Detailed information for compound 1610656

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 630.762 | Formula: C35H34N8O2S
  • H donors: 2 H acceptors: 4 LogP: 6.02 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1cccc(c1N(C)C)c1nc2n(c1c1ccnc(n1)Nc1cccc(c1)N1CCOCC1)ccs2)Cc1ccccc1
  • InChi: 1S/C35H34N8O2S/c1-41(2)32-27(12-7-13-28(32)38-30(44)22-24-8-4-3-5-9-24)31-33(43-18-21-46-35(43)40-31)29-14-15-36-34(39-29)37-25-10-6-11-26(23-25)42-16-19-45-20-17-42/h3-15,18,21,23H,16-17,19-20,22H2,1-2H3,(H,38,44)(H,36,37,39)
  • InChiKey: QRWHFUYBHXDYNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens FYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens Bruton agammaglobulinemia tyrosine kinase Starlite/ChEMBL No references
Homo sapiens protein kinase N2 Starlite/ChEMBL No references
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL No references
Homo sapiens misshapen-like kinase 1 Starlite/ChEMBL No references
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL No references
Homo sapiens TAO kinase 1 Starlite/ChEMBL No references
Homo sapiens protein tyrosine kinase 2 Starlite/ChEMBL No references
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens ret proto-oncogene Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K04429 thousand and one amino acid protein kinase, putative Get druggable targets OG5_129521 All targets in OG5_129521
Echinococcus granulosus serine:threonine protein kinase N2 Get druggable targets OG5_130229 All targets in OG5_130229
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus serine:threonine protein kinase TAO1 Get druggable targets OG5_129521 All targets in OG5_129521
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) AGC/PKN protein kinase Get druggable targets OG5_130229 All targets in OG5_130229
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis serine:threonine protein kinase N2 Get druggable targets OG5_130229 All targets in OG5_130229
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129521 All targets in OG5_129521
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis serine:threonine protein kinase TAO1 Get druggable targets OG5_129521 All targets in OG5_129521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum IPR000961,Protein kinase, C-terminal,domain-containing Get druggable targets OG5_130229 All targets in OG5_130229
Echinococcus multilocularis tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus serine:threonine protein kinase N2 Get druggable targets OG5_130229 All targets in OG5_130229
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Brugia malayi Serine/threonine-protein kinase SULU Get druggable targets OG5_129521 All targets in OG5_129521
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma japonicum expressed protein Get druggable targets OG5_130229 All targets in OG5_130229
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis serine:threonine protein kinase N2 Get druggable targets OG5_130229 All targets in OG5_130229
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Serine/threonine-protein kinase N1, putative Get druggable targets OG5_130229 All targets in OG5_130229
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Hr1 repeat family protein Get druggable targets OG5_130229 All targets in OG5_130229
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) STE/STE20/TAO protein kinase Get druggable targets OG5_129521 All targets in OG5_129521
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130229 All targets in OG5_130229
Schistosoma japonicum Serine/threonine-protein kinase N2, putative Get druggable targets OG5_130229 All targets in OG5_130229
Schistosoma japonicum Tyrosine-protein kinase BTK, putative Get druggable targets OG5_129320 All targets in OG5_129320
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi hypothetical protein Get druggable targets OG5_129521 All targets in OG5_129521
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.011 0.3021 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0171 0.511 0.5066
Entamoeba histolytica hypothetical protein 0.011 0.3021 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0061 0.1342 0.1359
Schistosoma mansoni tyrosine kinase 0.031 0.9876 1
Schistosoma mansoni hypothetical protein 0.0061 0.1342 0.1359
Schistosoma mansoni protein kinase 0.0147 0.4289 0.4343
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0066 0.1511 0.1529
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.1511 0.1529
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.1107 0.112
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0061 0.1342 0.1359
Entamoeba histolytica protein kinase, putative 0.011 0.3021 1
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.023 0.7124 0.7098
