Detailed information for compound 835889

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.336 | Formula: C17H18N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccc(cc1)C)NN=Cc1ccc(cc1O)C
  • InChi: 1S/C17H18N2O3/c1-12-4-7-15(8-5-12)22-11-17(21)19-18-10-14-6-3-13(2)9-16(14)20/h3-10,20H,11H2,1-2H3,(H,19,21)/b18-10-
  • InChiKey: IJURWNTYCRVSDJ-ZDLGFXPLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0181 0.0205
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1343 1
Brugia malayi hypothetical protein 0.0019 0.0089 0.01
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0452 0.0515
Echinococcus granulosus lamin 0.0028 0.0216 0.0374
Brugia malayi Pyruvate kinase, M2 isozyme 0.0066 0.0749 0.0853
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0029 0.0031
Brugia malayi Pyruvate kinase, muscle isozyme 0.0066 0.0749 0.0853
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0662 0.1176
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0585 0.1038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0452 0.08
Loa Loa (eye worm) hypothetical protein 0.0218 0.29 0.3308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0452 0.08
Toxoplasma gondii thioredoxin reductase 0.0075 0.0874 0.7505
Echinococcus multilocularis pyruvate kinase 0.0052 0.0552 0.0979
Schistosoma mansoni rab6-interacting 0.0019 0.0089 0.0068
Trichomonas vaginalis set domain proteins, putative 0.072 1 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1343 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0227 0.0494
Plasmodium falciparum glutathione reductase 0.0026 0.0181 0.1173
Giardia lamblia Pyruvate kinase 0.0066 0.0749 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0576 0.7961 1
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1343 0.2341
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1343 0.1342
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0227 0.1755
Echinococcus granulosus ferritin 0.0017 0.0051 0.0078
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0293 0.2606
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1343 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0217 0.0248
Echinococcus granulosus intermediate filament protein 0.0028 0.0216 0.0374
Brugia malayi CXXC zinc finger family protein 0.0029 0.0217 0.0247
Echinococcus multilocularis pyruvate kinase 0.0034 0.0293 0.0514
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.209 0.3743
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0181 0.018
Onchocerca volvulus 0.0028 0.0216 0.0214
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0181 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.0888 0.1584
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1343 0.1342
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0749 0.0748
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0181 0.1338
Brugia malayi 6-phosphofructokinase 0.0108 0.1343 0.1531
Loa Loa (eye worm) hypothetical protein 0.0066 0.0749 0.0854
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0181 0.0907
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0662 0.1176
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0749 0.0748
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1343 0.2401
Echinococcus granulosus lamin dm0 0.0028 0.0216 0.0374
Echinococcus granulosus cpg binding protein 0.003 0.024 0.0419
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0181 0.1338
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0216 0.0244
Mycobacterium ulcerans pyruvate kinase 0.0066 0.0749 0.0882
Echinococcus multilocularis Ubiquinol cytochrome c reductase complex 14 kDa 0.0218 0.29 0.5199
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0181 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0171 0.2233 0.2759
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0227 0.1678
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0293 0.1219
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0089 0.0146
Trichomonas vaginalis glutaminase, putative 0.0288 0.3891 0.3891
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0452 0.08
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1343 0.1342
Brugia malayi hypothetical protein 0.0019 0.0089 0.01
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0318 0.0559
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0318 0.0363
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0227 0.1359
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0718 0.1208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0452 0.0727
Plasmodium vivax glutathione reductase, putative 0.0075 0.0874 0.7732
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.0749 0.0748
Brugia malayi intermediate filament protein 0.0028 0.0216 0.0244
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0318 0.0317
Onchocerca volvulus 0.0019 0.0089 0.0087
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0181 0.1338
Schistosoma mansoni rab6-interacting 0.0019 0.0089 0.0068
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0181 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0317
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0318 0.1488
Onchocerca volvulus Huntingtin homolog 0.025 0.3353 0.3352
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0227 0.0225
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0662 0.0772
Treponema pallidum NADH oxidase 0.0026 0.0181 0.1005
Schistosoma mansoni polycystin 1-related 0.0019 0.0089 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Brugia malayi Pre-SET motif family protein 0.0091 0.1105 0.1259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0216 0.0246
Brugia malayi glutaminase DH11.1 0.0288 0.3891 0.4439
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0227 0.0225
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0083 0.0093
Schistosoma mansoni alpha-glucosidase 0.0139 0.1773 0.3119
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0662 0.0772
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0227 0.1357
Onchocerca volvulus 0.0028 0.0216 0.0214
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0171 0.2233 0.2759
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0318 0.0317
Brugia malayi 6-phosphofructokinase 0.0108 0.1343 0.1531
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0318 0.0559
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0662 0.1106
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0066 0.0749 0.0882
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0318 0.2363
