TDR Targets

Basic information

Technical information

TDR Targets ID: 662796
Name: N-(4-hydroxyphenyl)-4-phenylbenzenesulfonamid e
MW: 325.382 | Formula: C18H15NO3S
H donors: 2 H acceptors: 3 LogP: 3.72 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)NS(=O)(=O)c1ccc(cc1)c1ccccc1
InChi: 1S/C18H15NO3S/c20-17-10-8-16(9-11-17)19-23(21,22)18-12-6-15(7-13-18)14-4-2-1-3-5-14/h1-13,19-20H
InChiKey: SZOPCHOOHZIDKC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-hydroxyphenyl)-4-phenyl-benzenesulfonamide
ZINC00470855

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquinol-cytochrome c reductase binding protein	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	Ubiquinol cytochrome c reductase complex 14 kDa	Get druggable targets OG5_129503	All targets in OG5_129503
Candida albicans	Ubiquinol cytochrome-c reductase subunit 7	Get druggable targets OG5_129503	All targets in OG5_129503
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129503	All targets in OG5_129503
Schistosoma mansoni	Ubiquinol-cytochrome c reductase complex 14 kDa protein	Get druggable targets OG5_129503	All targets in OG5_129503
Echinococcus multilocularis	Ubiquinol cytochrome c reductase complex 14 kDa	Get druggable targets OG5_129503	All targets in OG5_129503
Candida albicans	Ubiquinol cytochrome-c reductase subunit 7	Get druggable targets OG5_129503	All targets in OG5_129503
Schistosoma japonicum	ko:K00417 ubiquinol-cytochrome c reductase subunit 7, putative	Get druggable targets OG5_129503	All targets in OG5_129503

