Detailed information for compound 1334404

Basic information

Technical information
  • TDR Targets ID: 1334404
  • Name: 4-chloro-N-[1-(4,5-dihydro-1,3-thiazol-2-ylam ino)-3-methyl-1-oxobutan-2-yl]benzamide
  • MW: 339.84 | Formula: C15H18ClN3O2S
  • H donors: 2 H acceptors: 2 LogP: 2.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(C(=O)NC1=NCCS1)NC(=O)c1ccc(cc1)Cl)C
  • InChi: 1S/C15H18ClN3O2S/c1-9(2)12(14(21)19-15-17-7-8-22-15)18-13(20)10-3-5-11(16)6-4-10/h3-6,9,12H,7-8H2,1-2H3,(H,18,20)(H,17,19,21)
  • InChiKey: CUWODHBBPBKZFO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-[1-(4,5-dihydrothiazol-2-ylcarbamoyl)-2-methyl-propyl]benzamide
  • 4-chloro-N-[1-[(4,5-dihydrothiazol-2-ylamino)-oxomethyl]-2-methylpropyl]benzamide
  • 4-chloro-N-[1-(4,5-dihydro-1,3-thiazol-2-ylamino)-3-methyl-1-oxo-butan-2-yl]benzamide
  • MLS000087957
  • SMR000072148
  • 4-chloro-N-{1-[(4,5-dihydro-1,3-thiazol-2-ylamino)carbonyl]-2-methylpropyl}benzamide (non-preferred name)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0104 0.0431 0.2236
Echinococcus multilocularis serine:threonine protein kinase N2 0.0567 0.4642 0.8146
Onchocerca volvulus 0.0083 0.0242 0.0948
Brugia malayi hypothetical protein 0.0083 0.0242 0.0311
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0111 0.05 0.0878
Giardia lamblia Kinase, CMGC CDK 0.0094 0.0341 0.2874
Echinococcus multilocularis neuroglian 0.0076 0.0179 0.0314
Entamoeba histolytica PH domain containing protein kinase, putative 0.0091 0.0314 0.5363
Echinococcus multilocularis insulin receptor 0.0664 0.553 0.9705
Trichomonas vaginalis AGC family protein kinase 0.012 0.0583 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0095 0.0354 0.0454
Schistosoma mansoni protein kinase 0.0059 0.0022 0.004
Echinococcus multilocularis tyrosine protein kinase Blk 0.0083 0.0242 0.0425
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0088 0.0289 0.0289
Schistosoma mansoni tyrosine kinase 0.0664 0.553 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0088 0.0289 0.0507
Brugia malayi Protein kinase domain containing protein 0.0913 0.7796 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.026 0.1849 0.3245
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0088 0.0289 0.146
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0683 0.5698 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0683 0.5698 0.5698
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0059 0.0022 0.0022
Echinococcus multilocularis serine:threonine protein kinase N2 0.0516 0.4184 0.7343
Brugia malayi Protein kinase domain containing protein 0.0417 0.3282 0.421
Loa Loa (eye worm) TK/EPH protein kinase 0.0352 0.2689 0.3449
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Echinococcus multilocularis roundabout 2 0.0108 0.0472 0.0828
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0057 0.0102
Schistosoma mansoni tyrosine kinase 0.0443 0.3521 0.6367
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Echinococcus granulosus cyclin dependent kinase 0.0094 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0414 0.3257 0.4178
Schistosoma mansoni tyrosine kinase 0.0664 0.553 1
Schistosoma mansoni tyrosine kinase 0.0349 0.2658 0.4807
Brugia malayi kinase, mitochondrial precursor 0.0238 0.1654 0.2122
Trypanosoma brucei cdc2-related kinase 3 0.0094 0.0341 0.1747
Giardia lamblia Kinase, CMGC GSK 0.0104 0.0431 0.5509
Echinococcus granulosus tyrosine protein kinase ABL1 0.0083 0.0242 0.0242
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0088 0.0289 0.0507
Echinococcus granulosus defective proboscis extension response 0.0065 0.0082 0.0082
Schistosoma mansoni tyrosine kinase 0.0475 0.3812 0.6895
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0088 0.0289 0.4748
Schistosoma mansoni pyruvate dehydrogenase 0.0238 0.1654 0.2992
Echinococcus multilocularis mitogen activated protein kinase 0.011 0.0484 0.0849
Schistosoma mansoni pyruvate dehydrogenase 0.0225 0.1534 0.2774
Plasmodium vivax serine/threonine protein kinase 6, putative 0.012 0.0583 1
Plasmodium falciparum glycogen synthase kinase 3 0.0104 0.0431 0.7284
Trypanosoma cruzi aurora B kinase, putative 0.012 0.0583 0.3069
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Echinococcus granulosus tyrosine kinase 0.0083 0.0242 0.0242
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.0341 0.0599