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0749 0.5571
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1105 0.1909
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0317
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.0466 0.3461
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0181 0.018
Echinococcus granulosus pyruvate kinase 0.0066 0.0749 0.1333
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0181 0.0907
Schistosoma mansoni alpha glucosidase 0.0036 0.0318 0.0484
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.1105 0.1972
Echinococcus granulosus pyruvate kinase 0.0034 0.0293 0.0514
Echinococcus multilocularis cpg binding protein 0.003 0.024 0.0419
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1343 0.1342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0452 0.0727
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0317
Plasmodium vivax ubiquinol-cytochrome c reductase complex subunit, putative 0.005 0.0523 0.4277
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0089 0.0146
Trypanosoma brucei ubiquinol-cytochrome c reductase complex 14 kda protein 0.005 0.0523 0.3889
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.1105 1
Mycobacterium ulcerans short chain dehydrogenase 0.0576 0.7961 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0029 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0227 0.0225
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0096 0.0108
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0083 0.0093
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0181 0.1338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1105 0.1909
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0227 0.0225
Schistosoma mansoni pyruvate kinase 0.0034 0.0293 0.0439
Plasmodium vivax SET domain protein, putative 0.0091 0.1105 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1343 0.1533
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0181 0.0312
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0181 0.1338
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0227 0.0494
Loa Loa (eye worm) hypothetical protein 0.025 0.3353 0.3825
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.1105 0.1972
Echinococcus granulosus pyruvate kinase 0.0066 0.0749 0.1333
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0181 0.1173
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1105 0.1909
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0171 0.2233 0.2759
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0181 0.1173
Plasmodium vivax pyruvate kinase, putative 0.0066 0.0749 0.6498
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.209 0.2384
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0227 0.0225
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.209 0.2383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0452 0.08
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.209 0.3743
Brugia malayi Pre-SET motif family protein 0.0633 0.8765 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0317
Leishmania major hypothetical protein, conserved 0.005 0.0523 0.3889
Schistosoma mansoni cpg binding protein 0.0029 0.0217 0.0302
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0181 0.1338
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0101
Schistosoma mansoni lipoxygenase 0.0055 0.0585 0.0967
Schistosoma mansoni glutaminase 0.0288 0.3891 0.6958
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0318 0.2363
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0633 0.8765 1
Trypanosoma cruzi ubiquinol-cytochrome c reductase complex 14kD subunit, putative 0.005 0.0523 0.3889
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1343 0.2401
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0749 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0318 0.2363
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1343 0.5269
Schistosoma mansoni intermediate filament proteins 0.0028 0.0216 0.0298
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1343 0.2341
Loa Loa (eye worm) hypothetical protein 0.025 0.3353 0.3825
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.019 0.2504 0.3101
Echinococcus multilocularis pyruvate kinase 0.0034 0.0293 0.0514
Brugia malayi Thioredoxin reductase 0.0075 0.0874 0.0996
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.0888 0.1584
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1343 0.1634
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0452 0.0516
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0662 0.4921
Plasmodium falciparum glutathione reductase 0.0075 0.0874 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0171 0.2233 0.8899
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0227 0.0225
Echinococcus multilocularis musashi 0.0028 0.0216 0.0374
Echinococcus granulosus pyruvate kinase 0.0034 0.0293 0.0514
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.0466 0.0531
Schistosoma mansoni lamin 0.0028 0.0216 0.0298
Echinococcus multilocularis pyruvate kinase 0.0066 0.0749 0.1333
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0662 0.1106
Echinococcus multilocularis lamin 0.0028 0.0216 0.0374
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0749 0.0854
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1343 0.1533
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0293 0.2015
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0181 0.0235
Brugia malayi Doublecortin family protein 0.0019 0.0089 0.01
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0318 0.0317
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.557 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.0749 0.5571
Trypanosoma brucei pyruvate kinase 1 0.0066 0.0749 0.5571
Loa Loa (eye worm) thioredoxin reductase 0.0075 0.0874 0.0997
Echinococcus granulosus RUN 0.0019 0.0089 0.0146
Trypanosoma brucei trypanothione reductase 0.0075 0.0874 0.6505
Schistosoma mansoni hypothetical protein 0.0019 0.0089 0.0068
Plasmodium falciparum thioredoxin reductase 0.0075 0.0874 1
Schistosoma mansoni Ubiquinol-cytochrome c reductase complex 14 kDa protein 0.0218 0.29 0.5161
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0181 0.1338
Trypanosoma cruzi ubiquinol-cytochrome c reductase complex 14kD subunit, putative 0.005 0.0523 0.3889
Brugia malayi hypothetical protein 0.025 0.3353 0.3824
Onchocerca volvulus 0.0091 0.1105 0.1103
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0227 0.1755
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1343 1