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	ubiquinol-cytochrome c reductase complex 14 kda protein	ubiquinol-cytochrome c reductase binding protein	79 aa	76 aa	30.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1836	0.1836
Schistosoma mansoni	importin beta-1	0.0029	0.0266	0.0266
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0883	0.0883
Trypanosoma cruzi	ubiquinol-cytochrome c reductase complex 14kD subunit, putative	0.003	0.0288	0.5366
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0883	0.0883
Echinococcus multilocularis	snurportin 1	0.0309	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0883	0.3527
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.025	0.025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0883	0.0883
Onchocerca volvulus		0.0037	0.0537	1
Brugia malayi	RNA, U transporter 1	0.0082	0.2121	0.8474
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.4241	1
Trypanosoma cruzi	ubiquinol-cytochrome c reductase complex 14kD subunit, putative	0.003	0.0288	0.5366
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0537	0.0537
Toxoplasma gondii	ubiquinol-cytochrome c reductase	0.003	0.0288	0.5366
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0075	0.008
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0266	0.4946
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0159	0.0159
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0637	0.0637
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.025	0.025
Onchocerca volvulus	Alhambra homolog	0.0028	0.025	0.2053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0537	0.0537
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.4241	0.538
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Schistosoma mansoni	hypothetical protein	0.0309	1	1
Onchocerca volvulus		0.0037	0.0537	1
Echinococcus multilocularis	peregrin	0.0028	0.025	0.025
Brugia malayi	beta-lactamase	0.0037	0.0537	0.2146
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0957	0.0957
Echinococcus multilocularis	Ubiquinol cytochrome c reductase complex 14 kDa	0.0129	0.3731	0.3731
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0458	0.0458
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0537	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.9457	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0883	0.0883
Echinococcus multilocularis	lamin	0.0026	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0028	0.025	0.025
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0458	0.0458
Brugia malayi	Importin beta-1 subunit	0.0029	0.0266	0.1062
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0075	0.008
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0537	0.0568
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0637	0.0637
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0537	0.0537
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0266	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	0.0175
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0266	0.4946
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.1304	0.1304
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0458	0.0458
Brugia malayi	beta-lactamase family protein	0.0037	0.0537	0.2146
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.025	0.4648
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.025	0.025
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0883	0.0883
Plasmodium vivax	ubiquinol-cytochrome c reductase complex subunit, putative	0.003	0.0288	0.5366
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0883	0.0883
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0458	0.0458
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0537	0.2146
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0537	0.0537
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Brugia malayi	PHD-finger family protein	0.0028	0.025	0.0998
Brugia malayi	jmjC domain containing protein	0.0034	0.0458	0.183
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0537	0.0537
Treponema pallidum	fructose-bisphosphate aldolase	0.0293	0.9457	0.5
Schistosoma mansoni	lamin	0.0026	0.0175	0.0175
Toxoplasma gondii	ABC1 family protein	0.0037	0.0537	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0537	0.0537
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Echinococcus multilocularis	lamin dm0	0.0026	0.0175	0.0175
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0537	1
Leishmania major	hypothetical protein, conserved	0.0037	0.0537	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0537	0.0537
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0883	0.0883
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.025	0.025
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Echinococcus granulosus	lamin dm0	0.0026	0.0175	0.0175
Plasmodium falciparum	importin beta, putative	0.0029	0.0266	0.9217
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Echinococcus granulosus	Ubiquinol cytochrome c reductase complex 14 kDa	0.0129	0.3731	0.3731
Brugia malayi	beta-lactamase family protein	0.0037	0.0537	0.2146
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0075	0.008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0537	0.0537
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0175	0.0175
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.2502	0.2502
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.4241	1
Schistosoma mansoni	hypothetical protein	0.0028	0.025	0.025
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0075	0.008
Giardia lamblia	Fructose-bisphosphate aldolase	0.0293	0.9457	1
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0175	0.0175
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0266	0.0266
Echinococcus granulosus	peregrin	0.0028	0.025	0.025
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0537	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0266	0.4946
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0175	0.0701
Plasmodium falciparum	phd finger protein, putative	0.0028	0.025	0.8662
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0293	0.9457	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0537	0.0537
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0293	0.9457	1
Schistosoma mansoni	lamin	0.0026	0.0175	0.0175
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0537	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.025	0.4648
Plasmodium falciparum	cytochrome b-c1 complex subunit 7, putative	0.003	0.0288	1
Schistosoma mansoni	Ubiquinol-cytochrome c reductase complex 14 kDa protein	0.0129	0.3731	0.3731
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0266	0.0266
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0309	1	1
Onchocerca volvulus		0.0037	0.0537	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0537	0.0537
Brugia malayi	intermediate filament protein	0.0026	0.0175	0.0701
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.025	0.4648
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0075	0.1403
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0537	0.0568
Echinococcus granulosus	intermediate filament protein	0.0026	0.0175	0.0175
Brugia malayi	Bromodomain containing protein	0.0028	0.025	0.0998
Trichomonas vaginalis	esterase, putative	0.0037	0.0537	0.0568
Echinococcus granulosus	lamin	0.0026	0.0175	0.0175
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0537	0.0568
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0075	0.1403
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.7422	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0458	0.0458
Trypanosoma brucei	ubiquinol-cytochrome c reductase complex 14 kda protein	0.003	0.0288	0.5366
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0537	0.0537
Giardia lamblia	PHD finger protein 15	0.0028	0.025	0.0264
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0537	0.0568
Echinococcus multilocularis	musashi	0.0026	0.0175	0.0175
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.2502	0.2502
Brugia malayi	jmjC domain containing protein	0.0093	0.2502	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0537	0.0568
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0266	0.4946
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0883	0.0883
Leishmania major	hypothetical protein, conserved	0.003	0.0288	0.5366
Loa Loa (eye worm)	hypothetical protein	0.0129	0.3731	0.3731

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.5 uM	Modulation of UQCRB in human HepG2 cells assessed as inhibition of HIF-1alpha for 4 hrs under 1%O2 by Western blot analysis	ChEMBL.	25244355
Inhibition (binding)	= 40 %	Displacement of biotin-labeled terpestacin from UQCRB (unknown origin) by surface plasmon resonance	ChEMBL.	25244355

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3360259
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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 662796