Schistosoma mansoni serine/threonine protein kinase 0.011 0.3021 0.3059
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0205 0.6275 0.6354
Loa Loa (eye worm) TK protein kinase 0.0054 0.1107 0.1027
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.023 0.7124 0.7213
Entamoeba histolytica p21-activated kinase 0.0023 0.0056 0.0187
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0089 0.0089
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0307 0.0311
Loa Loa (eye worm) SRC-1 0.0066 0.1511 0.1434
Echinococcus multilocularis protein tyrosine kinase 0.031 0.9876 1
Echinococcus granulosus protein tyrosine kinase 0.031 0.9876 1
Schistosoma mansoni serine/threonine protein kinase 0.023 0.7124 0.7213
Schistosoma mansoni nck2/grb4 0.0024 0.0089 0.009
Schistosoma mansoni tyrosine kinase 0.0025 0.0132 0.0134
Echinococcus granulosus Vam6:Vps39 protein 0.0061 0.1342 0.1359
Echinococcus multilocularis serine:threonine protein kinase N2 0.0171 0.511 0.5174
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0066 0.1511 0.1529
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.6242 0.632
Brugia malayi hypothetical protein 0.023 0.7124 0.7124
Echinococcus granulosus serine:threonine protein kinase N2 0.0156 0.4593 0.465
Giardia lamblia Kinase, STE STE20 0.0021 0 0.5
Entamoeba histolytica protein kinase, putative 0.0023 0.0056 0.0187
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0063 0.1428 0.1446
Brugia malayi Fes/CIP4 homology domain containing protein 0.0098 0.2621 0.2621
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0191 0.5782 0.5854
Schistosoma mansoni rap gtpase-activating protein 0.0061 0.1342 0.1359
Schistosoma mansoni tyrosine kinase 0.0179 0.5378 0.5445
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.511 0.5174
Brugia malayi Protein kinase domain containing protein 0.011 0.3021 0.3021
Schistosoma mansoni tyrosine kinase 0.0066 0.1511 0.1529
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.011 0.3021 0.5
Loa Loa (eye worm) TK/FAK protein kinase 0.0314 1 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0066 0.1511 0.1529
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0191 0.5782 0.5854
Loa Loa (eye worm) hypothetical protein 0.0107 0.2935 0.2872
Echinococcus granulosus serine:threonine protein kinase N2 0.0171 0.511 0.5174
Loa Loa (eye worm) hypothetical protein 0.0107 0.2935 0.2872
Echinococcus granulosus tyrosine protein kinase Src64B 0.0066 0.1511 0.1529
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.1511 0.1529
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.1511 0.1529
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.1511 0.1529
Brugia malayi SRC-1 0.0066 0.1511 0.1511
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0066 0.1511 0.1529
Schistosoma mansoni adapter molecule crk 0.0024 0.0089 0.009
Trichomonas vaginalis STE family protein kinase 0.0021 0 0.5
Echinococcus granulosus serine:threonine protein kinase TAO1 0.023 0.7124 0.7213
Echinococcus granulosus growth factor receptor bound protein 2 0.0024 0.0089 0.009
Trichomonas vaginalis STE family protein kinase 0.0021 0 0.5
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.011 0.3021 0.2958
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.0089 0.009
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0054 0.1107 0.112
Brugia malayi Variant SH3 domain containing protein 0.0024 0.0089 0.0089
Echinococcus multilocularis growth factor receptor bound protein 2 0.0024 0.0089 0.009
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0063 0.1428 0.1446
Schistosoma mansoni tyrosine kinase 0.0066 0.1511 0.1529
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0063 0.1428 0.1351
Echinococcus multilocularis tyrosine protein kinase Srms 0.0054 0.1107 0.112
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.3021 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1342 0.1264
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0147 0.4289 0.4238
Echinococcus multilocularis c src tyrosine kinase 0.003 0.0307 0.0311
Schistosoma mansoni tyrosine kinase 0.003 0.0307 0.0311
Entamoeba histolytica protein kinase, putative 0.0042 0.0692 0.2291
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.1428 0.1446
Echinococcus granulosus NCK adaptor protein 0.0024 0.0089 0.009
Trichomonas vaginalis STE family protein kinase 0.0021 0 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0066 0.1511 0.1529
Entamoeba histolytica protein kinase, putative 0.011 0.3021 1
Brugia malayi Temporarily assigned gene name protein 59 0.0061 0.1342 0.1342
Echinococcus granulosus protein kinase 0.0147 0.4289 0.4343
Echinococcus granulosus tyrosine protein kinase HCK 0.0042 0.0692 0.0701
Trichomonas vaginalis STE family protein kinase 0.0021 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0205 0.6275 0.6242
