322
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0075	0.6617
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0074	0.648
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0026	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0026	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0026	0.0322
Schistosoma mansoni	ap endonuclease	0.0019	0.0074	0.0986
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0006	0.0038
Brugia malayi	Biopterin-dependent aromatic amino acid hydroxylase family protein	0.0116	0.0663	1
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0546
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0074	0.103
Toxoplasma gondii	aromatic amino acid hydrolase AAH2	0.0116	0.0663	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0193	0.0594
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0026	0.002
Schistosoma mansoni	coup transcription factor	0.0011	0.0026	0.0322
Echinococcus multilocularis	cpg binding protein	0.0062	0.0338	0.0332
Entamoeba histolytica	hypothetical protein	0.0038	0.0193	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0026	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0114	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0006	0.004
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0069	0.6071
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.057	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0367	0.1148
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.005	0.0651
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.005	0.0139
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0026	0.0308
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0114	0.0343
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0026	0.0064
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0026	0.0064
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0026	0.0322
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0069	0.6071
Brugia malayi	Melibiase family protein	0.0067	0.0367	0.5499
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0006	0.0546
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.005	0.0139
Schistosoma mansoni	cpg binding protein	0.0059	0.0318	0.4403
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0367	0.5096
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0013	0.0042	0.1032
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.007	0.0976
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0026	0.002
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0114	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0026	0.0308
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0026	0.002
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0006	0.004
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0026	0.0649
Echinococcus granulosus	tryptophan hydroxylase	0.0529	0.3152	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0114	0.1641
Loa Loa (eye worm)	tryptophan hydroxylase 1	0.0116	0.0663	0.2088
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0026	0.0308
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0026	0.002
Trichomonas vaginalis	helicase, putative	0.0013	0.0042	0.1032
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0013	0.0042	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.022
Schistosoma mansoni	tyrosine/tryptophan monooxygenase	0.0116	0.0663	0.9236
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0114	0.5833
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0125	0.0718	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0546
Brugia malayi	steroid hormone receptor	0.0011	0.0026	0.0308
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0006	0.0546
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0026	0.0322
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0026	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0042	0.1032
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0114	0.1641
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0026	0.0064
Entamoeba histolytica	hypothetical protein	0.0038	0.0193	1
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.0006	0.0144
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0026	0.0064
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0026	0.002
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0074	0.103
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0101	0.057	0.0564
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0026	0.002
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0069	0.6071
Entamoeba histolytica	hypothetical protein	0.0038	0.0193	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0026	0.0308
Schistosoma mansoni	cpg binding protein	0.0062	0.0338	0.4688
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0026	0.0308
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0026	0.0322
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0074	0.5
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0101	0.057	0.1793
Leishmania major	phenylalanine-4-hydroxylase,phenylalanine-4-hydroxylase, putative	0.0116	0.0663	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0114	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0074	0.0986
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0075	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0026	0.0308
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.022
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0026	0.0064
Schistosoma mansoni	cpg binding protein	0.0062	0.0338	0.4688
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0193	0.2653
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.022
Brugia malayi	nuclear hormone receptor	0.0011	0.0026	0.0308
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0075	0.5
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0074	0.0068
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0067	0.0367	0.5096
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0074	0.9784
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0006	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0114	0.0343
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0026	0.0308
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0006	0.0546
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0026	0.0064
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0114	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.057	0.7937
Onchocerca volvulus		0.0011	0.0026	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0064
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0026	0.0064
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0026	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.022
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0026	0.0322
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.0006	0.038
Toxoplasma gondii	Alpha-galactosidase	0.0014	0.0048	0.063
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0026	0.0064
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0101	0.057	0.7937

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.77 uM	Inhibition of TPH1	ChEMBL.	18557609

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL472308

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 975322