Echinococcus multilocularis tyrosine kinase 0.0083 0.0242 0.0425
Leishmania major protein kinase A catalytic subunit isoform 2 0.0088 0.0289 0.146
Brugia malayi hypothetical protein 0.0084 0.025 0.0321
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0088 0.0289 0.146
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0341 0.0617
Plasmodium vivax tyrosine kinase-like protein, putative 0.0066 0.0086 0.1112
Echinococcus granulosus c src tyrosine kinase 0.0095 0.0354 0.0354
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0088 0.0289 0.0289
Schistosoma mansoni tyrosine kinase 0.0095 0.0354 0.064
Echinococcus granulosus cyclin dependent kinase 5 0.0094 0.0341 0.0341
Echinococcus granulosus dual specificity mitogen activated protein 0.0083 0.0244 0.0244
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.026 0.1849 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.026 0.1849 0.3245
Schistosoma mansoni ephrin receptor 0.0287 0.2099 0.3795
Toxoplasma gondii aurora kinase 0.012 0.0583 1
Plasmodium falciparum protein kinase 5 0.0094 0.0341 0.5691
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.011 0.0484 0.2525
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0083 0.0242 0.0425
Loa Loa (eye worm) hypothetical protein 0.0084 0.025 0.0321
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.0341 0.1747
Loa Loa (eye worm) TK/INSR protein kinase 0.0664 0.553 0.7093
Schistosoma mansoni tyrosine kinase 0.0393 0.3062 0.5538
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.026 0.1849 1
Brugia malayi Protein kinase domain containing protein 0.0083 0.0242 0.0311
Loa Loa (eye worm) TK/ALK protein kinase 0.0521 0.4229 0.5424
Echinococcus multilocularis cyclin dependent kinase 0.0094 0.0341 0.0599
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0361 0.277 0.4861
Brugia malayi MAP kinase sur-1 0.011 0.0484 0.062
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0088 0.0289 0.146
Loa Loa (eye worm) hypothetical protein 0.0286 0.2087 0.2677
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0088 0.0289 0.4758
Onchocerca volvulus Tyrosine kinase homolog 0.0337 0.2556 1
Onchocerca volvulus 0.0104 0.0431 0.1685
Loa Loa (eye worm) AGC/PKN protein kinase 0.0567 0.4642 0.5954
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.011 0.0484 0.2525
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0341 0.2874
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.026 0.1849 0.2372
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0153 0.0881 0.0881
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0095 0.0354 0.0621
Brugia malayi intracellular kinase 0.0104 0.0431 0.0552
Echinococcus granulosus epidermal growth factor receptor 0.0443 0.3521 0.3521
Onchocerca volvulus 0.0083 0.0242 0.0948
Echinococcus granulosus cyclin dependent kinase 1 0.0094 0.0341 0.0341
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0417 0.3282 0.421
Toxoplasma gondii AGC kinase 0.0088 0.0289 0.4758
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.012 0.0583 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0264 0.0339
Loa Loa (eye worm) hypothetical protein 0.009 0.0303 0.0389
Brugia malayi Protein kinase domain containing protein 0.0094 0.0341 0.0438
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0354 0.0621
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0065 0.0082 0.0143
Loa Loa (eye worm) hypothetical protein 0.0088 0.0289 0.0371
Loa Loa (eye worm) hypothetical protein 0.0065 0.0082 0.0105
Brugia malayi Furin-like cysteine rich region family protein 0.0582 0.4778 0.6128
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0111 0.05 0.0878
Echinococcus granulosus tyrosine protein kinase Blk 0.0083 0.0242 0.0242
Echinococcus granulosus mitogen activated protein kinase 3 0.011 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0065 0.0082 0.0105
Loa Loa (eye worm) AGC/PKA protein kinase 0.0088 0.0289 0.0371
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0059 0.0022 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0484 0.0874
Echinococcus multilocularis c src tyrosine kinase 0.0095 0.0354 0.0621
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.026 0.1849 1
Echinococcus multilocularis kinase protein 0.0111 0.05 0.0878
Brugia malayi Protein kinase domain containing protein 0.0083 0.0242 0.0311
