Detailed view for TVAG_044570

Basic information

TDR Targets ID: 844905
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 8.0913 | Length (AA): 443 | MW (Da): 48230 | Paralog Number: 13

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 10

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127815)

Species Accession Gene Product
Brugia malayi Bm1_07820   hypothetical protein
Caenorhabditis elegans CELE_F47B8.10   Protein F47B8.10
Chlamydia trachomatis CT_544   hexose phosphate transporter
Escherichia coli b2240   sn-glycerol-3-phosphate transporter
Escherichia coli b3667   membrane protein regulates uhpT expression
Giardia lamblia GL50803_9046   Sugar transport family protein
Homo sapiens ENSG00000137700   solute carrier family 37 (glucose-6-phosphate transporter), member 4
Mus musculus ENSMUSG00000032114   solute carrier family 37 (glucose-6-phosphate transporter), member 4
Mycobacterium tuberculosis Rv2994   Probable conserved integral membrane protein
Trichomonas vaginalis TVAG_042080   conserved hypothetical protein
Trichomonas vaginalis TVAG_388090   Hexuronate transporter, putative
Trichomonas vaginalis TVAG_044570   conserved hypothetical protein
Trichomonas vaginalis TVAG_097060   conserved hypothetical protein
Trichomonas vaginalis TVAG_329390   glucarate, hexuronate transporter, putative
Trichomonas vaginalis TVAG_147030   conserved hypothetical protein
Trichomonas vaginalis TVAG_253110   glucose-6-phosphate translocase, putative
Trichomonas vaginalis TVAG_240690   Regulatory protein uhpC, putative
Trichomonas vaginalis TVAG_458560   conserved hypothetical protein
Trichomonas vaginalis TVAG_241870   glucarate, hexuronate transporter, putative
Trichomonas vaginalis TVAG_250860   Regulatory protein uhpC, putative
Trichomonas vaginalis TVAG_283750   conserved hypothetical protein
Trichomonas vaginalis TVAG_308970   transport proetin, putative
Trichomonas vaginalis TVAG_229820   conserved hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0004   major facilitator superfamily permease

Essentiality

TVAG_044570 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3044 Mycobacterium tuberculosis non-essential nmpdr
b2240 Escherichia coli non-essential goodall
b3667 Escherichia coli non-essential goodall
CELE_F47B8.10 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens solute carrier family 37 (glucose-6-phosphate transporter), member 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0106 1 0.5
0.004 1 0.5
0.0061 0.8617 0.5
0.0141 0.5229 0.5222
0.0072 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_044570 (Trichomonas vaginalis), conserved hypothetical protein
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