TDR Targets

Basic information

Technical information

TDR Targets ID: 781322
Name: 6-[(4-chlorophenyl)methyl]-3-[(3-methylphenyl )amino]-2H-1,2,4-triazin-5-one
MW: 326.78 | Formula: C17H15ClN4O
H donors: 2 H acceptors: 4 LogP: 4 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)Cc1nnc(nc1O)Nc1cccc(c1)C
InChi: 1S/C17H15ClN4O/c1-11-3-2-4-14(9-11)19-17-20-16(23)15(21-22-17)10-12-5-7-13(18)8-6-12/h2-9H,10H2,1H3,(H2,19,20,22,23)
InChiKey: BBBWZCNWNLUQGL-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

6-(4-chlorobenzyl)-3-[(3-methylphenyl)amino]-2H-1,2,4-triazin-5-one
ZINC02718956
Oprea1_671771

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0247	0.0285
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0106	0.0122
Entamoeba histolytica	hypothetical protein	0.0036	0.086	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0106	0.0106
Plasmodium vivax	ubiquinol-cytochrome c reductase complex subunit, putative	0.0048	0.14	1
Schistosoma mansoni	Ubiquinol-cytochrome c reductase complex 14 kDa protein	0.0209	0.8653	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.086	0.0993
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.337	0.3299
Echinococcus granulosus	geminin	0.017	0.6894	0.7967
Schistosoma mansoni	hypothetical protein	0.0068	0.2306	0.2665
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0305	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0034	0.0034
Brugia malayi	Bromodomain containing protein	0.0075	0.2606	0.2527
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.337	0.3894
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0656	0.0758
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0656	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0305	0.0305
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0305	1
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0161	0.0161
Toxoplasma gondii	ubiquinol-cytochrome c reductase	0.0048	0.14	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2414	0.2414
Schistosoma mansoni	bromodomain containing protein	0.0063	0.2079	0.2403
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0305	0.0202
Loa Loa (eye worm)	MH2 domain-containing protein	0.0239	1	1
Trypanosoma cruzi	ubiquinol-cytochrome c reductase complex 14kD subunit, putative	0.0048	0.14	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0656	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0209	0.8653	0.8653
Schistosoma mansoni	hypothetical protein	0.0032	0.0656	0.0758
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0152	0.6065	0.6065
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0959	0.0959
Trypanosoma cruzi	ubiquinol-cytochrome c reductase complex 14kD subunit, putative	0.0048	0.14	1
Leishmania major	hypothetical protein, conserved	0.0048	0.14	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0305	0.0202
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.2306	0.2224
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0305	0.5
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0305	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0034	0.0034
Schistosoma mansoni	hypothetical protein	0.0021	0.0161	0.0186
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0106	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.086	0.0993
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0305	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0247	0.0285
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.3729	0.3662
Schistosoma mansoni	hypothetical protein	0.0032	0.0656	0.0758
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0305	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0656	0.0758
Plasmodium falciparum	cytochrome b-c1 complex subunit 7, putative	0.0048	0.14	1
Entamoeba histolytica	hypothetical protein	0.0036	0.086	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.3729	0.3662
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0656	0.0758
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0305	0.1541
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.337	0.3894
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0305	1
Echinococcus multilocularis	zinc finger protein	0.002	0.0113	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2306	0.2306
Brugia malayi	PHD-finger family protein	0.0025	0.0353	0.025
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0305	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0106	0.5
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0305	1
Schistosoma mansoni	hypothetical protein	0.017	0.6894	0.7967
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.086	0.0993
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.1918	0.2217
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0106	0.0106
Echinococcus granulosus	zinc finger protein	0.002	0.0113	0.0131
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0305	0.1541
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0106	0.0122
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0305	0.0202
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0305	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0106	0.0122
Echinococcus multilocularis	geminin	0.017	0.6894	0.7967
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0034	0.0034
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0849	0.0981
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.3729	0.3729
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.337	0.3894
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0034	0.0034
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0656	0.0556
Brugia malayi	hypothetical protein	0.0152	0.6065	0.6023
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.1918	0.2217
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0106	0.5
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0656	0.0758
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0106	0.2642
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.337	0.337
Schistosoma mansoni	hypothetical protein	0.017	0.6894	0.7967
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0305	0.5
Onchocerca volvulus		0.0152	0.6065	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0106	0.0122
Brugia malayi	Bromodomain containing protein	0.0038	0.0956	0.0859
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0656	0.0656
Schistosoma mansoni	hypothetical protein	0.0032	0.0656	0.0758
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0106	0.0122
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.337	0.3894
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.337	0.3894
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1151	0.1151
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0106	0.0122
Loa Loa (eye worm)	hypothetical protein	0.01	0.3729	0.3729
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0305	0.0305
Entamoeba histolytica	hypothetical protein	0.0036	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0305	0.0305
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.337	0.3894
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0305	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0305	0.2646
Schistosoma mansoni	hypothetical protein	0.0036	0.086	0.0993
Trypanosoma brucei	ubiquinol-cytochrome c reductase complex 14 kda protein	0.0048	0.14	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0849	0.0981
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0106	0.2642
Brugia malayi	hypothetical protein	0.0036	0.086	0.0762
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0106	0.2642
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0034	0.5
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0106	0.0122
Echinococcus granulosus	GPCR family 2	0.0032	0.0656	0.0758
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0106	0.2642
Echinococcus granulosus	dna polymerase eta	0.0019	0.0106	0.0122
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0656	0.0758
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0305	0.2646
Schistosoma mansoni	zinc finger protein	0.002	0.0113	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1065	0.1065
Echinococcus multilocularis	Ubiquinol cytochrome c reductase complex 14 kDa	0.0209	0.8653	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0247	0.0285
Entamoeba histolytica	hypothetical protein	0.0036	0.086	1
Echinococcus granulosus	Ubiquinol cytochrome c reductase complex 14 kDa	0.0209	0.8653	1
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0106	0.0122
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0305	0.2646
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.337	0.3894
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0656	0.0656
Loa Loa (eye worm)	transcription factor SMAD2	0.0239	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 781322