Brugia malayi Immunoglobulin I-set domain containing protein 0.0406 0.3178 0.4077
Schistosoma mansoni pyruvate dehydrogenase 0.0225 0.1534 0.2774
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0238 0.1654 0.2903
Loa Loa (eye worm) AUR protein kinase 0.012 0.0583 0.0748
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Brugia malayi ephrin receptor 1 precursor 0.0162 0.096 0.1232
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.011 0.0484 0.2525
Echinococcus multilocularis dual specificity mitogen activated protein 0.0083 0.0244 0.0428
Echinococcus granulosus activin receptor type 0.0059 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0084 0.025 0.0321
Leishmania major protein kinase A catalytic subunit 0.0088 0.0289 0.146
Schistosoma mansoni tyrosine kinase 0.0393 0.3062 0.5538
Echinococcus granulosus tyrosine kinase 0.0083 0.0242 0.0242
Echinococcus multilocularis mitogen activated protein kinase 11 0.026 0.1849 0.3245
Brugia malayi Fes/CIP4 homology domain containing protein 0.0298 0.2199 0.282
Onchocerca volvulus 0.0083 0.0242 0.0948
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.0341 0.5835
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0341 0.0617
Schistosoma mansoni tyrosine kinase 0.0443 0.3521 0.6367
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.0484 0.2525
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0289 0.133
Entamoeba histolytica protein kinase, putative 0.012 0.0583 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0094 0.0341 0.1747
Echinococcus multilocularis rho associated protein kinase 0.0299 0.221 0.3878
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0431 0.5509
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0341 0.2874
Schistosoma mansoni serine/threonine protein kinase 0.0567 0.4642 0.8394
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0354 0.0621
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0061 0.0043 0.0075
Brugia malayi SRC-1 0.0095 0.0354 0.0454
Echinococcus granulosus insulin receptor 0.0664 0.553 0.553
Echinococcus granulosus neuroglian 0.0076 0.0179 0.0179
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0153 0.0881 0.1131
Schistosoma mansoni protein kinase 0.0059 0.0022 0.004
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.0341 0.1747
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0238 0.1654 0.8933
Schistosoma mansoni tyrosine kinase 0.0075 0.0167 0.0302
Schistosoma mansoni tyrosine kinase 0.0095 0.0354 0.064
Loa Loa (eye worm) hypothetical protein 0.0238 0.1654 0.2122
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.221 0.3996
Echinococcus granulosus fibroblast growth factor receptor 4 0.0248 0.1741 0.1741
Echinococcus multilocularis tyrosine protein kinase shark 0.0508 0.411 0.7212
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.011 0.0484 0.8227
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.011 0.0484 0.2525
Loa Loa (eye worm) hypothetical protein 0.0083 0.0242 0.0311
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.008 0.0212 0.0372
Plasmodium falciparum serine/threonine protein kinase, putative 0.012 0.0583 1
Plasmodium falciparum protein kinase, putative 0.0066 0.0086 0.1129
Leishmania major protein kinase, putative 0.012 0.0583 0.3069
Echinococcus multilocularis Immunoglobulin 0.0065 0.0082 0.0143
Echinococcus multilocularis tyrosine protein kinase Abl 0.0095 0.0354 0.0621
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.011 0.0484 0.062
Echinococcus multilocularis Immunoglobulin 0.0065 0.0082 0.0143
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0083 0.0244 0.0313
Schistosoma mansoni tyrosine kinase 0.0248 0.1741 0.3148
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.0341 0.5835
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0289 0.0523
Plasmodium vivax glycogen synthase kinase 3, putative 0.0104 0.0431 0.7279
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0083 0.0242 0.0242
Trypanosoma brucei protein kinase, putative 0.011 0.0484 0.2525
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0095 0.0354 0.0621
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0083 0.0244 0.0313
Echinococcus multilocularis activin receptor type 0.0059 0.0022 0.0039
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0238 0.1654 0.2903
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0083 0.0242 0.4128