Chlamydia trachomatis pyruvate kinase 0.0066 0.0749 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0089 0.0146
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.019 0.2504 0.3101
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.019 0.2504 1
Toxoplasma gondii ubiquinol-cytochrome c reductase 0.005 0.0523 0.3706
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0662 0.0772
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0227 0.0494
Echinococcus multilocularis expressed protein 0.0017 0.0051 0.0078
Echinococcus multilocularis lamin dm0 0.0028 0.0216 0.0374
Echinococcus multilocularis ferritin 0.0017 0.0051 0.0078
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0216 0.0246
Toxoplasma gondii pyruvate kinase PyK1 0.0066 0.0749 0.6148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0452 0.0727
Schistosoma mansoni hypothetical protein 0.0407 0.557 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1343 0.1533
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0181 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0318 0.0317
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0749 0.0854
Onchocerca volvulus 0.0093 0.113 0.1129
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1343 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0066 0.0749 0.2845
Loa Loa (eye worm) glutaminase 2 0.0288 0.3891 0.444
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0662 0.0772
Mycobacterium ulcerans glutaminase 0.0288 0.3891 0.4855
Trypanosoma brucei glucosidase, putative 0.0036 0.0318 0.2363
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0318 0.2363
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.1105 0.1972
Leishmania major pyruvate kinase 0.0066 0.0749 0.5571
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.0874 0.6505
Schistosoma mansoni pyruvate kinase 0.0066 0.0749 0.1264
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0662 0.5204
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0181 0.1338
Echinococcus granulosus expressed protein 0.0017 0.0051 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.1105 0.1909
Plasmodium falciparum pyruvate kinase 0.0066 0.0749 0.8404
Mycobacterium tuberculosis Probable oxidoreductase 0.019 0.2504 0.3101
Schistosoma mansoni lamin 0.0028 0.0216 0.0298
Loa Loa (eye worm) pyruvate kinase 0.0014 0.001 0.0012
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0181 0.0164
Schistosoma mansoni loxhd1 0.0019 0.0089 0.0068
Brugia malayi phosphofructokinase 0.0108 0.1343 0.1531
Leishmania major trypanothione reductase 0.0075 0.0874 0.6505
Trichomonas vaginalis ferritin, putative 0.0017 0.0051 0.005
Giardia lamblia Pyruvate kinase 0.0034 0.0293 0.1982
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0101
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0227 0.0804
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1343 1
Onchocerca volvulus 0.0019 0.0089 0.0087
Schistosoma mansoni cpg binding protein 0.003 0.024 0.0343
Echinococcus granulosus dnaJ subfamily B 0.0407 0.557 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0318 0.0362
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.001 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0075 0.0874 0.1041
Schistosoma mansoni lipoxygenase 0.0019 0.0089 0.0068
Loa Loa (eye worm) hypothetical protein 0.0091 0.1105 0.126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0208 0.0238
Mycobacterium tuberculosis Probable reductase 0.0171 0.2233 0.2759
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0089 0.0146
Echinococcus granulosus Ubiquinol cytochrome c reductase complex 14 kDa 0.0218 0.29 0.5199
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Brugia malayi pyruvate kinase 0.0014 0.001 0.001
Loa Loa (eye worm) glutaminase 0.0288 0.3891 0.444
Echinococcus multilocularis pyruvate kinase 0.0066 0.0749 0.1333
Echinococcus multilocularis pyruvate kinase 0.0034 0.0293 0.0514
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0008
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1343 0.1634
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0181 0.1338
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.0749 0.0748
Brugia malayi glutathione reductase 0.0075 0.0874 0.0996
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1343 1
Leishmania major pyruvate kinase 0.0066 0.0749 0.5571
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.209 0.3743
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.1049 0.1872
Onchocerca volvulus 0.0029 0.0217 0.0216
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0181 0.0312
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0227 0.0804
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0089 0.0146
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0585 0.1038
Schistosoma mansoni pyruvate kinase 0.0066 0.0749 0.1264
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0227 0.1357
Loa Loa (eye worm) hypothetical protein 0.0028 0.0216 0.0246
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0181 0.0164
Mycobacterium tuberculosis Probable dehydrogenase 0.0171 0.2233 0.2759
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0181 0.1338
Loa Loa (eye worm) glutathione reductase 0.0075 0.0874 0.0997
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0171 0.2233 0.2759
Plasmodium vivax thioredoxin reductase, putative 0.0075 0.0874 0.7732
Onchocerca volvulus Huntingtin homolog 0.025 0.3353 0.3352
Loa Loa (eye worm) pyruvate kinase 0.0066 0.0749 0.0854
Plasmodium falciparum cytochrome b-c1 complex subunit 7, putative 0.005 0.0523 0.5532
Schistosoma mansoni alpha-glucosidase 0.0139 0.1773 0.3119
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0318 0.0317
Echinococcus granulosus pyruvate kinase 0.0034 0.0293 0.0514
Trypanosoma brucei pyruvate kinase 1, putative 0.0066 0.0749 0.5571
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0227 0.0225
Schistosoma mansoni cpg binding protein 0.003 0.024 0.0343
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0089 0.0146
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0318 0.2363
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0626 0.4821
Echinococcus multilocularis RUN 0.0019 0.0089 0.0146
Plasmodium falciparum thioredoxin reductase 0.0026 0.0181 0.1173
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0089 0.0101
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0227 0.0804
Loa Loa (eye worm) hypothetical protein 0.0046 0.0466 0.0531

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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