Detailed view for EgrG_000074500

Basic information

TDR Targets ID: 593862
Echinococcus granulosus, Ubiquinol cytochrome c reductase complex 14 kDa
Source Database / ID:  GeneDB

pI: 8.3767 | Length (AA): 130 | MW (Da): 15570 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02271   Ubiquinol-cytochrome C reductase complex 14kD subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0006122   mitochondrial electron transport, ubiquinol to cytochrome c  
GO:0005750   mitochondrial respiratory chain complex III  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 124 3cx5 (G) 6 124 30.00 0 0.97 1.32858 -0.6
23 121 3tgu (F) 10 108 37.00 0 1 1.31844 -0.96
23 121 1bcc (F) 10 108 43.00 0 1 1.34674 -0.82

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129503)

Species Accession Gene Product
Arabidopsis thaliana AT4G32470   Cytochrome bd ubiquinol oxidase
Arabidopsis thaliana AT5G25450   cytochrome bd ubiquinol oxidase
Candida albicans CaO19.13074   Ubiquinol cytochrome-c reductase subunit 7
Candida albicans CaO19.5629   Ubiquinol cytochrome-c reductase subunit 7
Caenorhabditis elegans CELE_T02H6.11   Protein T02H6.11
Dictyostelium discoideum DDB_G0286171   cytochrome bd ubiquinol oxidase, 14 kDa subunit
Drosophila melanogaster Dmel_CG3560   CG3560 gene product from transcript CG3560-RA
Drosophila melanogaster Dmel_CG17856   CG17856 gene product from transcript CG17856-RA
Echinococcus granulosus EgrG_000074500   Ubiquinol cytochrome c reductase complex 14 kDa
Echinococcus multilocularis EmuJ_000074500   Ubiquinol cytochrome c reductase complex 14 kDa
Homo sapiens ENSG00000156467   ubiquinol-cytochrome c reductase binding protein
Loa Loa (eye worm) LOAG_07393   hypothetical protein
Mus musculus ENSMUSG00000021520   ubiquinol-cytochrome c reductase binding protein
Oryza sativa 4342681   Os07g0205000
Oryza sativa 4334506   Os03g0806900
Saccharomyces cerevisiae YDR529C   ubiquinol--cytochrome-c reductase subunit 7
Schistosoma japonicum Sjp_0054240   ko:K00417 ubiquinol-cytochrome c reductase subunit 7, putative
Schistosoma mansoni Smp_024120   Ubiquinol-cytochrome c reductase complex 14 kDa protein
Schmidtea mediterranea mk4.001244.00   Putative ubiquinol-cytochrome c reductase complex 14 kDa protein

Essentiality

EgrG_000074500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T02H6.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_T02H6.11 Caenorhabditis elegans larval arrest wormbase
CELE_T02H6.11 Caenorhabditis elegans slow growth wormbase
CELE_T02H6.11 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ubiquinol-cytochrome c reductase binding protein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.021 0.584 0.584
0.0224 0.3195 0.3036
0.0209 0.8653 1
0.0218 0.29 0.5199
0.0232 0.3205 0.3081
0.0129 0.3731 0.3731
0.0336 0.2696 0.2696
0.0336 0.2696 0.2696
0.0213 0.3678 0.3678
0.0336 0.2696 0.2696
0.0207 0.2577 0.2571
0.0336 0.2696 0.2696
0.0423898 0.745524 1
0.0339 0.4543 0.4543
0.0213 0.3678 0.3678

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000074500 (Echinococcus granulosus), Ubiquinol cytochrome c reductase complex 14 kDa
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