Onchocerca volvulus 0.0237 0.164 0.6417
Entamoeba histolytica PH domain containing protein kinase, putative 0.0091 0.0314 0.5363
Echinococcus multilocularis 0.0161 0.0951 0.1669
Loa Loa (eye worm) AUR protein kinase 0.012 0.0583 0.0748
Echinococcus granulosus tyrosine protein kinase Src64B 0.0095 0.0354 0.0354
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0083 0.0245 0.3965
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.0341 0.0599
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0088 0.0289 0.0507
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0061 0.0043 0.0043
Giardia lamblia Kinase, AGC PKA 0.0088 0.0289 0.133
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.008 0.0212 0.0212
Brugia malayi Protein kinase domain containing protein 0.0083 0.0242 0.0311
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.012 0.0583 0.1023
Echinococcus multilocularis aurora kinase A 0.012 0.0583 0.1023
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0484 0.7068
Loa Loa (eye worm) hypothetical protein 0.0065 0.0082 0.0105
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0083 0.0244 0.1213
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Giardia lamblia Kinase, CMGC GSK 0.0104 0.0431 0.5509
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0095 0.0354 0.0621
Loa Loa (eye worm) hypothetical protein 0.0237 0.164 0.2104
Schistosoma mansoni protein kinase 0.0083 0.0244 0.0441
Toxoplasma gondii AGC kinase 0.0088 0.0289 0.4758
Onchocerca volvulus 0.0276 0.2001 0.7826
Entamoeba histolytica protein kinase, putative 0.0104 0.0431 0.7375
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0238 0.1654 0.1654
Echinococcus granulosus Immunoglobulin 0.0065 0.0082 0.0082
Loa Loa (eye worm) SRC-1 0.0095 0.0354 0.0454
Trichomonas vaginalis AGC family protein kinase 0.012 0.0583 1
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0022 0.0335
Echinococcus granulosus mitogen activated protein kinase 14 0.026 0.1849 0.1849
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0065 0.0082 0.0148
Plasmodium falciparum tyrosine kinase-like protein 0.0066 0.0086 0.1129
Echinococcus granulosus serine:threonine protein kinase N2 0.0567 0.4642 0.4642
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0111 0.05 0.0878
Echinococcus granulosus tyrosine protein kinase Src42A 0.0095 0.0354 0.0354
Brugia malayi Protein kinase domain containing protein 0.0664 0.553 0.7093
Brugia malayi cell division control protein 2 homolog 0.0094 0.0341 0.0438
Echinococcus granulosus ephrin type A receptor 4 A 0.0313 0.2335 0.2335
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0111 0.05 0.05
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.0242 0.0425
Loa Loa (eye worm) AGC/PKA protein kinase 0.0088 0.0289 0.0371
Brugia malayi Hr1 repeat family protein 0.0567 0.4642 0.5954
Echinococcus granulosus tyrosine protein kinase Srms 0.0083 0.0242 0.0242
Schistosoma mansoni cell adhesion molecule 0.0098 0.0374 0.0677
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.0341 0.0438
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0095 0.0354 0.0354
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0153 0.0881 0.1547
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0088 0.0289 0.0289
Loa Loa (eye worm) TK/ABL protein kinase 0.0083 0.0242 0.0311
Onchocerca volvulus 0.0299 0.221 0.8645
Giardia lamblia Kinase, CMGC CDK 0.0094 0.0341 0.2874
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0104 0.0431 0.0431
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0431 0.7375
Echinococcus granulosus tyrosine protein kinase shark 0.0508 0.411 0.411
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0354 0.0354
Brugia malayi Protein kinase domain containing protein 0.0083 0.0242 0.0311
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0095 0.0354 0.064
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.026 0.1849 1
Onchocerca volvulus 0.0083 0.0242 0.0948
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0484 0.7068
Brugia malayi Fibronectin type III domain containing protein 0.0084 0.025 0.0321
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0104 0.0431 0.0779
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.025 0.0321
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0111 0.05 0.0878
Brugia malayi serine/threonine protein kinase 6 0.012 0.0583 0.0748