Echinococcus granulosus tyrosine protein kinase Lyn 0.0068 0.1596 0.1616
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.0307 0.0311
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.1428 0.1446
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.1511 0.1529
Loa Loa (eye worm) thyroid receptor interactor 0.0098 0.2621 0.2555
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0066 0.1511 0.1529
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0063 0.1428 0.1446
Loa Loa (eye worm) TK protein kinase 0.0042 0.0692 0.0609
Trichomonas vaginalis STE family protein kinase 0.0021 0 0.5
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0061 0.1342 0.1359
Echinococcus granulosus dual specificity 0.011 0.3021 0.3059
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0066 0.1511 0.1529
Brugia malayi Serine/threonine-protein kinase SULU 0.023 0.7124 0.7124
Echinococcus granulosus tyrosine kinase 0.0054 0.1107 0.112
Echinococcus multilocularis tyrosine protein kinase Blk 0.0054 0.1107 0.112
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.6242 0.632
Onchocerca volvulus 0.0061 0.1342 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.0888 0.09
Schistosoma mansoni protein kinase 0.0063 0.1428 0.1446
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.011 0.3021 1
Brugia malayi Protein kinase domain containing protein 0.0063 0.1428 0.1428
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0063 0.1428 0.1446
Echinococcus multilocularis serine:threonine protein kinase N2 0.0156 0.4593 0.465
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0066 0.1511 0.1529
Brugia malayi hypothetical protein 0.0061 0.1342 0.1342
Echinococcus multilocularis tyrosine protein kinase HCK 0.0042 0.0692 0.0701
Entamoeba histolytica protein kinase domain containing protein 0.011 0.3021 1
Echinococcus multilocularis NCK adaptor protein 0.0024 0.0089 0.009
Brugia malayi Sex muscle abnormal protein 5 0.0024 0.0089 0.0089
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.0888 0.09
Entamoeba histolytica protein kinase, putative 0.0023 0.0056 0.0187
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.6886 0.6886
Schistosoma mansoni tyrosine kinase 0.003 0.0307 0.0311
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0061 0.1342 0.1359
Echinococcus multilocularis dual specificity 0.011 0.3021 0.3059
Schistosoma mansoni protein kinase 0.0207 0.6361 0.6441
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0024 0.0089 0.009
Loa Loa (eye worm) hypothetical protein 0.0061 0.1342 0.1264
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.0307 0.0307
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0066 0.1511 0.1529
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.6886 0.6858
Loa Loa (eye worm) hypothetical protein 0.0061 0.1342 0.1264
Schistosoma mansoni vam6/vps39 related 0.0061 0.1342 0.1359
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0063 0.1428 0.1446
Schistosoma mansoni growth factor receptor-bound protein 0.0024 0.0089 0.009
Brugia malayi protein-tyrosine kinase 0.0054 0.1107 0.1107
Brugia malayi Hr1 repeat family protein 0.0171 0.511 0.511
Brugia malayi probable protein kinase 0.0207 0.6361 0.6361
Echinococcus granulosus tyrosine protein kinase Blk 0.0054 0.1107 0.112
Echinococcus granulosus c src tyrosine kinase 0.003 0.0307 0.0311
Echinococcus multilocularis 0.0147 0.4289 0.4343
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.1511 0.1529
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0063 0.1428 0.1446
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0536 0.0543

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) > 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TAO1 ChEMBL. No reference
Ki (functional) > 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PTK2 ChEMBL. No reference
Ki (functional) > 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: BTK ChEMBL. No reference
Ki (functional) > 5.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FYN ChEMBL. No reference
Ki (functional) > 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MINK ChEMBL. No reference
Ki (functional) > 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PAK4 ChEMBL. No reference
Ki (functional) > 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PKN2 ChEMBL. No reference
Ki (functional) = 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 5.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LCK ChEMBL. No reference
Ki (functional) = 6.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: RET ChEMBL. No reference
Ki (functional) = 6.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK1A ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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