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0341 0.2874
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0088 0.0289 0.146
Brugia malayi Protein kinase domain containing protein 0.0521 0.423 0.5426
Onchocerca volvulus 0.0083 0.0242 0.0948
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0289 0.0523
Echinococcus granulosus mitogen activated protein kinase 0.011 0.0484 0.0484
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0913 0.7796 1
Onchocerca volvulus 0.0075 0.0168 0.0658
Echinococcus multilocularis mitogen activated protein kinase 14 0.026 0.1849 0.3245
Brugia malayi Protein kinase domain containing protein 0.0336 0.2546 0.3265
Echinococcus granulosus serine:threonine protein kinase N2 0.0516 0.4184 0.4184
Plasmodium vivax protein kinase Crk2 0.0094 0.0341 0.5683
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0088 0.0289 0.146
Brugia malayi Protein kinase domain containing protein 0.0083 0.0242 0.0311
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0248 0.1741 0.3055
Schistosoma mansoni nephrin 0.0095 0.0347 0.0628
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0083 0.0245 0.1217
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0083 0.0245 0.1217
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0361 0.277 0.277
Trichomonas vaginalis AGC family protein kinase 0.012 0.0583 1
Trypanosoma brucei developmentally regulated phosphoprotein 0.0238 0.1654 0.8933
Schistosoma mansoni protein kinase 0.012 0.0583 0.1054
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.0341 0.1747
Echinococcus granulosus twitchin 0.0085 0.0256 0.0256
Trypanosoma brucei aurora B kinase 0.012 0.0583 0.3069
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.0341 0.1747
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0354 0.0354
Schistosoma mansoni vesicular amine transporter 0.0065 0.0082 0.0148
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0111 0.05 0.05
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0094 0.0341 0.0341
Echinococcus granulosus mitogen activated protein kinase 11 0.026 0.1849 0.1849
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0248 0.1741 0.1741
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0094 0.0341 0.1747
Brugia malayi serine/threonine-protein kinase 6 0.012 0.0583 0.0748
Echinococcus granulosus roundabout 2 0.0108 0.0472 0.0472
Echinococcus granulosus aurora kinase A 0.012 0.0583 0.0583
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0095 0.0354 0.0621
Echinococcus multilocularis protein kinase shaggy 0.0104 0.0431 0.0756
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0083 0.0244 0.1213
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0443 0.3521 0.3521
Giardia lamblia Aurora kinase 0.012 0.0583 1
Echinococcus granulosus rho-associated protein kinase 1 0.0299 0.221 0.221
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0088 0.0289 0.4758
Trypanosoma brucei protein kinase, putative 0.0104 0.0431 0.2236
Loa Loa (eye worm) TK protein kinase 0.0258 0.1838 0.2358
Brugia malayi SH2 domain containing protein 0.0083 0.0242 0.0311
Loa Loa (eye worm) thyroid receptor interactor 0.0298 0.2199 0.282
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.0341 0.0438
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0248 0.1741 0.3055
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0088 0.0289 0.0371
Entamoeba histolytica protein kinase , putative 0.012 0.0583 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.011 0.0484 0.0849
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0083 0.0245 0.1217
Echinococcus granulosus tyrosine protein kinase Lyn 0.0104 0.0431 0.0431
Leishmania major protein kinase A catalytic subunit isoform 1 0.0088 0.0289 0.146
Echinococcus granulosus protein kinase shaggy 0.0104 0.0431 0.0431
Echinococcus multilocularis tyrosine protein kinase Srms 0.0083 0.0242 0.0425
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0431 0.5509
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0079 0.0206 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0484 0.7068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0258 0.1838 0.2358
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0095 0.0354 0.0621
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0065 0.0082 0.0148
Echinococcus multilocularis ephrin type A receptor 4 A 0.0313 0.2335 0.4099
Schistosoma mansoni tyrosine kinase 0.0095 0.0354 0.064
Echinococcus granulosus tyrosine protein kinase Fyn 0.0095 0.0354 0.0354
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.011 0.0484 0.2525
Echinococcus multilocularis cyclin dependent kinase 5 0.0094 0.0341 0.0599
Leishmania major developmentally regulated phosphoprotein-like protein 0.0238 0.1654 0.8933
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0094 0.0341 0.0438
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.0484 0.2525
Trichomonas vaginalis AGC family protein kinase 0.012 0.0583 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0094 0.0341 0.5691
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Echinococcus granulosus serine:threonine protein kinase 12 B 0.012 0.0583 0.0583
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0088 0.0289 0.0507
Entamoeba histolytica protein kinase domain containing protein 0.0104 0.0431 0.7375
Schistosoma mansoni tyrosine kinase 0.0393 0.3062 0.5538
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0095 0.0354 0.0621
Echinococcus granulosus epidermal growth factor receptor 0.0582 0.4778 0.4778
Loa Loa (eye worm) AUR protein kinase 0.012 0.0583 0.0748
Brugia malayi SH2 domain containing protein 0.0083 0.0242 0.0311
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0104 0.0431 0.0552
Loa Loa (eye worm) hypothetical protein 0.0079 0.0206 0.0264
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0583 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0061 0.0043 0.0055
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0088 0.0289 0.146
Loa Loa (eye worm) TK protein kinase 0.0083 0.0242 0.0311
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0104 0.0431 0.0756
Giardia lamblia Kinase, CMGC MAPK 0.011 0.0484 0.7068
Brugia malayi serine/threonine kinase 12 0.012 0.0583 0.0748
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0583 0.1054
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0406 0.3178 0.4077
Echinococcus multilocularis kinase protein 0.0111 0.05 0.0878
Echinococcus multilocularis epidermal growth factor receptor 0.0582 0.4778 0.8385
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0088 0.0289 0.146
Trypanosoma brucei cdc2-related kinase 1 0.0094 0.0341 0.1747
Trichomonas vaginalis CMGC family protein kinase 0.011 0.0484 0.7068
Entamoeba histolytica protein kinase, putative 0.012 0.0583 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0097 0.0365 0.6115
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0095 0.0354 0.0354
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0104 0.0431 0.0552
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0104 0.0431 0.2236
Loa Loa (eye worm) hypothetical protein 0.0084 0.025 0.0321
Onchocerca volvulus 0.0291 0.2133 0.8344
Brugia malayi protein-tyrosine kinase 0.0083 0.0242 0.0311
Loa Loa (eye worm) hypothetical protein 0.009 0.0303 0.0389
Loa Loa (eye worm) TK/FER protein kinase 0.0083 0.0242 0.0311
Schistosoma mansoni ephrin receptor 0.0069 0.0114 0.0205
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.012 0.0583 1
Schistosoma mansoni protein kinase 0.0059 0.0022 0.004
Schistosoma mansoni tyrosine kinase 0.0095 0.0354 0.064
Brugia malayi P38 map kinase family protein 2 0.026 0.1849 0.2372
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0083 0.0244 0.1213
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0289 0.0523
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0083 0.0242 0.0242
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0104 0.0431 0.7284
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0095 0.0354 0.0621
Loa Loa (eye worm) TK/EGFR protein kinase 0.0582 0.4778 0.6128
Schistosoma mansoni tyrosine kinase 0.0582 0.4778 0.864
Brugia malayi Protein kinase domain containing protein 0.0153 0.0881 0.1131
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0083 0.0242 0.0425
Schistosoma mansoni tyrosine kinase 0.0508 0.411 0.7432
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.086
Onchocerca volvulus 0.0083 0.0242 0.0948
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.012 0.0583 1
Echinococcus multilocularis epidermal growth factor receptor 0.0443 0.3521 0.6179

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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